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Emerging role of molecular diagnosis and personalized therapy for hepatocellular carcinoma

iLIVER 2024年第1期3卷 38-44页

作者： Ming-Da Wang yong-kang diao Lan-Qing Yao Zhong-Qi Fan Ke-Chun Wang Han Wu Li-Hui Gu Jia-Hao Xu Chao Li Guo-Yue Lv Tian Yang Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University(Navy Medical University)Shanghai 200438China Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterFirst Hospital of Jilin UniversityChangchun 130021China

Hepatocellular carcinoma(HCC)is a prevalent malignancy worldwide,ranking as the sixth most common malignancy and the third leading cause of cancer-related *** diagnosis,limited management options,and its complex etiology contribute to the poor prognosis and high mortality *** advances in understanding the molecular mechanisms of HCC and innovations in high-throughput sequencing technologies have led to the development of molecular diagnostics and personalized therapies for this challenging *** review provides a comprehensive overview of research on the molecular diagnosis and individualized treatment for *** highlight key advances and potential future directions and discuss the application of next-generation sequencing technologies to identify and characterize genetic and epigenetic alterations in HCC *** technologies may aid in the selection of targeted therapies,prediction of treatment response,and monitoring disease ***,we explore the role of liquid biopsy in HCC diagnosis,prognosis prediction,and treatment monitoring,focusing on circulating tumor cells,circulating tumor DNA,and extracellular *** also explore the evolving landscape of personalized therapy for HCC,including targeted therapies against key oncogenic signaling pathways,immune checkpoint inhibitors,tumor-agnostic therapies,and innovative cellbased *** discuss the challenges and opportunities that lie ahead in the quest to improve HCC patient outcomes through the integration of molecular diagnostics and individualized precision *** emphasize the need for multi-interdisciplinary collaboration,refinement of predictive and prognostic biomarkers,and the development of more effective combination strategies for HCC management in the new area of precision medicine.

关键词： Hepatocellular carcinoma Liquid biopsy Diagnosis Immune checkpoint inhibitors Targeted therapy

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Grading severity of microscopic vascular invasion was independently associated with recurrence and survival following hepatectomy for solitary hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 16-28页

作者： Lan-Qing Yao Chao Li yong-kang diao Lei Liang Hang-Dong Jia Shi-Chuan Tang yong-Yi Zeng Han Wu Ming-Da Wang Li-Hui Gu Timothy M.Pawlik Wan Yee Lau Cheng-Wu Zhang Feng Shen Kui Wang Tian Yang Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University(Navy Medical University)ShanghaiChina Department of General Surgery Cancer CenterDivision of Hepatobiliary and Pancreatic SurgeryZhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhouChina Department of Hepatobiliary Surgery Mengchao Hepatobiliary HospitalFujian Medical UniversityFuzhouChina Department of Surgery Ohio State UniversityWexner Medical CenterColumbusOHUSA Faculty of Medicine the Chinese University of Hong KongShatinNew TerritoriesHong KongChina Eastern Hepatobiliary Clinical Research Institute Third Affiliated Hospital of Navy Medical UniversityShanghaiChina

Background:Hepatectomy is the preferred treatment for solitary hepatocellular carcinoma(HCC)without macrovascular invasion and distant metastasis,but long-term survival remains unsatisfactory in certain *** sought to identify whether the grading severity of microscopic vascular invasion(MVI)was associated with recurrence and survival among patients with solitary ***:Consecutive patients who underwent hepatectomy for solitary HCC were identified from a multicenter prospectively-collected *** were categorized into three groups according to the MVI grading system proposed by the Liver Cancer Pathology Group of China:M0(no MVI),M1(1-5 sites of MVI occurring≤1.0 cm away from the tumor),and M2(>5 sites occurring≤1.0 cm or any site occurring>1 cm away from the tumor).Recurrence-free survival(RFS)and overall survival(OS)were compared among the ***:Among 227 patients,97(42.7%),83(36.6%),and 47(20.7%)patients had M0,M1,and M2,*** RFS rates among patients with M0,M1,and M2 were 38.3,35.1,11.6 months,respectively,while OS rates were 66.8,62.3,30.6 months,respectively(both P<0.001).Multivariate Cox-regression analyses demonstrated that both M1 and M2 were independent risk factors for RFS(hazard ratio 1.20,95%CI:1.03-1.89,P=0.040;and hazard ratio 1.67,95%CI:1.06-2.64,P=0.027)and OS(hazard ratio 1.28,95%CI:1.05-2.07,P=0.035;and hazard ratio 1.97,95%CI:1.15-3.38,P=0.013).Conclusions:Grading severity of MVI was independently associated with RFS and OS after hepatectomy for solitary *** surveillance for recurrence and potentially adjuvant therapy may be considered for patients with MVI,especially individuals with more severe MVI grading(M2).

