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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 283-292页

作者： yong-Chao Gai Rui Zhang Chuan-yong cui Zi-Jian Zhou Yi Tan Yi-Zhou Zhou Xiao-Feng Sun Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)School of Materials Science and EngineeringDalian University of TechnologyDalian116024China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

The hot compression behavior and tensile strength after compression of a new Ni-Co-based superalloy produced using electron beam smelting layered(EBSL)solidification technology were *** compression tests were performed at temperatures of 1120℃and 1150℃,with strain rates of 1 s^(-1) and 0.01 s^(-1),reaching a true strain of *** strength was evaluated at room *** results revealed that this EBSL technology accelerates dynamic recrystallization(DRX),without compromising the strength of alloy.A significant correlation between the volume fraction of DRX and the strain rate was observed,with higher fractions at lower strain rates,leading to higher tensile ***,at the same strain rate,the specimens compressed at 1120℃exhibited higher tensile strength due to undissolvedγ′*** solution and aging heat treatment,the alloy maintained high tensile *** results suggested that the EBSL Ni-Co-based superalloy offers excellent prospects for practical applications.

关键词： Ni-Co-based superalloy Hot deformation Electron beam smelting Tensile strength

A Bibliometric Analysis Unveils Valuable Insights into the Past,Present,and Future Dynamics of Plant Acclimation to Temperature

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Phyton-International Journal of Experimental Botany 2024年第2期93卷 291-312页

作者： yong cui yongju Zhao Shengnan Ouyang Changchang Shao Liangliang Li Honglang Duan Institute for Forest Resources&Environment of Guizhou Key Laboratory of Forest Cultivation in Plateau Mountain of Guizhou ProvinceCollege of ForestryGuizhou UniversityGuiyangChina

Plant temperature acclimation is closely related to maintaining a positive carbon gain under future climate ***,no systematic summary of the field has been *** on this,we analyzed data on plant temperature acclimation from the Web of Science Core Collection database using bibliometric software R,RStudio and *** study demonstrated that a stabilized upward trajectory was noted in publications(298 papers)from 1986 to 2011,followed by a swift growth(373 papers)from 2012 to *** most impactful journals were Plant Cell and Environment,boasting the greatest count of worldwide citations and articles,the highest H-index and G-index,followed by Global Change Biology and New Phytologist,and Frontiers in Plant Science which had the highest *** USA and China were identified as the most influential countries,while Atkin was the most influential author,and the Chinese Academy of Sciences was the most influential research *** most cited articles were published in the Annual Review of Plant Biology in 1999.“Cold acclimation”was the most prominent *** plant temperature acclimation research is expected to focus on thermal acclimation and photosynthesis,which have important significance for future agricultural production,forestry carbon sequestration,and global food *** general,this study provides a systematic insight of the advancement,trend,and future of plant temperature acclimation research,enhancing the comprehension of how plants will deal with forthcoming climate change.

关键词： Temperature acclimation plant responses climate change bibliometric

Artemordins A-S, Cadinane-Type Sesquiterpenoid Dimers from Artemisia ordosica and Their Antihepatoma Activities

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Chinese Journal of Chemistry 2024年第13期42卷 1493-1508页

作者： Yuan Wang Tian-Ze Li Yun-Bao Ma Chang-An Geng yong-cui Wang Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China

Nineteen new cadinane-involving sesquiterpenoid dimers,artemordins A-S(1-—19),together with 13 known SDs(20-32)were isolated from Artemisia *** structures and absolute configurations were established by comprehensive spectral analyses,X-ray single crystal diffraction,theoretical ECD,and NMR ***,artemordins A-F(1—6)were the first examples of two cadinane units constructed by unprecedented C-3−C-15′or C-3−C-13′single bond with an oxido-rearranged 6/5/6/6 fused ring system;artemordins G-K(7-11)were biogenetically connected by[4+2]cycloaddition reaction and artemordins G-J(7-10)possessed a novel 5/6/6/6/6/6/5-heptacyclic fused ring *** L-S(12-19)were formed by esterification,which involved three different types of *** assay suggested that the most active compounds,artemordins B and H(2 and 8),exhibited inhibitory activities on three hepatoma cell lines with IC50 values of 26.9 and 25.1μmol/L(HepG2),29.5 and 18.3μmol/L(Huh7),19.7 and 15.7μmol/L(SK-Hep-1).

