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棒柄杯伞的化学成分及其抗肿瘤活性研究

中国中药杂志 2024年第11期49卷 2947-2952页

作者：雷启军吕杰马国需孙照翠许旭东魏华石磊岭逯永满新疆大学新疆乌鲁木齐830046 新疆维吾尔自治区中药民族药研究所新疆乌鲁木齐830002 中国医学科学院北京协和医学院药用植物研究所北京100193 吉首大学湖南吉首416000

对棒柄杯伞进行化学成分研究,采用硅胶、ODS、Sephadex LH-20柱色谱和半制备液相等多种色谱学技术对棒柄杯伞乙醇提取物进行分离纯化,通过^(1)H-NMR、^(13)C-NMR以及质谱等多种波谱学方法共鉴定出6个化合物,分别为clavilactone L(1)、cl... 详细信息

对棒柄杯伞进行化学成分研究,采用硅胶、ODS、Sephadex LH-20柱色谱和半制备液相等多种色谱学技术对棒柄杯伞乙醇提取物进行分离纯化,通过^(1)H-NMR、^(13)C-NMR以及质谱等多种波谱学方法共鉴定出6个化合物,分别为clavilactone L(1)、clavilactone A (2)、clavilactone B (3)、clavilactone E (4)、clavilactone H (5)和clavilactone I (6)。其中,化合物1是1个新的苯并十元碳环混源萜。通过MTT法测定了化合物1~6的抗肿瘤活性,结果表明化合物1~6对人胃癌细胞(MGC-803)、人非小细胞肺癌细胞(A549)、宫颈癌细胞(HeLa)具有不同程度的增殖抑制作用。其中化合物1对人胃癌细胞MGC-803具有较显著的抑制活性,IC_(50)为11.76μmol·L^(-1)。

关键词：棒柄杯伞化学成分混源萜 clavilactone L 抗肿瘤活性

Mold breakout prediction based on computer vision and machine learning

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Journal of Iron and Steel Research International 2024年第8期31卷 1947-1959页

作者： Yan-yu Wang Qi-can Wang yong-chang Zhang yong-hui Cheng man Yao Xu-dong Wang School of Materials Science and Engineering Dalian University of TechnologyDalian 116024LiaoningChina Key Laboratory of Solidification Control and Digital Preparation Technology Dalian University of TechnologyDalian 116024LiaoningChina

Breakout is the most serious production accident in continuous casting and must be detected and predicted by stable and reliable *** sticking region,which forms on the local copper plate and expanded into a"V"shape,is the typical precursor of ***,computer vision technology was exploited to visualize the temperature change rate of the copper plate based on the temperature signals from thermocouples;then,the static and dynamic features of the abnormal sticking region were ***,logistic regression and Adaboost models were used to study and identify these features,resulting in the development of a mold breakout prediction model based on computer vision and machine *** test results demonstrate that the proposed model can effectively distinguish anomalous temperature patterns and considerably reduce false alarms without any missing *** a result,the proposed method could offer valuable insights into the realm of abnormality detection and prediction during continuous casting process.

关键词： Abnormality detection Image processing Adaboost Logistic regression Continuous casting

The epidermal immune microenvironment plays a dominant role in psoriasis development,as revealed by mass cytometry

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Cellular & Molecular Immunology 2022年第12期19卷 1400-1413页

作者： Yuan Zhou Fan Xu Xue-Yan Chen Bing-Xi Yan Zhao-Yuan Wang Si-Qi Chen Min Zheng Xiao-yong man Department of Dermatology Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina

Psoriasis is a common chronic inflammatory skin *** diversity and heterogeneity of immune cells in human skin have been studied in recent years,but the spatial distribution of immune cells at the single-cell level in the human psoriatic epidermis and dermis remains *** this study,we mapped psoriatic skin immune cells from paired lesional,perilesional,and nonlesional skin samples using mass *** dendritic cells(DCs)were found in the psoriatic epidermis and *** dermal CD1c^(+)CD11b^(+)cDC2s migrated to the epidermis in the perilesional skin during the preinitiation ***1c^(+)CD11b^(+)cDC2s rapidly replaced EpCAM^(+)CD11c^(low) LC cells and initiated ***,CD207^(+)CD11c^(hi) LC and CD5^(+)T cells accumulated in the psoriatic epidermis and orchestrated epidermal inflammation in *** immune cell pool in the psoriatic dermis primarily included APCs and T ***,unlike that in the dermis,the epidermal immune environment was more significant and coincided with the inflammation occurring during psoriasis.

