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Ferroptosis inhibitors reduce celastrol toxicity and preserve its insulin sensitizing effects in insulin resistant HepG2 cells

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Journal of Integrative Medicine 2024年第3期22卷 286-294页

作者： Jia-jia Liu Xue Zhang Bang-lan Cai Man-man Qi yong-bin chi Bin Peng Deng-hai Zhang School of Medicine Shanghai UniversityShanghai 200444China Shanghai Health Commission Key Lab of Artificial Intelligence-Based Management of Inflammation and Chronic Diseases Shanghai Pudong Gongli HospitalSecondary Military Medical UniversityShanghai 200135China School of Basic Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

Objective:Research has shown that celastrol can effectively treat a variety of diseases,yet when passing a certain dosage threshold,celastrol becomes toxic,causing complications such as liver and kidney damage and erythrocytopenia,among *** this dichotomy in mind,it is extremely important to find ways to preserve celastrol’s efficacy while reducing or preventing its ***:In this study,insulin-resistant Hep G2(IR-Hep G2)cells were prepared using palmitic acid and used for in vitro ***-Hep G2 cells were treated with celastrol alone or in combination with Nacetylcysteine(NAC)or ferrostatin-1(Fer-1)for 12,24 or 48 h,at a range of *** counting kit-8assay,Western blotting,quantitative reverse transcription-polymerase chain reaction,glucose consumption assessment,and flow cytometry were performed to measure celastrol’s cytotoxicity and whether the cell death was linked to ***:Celastrol treatment increased lipid oxidation and decreased expression of anti-ferroptosis proteins in IR-Hep G2 *** downregulated glutathione peroxidase 4(GPX4)m *** docking models predicted that solute carrier family 7 member 11(SLC7A11)and GPX4 were covalently bound by ***,we found for the first time that the application of ferroptosis inhibitors(especially NAC)was able to reduce celastrol’s toxicity while preserving its ability to improve insulin sensitivity in IR-Hep G2 ***:One potential mechanism of celastrol’s cytotoxicity is the induction of ferroptosis,which can be alleviated by treatment with ferroptosis *** findings provide a new strategy to block celastrol’s toxicity while preserving its therapeutic effects.

关键词： Celastrol Insulin resistance Ferroptosis N-Acetylcysteine Palmitic acid Molecular docking

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Exploring the biogeography,morphology,and phylogeny of the condylostomatid ciliates(Alveolata,Ciliophora,Heterotrichea),with establishment of four new Condylostoma species and a revision including redescriptions of five species found in china

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Marine Life Science & Technology 2024年第3期6卷 365-404页

作者： yong chi Fan Wei Danxu Tang Changjun Mu Honggang Ma Zhe Wang Khaled A.SAl-Rasheid Hunter N.Hines Xiangrui Chen School of Marine Sciences Ningbo UniversityNingbo 315211China Institute of Evolution&Marine Biodiversity and Key Laboratory of Evolution&Marine Biodiversity(Education Ministry)Ocean University of ChinaQingdao 266003 china3 Marine College Shandong UniversityWeihai 264209China Weishan Special Aquaculture Base Jining 277600China Zoology Department College of SciencesKing Saud UniversityRiyadh 11451Saudi Arabia Harbor Branch Oceanographic Institute Florida Atlantic UniversityFlorida 34946USA

