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Intraoperative bioprinting of human adipose-derived stem cells and extra-cellular matrix induces hair follicle-like downgrowths and adipose tissue formation during full-thickness craniomaxillofacial skin reconstruction

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Bioactive Materials 2024年第3期33卷 114-128页

作者： Youngnam Kang Miji Yeo Irem Deniz Derman Dino JRavnic yogendra pratap singh Mecit Altan Alioglu Yang Wu Jasson Makkar Ryan R.Driskell Ibrahim T.Ozbolat Engineering Science and Mechanics Department Penn State UniversityUniversity ParkPA16802USA The Huck Institutes of the Life Sciences Penn State UniversityUniversity ParkPA16802USA Department of Surgery College of MedicinePenn State UniversityHersheyPA17033USA School of Mechanical Engineering and Automation Harbin Institute of TechnologyShenzhen518055China School of Molecular Biosciences College of Veterinary MedicineWashington State UniversityPullmanWA99164USA Department of Biomedical Engineering Penn State UniversityUniversity ParkPA16802USA Materials Research Institute Penn State UniversityUniversity ParkPA16802USA Department of Neurosurgery Pennsylvania State College of MedicineHersheyPA17033USA Penn State Cancer Institute Penn State UniversityHersheyPA17033USA Department of Medical Oncology Cukurova UniversityAdan101130Turkey

Craniomaxillofacial(CMF)reconstruction is a challenging clinical *** often necessitates skin replacement in the form of autologous graft or flap surgery,which differ from one another based on hypodermal/dermal ***,both approaches are plagued by scarring,poor cosmesis,inadequate restoration of native anatomy and hair,alopecia,donor site morbidity,and potential for ***,new reconstructive approaches are warranted,and tissue engineered skin represents an exciting *** this study,we demonstrated the reconstruction of CMF full-thickness skin defects using intraoperative bioprinting(IOB),which enabled the repair of defects via direct bioprinting of multiple layers of skin on immunodeficient rats in a surgical *** a newly formulated patient-sourced allogenic bioink consisting of both human adipose-derived extracellular matrix(adECM)and stem cells(ADSCs),skin loss was reconstructed by precise deposition of the hypodermal and dermal components under three different sets of animal ***,even at a very low concentration such as 2%or less,has shown to be bioprintable via droplet-based bioprinting and exhibited de novo adipogenic capabilities both in vitro and in *** findings demonstrate that the combinatorial delivery of adECM and ADSCs facilitated the reconstruction of three full-thickness skin defects,accomplishing near-complete wound closure within two *** importantly,both hypodermal adipogenesis and downgrowth of hair follicle-like structures were achieved in this two-week time *** approach illustrates the translational potential of using human-derived materials and IOB technologies for full-thickness skin loss.

关键词： Intraoperative bioprinting Adipose-derived extracellular matrix Adipose-derived stem cells Skin tissue engineering

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再生医学中器官生物打印的进展（英文）

Engineering 2024年第11期 121-142页

作者：王象张迪 yogendra pratap singh Miji Yeo 邓国滔赖嘉琪陈飞 Ibrahim T.Ozbolat 于寅 Center for Materials Synthetic Biology Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic Biology Shenzhen Institute of Advanced Technology Chinese Academy of Sciences The Huck Institutes of the Life Sciences Pennsylvania State University University Park Engineering Science and Mechanics Department Pennsylvania State University University Park Department of Biomedical Engineering Pennsylvania State University University Park Materials Research Institute Pennsylvania State University University Park Department of Neurosurgery Pennsylvania State College of Medicine Pennsylvania State Cancer Institute Pennsylvania State University University Park Biotechnology Research and Application Center Cukurova University

Organ damage or failure arising from injury, disease, and aging poses challenges due to the body's limited regenerative capabilities. Organ transplantation presents the issues of donor shortages and immune rejection risks, necessitating innovative solutions. The three-dimensional(3D) bioprinting of organs on demand offers promise in tissue engineering and regenerative medicine. In this review, we explore the state-of-the-art bioprinting technologies, with a focus on bioink and cell type selections. We follow with discussions on advances in the bioprinting of solid organs, such as the heart, liver, kidney, and pancreas,highlighting the importance of vascularization and cell integration. Finally, we provide insights into key challenges and future directions in the context of the clinical translation of bioprinted organs and their large-scale production.

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Displacement-based seismic design of flat slab-shear wall buildings

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Earthquake Engineering and Engineering Vibration 2016年第2期15卷 209-221页

作者： Subhajit Sen yogendra singh Department of Earthquake Engineering IIT Roorkee

Flat slab system is becoming widely popular for multistory buildings due to its several advantages. However, the performance of flat slab buildings under earthquake loading is unsatisfactory due to their vulnerability to punching shear failure. Several national design codes provide guidelines for designing flat slab system under gravity load only. Nevertheless, flat slab buildings are also being constructed in high seismicity regions. In this paper, performance of flat slab buildings of various heights, designed for gravity load alone according to code, is evaluated under earthquake loading as per ASCE/SEI 41 methodology. Continuity of slab bottom reinforcement through column cage improves the performance of flat slab buildings to some extent, but it is observed that these flat slab systems are not adequate in high seismicity areas and need additional primary lateral load resisting systems such as shear walls. A displacement-based method is proposed to proportion shear walls as primary lateral load resisting elements to ensure satisfactory performance. The methodology is validated using design examples of flat slab buildings with various heights.

