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Effect of Jinlong capsule on proliferation and apoptosis of human pancreatic cancer cells BxPC-3

Journal of Traditional Chinese Medicine 2013年第2期33卷 205-210页

作者： Yaoyuan Li Jieqing Hu Hui Huang yonghe he Department of Oncology Guang'an men Hospital Affiliated to China Academy of Chinese Medical Sciences Department of Traditional Chinese Medicine Fengtai District Community Health Center Jiansheng Pharmaceutical Co. Ltd.

OBJECTIVE:To study the possible roles of Jinlong capsule(JLC) on the proliferation and apoptosis of human pancreatic cancer cells ***:The human pancreatic cancer cells BxPC-3 were treated with JLC at the concentration of 0.05-1.00 mg/mL for 24-120 *** inhibition rate of JLC on human pancreatic cancer cells BxPC-3 was detected by 3-(4,5-dimethiylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT) *** cytometry was employed to measure cell apoptosis using Annexin V-FITC/Propidium iodide(AV-FITC/PI) *** cycles were determined by PI *** expression of S100 Calcium binding protein A4(S100A4) in cell matrix was measured by enzyme-linked immunosorbent assay(ELISA).The expression levels of apoptosis-related protein such as BCL2/adenovirus E1B 19 kDa interacting protein 3(BNIP3),B-cell lymphoma/leukemia-2(Bcl-2) and Cys-teinylaspartate specific proteinase 3(Caspase-3) were detected byWestern ***:JLC significantly inhibited the proliferation of human pancreatic cancer cells BxPC-3 in a dose-dependent and time-dependent *** promoted cell apoptosis and maintained cell cycle in S and G 2 /M phase rather than G 1 /G 0 *** expression of S100A4 in the cell matrix was *** expression of cell apoptotic protein BNIP3 was increased while Bcl-2 was ***:JLC can inhibit the proliferation of human pancreatic cancer cells BxPC-3 by stimulating cell apoptosis,arresting the cell cycle at S and G 2 /M phase which blocks the circulation of normal cell cycle and reducing the expression of S100A4 *** pro-apoptosis protein BNIP3 and lower anti-apoptosis protein Bcl-2 levels were found,which may be related to the apoptotic effects of JLC.

关键词： Pancreatic neoplasms Cell prolifera-tion Apoptosis Jinlong capsule

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Guidance strategy of motion camouflage for spacecraft pursuit-evasion game

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Chinese Journal of Aeronautics 2024年第3期37卷 312-319页

作者： Jianqing LI Chaoyong LI yonghe ZHANG Space Information Research Institute Hangzhou Dianzi UniversityHangzhou 310018China College of Electrical Engineering Zhejiang UniversityHangzhou 310027China Key Lab of Microsatellites Chinese Academy of SciencesShanghai 201210China

This work is inspired by a stealth pursuit behavior called motion camouflage whereby a pursuer approaches an evader while the pursuer camouflages itself against a predetermined *** formulate the spacecraft pursuit-evasion problem as a stealth pursuit strategy of motion camouflage,in which the pursuer tries to minimize a motion camouflage index defined in this *** Euler-Hill reference frame whose origin is set on the circular reference orbit is used to describe the *** on the rule of motion camouflage,a guidance strategy in open-loop form to achieve motion camouflage index is derived in which the pursuer lies on the camouflage constraint line connecting the central spacecraft and *** order to dispose of the dependence on the evader acceleration in the open-loop guidance strategy,we further consider the motion camouflage pursuit problem within an infinite-horizon nonlinear quadratic differential *** saddle point solution to the game is derived by using the state-dependent Riccati equation method,and the resulting closed-loop guidance strategy is effective in achieving motion *** are performed to demonstrate the capabilities of the proposed guidance strategies for the pursuit–evasion game scenario.

