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Suppression of laser-induced choroidal neovascularization by intravitreal injection of tristetraprolin

International Journal of Ophthalmology(English edition) 2014年第6期7卷 952-958页

作者： yong Wun Cho yong Seop Han In Young chung Seong Jae Kim Seong Wook Seo Ji Myong Yoo Jong Moon Park Department of Ophthalmology Gyeongsang National University School of Medicine Gyeongsang Institute of Health Science Gyeongsang National University

AIM: To examine the effect of intravitreal adenoviral vector-mediated tristetraprolin(Ad-TTP) on VEGF m RNA expression in a rat model of laser-induced choroidal ***: Ad-TTP was prepared using a commercial kit. Retinal laser-induced photocoagulation(10 spots per eye) was performed on rats in this experimental choroidal neovascularization(CNV) model. Rats were divided into four groups: control(single intravitreal injection of balanced salt solution, n =10), laser-induced CNV(photocoagulation only, n =20), laser-induced CNV plus Ad-TTP injection(photocoagulation plus a single intravitreal Ad-TTP injection, n =20) and Ad-TTP injection only(n =10). Changes in choroidal morphology were evaluated in ten rats in the laser only and the laser plus Ad-TTP groups. Two weeks after laser injury, the size of CNV was calculated by perfusion with high-molecular-weight fluorescein isothiocyanate(FITC)-dextran. VEGF m RNA expression in retina-choroid tissue from ten rats in each group was measured by reverse transcription polymerase chain reaction(RT-PCR). RESULTS: Two weeks after treatment, the area of laser-induced CNV was reduced by approximately 60% in the rats given the Ad-TTP injection compared with that in the laser-only group. There was a tendency toward decreased VEGF m RNA expression in the Ad-TTP injection ***: A single intravitreal injection of Ad-TTP significantly suppressed CNV size in this experimental laser-induced CNV model. Ad-TTP injection also decreased VEGF m RNA expression compared with that inthe laser-induced CNV group. The present study is meaningful as the first study to investigate the effect of tristetraprolin delivered via intravitreal injection.

关键词： laser-induced choroidal neovascularization tristetraprolin adenoviral vectors

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Insight into Reaction Mechanism of Sirtuins via Molecular Simulation and Density Functional Theory Study

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Chemical Research in Chinese Universities 2010年第5期26卷 833-837页

作者： ZHAO yong-shan HOU Rui-zhe ZHANG Hong-xing ZHENG Qing-chuan SUN Chia-chung State Key Laboratory of Theoretical and Computational Chemistry Institute of Theoretical Chemistry Norman Bethune College of Medicine Jilin University Changchun 130021 P. R. China School of Life Sciences ＆ Biopharmaceutical Sciences Shenyang Pharmaceutical University Shenyang 110016 P R. China

With density functional theory（DFT） and molecular mechanics method, the catalytic mechanism of silent information regulator（sirtuins） has been investigated. The calculations support the SN2-1ike reaction of the initial step of the catalysis, and are consistent with experiment results. We further explored the second step of the catalysis and proposed that this step took place in a concerted reaction. In addition, the side chain of Phenylalanine33 may help to shield the glycosidic bond from water and be in a position to protect the developing oxacabenium transition state from hydrolysis. Our results of the calculations support this hypothesis that the phenylalanine33 plays a critical role in the sirtuins biology function.

关键词： Sirtuin NAD^+ p53 Model Density functional theory

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Validity,Reliability,and Measurement Invariance of the Thai Smartphone Application-Based Addiction Scale and Bergen Social Media Addiction Scale

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International Journal of Mental Health Promotion 2024年第4期26卷 293-302页

作者： Kamolthip Ruckwongpatr Chirawat Paratthakonkun Usanut Sangtongdee Iqbal Pramukti Ira Nurmala Kanokwan Angkasith Weena Thanachaisakul Jatuphum Ketchatturat Mark DGriffiths Yi-Kai Kao chung-Ying Lin Institute of Allied Health Sciences College of MedicineNational Cheng Kung UniversityTainan701401Taiwan College of Sports Science and Technology Mahidol UniversityNakhon Pathom73170Thailand Department of Forensic Science Royal Police Cadet AcademyNakhon Pathom73110Thailand School of Computing Engineeringand Digital TechnologyTeesside UniversityMiddlesbroughUK Faculty of Nursing Universitas PadjadjaranWest Java45363Indonesia Division of Health Promotion and Behavioral Sciences Faculty of Public HealthUniversitas AirlanggaSurabaya60115Indonesia Faculty of Education Chiang Mai UniversityChiang Mai50200Thailand Faculty of Education Khon Kaen UniversityKhon Kaen40002Thailand International Gaming Research Unit Psychology DepartmentNottingham Trent UniversityNottinghamNG14FQUK Division of Colorectal Surgery E-DA HospitalKaohsiung82445Taiwan College of Medicine National Cheng Kung UniversityTainan701401Taiwan Biostatistics Consulting Center National Cheng Kung University HospitalTainan701401Taiwan