Species of the ciliate class Heterotrichea Stein,1859 are a cosmopolitan group of unicellular eukaryotic microorganisms,many of which have been widely used as models in various fields of research such as regenerative biology,functional ecol-ogy,environmental toxicology,and symbiotic ***,species identification in the heterotrich family Condylos-tomatidae,especially the most species-rich and type genus Condylostoma Bory de Saint-Vincent,1824,remains challenging due to incomplete original descriptions,few reliable distinguishing characters,and overlapping features between different *** study presents an updated revision of Condylostoma and its related genus Condylostomides da Silva Neto,1994 based on descriptions of five species,including nine populations collected from china,using both morphological and molecular *** main findings are as follows:(1)43 nominal species and about 130 populations are reviewed,result-ing in the recognition of 30 valid species of Condylostoma and eight valid species of Condylostomides;(2)keys,synonyms,biogeographic distributions and amended/improved diagnoses of all valid species are provided;(3)based on the available data,four new Condylostoma species(*** ***.,*** ***.,*** ***.,and *** ***.),one new combination(Condylostomides minimus(Dragesco,1954)***.&***.),and two corrected names(Condylostoma ancestrale Villeneuve-Brachon,1940 *** Condylostomides nigrus(Dragesco,1960)***.)are suggested;(4)cryptic species are detected and proposed for the first time to form the Condylostoma curvum spe-cies complex;(5)three highly confusing Condylostoma species,***,***,and ***,are redefined for the first time based on modern taxonomic methods;(6)a‘flagship’species,Condylostomides coeruleus,is recorded for the first time from the continent of Asia,substantially expanding its biogeography;(7)ciliature adjacent to the distal end of the paroral mem

关键词： Condylostoma Condylostomides New species Phylogeny Revision Taxonomy

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Knowledge Distillation via Hierarchical Matching for Small Object Detection

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Journal of Computer Science & Technology 2024年第4期39卷 798-810页

作者： yong-chi Ma Xiao Ma Tian-Ran Hao Li-Sha Cui Shao-Hui Jin Pei Lyu School of Computer Science and Artificial Intelligence Zhengzhou UniversityZhengzhou 450000China

Knowledge distillation is often used for model compression and has achieved a great breakthrough in image classification,but there still remains scope for improvement in object detection,especially for knowledge extraction of small *** main problem is the features of small objects are often polluted by background noise and not prominent due to down-sampling of convolutional neural network(CNN),resulting in the insufficient refinement of small object features during *** this paper,we propose Hierarchical Matching Knowledge Distillation Network(HMKD)that operates on the pyramid level P2 to pyramid level P4 of the feature pyramid network(FPN),aiming to intervene on small object features before *** employ an encoder-decoder network to encapsulate low-resolution,highly semantic information,akin to eliciting insights from profound strata within a teacher network,and then match the encapsulated information with high-resolution feature values of small objects from shallow layers as the *** this period,we use an attention mechanism to measure the relevance of the inquiry to the feature *** in the process of decoding,knowledge is distilled to the *** addition,we introduce a supplementary distillation module to mitigate the effects of background *** show that our method achieves excellent improvements for both one-stage and twostage object ***,applying the proposed method on Faster R-CNN achieves 41.7%mAP on COCO2017(ResNet50 as the backbone),which is 3.8%higher than that of the baseline.

关键词： knowledge distillation object detection small object detection machine learning

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浅谈大型综合体公共建筑中庭消防疏散难点及其应用

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工程建设与设计 2024年第19期 55-57页

作者：池永军上海市政工程设计研究总院(集团)有限公司上海200092

阐述中庭的定义,分析对比单独中庭、中庭+回廊、中庭+回廊设置为亚安全区3种中庭消防疏散的设计模式,并从建筑中庭的防火分隔、安全疏散等方面探讨中庭消防疏散的几个要点,最后结合工程案例,探讨在实际项目的中庭建筑消防的应用。

关键词：中庭回廊亚安全区防火分区防火卷帘

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艾司氯胺酮在围手术期的应用进展

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中国新药与临床杂志 2024年第1期43卷 12-16页

作者：王群季加富迟永良苏帆山东中医药大学第一临床医学院山东济南250014 山东中医药大学附属医院麻醉科山东济南250014

艾司氯胺酮是一种强效麻醉性镇痛药,目前已用于临床麻醉和术后镇痛中。艾司氯胺酮可通过多种途径给药,有镇痛作用强、起效迅速、消除迅速、不抑制自主呼吸的优点,在小儿麻醉、产科麻醉以及低血容量患者或烧伤患者的麻醉中有一定的优势,... 详细信息

