The epidermal immune microenvironment plays a dominant role in psoriasis development,as revealed by mass cytometry
作者机构:Department of DermatologySecond Affiliated HospitalZhejiang University School of MedicineHangzhouChina
出 版 物:《Cellular & Molecular Immunology》 (中国免疫学杂志(英文版))
年 卷 期:2022年第19卷第12期
页 面:1400-1413页
核心收录:
学科分类:1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学]
基 金:supported by grants from the National Natural Science Foundation of China (Nos.81930089 82103709 and 82230104)
主 题:Psoriasis Cutaneous immune Mass cytometry Dendritic cell
摘 要:Psoriasis is a common chronic inflammatory skin *** diversity and heterogeneity of immune cells in human skin have been studied in recent years,but the spatial distribution of immune cells at the single-cell level in the human psoriatic epidermis and dermis remains *** this study,we mapped psoriatic skin immune cells from paired lesional,perilesional,and nonlesional skin samples using mass *** dendritic cells(DCs)were found in the psoriatic epidermis and *** dermal CD1c^(+)CD11b^(+)cDC2s migrated to the epidermis in the perilesional skin during the preinitiation ***1c^(+)CD11b^(+)cDC2s rapidly replaced EpCAM^(+)CD11c^(low) LC cells and initiated ***,CD207^(+)CD11c^(hi) LC and CD5^(+)T cells accumulated in the psoriatic epidermis and orchestrated epidermal inflammation in *** immune cell pool in the psoriatic dermis primarily included APCs and T ***,unlike that in the dermis,the epidermal immune environment was more significant and coincided with the inflammation occurring during psoriasis.