关键词： Psoriasis Cutaneous immune Mass cytometry Dendritic cell

Therapeutic DC vaccination with IL-2 as a consolidation therapy for ovarian cancer patients： a phase Ⅰ/Ⅱ trial

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Cellular & Molecular Immunology 2015年第1期12卷 87-95页

作者： Soyoung Baek yong-man Kim Sung-Bae Kim Choung-Soo Kim Seog-Woon Kwon yongman Kim HyunSoo Kim Hyunah Lee Office of Biomedical Professors Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea Department of Gynecology Asan Medical Center University of Ulsan College of Medicine Seoul Korea Department of Oncology Asan Medical Center University of Ulsan College of Medicine Seoul Korean Department of Urology Asan Medical Center University of Ulsan College of Medicine Seoul Korean Department of Laboratory Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea FCB-Pharmicell Co Ltd Seoul Korea

While ovarian cancer （OvCa） responds well to surgery and conventional chemotherapy, a high recurrence rate of advanced OvCa is observed. In this phase Ⅰ/Ⅱ study, 10 OvCa patients with minimal residual disease were treated with autologous dendritic cells （DCs） and IL-2 to evaluate the safety and feasibility of this therapeutic strategy and to characterize the antigen-specific immune alterations induced through this treatment. Approximately 4 months after initial debulking and chemotherapy, patients received two subcutaneous doses of autologous monocyte-derived DCs pulsed with autologous tumor lysate and keyhole limpet hemocyanin （KLH） at 4-week intervals. After each DC inoculation, low-dose （200 mlU） IL-2 was introduced for 14 consecutive days as an immune adjuvant. The vaccination was well tolerated. In three out of 10 patients, the inclusion status after the initial therapy showed the maintenance of complete remission （CR） after DC vaccination for 83, 80.9 and 38.2 months without disease relapse. One patient with stable disease （SD） experienced the complete disappearance of tumor after DC vaccination, and this status was maintained for 50.8 months until tumor recurrence. In two patients with partial response （PR） was not responding to DC vaccination and their disease recurred. In the three patients with disease free long-term survival, significant immune alterations were observed, including increased natural killer （NK） activity, IFN-γ-secreting T cells, immune-stimulatory cytokine secretion and reduced immune-suppressive factor secretion after DC vaccination. Thus, in patients with NED status and increased overall survival, DC vaccination induced tumor-related immunity, potentially associated with long-term clinical responses against OvCa.

关键词： dendritic cell vaccine immune response ovarian cancer phase Ⅰ/Ⅱ trial

Ferroptosis inhibitors reduce celastrol toxicity and preserve its insulin sensitizing effects in insulin resistant HepG2 cells

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Journal of Integrative Medicine 2024年第3期22卷 286-294页

作者： Jia-jia Liu Xue Zhang Bang-lan Cai man-man Qi yong-bin Chi Bin Peng Deng-hai Zhang School of Medicine Shanghai UniversityShanghai 200444China Shanghai Health Commission Key Lab of Artificial Intelligence-Based management of Inflammation and Chronic Diseases Shanghai Pudong Gongli HospitalSecondary Military Medical UniversityShanghai 200135China School of Basic Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

