Grading severity of microscopic vascular invasion was independently associated with recurrence and survival following hepatectomy for solitary hepatocellular carcinoma

作     者：Lan-Qing Yao Chao Li Yong-Kang Diao Lei Liang Hang-Dong Jia Shi-Chuan Tang Yong-Yi Zeng Han Wu Ming-Da Wang Li-Hui Gu Timothy M.Pawlik Wan Yee Lau Cheng-Wu Zhang Feng Shen Kui Wang Tian Yang 

作者机构：Department of Hepatobiliary SurgeryEastern Hepatobiliary Surgery HospitalSecond Military Medical University(Navy Medical University)ShanghaiChina Department of General SurgeryCancer CenterDivision of Hepatobiliary and Pancreatic SurgeryZhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhouChina Department of Hepatobiliary SurgeryMengchao Hepatobiliary HospitalFujian Medical UniversityFuzhouChina Department of SurgeryOhio State UniversityWexner Medical CenterColumbusOHUSA Faculty of Medicinethe Chinese University of Hong KongShatinNew TerritoriesHong KongChina Eastern Hepatobiliary Clinical Research InstituteThird Affiliated Hospital of Navy Medical UniversityShanghaiChina 

出 版 物：《Hepatobiliary Surgery and Nutrition》 (肝胆外科与营养（英文）)

年 卷 期：2024年第13卷第1期

页      面：16-28页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.81972726 and 82273074) Dawn Project Foundation of Shanghai(No.21SG36) Adjunct Talent Fund of Zhejiang Provincial People’s Hospital(No.2021-YT) Shanghai Health and Hygiene Discipline Leader Project(No.2022XD001) the Natural Science Foundation of Shanghai(No.22ZR1477900) Shanghai Science and Technology Committee Rising-Star Program(No.22QA1411600) 

主　　题：Hepatocellular carcinoma microscopic vascular invasion recurrence survival hepatectomy 

摘      要：Background:Hepatectomy is the preferred treatment for solitary hepatocellular carcinoma(HCC)without macrovascular invasion and distant metastasis,but long-term survival remains unsatisfactory in certain *** sought to identify whether the grading severity of microscopic vascular invasion(MVI)was associated with recurrence and survival among patients with solitary ***:Consecutive patients who underwent hepatectomy for solitary HCC were identified from a multicenter prospectively-collected *** were categorized into three groups according to the MVI grading system proposed by the Liver Cancer Pathology Group of China:M0(no MVI),M1(1-5 sites of MVI occurring≤1.0 cm away from the tumor),and M2(5 sites occurring≤1.0 cm or any site occurring1 cm away from the tumor).Recurrence-free survival(RFS)and overall survival(OS)were compared among the ***:Among 227 patients,97(42.7%),83(36.6%),and 47(20.7%)patients had M0,M1,and M2,*** RFS rates among patients with M0,M1,and M2 were 38.3,35.1,11.6 months,respectively,while OS rates were 66.8,62.3,30.6 months,respectively(both P0.001).Multivariate Cox-regression analyses demonstrated that both M1 and M2 were independent risk factors for RFS(hazard ratio 1.20,95%CI:1.03-1.89,P=0.040;and hazard ratio 1.67,95%CI:1.06-2.64,P=0.027)and OS(hazard ratio 1.28,95%CI:1.05-2.07,P=0.035;and hazard ratio 1.97,95%CI:1.15-3.38,P=0.013).Conclusions:Grading severity of MVI was independently associated with RFS and OS after hepatectomy for solitary *** surveillance for recurrence and potentially adjuvant therapy may be considered for patients with MVI,especially individuals with more severe MVI grading(M2).