关键词： satisfactory continuity vulnerability validated reinforcement gravity walls drift alone details

Seismic safety evaluation methodology for masonry building and retrofitting using splint and bandage technique with wire mesh

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Frontiers of Structural and Civil Engineering 2022年第4期16卷 478-505页

作者： Pravin Kumar Venkat Rao PADALU yogendra singh Earthquake Engineering Research Center International Institute of Information Technology Hyderabad(IIIT-H)Telangana 500032India Department of Earthquake Engineering Indian Institute of Technology Roorkee(IITR)Uttarakhand 247667India

The paper presents a seismic safety assessment of unreinforced masonry(URM)building using two *** first approach uses the‘Pier Analysis’method,based on the concept of equivalent lateral stiffness,where in-plane and out-of-plane actions are considered *** second approach is developed with the program SAP2000,where the linear response is evaluated using continuum‘finite element modelling’(FEM).Both methods are compared to evaluate the safety of wall piers and the differences in the outcomes under combined gravitational and lateral seismic *** analysis results showed that few wall elements are unsafe in in-plane and out-of-plane *** is also observed that the pier analysis method is conservative compared to FEM,but can be used as a simplified and quick tool in design offices for safety assessment,with reasonable *** safeguard the URM wall piers under lateral loads,a retrofitting technique is adopted by providing vertical and horizontal belts called splints and bandages,respectively,using welded wire mesh(WWM)*** study using the‘Pier Analysis’shows that the lateral load capacity of unsafe URM piers can be enhanced up to 3.67 times and made safe using the applied retrofitting ***,the retrofitting design methodology and recommendations for application procedures to on-site URM buildings are discussed in detail.

关键词： unreinforced masonry seismic in-plane and out-of-plane forces pier analysis finite element modelling splint and bandage technique with wire mesh

Seismic fragility reduction of an unreinforced masonry school building through retrofit using ferrocement overlay

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Earthquake Engineering and Engineering Vibration 2020年第2期19卷 397-412页

作者： Sachin B Kadam yogendra singh Li Bing Department of Applied Mechanics Walchand College of EngineeringSangliMaharastra 416415India Department of Earthquake Engineering Indian Institute of Technology RoorkeeRoorkeeUttarakhand 247667India Natural Hazard Research Centre School of Civil and Environmental EngineeringNanyang Technological UniversitySingapore 639798Singapore

The Himalayan region is one of the major seismic areas in the ***,similar to many other seismically active locations,there are substantial numbers of unreinforced masonry(URM)buildings;the majority of which have not been designed for seismic *** seismic events have shown that such buildings are highly vulnerable to *** of these URM buildings is an important concern in earthquake mitigation *** government school buildings in rural areas of northern India are constructed of unreinforced *** school buildings are socially important structures and serve as a crucial resource for rehabilitation during any *** effectiveness of ferrocement(FC)to create a URM-FC composite is described in this study by estimating the performance and fragility of a URM school building before and after a *** models,based on the equivalent frame method,are developed and used for nonlinear static analysis to estimate the enhancement in *** capacity enhancement due to retrofitting is presented in terms of the maximum PGA sustained and damage probabilities at the expected level of earthquake hazard.

关键词： unreinforced masonry school building pushover analysis seismic fragility

Effect of URM infills on seismic vulnerability of Indian code designed RC frame buildings

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Earthquake Engineering and Engineering Vibration 2012年第2期11卷 233-241页

作者： Putul Haldar yogendra singh D.K.Paul Department of Earthquake Engineering IIT RoorkeeRoorkee-247667India

Unreinforced Masonry (URM) is the most common partitioning material in framed buildings in India and many other countries. Although it is well-known that under lateral loading the behavior and modes of failure of the frame buildings change significantly due to infill-frame interaction, the general design practice is to treat infills as nonstructural elements and their stiffness, strength and interaction with the frame is often ignored, primarily because of difficulties in simulation and lack of modeling guidelines in design codes. The Indian Standard, like many other national codes, does not provide explicit insight into the anticipated performance and associated vulnerability of infilled frames. This paper presents an analytical study on the seismic performance and fragility analysis of Indian code-designed RC frame buildings with and without URM infills. Infills are modeled as diagonal struts as per ASCE 41 guidelines and various modes of failure are considered. HAZUS methodology along with nonlinear static analysis is used to compare the seismic vulnerability of bare and infilled frames. The comparative study suggests that URM infills result in a significant increase in the seismic vulnerability of RC frames and their effect needs to be properly incorporated in design codes.