关键词： Hepatocellular carcinoma microscopic vascular invasion recurrence survival hepatectomy

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Association of Pringle maneuver with postoperative recurrence and survival following hepatectomy for hepatocellular carcinoma: a multicenter propensity score and competing-risks regression analysis

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 412-424,I0003-I0010页

作者： Shi-Chuan Tang yong-kang diao Kong-Ying Lin Chao Li Xiao Xu Lei Liang Jie Kong Qing-Jing Chen Xian-Ming Wang Fu-Bao Liu Wei-Min Gu Ya-Hao Zhou Ying-Jian Liang Hong-Zhi Liu Ming-Da Wang Lan-Qing Yao Timothy M.Pawlik Feng Shen Wan Yee Lau Tian Yang yong-Yi Zeng Department of Hepatobiliary Surgery Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouChina Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalNavy Medical University(Second Military Medical University)ShanghaiChina Department of Hepatobiliary Surgery Affiliated Hospital of Nantong UniversityNantongChina Department of Hepatobiliary Surgery People’s Hospital of Zhejiang ProvincialPeople’s Hospital of Hangzhou Medical CollegeHangzhouChina Department of Hepatobiliary Heze Municiple HospitalHezeChina Department of General Surgery First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinanChina Department of Hepatobiliary Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiChina The First Department of General Surgery Fourth Hospital of HarbinHarbinChina Department of Hepatobiliary Surgery Pu’er People’s HospitalPu’erChina Department of Hepatobiliary Surgery First Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Surgery Ohio State UniversityWexner Medical CenterColumbusOHUSA Faculty of Medicine The Chinese University of Hong KongHong KongChina Department of Hepatopancreatobiliary Surgery First Affiliated Hospital of Fujian Medical UniversityFuzhouChina The Liver Disease Research Center of Fujian Province FuzhouChina

Background:The application of Pringle maneuver(PM)during hepatectomy reduces intraoperative blood loss and the need for perioperative transfusion,but its effect on long-term recurrence and survival for patients with hepatocellular carcinoma(HCC)remains *** sought to determine the association between the application of PM and post-hepatectomy oncologic outcomes for patients with ***:Patients who underwent curative hepatectomy for HCC at 9 Chinese hospitals from January 2010 to December 2018 were *** two propensity score methods[propensity score matching(PSM)and inverse probability of treatment weight(IPTW)],cumulative recurrence rate and cancer-specific mortality(CSM)were compared between the patients in the PM and non-PM *** competing-risks regression models were performed to adjust for the effect of non-cancer-specific mortality and other prognostic risk ***:Of the 2,798 included patients,2,404 and 394 did and did not adopt PM(the PM and non-PM groups),*** rates of intraoperative blood transfusion,postoperative 30-day mortality and morbidity were comparable between the two groups(all P>0.05).In the PSM cohort by the 1:3 ratio,compared to 382 patients in the non-PM group,1,146 patients in the PM group also had the higher cumulative 5-year recurrence rate and CSM(63.9%and 39.1%vs.55.3%and 31.6%,both P<0.05).Similar results were also yielded in the entire cohort and the IPTW *** competing-risks regression analyses demonstrated that no application of the PM was independently associated with lower recurrence rate and CSM based on various analytical cohorts[hazard ratio(HR),0.82 and 0.77 in the adjusted entire cohort,HR 0.80 and 0.73 in the PSM cohort,and HR 0.80 and 0.76 in the IPTW cohort,respectively].Conclusions:The findings suggested that no application of PM during hepatectomy for patients with HCC reduced the risk of postoperative recurrence and cancer-specific death by appr

关键词： Hepatocellular carcinoma(HCC) Pringle maneuver(PM) recurrence survival hepatectomy

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Association of tumor morphology with long-term prognosis after liver resection for patients with a solitary huge hepatocellular carcinoma-a multicenter propensity score matching analysis

