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Influence of HbA1c on short-term blood pressure variability in type 2 diabetic patients with diabetic nephropathy

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第11期14卷 1033-1040页

作者： Fang LIU Min WU Yan-huan FENG Hui ZHONG Tian-lei CUI You-qun HUANG Ya-ping LIANG yong-shu diao Li ZANG Ling LI Jing ZANG Hong-yu QIU Song-min HUANG Ping FU Division of Nephrology West China Hospital of Sichuan University

The aim of this study was to understand the characteristics of blood pressure （BP） variability in subjects with diabetic nephropathy （DN）, and identify the probable predictors affecting BP variability. Fifty-one chronic kidney disease （CKD）-hypertensive patients without diabetes （NDN group） and sixty type 2 diabetic patients with overt DN （DN group） were enrolled in this study. The values of short-term BP variability were obtained from 24 h ambulatory BP monitoring （ABPM）. Variance analysis or nonparametric analysis revealed that 24-h systolic BP variability and night- time systolic BP variability of the DN group were significantly higher than those of the NDN group [（12.23±3.66） vs. （10.74±3.83） mmHg, P〈0.05; （11.23±4.82） vs. （9.48±3.69） mmHg, P〈0.05]. Then the patients of the DN group were divided into two groups according to glycated hemoglobin （HbAlc） level： Group A （HbA1c〈7%） and Group B （HbA1c〉7%）, and the t-test showed that patients in Group B had larger 24-h diastolic, daytime diastolic, and nighttime systolic/diastolic BP variability compared with Group A. In the DN group, partial correlation analysis revealed that HbAlc exhibited a strong association with 24-h diastolic, daytime diastolic, nighttime systolic and diastolic BP vari- ability （P〈0.001, P〈0.001, P〈0.05, and P〈0.001, respectively）. Taken together, larger short-term BP variability was detected in hypertensive type 2 diabetic patients with overt nephropathy and renal insufficiency. It may imply that the optimal BP variability level could benefit from a better glycaemic control.

关键词： Short-term blood pressure variability Diabetic nephropathy Glycated hemoglobin (HbAlc) Hypertension Glycaemic control

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Efficacy of exercises in improving the quality of life for chronic kidney disease patients without dialysis

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Chinese Medical Journal 2020年第14期133卷 1738-1740页

作者： Deng-Yan Ma Chong-Cheng Chen yong-shu diao Kun Yang Yi Li Steve Salerno Ping Fu Department of Nephrology/West China School of Nursing West China HospitalSichuan UniversityChengduSichuan 610041China Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Biostatistics University of MichiganAnn ArborMI 48109USA

To the Editor:Chronic kidney disease(CKD)is rapidly becoming a major public disease burden,affecting approximately 11%to 13%of the general population.[1]Its related treatments severely influence the physical,psychological,and social well-being of patients by restricting their daily *** has been shown that exercise may have multiple benefits for patients with CKD in terms of improving their physical activity,enhancing cardio-respiratory function,and promoting quality of life(QoL).

关键词： patients dialysis kidney

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Charlson comorbidity index helps predict the risk of mortality for patients with type 2 diabetic nephropathy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第1期15卷 58-66页

作者： You-qun HUANG Rong GOU yong-shu diao Qing-hua YIN Wen-xing FAN Ya-ping LIANG Yi CHEN Min WU Li ZANG Ling LI Jing ZANG Lu CHENG Ping FU Fang LIU Division of Nephrology West China Hospital of Sichuan University Chengdu 610041 China