关键词： Pursuit-evasion problem Motion camouflage Differential game Guidance strategy Orbit control

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恶性肿瘤络病论

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北京中医药大学学报 2005年第5期28卷 75-77页

作者：贺用和中国中医研究院广安门医院北京100053

恶性肿瘤是临床常见疾病,其发病率与死亡率逐年上升,成为导致人类死亡的主要疾病之一.古今中医学者从不同角度对肿瘤的病因病机、治则用药进行了深入的研究.叶天士提出积"著而不移,是为阴邪聚络",认为肿瘤乃痰浊、瘀血等有形之阴邪凝聚... 详细信息

恶性肿瘤是临床常见疾病,其发病率与死亡率逐年上升,成为导致人类死亡的主要疾病之一.古今中医学者从不同角度对肿瘤的病因病机、治则用药进行了深入的研究.叶天士提出积"著而不移,是为阴邪聚络",认为肿瘤乃痰浊、瘀血等有形之阴邪凝聚于络脉而成,提出了肿瘤的络病论.……

关键词：恶性肿瘤络病病机治则

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Numerical simulation of flow field deposition and erosion characteristics around bridge-road transition section

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Journal of Mountain Science 2024年第5期21卷 1491-1508页

作者： ZHANG Kai WANG Zhenghui WANG Tao TIAN Jianjin ZHANG Hailong LIU yonghe College of Civil Engineering Lanzhou Jiaotong UniversityLanzhou 730000China Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Wind-sand flow generates erosion and deposition around obstacles such as bridges and roadbeds, resulting in sand damage and endangering railway systems in sandy regions. Previous studies have mainly focused on the flow field around roadbeds, overlooking detailed examinations of sand particle erosion and deposition patterns near bridges and roadbeds. This study employs numerical simulations to analyze the influence of varying heights and wind speeds on sand deposition and erosion characteristics at different locations: the bridge-road transition section(side piers), middle piers, and roadbeds. The results show that the side piers, experience greater accumulation than the middle piers. Similarly, the leeward side of the roadbed witnesses more deposition compared to the windward side. Another finding reveals a reduced sand deposition length as the vertical profile, in alignment with the wind direction, moves further from the bridge abutments at the same clearance height. As wind speeds rise, there’s a decline in sand deposition and a marked increase in erosion around the side piers, middle piers and roadbeds. In conclusion, a bridge clearance that’s too low can cause intense sand damage near the side piers, while an extremely high roadbed may lead to extensive surface sand deposition. hence, railway bridges in areas prone to sandy winds should strike a balance in clearance height. This research provides valuable guidelines for determining the most suitable bridge and roadbed heights in regions affected by wind and sand.

关键词： Sandstorm Flow field Bridge-road transition section Sedimentation erosion Numerical simulation

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风药抗肿瘤的研究进展

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中国中药杂志 2011年第23期36卷 3375-3379页

作者：李要远萧百圆贺用和北京中医药大学研究生院北京100029 中国中医科学院广安门医院肿瘤科北京100053

中医对肿瘤的研究已形成了扶正培本、清热解毒及活血化瘀等几大流派,并且在实验室研究及临床研究中都取得了一定的成绩。而"风药抗肿瘤理论"从一个全新视角阐述中药抗肿瘤作用。本文对近年来有关风药抗肿瘤的相关研究作一综合分析,总结... 详细信息

中医对肿瘤的研究已形成了扶正培本、清热解毒及活血化瘀等几大流派,并且在实验室研究及临床研究中都取得了一定的成绩。而"风药抗肿瘤理论"从一个全新视角阐述中药抗肿瘤作用。本文对近年来有关风药抗肿瘤的相关研究作一综合分析,总结风药抗肿瘤作用机制及优势,并且提出目前风药抗肿瘤研究中存在的问题。

关键词：风药抗肿瘤综述

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The Magnaporthe oryzae effector Avr-PikD suppresses rice immunity by inhibiting an LSD1-like transcriptional activator

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The Crop Journal 2024年第2期12卷 482-492页