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 314-327,I0006,I0007页

作者： Xin-Fei Xu Han Wu Ju-Dong Li Lan-Qing Yao Bin Huang yong-kang diao Ting-Hao Chen Wei-Min Gu Zhong Chen Jie Li Yao-Ming Zhang Hong Wang Ying-Jian Liang Ya-Hao Zhou Chao Li Ming-Da Wang Cheng-Wu Zhang Timothy MPawlik Wan Yee Lau Feng Shen Tian Yang Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalNaval Medical University(Second Military Medical University)ShanghaiChina Department of General Surgery Changzheng HospitalNaval Medical University(Second Military Medical University)ShanghaiChina Department of Radiology Eastern Hepatobiliary Surgery HospitalNaval Medical University(Second Military Medical University)ShanghaiChina Division of Hepatobiliary and Pancreatic Surgery Department of General SurgeryCancer CenterZhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhouChina Department of General Surgery Ziyang First People’s HospitalZiyangChina The First Department of General Surgery the Fourth Hospital of HarbinHarbinChina Department of Hepatobiliary Surgery Affiliated Hospital of Nantong UniversityNantongChina Department of Hepatobiliary Surgery Fuyang People’s HospitalFuyangChina The Second Department of Hepatobiliary Surgery Meizhou People’s HospitalMeizhouChina Department of General Surgery Liuyang People’s HospitalChangshaChina Department of Hepatobiliary Surgery the First Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Hepatobiliary Surgery Pu’er People’s HospitalPu’erChina Department of Surgery Ohio State UniversityWexner Medical CenterColumbusOHUSA Faculty of Medicine the Chinese University of Hong KongHong KongChina

Background:A solitary hepatocellular carcinoma(HCC)without macrovascular invasion and distant metastasis,regardless of tumor size,is currently classified as early-stage disease by the latest Barcelona Clinic Liver Cancer(BCLC)staging *** the preferred treatment is surgical resection,the association of tumor morphology with long-term survival outcomes after liver resection for a solitary huge HCC of≥10 cm has not been ***:Patients who underwent curative liver resection for a solitary huge HCC were identified from a multicenter *** imaging findings were used to define spherical-or ellipsoidal-shaped lesions with smooth edges as balloon-shaped HCCs(BS-HCCs);out-of-shape lesions or lesions of any shape with matt edges were defined as non-balloon-shaped HCCs(NBS-HCCs).The two groups of patients with BS-HCCs and NBS-HCCs were matched in a 1:1 ratio using propensity score matching(PSM).Clinicopathologic characteristics,long-term overall survival(OS)and recurrence-free survival(RFS)were ***:Among patients with a solitary huge HCC,74 pairs of patients with BS-HCC and NBS-HCC were *** pathological features including proportions of microvascular invasion,satellite nodules,and incomplete tumor encapsulation in the BS-HCC group were lower than the NBS-HCC *** a median follow-up of 50.7 months,median OS and RFS of all patients with a solitary huge HCC after PSM were 27.8 and 10.1 months,*** BS-HCC group had better median OS and RFS than the NBS-HCC group(31.9 vs.21.0 months,P=0.01;and 19.7 vs.6.4 months,P=0.015).Multivariate analyses identified BS-HCC as independently associated with better OS(HR=0.592,P=0.009)and RFS(HR=0.633,P=0.013).Conclusions:For a solitary huge HCC,preoperative imaging on tumor morphology was associated with prognosis following *** particular,patients with BS-HCCs had better long-term survival following liver resection versus patients with large NBS-HCCs.

关键词： Hepatocellular carcinoma(HCC) survival recurrence tumor morphology hepatectomy

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Diagnostic performance comparisons of two commonly used multi-biomarker-based scores for detection of hepatocellular carcinoma in non-alcoholic fatty liver disease

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iLIVER 2024年第2期3卷 3-10页

作者： Wei Ouyang Ming-Da Wang Ming-Cheng Guan yong-kang diao Li-Yang Sun Nan-Ya Wang Feng Shen Hong Zhu Tian Yang Hubei Cancer Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430070China Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200438China Department of Medical Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Cancer Center First Hospital of Jilin UniversityChangchun 130015China Department of Graduate Bengbu Medical CollegeBengbu 233099China