Background:In recent years,there has been increased research interest in both smartphone addiction and social media addiction as well as the development of psychometric instruments to assess these ***,there is a lack of psychometric evaluation for instruments assessing smartphone addiction and social media addiction in *** present study evaluated the psychometric properties and gender measurement invariance of the Thai version of the Smartphone Application-Based Addiction Scale(SABAS)and Bergen Social Media Addiction Scale(BSMAS).Method:A total of 801 Thai university students participated in an online survey from January 2022 to July 2022 which included demographic information,SABAS,BSMAS,and the Internet Gaming Disorder Scale-Short Form(IGDS9-SF).Results:Confirmatory Factor Analyses(CFAs)found that both the SABAS and BSMAS had a one-factor *** demonstrated adequate psychometric properties of both instruments and also supported measurement invariance across ***,scores on the SABAS and BSMAS were correlated with scores on the ***:The results indicated that the SABAS and BSMAS are useful psychometric instruments for assessing the risk of smartphone addiction and social media addiction among Thai young adults.

关键词： Factor analysis smartphone addiction social media addiction smartphone application-based addiction scale bergen social media addiction scale psychometric validation

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华人本土心理学与中国心理学自主知识体系建构——杨中芳教授专访

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苏州大学学报（教育科学版） 2024年第3期12卷 86-94页

作者：杨中芳韦庆旺北京大学人格与社会心理研究中心北京100871 中国人民大学心理学系北京100872

发端于中国台湾的华人本土心理学,旨在跳出西方心理学理论、方法及知识体系,“将华人当华人来研究”,最终建构基于中国文化/社会/历史背景的,贴合中国人的心理学知识体系。自20世纪80年代以来,亲历过美国社会心理学文化反思的杨中芳教... 详细信息

发端于中国台湾的华人本土心理学,旨在跳出西方心理学理论、方法及知识体系,“将华人当华人来研究”,最终建构基于中国文化/社会/历史背景的,贴合中国人的心理学知识体系。自20世纪80年代以来,亲历过美国社会心理学文化反思的杨中芳教授长期游走于海峡两岸和香港,在大陆心理学及社会心理学重建之初,即将华人本土心理学介绍给大陆心理学界,并通过培训人才和组建中山大学心理学系,对大陆心理学的发展产生了重要的推动作用。然而,40多年来,大陆的心理学仍然不可避免地经历了以学习西方为主的发展与繁荣,本土心理学的声势却相对微弱。直到最近,我国社会科学界兴起中国自主知识体系建构的大潮,围绕心理学及社会科学本土化的争论高潮迭起。杨中芳教授以其持续40多年的华人本土心理学探索经验,以及围绕中庸心理学所建构的中国文化视角下的心理学知识体系,对当下如何建构中国心理学自主知识体系提供了典范和宝贵的经验借鉴。

关键词：传统文化心理学本土化中庸思维华人本土心理学心理学自主知识体系

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Asymmetric optical camouflage:tuneable reflective colour accompanied by the optical Janus effect

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Light(Science & Applications) 2020年第1期9卷 325-334页

作者： Taehyun Kim Eui-Sang Yu Young-Gyu Bae Jongsu Lee In Soo Kim Seok chung Seung-Yeol Lee yong-Sang Ryu Sensor System Research Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Micro/Nano Systems Korea UniversitySeoul 02841Republic of Korea School of Electronic and Electrical Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Nanophotonics Research Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea School of Mechanical Engineering Korea UniversitySeoul 02841Republic of Korea

Going beyond an improved colour gamut,an asymmetric colour contrast,which depends on the viewing direction,and its ability to readily deliver information could create opportunities for a wide range of applications,such as nextgeneration optical switches,colour displays,and security features in anti-counterfeiting ***,we propose a simple Fabry–Perot etalon architecture capable of generating viewing-direction-sensitive colour contrasts and encrypting pre-inscribed information upon immersion in particular solvents(optical camouflage).Based on the experimental verification of the theoretical modelling,we have discovered a completely new and exotic optical phenomenon involving a tuneable colour switch for viewing-direction-dependent information delivery,which we define as asymmetric optical camouflage.