作者： Jiayuan Guo Yiling Wu Jianqiang Huang Kaihui Yu Meilian Chen Yijuan Han Zhenhui Zhong Guodong Lu yonghe Hong Zonghua Wang Xiaofeng Chen Fujian Universities Engineering Research Center of Marine Biology and Drugs Fuzhou Institute of OceanographyCollege of Geography and OceanographyMinjiang UniversityFuzhou 350108FujianChina Rice Research Institute Fujian Academy of Agricultural SciencesFuzhou 350018FujianChina Ministerial and Provincial Joint Innovation Center for Safety Production of Cross-Strait Crops Minjiang UniversityFuzhou 350108FujianChina State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops College of Plant ProtectionFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina

Avirulence effectors(Avrs),encoded by plant pathogens,can be recognized by plants harboring the corresponding resistance proteins,thereby initiating effector-triggered immunity(ETI).In susceptible plants,however,Avrs can function as effectors,facilitating infection via effector-triggered susceptibility(ETS).Mechanisms of Avr-mediated ETS remain largely *** we report that the Magnaporthe oryzae effector Avr-PikD enters rice cells via the canonical cytoplasmic secretion pathway and suppresses rice basal ***-PikD interacts with an LSD1-like transcriptional activator AKIP30 of rice,and AKIP30 is also a positive regulator of rice immunity,whereas Avr-PikD impedes its nuclear localization and suppresses its transcriptional *** summary,*** delivers Avr-PikD into rice cells to facilitate ETS by inhibiting AKIP30-mediated transcriptional regulation of immune response against ***.

关键词： Magnaporthe oryzae Avirulence effector Avr-PikD Effector-triggered susceptibility Rice immunity Transcriptional activator

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长三角地区城市密度对碳排放绩效的影响效应与机制

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生态学报 2024年第10期44卷 4092-4104页

作者：陈飞徐鹤李永贺上海应用技术大学城市建设与安全工程学院上海201418

城市密度是衡量城市各要素空间集聚程度的表征也是调控城市各要素资源分配效率的重要手段。过往主要围绕城市密度的物质形态测度来研究城市空间资源利用与环境问题,少有立足碳排放绩效的视角来研究城市密度的演变逻辑。立足生态效益中... 详细信息

城市密度是衡量城市各要素空间集聚程度的表征也是调控城市各要素资源分配效率的重要手段。过往主要围绕城市密度的物质形态测度来研究城市空间资源利用与环境问题,少有立足碳排放绩效的视角来研究城市密度的演变逻辑。立足生态效益中自然资源投入最小化与获得价值最大化的观点,从经济、社会、环境三个维度构建碳排放绩效综合评价指标,以长三角41个城市为例,基于标准差椭圆分析城市密度与碳排放绩效的时空演变及关联特征,采用地理加权回归模型与地理探测器相结合的方法,确定城市密度对碳排放绩效的影响效应及机制。结果表明:(1)城市密度与碳排放绩效均升高,城市密度增速减慢,而碳排放绩效增速加快;二者均呈东南—西北向发展且关联性不断增强。(2)城市密度分指标对碳排放绩效的影响效应存在时空差异,东南部多数城市各分指标影响系数增大且作用方向不变;西北部人口密度负向影响显著增强,经济密度的影响由负转正,而空间密度的影响由正转负。(3)城市密度与其他经济社会因素交互后对碳排放绩效产生影响,其中经济密度与产业结构协同作用对碳排放绩效的影响最大,且与因子独立作用相比,人口密度与其他影响因素的交互效应增幅最大。理清城市密度对碳排放绩效的影响效应及机制,可以为城市空间结构的合理优化提供依据。

关键词：碳排放绩效城市密度影响效应交互作用

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A review on DFACS(I):System design and dynamics modeling

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Chinese Journal of Aeronautics 2024年第5期37卷 92-119页