关键词： URM infill RC frame building Indian seismic design code seismic performance seismic vulnerability

ON APPROXIMATE EFFICIENCY FOR NONSMOOTH ROBUST VECTOR OPTIMIZATION PROBLEMS

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Acta Mathematica Scientia 2020年第3期40卷 887-902页

作者： Tadeusz ANTCZAK yogendra PANDEY Vinay singh Shashi Kant MISHRA Faculty of Mathematics and Computer Science University of LódźBanacha 2290-238 LódźPoland Department of Mathematics Satish Chandra CollegeBallia 277001India Department of Mathematics National Institute of TechnologyAizawl-796012MizoramIndia Department of Mathematics Banaras Hindu UniversityVaranasi-221005India

In this article,we use the robust optimization approach(also called the worst-case approach)for findingε-efficient solutions of the robust multiobjective optimization problem defined as a robust(worst-case)counterpart for the considered nonsmooth multiobjective programming problem with the uncertainty in both the objective and constraint ***,we establish both necessary and sufficient optimality conditions for a feasible solution to be anε-efficient solution(an approximate efficient solution)of the considered robust multiobjective optimization *** also use a scalarizing method in proving these optimality conditions.

关键词： Robust optimization approach robust multiobjective optimization ε-efficient solution ε-optimality conditions scalarization

Torque teno virus:Its prevalence and isotypes in North India

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World Journal of Gastroenterology 2008年第39期14卷 6044-6051页

作者： Mohammad Irshad Shiwani singh Khushboo Irshad Sanjay Kumar Agarwal yogendra Kumar Joshi Clinical Biochemistry Division Department of Laboratory MedicineAll India Institute of Medical SciencesNew Delhi-110029India Department of Biochemistry All India Institute of Medical SciencesNew Delhi-110029India Department of Nephrology All India Institute of Medical SciencesNew Delhi-110029India Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi-110029India

AIM： To investigate the prevalence and genotype distribution of Torque teno virus （TTV） in patients with different liver diseases and chronic renal failure treated at a referral hospital in North India. METHODS： Whereas prevalence of TFV was based on amplification of conserved region of ORF2 of TTV genome, the genotyping of TFV was carried out using restriction fragment length polymorphism （RFLP） procedure on the N22 region of ORFI. RESULTS： TTV-DNA was detected in 137 of 513 （26.7%） patients with liver diseases and 38 of 65 （58.5%） patients with chronic renal failure. Trv was also detected in 2/7% of healthy controls. The sequence analysis of the PCR product from 10 randomly selected cases failed to show a significant sequence divergence when compared with that of the TRM1 isolate of TTV genotype 1. The results of genotyping in 55 randomly selected patients showed the presence of genotype 1 （G1） in 53 （96.4%） and genotype 2 （G2） in 2 cases （3.6%）, respectively. Other genotypes were not identified in this patient subgroup, suggesting that G1 is predominant in this area. The results of genotyping by RFLP were also supported by phylogenetic tree analysis, where G1 was found to be the major genotype. CONCLUSION： These results indicate that TTV is moderately present in Indian patients, with G1 to be the major genotype in North India. The pathogenicity and etiological role of TTV in different diseases is still a question mark and warrant further studies.

关键词： Torque teno virus Genotype Restriction fragment length polymorphism Torque Teno Hepatocellular carcinoma

Structural,optical and antimicrobial properties of pure and Agdoped ZnO nanostructures

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Journal of Semiconductors 2022年第3期43卷 78-86页

作者： Sagar Vikal yogendra K.Gautam Anit K.Ambedkar Durvesh Gautam Jyoti singh Dharmendra pratap Ashwani Kumar Sanjay Kumar Meenal Gupta Beer Pal singh Smart Materials and Sensor Laboratory Department of PhysicsCh.Charan Singh UniversityMeerutUttar Pradesh 250004India Department of Genetics and Plant Breeding Ch.Charan Singh UniversityMeerutUttar Pradesh 250004India Nanoscience Laboratory Institute Instrumentation CentreIIT RoorkeeRoorkee 247667India Department of Physics University of RajasthanJaipur 302004India Department of Physics SBSRSharda UniversityGreater NoidaUttar PradeshIndia

In the present work,zinc oxide(ZnO)and silver(Ag)doped ZnO nanostructures are synthesized using a hydrothermal *** quality of the products is attested using X-ray diffraction,which confirms the hexagonal wurtzite struc-ture of pure ZnO and Ag-doped ZnO *** further confirms the crystallite orientation along the c-axis,(101)*** field emission scanning electron microscope study reveals the change in shape of the synthesized ZnO particles from hexagonal nanoparticles to needle-shaped nanostructures for 3 wt%Ag-doped *** optical band gaps and lattice strain of nanostructures is increased significantly with the increase of doping concentration of Ag in ZnO *** anti-microbial activity of synthesized nanostructures has been evaluated against the gram-positive human pathogenic bacteria,Staphylococcus aureus via an agarose gel diffusion *** maximum value of zone of inhibition(22 mm)is achieved for 3 wt%Ag-doped ZnO nanostructure and it clearly demonstrates the remarkable antibacterial activity.

关键词： zinc oxide silver hydrothermal FESEM antimicrobial activity Staphylococcus