关键词： Artemisia ordosica Artemordins A-s Cadinane-type sesquiterpenoid dimers Antihepatoma activities Terpenoids Natural products Cytotoxicity

Three Types of Isocoumarins with Unusual Carbon Skeletons from Artemisia dubia var. subdigitata and Their Antihepatoma Activity

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Chinese Journal of Chemistry 2024年第16期42卷 1901-1912页

作者： Ke-Xin Yang Tian-Ze Li Yun-Bao Ma yong-cui Wang Feng-Jiao Li Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China

Ten novel isocoumarins,including four pairs of enantiomers,were isolated from Artemisia dubia ***(Asteraceae).Compounds 1,2 and 3a/3b possessed a unique 6/6/6-tricyclic system comprising an unusual 1-(2-methylcyclohexyl)propan-1-one moiety fused with isocoumarin core *** 4a/4b were characterized as an unexpected 2,5-dimethylcyclohexan-1-one scaffold,and compounds 5a/5b and 6a/6b were rare 1,*** structures and absolute configurations were elucidated through spectroscopic data,X-ray crystallography,ECD and NMR calculations with DP4+*** biosynthetic pathways were proposed from the naturally occurring *** pharmacological analysis suggested that the targets of compound 1 were significantly enriched in the cell cycle and Pl3K-Akt signaling *** molecular docking revealed that compound 1 had high binding affinity with CDK2(total score:6.8717).Furthermore,compounds 1 and 2 exhibited inhibitory activity on three human hepatoma cell lines,with inhibitory ratios of 85.1% and 84.5%(HepG2),88.2% and 87.3%(Huh7),and 69.2% and 69.1%(SK-Hep-1)at 200μmol·L^(-1),respectively.

关键词： Artemisia dubia var.subdigitata Isocoumarins Antihepatoma activity Cancer Natural products X-ray diffraction

Coordination of networking and computing: toward new information infrastructure and new services mode

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Frontiers of Information Technology & Electronic Engineering 2024年第5期25卷 629-632页

作者： Xiaoyun WANG Tao SUN yong cui Rajkumar BUYYA Deke GUO Qun HUANG Hassnaa MOUSTAFA Chen TIAN Shangguang WANG China Mobile Communications Corporation Beijing 100032China China Mobile Research Institute Beijing 100053China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China CLOUDS Lab School of Computing and Information SystemsUniversity of MelbourneMelbourneVIC 3010Australia National Key Laboratory of Information Systems Engineering National University of Defense TechnologyChangsha 410073China School of Computer Science Peking UniversityBeijing 100871China Intel Corporation Santa ClaraCA 95054USA State Key Laboratory for Novel Sofiware Technology Nanjing UniversityNanjing 210023China State Key Laboratory of Networking and Switching Technology Bejing University of Posts and TelecommunicationsBeijing 100876China

Computing,serving as the cornerstone of information processing,plays a pivotal role in the digital service ***"network"and"computing,"responsible for information transmission and processing respectively,traditionally belong to different stakeholders and have evolved ***,the recent trend toward the coordination and integration of computing and networks has garnered significant attention from both industry and *** such as"computility network"and"computing force network"have emerged,and the International Telecommunication Union-Telecommunication Standardization(ITU-T)has initiated efforts to develop standards for the coordination of networking and computing(CNC),focusing on the architecture and framework.

关键词： computing services network

Non-invasive imaging of pathological scars using a portable handheld two-photon microscope

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Chinese Medical Journal 2024年第3期137卷 329-337页

作者： Yang Han Yuxuan Sun Feili Yang Qingwu Liu Wenmin Fei Wenzhuo Qiu Junjie Wang Linshuang Li Xuejun Zhang Aimin Wang yong cui Graduate School Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China College of Engineering Peking UniversityBeijing 100871China School of Chemical Biology and Biotechnology State Key Laboratory of Chemical OncogenomicsPeking University Shenzhen Graduate SchoolShenzhenGuangdong 518055China Department of Dermatology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China College of Future Technology Peking UniversityBeijing 100871China Beijing Transcend Vivoscope Biotech Beijing 100085China Department of Dermatology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230001China Institute of Dermatology Anhui Medical UniversityHefeiAnhui 230001China School of Electronics Peking UniversityBeijing 100871China