Background and aims:The ASAP and GALAD scores are widely used diagnostic models for detecting hepatocellular carcinoma(HCC),incorporating factors such as sex,age,alpha-fetoprotein(AFP),protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ),and lens culinaris agglutinin-reactive fraction of AFP(AFP-L3%).This study compares the diagnostic efficacy of the ASAP and GALAD scores in the early detection of HCC in patients with non-alcoholic fatty liver disease(NAFLD).Methods:NAFLD patients with and without HCC were recruited from 12 Chinese tertiary *** levels of AFP,PIVKA-II,and AFP-L3%were *** diagnostic accuracy of individual biomarkers,the ASAP score,and the GALAD score in detecting NAFLD-HCC at various stages was evaluated using receiver operating characteristic(ROC)curves and area under the curve(AUC)***:In a cohort of 147 NAFLD-HCC cases and 460 NAFLD controls,both the ASAP and GALAD scores outperformed individual biomarkers in detecting *** ASAP score demonstrated a high AUC of 0.910(sensitivity:80.3%,specificity:92.8%)for identifying NAFLD-HCC at all stages,surpassing AFP(AUC:0.716,P<0.001),PIVKA-II(AUC:0.849,P<0.001),AFP-L3%(AUC:0.663,P<0.001),and the GALAD score(AUC:0.882,P?0.014).Comparable results were observed for early-stage NAFLD-HCC and for detecting HCC in NAFLD patients with or without ***:The ASAP score,which excludes the AFP-L3%indicator,demonstrated superior performance in differentiating NAFLD-HCC compared to the GALAD score,suggesting its potential for early screening of HCC in NAFLD patients.

关键词： Hepatocellular carcinoma Nonalcoholic fatty liver disease Alpha-fetoprotein Lens culinaris agglutinin-reactive alpha-fetoprotein Protein induced by vitamin K absence or antagonist-II ASAP score GALAD score Early diagnosis

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Bioinspired Passive Tactile Sensors Enabled by Reversible Polarization of Conjugated Polymers

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Nano-Micro Letters 2025年第1期17卷 361-377页

作者： Feng He Sitong Chen Ruili Zhou Hanyu diao Yangyang Han Xiaodong Wu School of Mechanical Engineering Sichuan UniversityChengdu 610065People’s Republic of China School of Software Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065People’s Republic of China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065People’s Republic of China

Tactile perception plays a vital role for the human body and is also highly desired for smart prosthesis and advanced *** to active sensing devices,passive piezoelectric and triboelectric tactile sensors consume less power,but lack the capability to resolve static ***,we address this issue by utilizing the unique polarization chemistry of conjugated polymers for the first time and propose a new type of bioinspired,passive,and bio-friendly tactile sensors for resolving both static and dynamic ***,to emulate the polarization process of natural sensory cells,conjugated polymers(including poly(3,4-ethylenedioxythiophen e):poly(styrenesulfonate),polyaniline,or polypyrrole)are controllably polarized into two opposite states to create artificial potential *** controllable and reversible polarization process of the conjugated polymers is fully in situ ***,a micro-structured ionic electrolyte is employed to imitate the natural ion channels and to encode external touch stimulations into the variation in potential difference *** with the currently existing tactile sensing devices,the developed tactile sensors feature distinct characteristics including fully organic composition,high sensitivity(up to 773 mV N^(−1)),ultralow power consumption(nW),as well as superior *** demonstrations,both single point tactile perception(surface texture perception and material property perception)and two-dimensional tactile recognitions(shape or profile perception)with high accuracy are successfully realized using self-defined machine learning *** tactile sensing concept innovation based on the polarization chemistry of conjugated polymers opens up a new path to create robotic tactile sensors and prosthetic electronic skins.

关键词： Passive tactile sensors Reversible polarization of conjugated polymers Tactile perception Machine learning algorithm Object recognition

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从1.0到2.0:特朗普政府对华安全战略的延续与政策变化

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国际安全研究 2025年第1期43卷 96-114,158页

作者：刁大明中国人民大学国际关系学院北京100872 中国人民大学外交学系北京100872

2024年美国总统大选以第45任总统唐纳德·特朗普的回归落幕。从“特朗普1.0”到“特朗普2.0”的八年间,国际安全环境、中美关系、美国政经态势以及特朗普个人状态等都发生了重大变化。国际安全环境日益严峻并进入历史转折点;中美关系因... 详细信息

2024年美国总统大选以第45任总统唐纳德·特朗普的回归落幕。从“特朗普1.0”到“特朗普2.0”的八年间,国际安全环境、中美关系、美国政经态势以及特朗普个人状态等都发生了重大变化。国际安全环境日益严峻并进入历史转折点;中美关系因美方对华战略竞争而陷入历史低谷;美国自身政治与社会持续撕裂且经济状况存在隐忧;美国国内期待“特朗普2.0”明确回应国内诉求;特朗普个人则在偏好商人思维的同时也凸显强势与遗产导向。比较而言,“特朗普2.0”的对华安全战略将突出延续性,将延续拜登政府的相关政策,体现为延续对华战略竞争、推进“拜登+特朗普”复合议程并继续将经贸议题置于对华战略竞争的核心地位。在延续战略之下,“特朗普2.0”的对华政策也有可能呈现出一些变化,表现为对外事务聚焦于俄乌冲突和巴以冲突而非中国、经贸作为个人偏好成为主线后的不可控性、国际与国内两个维度对其经贸政策制造的更大压力以及陷入历史低谷的中美关系面对新“特朗普冲击”的自限性。