Objective:Research has shown that celastrol can effectively treat a variety of diseases,yet when passing a certain dosage threshold,celastrol becomes toxic,causing complications such as liver and kidney damage and erythrocytopenia,among *** this dichotomy in mind,it is extremely important to find ways to preserve celastrol’s efficacy while reducing or preventing its ***:In this study,insulin-resistant Hep G2(IR-Hep G2)cells were prepared using palmitic acid and used for in vitro ***-Hep G2 cells were treated with celastrol alone or in combination with Nacetylcysteine(NAC)or ferrostatin-1(Fer-1)for 12,24 or 48 h,at a range of *** counting kit-8assay,Western blotting,quantitative reverse transcription-polymerase chain reaction,glucose consumption assessment,and flow cytometry were performed to measure celastrol’s cytotoxicity and whether the cell death was linked to ***:Celastrol treatment increased lipid oxidation and decreased expression of anti-ferroptosis proteins in IR-Hep G2 *** downregulated glutathione peroxidase 4(GPX4)m *** docking models predicted that solute carrier family 7 member 11(SLC7A11)and GPX4 were covalently bound by ***,we found for the first time that the application of ferroptosis inhibitors(especially NAC)was able to reduce celastrol’s toxicity while preserving its ability to improve insulin sensitivity in IR-Hep G2 ***:One potential mechanism of celastrol’s cytotoxicity is the induction of ferroptosis,which can be alleviated by treatment with ferroptosis *** findings provide a new strategy to block celastrol’s toxicity while preserving its therapeutic effects.

关键词： Celastrol Insulin resistance Ferroptosis N-Acetylcysteine Palmitic acid Molecular docking

Controllable nucleation and deformation of skyrmions on surface of magnetic nanotubular monolayer

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Rare Metals 2024年第7期43卷 3250-3259页

作者： Xin-Xin Zhang Chen-Yu Zhang Yi-Xin Xing Chao man Jiao Liu yong Hu Department of Physics College of SciencesNortheastern UniversityShenyang 110819China School of Materials and Mineral Resources Engineering Universiti Sains MalaysiaEngineering Campus14300 Nibong TebalPenangMalaysia State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819China

Magnetic skyrmions emerge when the energy of ferromagnetic exchange interaction promoting parallel alignment of spins enters in competition with energies favoring non-collinear alignment of spins such as Dzy aloshinskii-Moriya interaction(DMI),long-rang dipole-dipole interaction(DDI),or higher-order exchange *** perform an unbiased Monte Carlo simulation to study the DMI-based skyrmion nucleation and stabilization on the surface of magnetic nanotubular monolayer controlled by tuning constants of DDI(g) and next-nearest-neighbor antiferromagnetic exchange interaction(j') with appropriate *** g and j',the loosely distributed skyrmions initially nucleate on the surface of nanotube approaching to the magnetic field(h) direction with increasing h in the intermediate ***,the skyrmion size,shape,density,distribution and crystal structure,as well as its driven field range,are tailored by g and j'.This work demonstrates the skyrmion nucleation mechanisms in three-dimensional magnetic nanostructures with curvature effect and multiple interactions,serving as a benchmark for a guide to experimentalists for preparation of samples in magnetic skyrmion states.

关键词： Magnetic nanotube Magnetic skyrmion Dzyaloshinskii-Moriya interaction Dipole-dipole interaction Monte Carlo simulation

Study on the influence of crown ether on arsenic behavior during coal pyrolysis

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Journal of Coal Science & Engineering(China) 2013年第3期19卷 375-380页

作者： Bao-Feng WANG Li-Rong LI yong-man ZHU Qiang KANG Jin-Jun ZHANG School of Chemistry and Material Science Shanxi Normal University Linfen 041004 China

The influence of crown ether on behaviors of arsenic at different temperatures and residence time was investigated during the pyrolysis of Tuanbo （TB） coal. The modes of occurrence of arsenic were determined by sequential chemical extraction, density fractionation and demineralization. The results indicated that at the same temperature and residence time, the arsenic removal adding dibenzo-18-crown-6 was higher than that adding 18-crown-6, and were all higher than that of TB coal during pyrolysis. When temperature was 850 ℃ and residence time was 30 min, the arsenic removal of TB coal was 30.63%; at the same condition, the arsenic removal while adding 18-crown-6 was 33.21%, higher than that of TB coal; and the arsenic removal while adding dibenzo-18-crown-6 was 67.41%, significantly higher than that of TB coal. From the results, we can see that adding crown ether can improve the arsenic removal during coal pyrolysis, and especially be conducive to the arsenic which is mainly associated with sulfates ＆ monosulfides and that in stable forms.