作者： Bohan JIAO Qifan LIU Zhaohui DANG Xiaokui YUE yonghe ZHANG Yuanqing XIA Li DUAN Qinglei HU Chenglei YUE Pengcheng WANG Ming GUO Zhansheng DUAN Bing CUI Chu ZHANG Xiaodong SHAO School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 710699China School of Automation Beijing Institute of TechnologyBeijing 100081China Institute of Mechanics Chinese Academy of SciencesBeijing 710043China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Automation Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

The Drag-Free and Attitude Control System(DFACS)is a critical platform for various space missions,including high precision satellite navigation,geoscience and gravity field measurement,and space scientific *** paper presents a comprehensive review of over sixty years of research on the design and dynamics model of ***,we examine the open literature on DFACS and its applications in Drag-Free missions,providing readers with necessary background information on the ***,we analyze the system configurations and main characteristics of different DFACSs,paying particular attention to the coupling mechanism between the system configuration and dynamics ***,we summarize the dynamics modeling methods and main dynamics models of DFACS from multiple perspectives,including common fundamentals and specific ***,we identify current challenges and technological difficulties in the system design and dynamics modeling of DFACS,while suggesting potential avenues for future *** paper aims to provide readers with a comprehensive understanding of the state-of-the-art in DFACS research,as well as the future prospects and challenges in this field.

关键词： Drag-Free DFACS System Design Dynamics Modeling Control design

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A review on DFACS(II):Modeling and analysis of disturbances and noises

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Chinese Journal of Aeronautics 2024年第5期37卷 120-147页

作者： Chenglei YUE Bohan JIAO Zhaohui DANG Xiaokui YUE yonghe ZHANG Yuanqing XIA Li DUAN Qinglei HU Qifan LIU Pengcheng WANG Ming GUO Zhansheng DUAN Bing CUI Chu ZHANG Xiaodong SHAO School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 710699China School of Automation Beijing Institute of TechnologyBeijing 100081China Institute of Mechanics Chinese Academy of SciencesBeijing 710043China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Automation Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

This paper presents Part II of a review on DFACS,which specifically focuses on the modeling and analysis of disturbances and noises in *** Part I,the system composition and dynamics model of the DFACS were *** this paper,we discuss the effects of disturbance forces and noises on the system,and summarize various analysis and modeling methods for these interferences,including the integral method,frequency domain analysis method,and magnitude evaluation *** analyzing the impact of disturbances and noises on the system,the paper also summarizes the system’s performance under slight ***,we highlight current research difficulties in the field of DFACS noise ***,this paper provides valuable insights into the modeling and analysis of disturbances and noises in DFACSs,and identifies key areas for future research.

关键词： Drag-free DFACS Disturbance Analysis Noise Analysis Frequency Domain Analysis Performance Evaluation

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甘麦大枣汤古今应用探究

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辽宁中医杂志 2015年第7期42卷 1292-1293页

作者：王亚杰杜建超贺用和中国中医科学院广安门医院北京100053

目的:探究甘麦大枣汤的临床疗效。方法:试将以叶天士为代表的古代医家及现代临床大家对《金匮要略》名方甘麦大枣汤的临证心得作一总结,归纳其在现代诸多疾病展开的大规模临床研究及现代实验研究的疗效。结果:甘麦大枣汤广泛应用于多种... 详细信息

目的:探究甘麦大枣汤的临床疗效。方法:试将以叶天士为代表的古代医家及现代临床大家对《金匮要略》名方甘麦大枣汤的临证心得作一总结,归纳其在现代诸多疾病展开的大规模临床研究及现代实验研究的疗效。结果:甘麦大枣汤广泛应用于多种身心疾病、儿科疾病、消化系统疾病、肿瘤等内科杂病中。结论:甘麦大枣汤为诸多疾病抑郁状态下的有效治疗方剂。

关键词：甘麦大枣汤古代医家近现代医家临床研究现代实验研究

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