关键词：特朗普2.0 战略竞争对华安全战略对华政策中美关系

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Two-level consensus modeling with utility and cost constraints

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Journal of Systems Engineering and Electronics 2022年第3期33卷 716-726页

作者： diao Weixue LIU yong School of Business Jiangnan UniversityWuxi 214122China

There exist many two-level group consensus problems with different psychological behaviors of decision *** deal with these group consensus problems and reach a stable consensus,based on the principles and methods of grey system,utility theory and group consensus,we use grey utility function to describe and reflect decision makers’opinion preferences in different subgroups and different levels,and then we construct a two-level group consensus method with a moderator,and exploit it to solve the negotiation problems of the natural gas subsidy.

关键词： two-level group consensus group negotiation uti-lity function natural gas subsidy

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A multi-component nanocrystalline FeCrV alloy with improved mechanical properties and excellent irradiation resistance

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Progress in Natural Science:Materials International 2022年第4期32卷 433-442页

作者： Tingting Li Sizhe diao Pingping Liu yong Zhang Qian Zhan School of Materials Science and Engineering University of Science and Technology Beijing Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing

An equiatomic low-activated Fe Cr V ternary alloy was prepared by mechanical alloying and spark plasma sintering. The BCC solid solution alloy exhibited an excellent strength-ductility synergy properties, which was 1.85GPa compressive yield strength, 3.04 GPa fracture strength and more than 28% plasticity at room *** at an elevated temperature of 600°C, its yield strength was still more than 1 GPa, revealing a pronounced high temperature resistance. The Fe Cr V alloy had a homogeneous microstructure with high-density dislocations.A nanocrystalline characteristic was demonstrated and the average grain size was about 322 nm, leading to the improved mechanical properties. The strengthening mechanism was discussed in detail and the contributions of strengthening factors were calculated. The Fe Cr V alloy was irradiated up to 160 dpa with 2 Me V Au2+ions at 573K. The nanoindentation test was carried out to simply evaluate the hardening degree under such a high dose irradiation with heavy ions. The semi-quantitative analysis results show that Fe Cr V alloy has an excellent irradiation tolerance compared with pure Fe.

关键词： Mechanical properties Nanocrystalline Strengthening mechanism Au 2+ irradiation Multi-component alloy Mechanical alloying

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Static slip model of the M_w 9.0 Tohoku (Japan) earthquake:Results from joint inversion of terrestrial GPS data and seafloor GPS/acoustic data

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Chinese Science Bulletin 2012年第16期57卷 1990-1997页

作者： diao FaQi XIONG Xiong ZHENG yong State Key Laboratory of Geodesy and Earth's Dyanmics Institute of Geodesy and GeophysicsChinese Academy of SciencesWuhan 430077China

Based on co-seismic displacements recorded by terrestrial GPS stations and seafloor GPS/acoustic stations, the static slip model of the 2011 Mw 9.0 Tohoku earthquake was determined by inverting the data using a layered earth model. According to a priori information, the rupture surface was modeled with a geometry that is close to the actual rupture, in which the fault dip angle increases with depth and the fault strike varies with the trend of the trench. As shown by the results inferred from the joint inversion, the "geodetic" moment is 3.68 × 10 22 Nm, corresponding to Mw 9.01, and the maximum slip is positioned at a depth of 13.5 km with a slip magnitude of 45.8 m. Rupture asperities with slip exceeding 10 m are mainly distributed from 39.6 to 36.97°N, over a length of almost 240 km along the trench. The slip was mostly concentrated at depths shallower than 40 km, up-dip of the hypocenter. "Checkerboard" tests reveal that a joint inversion of multiple datasets can resolve the slip distribution better than an inversion with terrestrial GPS data only-especially when aiming to resolve slip at shallow depths. Thus, the joint inversion results obtained by this work may provide a more reliable slip model than the results of other studies that are only derived from terrestrial GPS data or seismic waveform data.

关键词： GPS数据联合反演滑移模型地震位移地面海底静态东北

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