关键词： asymmetric generating readily

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Nuclear mass predictions based on a deep neural network and finite-range droplet model(2012)

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Chinese Physics C 2024年第2期48卷 112-123页

作者：姚道驄梁豪兆李曉菁 Department of Physics The University of Hong KongHong Kong 999077China Department of Physics Graduate School of ScienceThe University of TokyoTokyo 113-0033Japan Interdisciplinary Theoretical and Mathematical Sciences Program(iTHEMS) RIKENWako 351-0198Japan

A neural network with two hidden layers is developed for nuclear mass prediction,based on the finiterange droplet model(FRDM12).Different hyperparameters,including the number of hidden units,choice of activation functions,initializers,and learning rates,are adjusted explicitly and *** resulting mass predictions are achieved by averaging the predictions given by several different sets of hyperparameters with different regularizers and seed *** can provide not only the average values of mass predictions but also reliable estimations in the mass prediction *** overall root-mean-square deviations of nuclear mass are reduced from 0.603 MeV for the FRDM12 model to 0.200 MeV and 0.232 MeV for the training and validation sets,respectively.

关键词： nuclear mass machine learning deep neural network

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Friction characteristics of mechanically exfoliated and CVD-grown single-layer MoS_2

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Friction 2018年第4期6卷 395-406页

作者： Dinh Le Cao KY Bien-Cuong TRAN KHAC Chinh Tam LE yong Soo KIM Koo-Hyun chung School of Mechanical Engineering University of Ulsan Department of Physics and Energy Harvest Storage Research Center University of Ulsan

In this work, the friction characteristics of single-layer MoS2 prepared with chemical vapor deposition （CVD） at three different temperatures were quantitatively investigated and compared to those of single-layer MoS2 prepared using mechanical exfoliation. The surface and crystalline qualities of the MoS2 specimens were characterized using an optical microscope, atomic force microscope （AFM）, and Raman spectroscopy. The surfaces of the MoS2 specimens were generally flat and smooth. However, the Raman data showed that the crystalline qualities of CVD-grown single-layer MoS2 at 800 ℃ and 850 ℃ were relatively similar to those of mechanically exfoliated MoS2 whereas the crystalline quality of the CVD-grown single-layer MoS2 at 900 ℃ was lower. The CVD-grown single-layer MoS2 exhibited higher friction than mechanically exfoliated single-layer MoS2, which might be related to the crystalline imperfections in the CVD-grown MoS2. In addition, the friction of CVD-grown single-layer MoS2 increased as the CVD growth temperature increased. In terms of tribological properties, 800 ℃ was the optimal temperature for the CVD process used in this work. Furthermore, it was observed that the friction at the grain boundary was significantly larger than that at the grain, potentially due to defects at the grain boundary. This result indicates that the temperature used during CVD should be optimized considering the grain size to achieve low friction characteristics. The outcomes of this work will be useful for understanding the intrinsic friction characteristics of single-layer MoS2 and elucidating the feasibility of single-layer MoS2 as protective or lubricant layers for micro- and nano-devices.

关键词： atomic force microscope chemical vapor deposition grain boundary friction mechanical exfoliation MoS2

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致力保障個人资料私隱,促進大灣區之互聨互通

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中国法律（中英文版） 2024年第1期 66-68,152-154页

作者：鐘麗玲不详

自回歸祖國以来,香港地區在國家的大力支持下成功落實“一國兩制”,“一國兩制”原则爲香港地區長期的繁榮稳定及經濟體系提供制度上最佳的保障。

关键词：制度保障互通

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翼腭缝宏观解剖及其发育模式研究

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上海交通大学学报（医学版） 2024年第8期44卷 944-950页

作者：章文益郑美里谢羽番江凌勇上海交通大学医学院附属第九人民医院口腔颅颌面科·正颌正畸中心上海交通大学口腔医学院国家口腔医学中心国家口腔疾病临床医学研究中心上海市口腔医学重点实验室上海市口腔医学研究所中国医学科学院口腔颌面再生医学创新单元上海200011

目的·利用锥形束计算机断层扫描(cone-beam computed tomography,CBCT)技术分析中国人群中翼腭缝(pterygopalatine suture,PPS)的解剖及宏观形态特征,并初步探讨其发育模式及其与矫正上颌发育不足之间的关联。方法·纳入2023年7月—8... 详细信息