Our intent is to examine the predictive role of Charlson comorbidity index （CCI） on mortality of patients with type 2 diabetic nephropathy （DN）. Based on the CCI score, the severity of comorbidity was categorized into three grades： mild, with CCI scores of 1-2; moderate, with CCI scores of 3-4; and severe, with CCI scores 〉5. Factors influencing mortality and differences between groups stratified by CCI were determined by logistical regression analysis and one-way analysis of variance （ANOVA）. The impact of CCI on mortality was assessed by the Kaplan- Meier analysis. A total of 533 patients with type 2 DN were enrolled in this study, all of them had comorbidity （CCI score 〉1）, and 44.7% （238/533） died. The mortality increased with CCI scores： 21.0% （50/238） patients with CCI scores of 1-2, 56.7% （135/238） patients with CCI scores of 3-4, and 22.3% （53/238） patients with CCI scores 〉5. Logistical regression analysis showed that CCI scores, hemoglobin, and serum albumin were the potential predictors of mortality （P〈0.05）. One-way ANOVA analysis showed that DN patients with higher CCI scores had lower levels of hemoglobulin, higher levels of serum creatinine, and higher mortality rates than those with lower CCI scores. The Kaplan-Meier curves showed that survival time decreased when the CCI scores and mortality rates went up. In con- clusion, CCI provides a simple, readily applicable, and valid method for classifying comorbidities and predicting the mortality of type 2 DN. An increased awareness of the potential comorbidities in type 2 DN patients may provide insights into this complicated disease and improve the outcomes by identifying and treating patients earlier and more effectively.

关键词： Diabetic nephropathy (DN) Charlson comorbidity index (CCI) Mortality

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Two-level consensus modeling with utility and cost constraints

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Journal of Systems Engineering and Electronics 2022年第3期33卷 716-726页

作者： diao Weixue LIU yong School of Business Jiangnan UniversityWuxi 214122China

There exist many two-level group consensus problems with different psychological behaviors of decision *** deal with these group consensus problems and reach a stable consensus,based on the principles and methods of grey system,utility theory and group consensus,we use grey utility function to describe and reflect decision makers’opinion preferences in different subgroups and different levels,and then we construct a two-level group consensus method with a moderator,and exploit it to solve the negotiation problems of the natural gas subsidy.

关键词： two-level group consensus group negotiation uti-lity function natural gas subsidy

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Preoperative albumin-bilirubin score predicts short-term outcomes and long-term prognosis in colorectal cancer patients undergoing radical surgery

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2096-2105页

作者： Yu-Hang diao Xin-Peng shu Can Tan Li-Juan Wang yong Cheng Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND The albumin-bilirubin(ALBI)score is a serum biochemical indicator of liver function and has been proven to have prognostic value in a variety of *** colorectal cancer(CRC),a high ALBI score tends to be associated with poorer *** To investigate the correlation between the preoperative ALBI score and outcomes in CRC patients who underwent radical *** Patients who underwent radical CRC surgery between January 2011 and January 2020 at a single clinical center were *** ALBI score was calculated by the formula(log10 bilirubin×0.66)+(albumin×-0.085),and the cutoff value for grouping patients *** short-term outcomes,overall survival(OS),and disease-free survival(DFS)were *** A total of 4025 CRC patients who underwent radical surgery were enrolled in this study,and there were 1908 patients in the low ALBI group and 2117 patients in the high ALBI *** regression analysis revealed that age,tumor size,tumor stage,ALBI score,and overall complications were independent risk factors for OS;age,tumor stage,ALBI score,and overall complications were identified as independent risk factors for *** A high preoperative ALBI score is correlated with adverse short-term outcomes,and the ALBI score is an independent risk factor for OS and DFS in patients with CRC undergoing radical surgery.

关键词： Colorectal cancer Albumin-bilirubin score Overall survival Disease-free survival Outcomes

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A multi-component nanocrystalline FeCrV alloy with improved mechanical properties and excellent irradiation resistance

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Progress in Natural Science:Materials International 2022年第4期32卷 433-442页

作者： Tingting Li Sizhe diao Pingping Liu yong Zhang Qian Zhan School of Materials Science and Engineering University of Science and Technology Beijing Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing

An equiatomic low-activated Fe Cr V ternary alloy was prepared by mechanical alloying and spark plasma sintering. The BCC solid solution alloy exhibited an excellent strength-ductility synergy properties, which was 1.85GPa compressive yield strength, 3.04 GPa fracture strength and more than 28% plasticity at room *** at an elevated temperature of 600°C, its yield strength was still more than 1 GPa, revealing a pronounced high temperature resistance. The Fe Cr V alloy had a homogeneous microstructure with high-density dislocations.A nanocrystalline characteristic was demonstrated and the average grain size was about 322 nm, leading to the improved mechanical properties. The strengthening mechanism was discussed in detail and the contributions of strengthening factors were calculated. The Fe Cr V alloy was irradiated up to 160 dpa with 2 Me V Au2+ions at 573K. The nanoindentation test was carried out to simply evaluate the hardening degree under such a high dose irradiation with heavy ions. The semi-quantitative analysis results show that Fe Cr V alloy has an excellent irradiation tolerance compared with pure Fe.

关键词： Mechanical properties Nanocrystalline Strengthening mechanism Au2+ irradiation Multi-component alloy Mechanical alloying

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Bending fatigue behavior of thin Zr_(61)Ti_(2)Cu_(25)Al_(12)bulk metallic glass beams for compliant mechanisms application

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Journal of Materials Science & Technology 2021年第30期89卷 1-15页

作者： diao-Feng Li Ya-Long Yang yong Shen Jian Xu Institute of Metal Research Chinese Academy of SciencesShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China

In this work,bending fatigue behavior of thinner Zr_(61)Ti_(2)Cu_(25)Al_(12)(ZT1)BMG beams with thicknesses of 500μm and 100μm were investigated with three-point bending(3PB),to evaluate the reliability and safety of this potentially material used in compliant mechanisms under cyclic bending *** endurance limits(FELs)of ZT1 beams with thicknesses of 500μm and 100μm were determined to be 470 MPa,and~0.3 of its tensile *** life and FEL of ZT1 beams in bending are substantially independent of the beam thickness,in the scale from 500μm down to 100μ*** cracks of all ZT1 beams initiated at the extrinsic microvoids,either indirectly derived from surface scratches during mechanical polishing or originated from as-cast ***,fatigue crack propagation behavior is highly related to the magnitude of cyclic stress *** interrupted fatigue tests,larger proportion about 60-70%of fatigue life was spent on crack propagation under high stress level,while crack initiation occupied larger proportion about 80-85%under low stress *** medium stress level of about 590 MPa almost shared the crack-initiation life and crack-propagation *** addition,there are two crack deflection mechanisms during cracks steady propagation *** mechanism is crack deflection along the interacted shear bands ahead of crack-tip,the other one is crack"jump"from one shear band to another shear band at a certain *** two mechanisms alternate dominate the crack propagation process,generating typical staircase-like crack propagation *** endurance limits of ZT1 beams in the form of either stress amplitude or strain amplitude are superior to traditional candidate materials in the field of compliant mechanisms,showing that the better reliability and larger deflection deformation can be achieved for flexible members made by ZT1 BMG even under cyclic loading.

关键词： Metallic glasses Bending fatigue Crack initiation Crack propagation Compliant mechanisms

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Static slip model of the M_w 9.0 Tohoku (Japan) earthquake:Results from joint inversion of terrestrial GPS data and seafloor GPS/acoustic data

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Chinese Science Bulletin 2012年第16期57卷 1990-1997页

作者： diao FaQi XIONG Xiong ZHENG yong State Key Laboratory of Geodesy and Earth's Dyanmics Institute of Geodesy and GeophysicsChinese Academy of SciencesWuhan 430077China

Based on co-seismic displacements recorded by terrestrial GPS stations and seafloor GPS/acoustic stations, the static slip model of the 2011 Mw 9.0 Tohoku earthquake was determined by inverting the data using a layered earth model. According to a priori information, the rupture surface was modeled with a geometry that is close to the actual rupture, in which the fault dip angle increases with depth and the fault strike varies with the trend of the trench. As shown by the results inferred from the joint inversion, the "geodetic" moment is 3.68 × 10 22 Nm, corresponding to Mw 9.01, and the maximum slip is positioned at a depth of 13.5 km with a slip magnitude of 45.8 m. Rupture asperities with slip exceeding 10 m are mainly distributed from 39.6 to 36.97°N, over a length of almost 240 km along the trench. The slip was mostly concentrated at depths shallower than 40 km, up-dip of the hypocenter. "Checkerboard" tests reveal that a joint inversion of multiple datasets can resolve the slip distribution better than an inversion with terrestrial GPS data only-especially when aiming to resolve slip at shallow depths. Thus, the joint inversion results obtained by this work may provide a more reliable slip model than the results of other studies that are only derived from terrestrial GPS data or seismic waveform data.