艾司氯胺酮是一种强效麻醉性镇痛药,目前已用于临床麻醉和术后镇痛中。艾司氯胺酮可通过多种途径给药,有镇痛作用强、起效迅速、消除迅速、不抑制自主呼吸的优点,在小儿麻醉、产科麻醉以及低血容量患者或烧伤患者的麻醉中有一定的优势,且适用于老年患者,在临床中的应用日益广泛。但艾司氯胺酮的使用剂量、应用方法及联用药物的选择等尚有待进一步探讨。

关键词：艾司氯胺酮麻醉镇痛围手术期镇静

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框架竞争与危机走向:时空、形式、偏好影响下的公众选择

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中国地质大学学报（社会科学版） 2024年第5期24卷 117-133页

作者：马永驰任昊杰康传彬山东大学政治学与公共管理学院山东青岛266200 复旦大学国际关系与公共事务学院上海200433 四川大学公共管理学院四川成都610065

危机发生后,相关方以公众为面向展开框架竞争,试图最大化地争取公众认同,获得危机应对和处理上的主动权。但已有的框架竞争研究明显忽视了公众选择,缺乏从框架竞争到危机走向的动态考察。本研究从公众选择这一关键中介出发,选取甘肃阳... 详细信息

危机发生后,相关方以公众为面向展开框架竞争,试图最大化地争取公众认同,获得危机应对和处理上的主动权。但已有的框架竞争研究明显忽视了公众选择,缺乏从框架竞争到危机走向的动态考察。本研究从公众选择这一关键中介出发,选取甘肃阳关林场事件为典型案例,在案例呈现与分析的基础上,构建出框架竞争、公众选择、危机走向三者关系的整合式模型。研究发现:意义建构的时空情境、意义给赋的形式差异、差序信任的固有偏好分别影响着公众对于危机有无的判断、证据真假的判断、主体善恶的判断,以上三重判断共同作用于公众选择的生成和支配性框架的确立。承载公众注意力的支配性框架是化解危机的靶向所在和重要参照,为政治问责和政策变革指明依据和方向,从而切实作用于危机走向。研究为打开框架竞争影响危机走向的黑箱提供了合适的切入点,有助于加深危机管理者对框架竞争、公众选择和危机走向三者之间关系的理解。

关键词：框架竞争危机走向公众选择支配性框架

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改良电休克疗法治疗Tourette综合征共病强迫性障碍1例并文献复习

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神经疾病与精神卫生 2024年第8期24卷 602-605页

作者：田璐迟勇首都医科大学附属北京安定医院国家精神疾病医学中心、国家精神心理疾病临床医学研究中心、精神疾病诊断与治疗北京市重点实验室 100088 首都医科大学人脑保护高精尖创新中心北京100069

Tourette综合征(Tourette syndrome,TS)是一类以突然的、反复的、非节律性的运动抽动和发声抽动为特征的精神障碍,常起病于儿童青少年时期,临床表现复杂而严重。超过80%的TS患者共患其他精神疾病,给患者造成明显的痛苦和损害,是抽动障... 详细信息

Tourette综合征(Tourette syndrome,TS)是一类以突然的、反复的、非节律性的运动抽动和发声抽动为特征的精神障碍,常起病于儿童青少年时期,临床表现复杂而严重。超过80%的TS患者共患其他精神疾病,给患者造成明显的痛苦和损害,是抽动障碍最严重的亚型^([1-2])。然而,目前TS的治疗仍相对困难,其中药物治疗仍以氟哌啶醇、硫必利、阿立哌唑等抗精神病药物为主,而心理及行为治疗耗时长且对重度患者疗效有限^([3-5]),神经调控治疗方面尚缺乏大样本的临床试验验证其疗效与最佳刺激参数^([6])。改良电休克疗法(modified electroconvulsive therapy,MECT)作为疗效确切的物理治疗方式,往往用于难治性精神疾病的治疗。