目的·利用锥形束计算机断层扫描(cone-beam computed tomography,CBCT)技术分析中国人群中翼腭缝(pterygopalatine suture,PPS)的解剖及宏观形态特征,并初步探讨其发育模式及其与矫正上颌发育不足之间的关联。方法·纳入2023年7月—8月在上海交通大学医学院附属第九人民医院拍摄的134例CBCT影像资料,根据年龄分为6组。以PPS标志点为依据,计算得出PPS整体的横向位置(transverse position of PPS,X_(PPS)),PPS整体的矢状向位置(sagittal position of PPS,Y_(PPS)),以及PPS的锥突嵌入角(insertion angle of PPS,IAP)、锥突嵌入宽度(insertion width of pyramidal process,IWP)和锥突嵌入深度(insertion depth of pyramidal process,IDP),并通过多平面观察确定翼上颌联合情况。采用回归分析评估各参数与年龄、性别的相关性,并通过两两比较确定参数变化的稳定年龄段。采用配对t检验及配对χ^(2)检验分析双侧参数的差异性。结果·Y_(PPS)、IDP与年龄无显著相关性,而X_(PPS)、IAP、IWP、翼上颌连接的发生率均与年龄呈显著正相关(P<0.01)。性别差异仅在X_(PPS)中显著,男性大于女性(P<0.01)。参数的年龄变化趋势分析表明:X_(PPS)在组1(6岁≤年龄<9岁)和组2 (9岁≤年龄<12岁)间差异显著(女性:P=0.006;男性:P=0.004);IAP在组2与组3 (12岁≤年龄<15岁)间差异显著(P=0.042),98.5%样本的IAP大于45°;IWP在组1与组3间差异显著(P=0.016);翼上颌联合情况在组1、2、3间差异显著(组1、2间P<0.001,组2、3间P=0.037,组1、3间P<0.001),成人发生率高于90%。各项指标双侧比较均未见统计学差异。结论·6岁以后Y_(PPS)及IDP未表现出明显改变,上颌骨与翼突趋于融合。PPS整体横向位置在12岁左右趋于稳定,而IAP及IWP持续增长,至15岁左右达到稳定且翼腭缝锥突嵌入翼切迹的方向偏向矢状向。

关键词：翼腭缝形态学生长发育上颌扩弓上颌前方牵引

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寒武系张夏组树形石中的钙化蓝细菌——以山东淄博峨庄镇后紫峪剖面为例

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沉积与特提斯地质 2024年第2期44卷 339-350页

作者：王璇梅朝佳李忠日中国地质大学地球科学学院湖北武汉430074 中国地质大学(北京)地球科学与资源学院北京100083 中国海洋石油国际有限公司海外技术支持中心北京100028 朝鲜国家科学院地质学研究所平壤3812100

山东淄博峨庄镇后紫峪剖面寒武系张夏组顶部发育树形石,根据宏观露头岩性变化所反映的沉积相特征,研究区张夏组层序可以划分为三个四级亚层序。随着微生物影响树形石的形成过程的证据不断丰富,广为接受的“CCM机制引发蓝细菌鞘钙化作用... 详细信息

山东淄博峨庄镇后紫峪剖面寒武系张夏组顶部发育树形石,根据宏观露头岩性变化所反映的沉积相特征,研究区张夏组层序可以划分为三个四级亚层序。随着微生物影响树形石的形成过程的证据不断丰富,广为接受的“CCM机制引发蓝细菌鞘钙化作用”的观点正不断受到挑战。本文通过野外勘探采样、室内薄片分析相结合的方式,镜下识别刻画树形石的组构,并与现代实例进行类比进而分析其成因机制。树形石的主要组构为暗色泥晶基质、亮晶方解石胶结物和碎屑颗粒,显微镜下显示,树形石内部发育钙化蓝细菌生物化石,包括附枝菌(Epiphyton)、基座菌(Hedstroemia)、肾形菌(Renalcis),还可见孢网菌(Bacinella)、石松藻(Lithocodium)状组构。通过对研究区树形石中多种类型钙化蓝细菌和钙化蓝细菌微生物膜钙化残余物质的研究,为树形石内钙化微生物多样性做出了较为翔实的补充,明确了树形石是附枝菌等蓝细菌主导的微生物膜或微生物席钙化作用的产物,其中胞外聚合物(EPS)在树形石的发育和矿物沉淀过程中起关键作用,为树形石的“微生物影响成因”提供了一个典型实例。

关键词：钙化蓝细菌树形石钙化作用后紫峪剖面山东

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