关键词： GPS数据联合反演滑移模型地震位移地面海底静态东北

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The Rapidly Changing Arctic and Its Impact on Global Climate

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Journal of Ocean University of China 2019年第3期18卷 537-541页

作者： ZHAO Jinping ZHONG Wenli diao Yina CAO yong College of Oceanic and Atmospheric Sciences Ocean University of China Qingdao 266100 China Key Laboratory of Physical Oceanography Ocean University of China Qingdao 266100 China

Arctic sea ice has significant seasonal variability. Prior to the 2000 s, it retreated about 15% in summer and fully recovered in winter. However, by the year 2007, Arctic sea ice extent experienced a catastrophic decline to about 4.28×10^6 km^2, which was 50% lower than conditions in the 1950 s to the 1970 s(Serreze et al., 2008). That was a record low over the course of the modern satellite record, since 1979(note that the year 2012 became the new record low). This astonishing event drew wide-ranging attention in 2007-2009 during the 4 th International Polar Year. The dramatic decline of sea ice attracts many scientists’ interest and has become the focus of intense research since then. Currently, sea ice retreat is not only appearing around the marginal ice zone, but also in the pack ice inside the central Arctic(Zhao et al., 2018). In fact, premonitory signs had already been seen through other evidence. Before the disintegration of the Soviet Union, US naval submarines had been conducting an extensive survey under the sea ice and taking measurements of sea ice thickness. Their measurements revealed a gradual decrease of ice thickness to 1.8 m during winter by the end of the 20 th century, in contrast to the climatological mean of 3.1 m(Rothrock et al., 1999). However, this alarming result did not draw much attention since the Arctic was still severely cold at that time.

关键词： Arctic Ocean climate change sea ice retreat freshwater accumulation Arctic amplification global impacts

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Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of randomized controlled trials

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Journal of Integrative Medicine 2024年第2期22卷 126-136页

作者： Zhen-yu Ma shu-ping Yang Ying Li Tian-tian Xu Ya-lin Yang Hui-yong Yang Heng-bing Li Le-jin Zhou yong diao Su-yun Li School of Medicine Huaqiao UniversityQuanzhou 362021Fujian ProvinceChina College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355Shandong ProvinceChina Second Clinical Medical College Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

Background:Red yeast rice(RYR),a natural lipid-lowering agent,is widely used in clinical ***,the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results,and the credibility of the evidence has not been ***:This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health *** strategy:Seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,“red yeast rice,”“Xuezhikang,”and“Zhibitai”).Inclusion criteria:Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this *** extraction and analysis:Two researchers independently extracted data using a standardized data collection table;any disagreements were resolved by consulting a third *** on the participant,intervention,comparator and outcome(PICO)framework in each eligible meta-analysis,a series of unique associations between the use of RYR preparations and adverse health outcomes were *** associations’effect estimates were re-evaluated using random-effect ***:Fifteen meta-analyses,comprising 186(164 unique)randomized controlled trials,were *** on A Mea Surement Tool to Assess Systematic Reviews version 2,3(20%)and 12(80%)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible *** on the random-effect models,10(16.4%)associations indicated a significant protective effect of RYR preparations against adverse health outcomes,while 5(8.2%)indicated an increased risk of adverse health outcomes related to uric acid,alanine transaminase and aspartate trans

关键词： Red yeast rice Safety Adverse health outcomes Umbrella review Meta-analysis Systematic review

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