Background:Pathological scars are a disorder that can lead to various cosmetic,psychological,and functional problems,and no effective assessment methods are currently *** and treatment of pathological scars are based on cutaneous manifestations.A two-photon microscope(TPM)with the potential for real-time non-invasive assessment may help determine the under-surface pathophysiological conditions in *** study used a portable handheld TPM to image epidermal cells and dermal collagen structures in pathological scars and normal skin in vivo to evaluate the effectiveness of treatment in scar ***:Fifteen patients with pathological scars and three healthy controls were *** was performed using a portable handheld *** indexes were extracted from two dimensional(2D)and three dimensional(3D)perspectives,including collagen depth,dermo-epidermal junction(DEJ)contour ratio,thickness,orientation,and occupation(proportion of collagen fibers in the field of view)of *** depth-dependent indexes were computed through the 3D second harmonic generation image and three morphology-related indexes from the 2D *** assessed index differences between scar and normal skin and changes before and after ***:Pathological scars and normal skin differed markedly regarding the epidermal morphological structure and the spectral characteristics of collagen *** indexes were employed to distinguish between normal skin and scar *** significant differences were found in average depth(t=9.917,P<0.001),thickness(t=4.037,P<0.001),occupation(t=2.169,P<0.050),orientation of collagen(t=3.669,P<0.001),and the DEJ contour ratio(t=5.105,P<0.001).Conclusions:Use of portable handheld TPM can distinguish collagen from skin tissues;thus,it is more suitable for scar imaging than reflectance confocal ***,a TPM may be an auxiliary tool for scar treatment selection and assessing treatment efficacy.

关键词： Scars Two-photon microscope Two-photon excitation fluorescence Second harmonic generation microscopy

EGFR突变可切除的NSCLC围手术期辅助靶向治疗研究进展及问题探讨

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中国肺癌杂志 2024年第5期27卷 383-390页

作者：宋朋崔永首都医科大学附属北京友谊医院胸外科北京100050

肺癌在全球范围内仍是导致癌症死亡的首要原因,非小细胞肺癌(non-small cell lung cancer,NSCLC)是肺癌的主要病理类型,占80%左右。在所有NSCLC患者中,约30%初诊时为可切除的早中期NSCLC。近期表皮生长因子受体-酪氨酸激酶抑制剂(epider... 详细信息

肺癌在全球范围内仍是导致癌症死亡的首要原因,非小细胞肺癌(non-small cell lung cancer,NSCLC)是肺癌的主要病理类型,占80%左右。在所有NSCLC患者中,约30%初诊时为可切除的早中期NSCLC。近期表皮生长因子受体-酪氨酸激酶抑制剂(epidermal growth factor receptor-tyrosine kinase inhibitors,EGFR-TKIs)在EGFR突变可切除的NSCLC围手术期辅助靶向治疗中取得重大突破,并被指南推荐应用于临床。本文在总结EGFR突变可切除NSCLC围手术期辅助靶向治疗临床研究进展的基础上,针对临床研究中的关键问题进行探讨。

关键词：肺肿瘤围手术期治疗新辅助治疗辅助治疗靶向治疗

Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment

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Cellular & Molecular Immunology 2024年第1期21卷 47-59页

作者： Yu Zheng Haihui Jiang Naixue Yang Shaoping Shen Daosheng Huang Lemei Jia Jing Ling Longchen Xu Mingxiao Li Kefu Yu Xiaohui Ren yong cui Xun Lan Song Lin Xin Lin Institute for Immunology and School of Medicine Tsinghua UniversityBeijing100084China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityChina.National Clinical Research Center for Neurological DiseasesCenter of Brain TumorBeijing Institute for Brain Disorders and Beijing Key Laboratory of Brain TumorBeijing100070China Department of Neurosurgery Peking University Third HospitalPeking UniversityBeijing100191China Tsinghua-Peking Center for Life Sciences Beijing100084China