关键词： coal pyrolysis crown ether arsenic removal transformation behavior

艾草R2R3-MYB转录因子家族成员的鉴定及表达分析

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中国中药杂志 2024年第16期49卷 4407-4419页

作者：崔占虎李淑娇满永宏李明杰古力张重义李孟芝黄显章王宇卿南阳医学高等专科学校、河南省中药效应物质与质量控制研究中医药重点实验室、南阳道地药材(艾草)研究院河南南阳473061 福建农林大学福建福州350002 南阳理工学院、河南省张仲景方药与免疫调节重点实验室河南南阳473004

MYB(v-myb avian myeloblastosis viral oncogene homolog)家族转录因子是高等植物转录因子中数目最多的一类基因家族成员,可分为4个亚家族,其中R2R3-MYB是最常见的亚家族类型。R2R3-MYB类转录因子广泛参与植物的器官发育和次生代谢产... 详细信息

MYB(v-myb avian myeloblastosis viral oncogene homolog)家族转录因子是高等植物转录因子中数目最多的一类基因家族成员,可分为4个亚家族,其中R2R3-MYB是最常见的亚家族类型。R2R3-MYB类转录因子广泛参与植物的器官发育和次生代谢产物生物合成的调控。为研究R2R3-MYB家族转录因子在艾叶黄酮合成和腺毛发育中发挥的作用,该研究基于艾的全基因组数据筛选、鉴定出92个R2R3-MYB转录因子,并利用生物信息学预测其潜在功能。结果表明,92个转录因子的氨基酸长度为168~547 aa,相对分子质量为19.6~60.5 kDa,均为亲水性蛋白。亚细胞定位分析表明,89个AaMYB蛋白定位结果为细胞核,3个蛋白同时定位于细胞核和细胞质中。依据拟南芥R2R3-MYB家族分类,92个艾R2R3-MYB蛋白分为26个亚家族,同一亚族基因结构基本类似。顺式作用元件预测结果表明光响应元件、茉莉酸甲酯元件和脱落酸元件在R2R3-MYB基因启动子区域分布广泛。转录组表达分析结果显示,AaMYB60、AaMYB63和AaMYB86在叶片中的表达均高于茎和根中的表达,说明这3个转录因子主要在叶片中发挥作用。此外,利用系统进化分析筛选出5个参与艾叶黄酮生物合成或腺毛发育的候选R2R3-MYB转录因子。该研究可为后期艾的优良品种选育和种质创新等提供重要的基因资源。

关键词：艾 R2R3-MYB转录因子基因组生物信息学系统进化

An integrated MINLP model for multi-party coordination in downstream oil supply chain

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Petroleum Science 2024年第3期21卷 2066-2079页

作者： Rui Qiu Bo Zhang Wei Zhao Ren-Fu Tu man-Qiu He Qi Liao yong-Tu Liang National Engineering Laboratory for Pipeline Safety/Beijing Key Laboratory of Urban Oil and Gas Distribution Technology China University of Petroleum-BeijingFuxue Road No.18Changping DistrictBeijing102249PR China Strategy&Implementation Department PipeChinaDongtucheng Road No.5Chaoyang DistrictBeijing100013PR China

Cooperation among enterprises can bring overall and individual performance improvement,and a smooth coordination method is ***,due to the lack of customized coordination methods,cooperation in the downstream oil supply chain cannot be carried out *** paper intends to propose a multi-party coordination method to promote cooperation between oil shippers and pipeline operator by optimizing oil transportation,oil substitution and pipeline pricing *** integrated game-theoretic modeling and analysis approach is developed to characterize the operation behaviors of all stakeholders in the downstream oil supply *** proposed mixed integer nonlinear programming model constrains supply and demand capacity,transportation routes,oil substitution rules and pipeline freight *** transformation and price discretization are introduced for model linear *** experiments are carried out in the oil distribution system in South *** results show that compared to the business-as-usual scheme,the new scheme saves transportation cost by 3.48%,increases pipeline turnover by 5.7%,and reduces energy consumption and emissions by 7.66%and 6.77%.It is proved that the proposed method improves the revenue of the whole system,achieves fair revenue distribution,and also improves the energy and environmental benefits of the oil supply chain.

关键词： Downstreamoil supplychain Multi-partycoordination Cooperative game Mixed integernonlinear programming model Pipeline transportation Revenue distribution