关键词：强迫性障碍 Tourette综合征青少年共患病

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新兴技术前瞻性治理工具及中国场景实践

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山东工商学院学报 2024年第1期38卷 89-98页

作者：陈瑜马永驰大连海洋大学海洋法律与人文学院辽宁大连116033 山东大学政治学与公共管理学院山东青岛266237

从新兴技术应用引发社会风险的角度出发,探讨了防范新兴技术社会风险管理方式从专家决策向前瞻性治理的转变。围绕前瞻性治理和新兴技术社会风险关系的演变,梳理发现前瞻性治理在不同国家的效果各异,其原因在于前瞻性治理尚未成为统一... 详细信息

从新兴技术应用引发社会风险的角度出发,探讨了防范新兴技术社会风险管理方式从专家决策向前瞻性治理的转变。围绕前瞻性治理和新兴技术社会风险关系的演变,梳理发现前瞻性治理在不同国家的效果各异,其原因在于前瞻性治理尚未成为统一规范的制度化治理工具或政策规则,应提高前瞻性治理工具的社会风险防范能力,完善和补充新兴技术治理工具。

关键词：新兴技术社会风险治理工具

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Andrographolide as a potent and promising antiviral agent

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chinese Journal of Natural Medicines 2020年第10期18卷 760-769页

作者： Latif Reshi Wang chi-yong Department of Veterinary Medicine College of Veterinaiy MedicineNational Chung Hsing UniversityTaichung 40227TaiwanChina

Andrographolide is a labdane diterpenoid extracted and purified from the aerial parts of plants belonging to genus Andrographis(Acanthaceae).The research has shown the plant based compound is low cytotoxic,having antimicrobial,anti-cancer,antiviral and anti-parasitic *** both prevent spread as well as transmission of virus to neighboring cells by interfering with different cell signaling *** addition to its medicinal value,plant has been found having nutritional *** being cost effective,easy availability and having nutritional value as a natural supplement,can be used to improve the quality of life in countries having low standard of *** to the limited number of effective vaccines,the plant-based antiviral drugs have provided considerable hope for fighting against the viral *** plant-derived compound when produced in large quantities is cost effective with low cytotoxic ***,much deep insight research at the molecular level is needed to develop the molecules against the viral *** paper aims to highlight the antiviral role of Andrographolide that can made significant contributions toward the improvement of human health and will also summarize the current status and future strategies concerning the therapeutic applications of Andrographolide to combat different viral disease in humans.

关键词： Andrographolide Vaccines Antiviral drugs Antimicrobial Life cycle Viral infection

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Influence of chlorine on methane oxidation

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Journal of Environmental Sciences 2009年第9期21卷 1315-1320页

作者： chi yong WANG Bo YAN Jianhua NI Mingjiang Institute for Thermal Power Engineering State Key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou 310027 China. School of Energy and Power Engineering University of Shanghai for Science and Technology Shanghai 200093 China

Experiments on CH4/Cl2/O2/N2 oxidation were conducted in an atmospheric pressure flow reactor to understand the influence of chlorine on hydrocarbon oxidation in hazardous waste incineration. The reaction temperature varied from 973 to 1273 K and the chlorine to hydrogen mole ratio （Cl/H） of the irdet mixture varied from 0 to 0.44. The species produced in the reaction were measured online with Fourier transform infrared spectroscopy （FT-IR）. It was found that the destruction and removal efficiency of CH4 increased with Clfl-I mole ratio. Increasing Cl/H favored COCl2 and CO formation and inhibited the CO oxidation process. As Cl/H approached 0.44, the concentrations of CH2Cl2 and CH3Cl first increased, and then declined. Reaction temperature greatly affected the reaction system. Increasing temperatures raised the destruction removal efficiency of CH4 and decreased the concentrations of CH3Cl and CH2Cl2. With a certain ratio of Cl/H, the concentrations of CO and COCl2 first increased and then declined. The CO and COCl2 concentration peak was observed around 1100 K and 1023 K, respectively. When the reaction temperature exceeded 1273 K, carbon in CH4 was mostly converted to CO2. It could be concluded that the presence of chlorine enhanced the destruction of CH4, but resulted in the more toxic incomplete combustion products emission such as COCl2 when the reaction temperature was not high enough.

关键词： hazardous waste incineration methane oxidation chlorine

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