A highly immunosuppressive tumor microenvironment(TME)and the presence of the blood‒brain barrier are the two major obstacles to eliciting an effective immune response in patients with high-grade glioma(HGG).Here,we tried to enhance the local innate immune response in relapsed HGG by intracranially injecting poly(I:C)to establish a robust antitumor immune response in this registered clinical trial(NCT03392545).During the follow-up,12/27(44.4%)patients who achieved tumor control concomitant with survival benefit were regarded as responders in our *** found that the T-cell receptor(TCR)repertoire in the TME was reshaped after poly(I:C)*** on the RNA-seq analysis of tumor samples,the expression of annexin A1(ANXA1)was significantly upregulated in the tumor cells of nonresponders,which was further validated at the protein *** vitro and in vivo experiments showed that ANXA1 could induce the production of M2-like macrophages and microglia via its surface receptor formyl peptide receptor 1(FPR1)to establish a Treg cell-driven immunosuppressive TME and suppress the antitumor immune response facilitated by poly(I:C).The ANXA1/FPR1 signaling axis can inhibit the innate immune response of glioma patients by promoting an anti-inflammatory and Treg-driven ***,ANXA1 could serve as a reliable predictor of response to poly(I:C),with a notable predictive accuracy rate of 92.3%.In light of these notable findings,this study unveils a new perspective of immunotherapy for gliomas.

关键词： glioma ANXA1 TLR3 poly(I:C) immunotherapy

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坚定不移走好中国特色金融发展之路

中国金融 2024年第14期 9-11页

作者：崔勇光大集团党委

《习近平关于金融工作论述摘编》是习近平同志对金融事业发展的重大理论和实践问题作出的一系列重要论述,立意高远,内涵丰富,思想深刻,把我们党对金融工作本质规律和发展道路的认识提升到了新高度,是马克思主义政治经济学关于金融问题... 详细信息

《习近平关于金融工作论述摘编》是习近平同志对金融事业发展的重大理论和实践问题作出的一系列重要论述,立意高远,内涵丰富,思想深刻,把我们党对金融工作本质规律和发展道路的认识提升到了新高度,是马克思主义政治经济学关于金融问题的重要创新成果,构成习近平经济思想的金融篇,对于新时代新征程坚定不移走中国特色金融发展之路,推进金融高质量发展、加快建设金融强国,为以中国式现代化全面推进强国建设、民族复兴伟业提供强有力的金融支撑,具有十分重要的意义。本刊特别开设专栏,梳理汇总金融系统学习贯彻《习近平关于金融工作论述摘编》,将学习成果转化为坚定不移走中国特色金融发展之路、推动金融高质量发展、加快建设金融强国的具体行动和实际成效。

关键词：金融支撑马克思主义政治经济学特色金融习近平经济思想中国式现代化成果转化本质规律金融强国

上海轨道交通16号线列车在站解挂编实施方案

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城市轨道交通研究 2024年第6期27卷 323-325页

作者：崔勇上海磁浮交通发展有限公司上海200120

[目的]上海轨道交通16号线采用灵活编组运营模式,但列车解挂编过程周转时间较长,导致行车组织难度较大。为进一步提高运营效率,简化行车组织,提出了在站解挂编作业实施方案。[方法]针对上海轨道交通16号线,分析了列车在车站进行解挂编... 详细信息

[目的]上海轨道交通16号线采用灵活编组运营模式,但列车解挂编过程周转时间较长,导致行车组织难度较大。为进一步提高运营效率,简化行车组织,提出了在站解挂编作业实施方案。[方法]针对上海轨道交通16号线,分析了列车在车站进行解挂编作业需解决的问题,并针对需解决问题提出具体的在站解挂编实施方案。在上海轨道交通16号线进行了多次测试,以验证方案实施效果。介绍了《上海轨道交通16号线龙阳路站解挂编作业规定》中的作业安全主要规定。[结果及结论]选择作业过程对线路运营影响较小的终端折返站(龙阳路站)作为解挂编作业车站;通过修改ATS(列车自动监控)软件连锁逻辑,并定义解挂编组作业专用停车区,实现了在站解挂编作业功能。测试结果验证了该方案的可行性和安全性。

关键词：城市轨道交通在站解挂编方案信号系统作业规范