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CCGD-ESCC： A Comprehensive Database for Genetic Variants Associated with Esophageal Squamous Cell Carcinoma in Chinese Population

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Genomics, Proteomics & Bioinformatics 2018年第4期16卷 262-268页

作者： Linna Peng Sijin Cheng Yuan Lin Qionghua Cui Yingying Luo Jiahui Chu Mingming Shao Wenyi Fan Yamei Chen Ai Lin yiyi xi Yanxia Sun Lei Zhang Chao Zhang Wen Tan Ge Gao Chen Wu Dongxin Lin Department of Etiology and Carcinogenesis National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Protein and Plant Gene Research School of Life Sciences Center for Bioinformatics Peking UniversityBeijing 100871China Beijing Advanced Innovation Center for Genomics (ICG) Peking UniversityBeijing 100871China National Engineering Research Center for Beijing Biochip Technology Beijing 102206China School of Life Sciences Peking UniversityBeijing 100871China

Esophageal squamous-cell carcinoma （ESCC） is one of the most lethal malignancies in the world and occurs at particularly higher frequency in China. While several genome-wide association studies （GWAS） of germline variants and whole-genome or whole-exome sequencing studies of somatic mutations in ESCC have been published, there is no comprehensive database publically available for this cancer. Here, we developed the Chinese Cancer Genomic Database-Esophageal Squamous Cell Carcinoma （CCGD-ESCC） database, which contains the associations of 69,593 single nucleotide polymorphisms （SNPs） with ESCC risk in 2022 cases and 2039 controls, survival time of 1006 ESCC patients （survival GWAS） and gene expression （expression quantitative trait loci,eQTL） in 94 ESCC patients. Moreover, this database also provides the associations between8833 somatic mutations and survival time in 675 ESCC patients. Our user-friendly database is a resource useful for biologists and oncologists not only in identifying the associations of genetic variants or somatic mutations with the development and progression of ESCC but also in studying the underlying mechanisms for tumorigenesis of the cancer. CCGD-ESCC is freely accessible at http：//***/ccgd/ESCCdb.

关键词： Esophageal cancer Germline variants Somatic mutations Association databaseChinese population

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VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2906-2919页

作者： Weiling Liu Chuanwang Miao Shaosen Zhang Yachen Liu xiangjie Niu yiyi xi Wenjia Guo Jiahui Chu Ai Lin Hongjin Liu xinyu Yang xinjie Chen Ce Zhong Yuling Ma Yuqian Wang Shihao Zhu Shuning Liu Wen Tan Dongxin Lin Chen Wu Department of Etiology and Carcinogenesis National Cancer Center/National Clinical Research Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cancer Institute Affiliated Cancer Hospital of Xinjiang Medical UniversityUrumqiChina Key Laboratory of Oncology of xinjiang Uygur Autonomous Region UrumqiChina Department of pharmacy Qilu HospitalCheeloo College of MedicineShandong UniversityJinanChina Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhouChina Jiangsu Key Laboratory of Cancer Biomarkers Prevention and TreatmentCollaborative Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingChina CAMS Key Laboratory of Genetics and Genomic Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Radiotherapy remains the mainstay for treatment of various types of human cancer;however,the clinical efficacy is often limited by radioresistance,in which the underlying mechanism is largely ***,using esophageal squamous cell carcinoma(ESCC)as a model,we demonstrate that guanine nucleotide exchange factor 2(VAV2),which is overexpressed in most human cancers,plays an important role in primary and secondary *** have discovered for the first time that VAV2 is required for the Ku70/Ku80 complex formation and participates in non-homologous end joining repair of DNA damages caused by ionizing radiation.

关键词： cancer clinical resistance

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Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma

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Signal Transduction and Targeted Therapy 2022年第3期7卷 896-908页

作者： yiyi xi Yuan Lin Wenjia Guo xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin Department of Etiology and Carcinogenesis National Cancer Center/National Clinical Research Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Beijing Advanced Innovation Center for Genomics Biomedical Pioneering Innovation CenterPeking UniversityBeijing 100871China Cancer Institute Affiliated Cancer Hospital of Xinjiang Medical UniversityUrumqi 830000China School of Biomedical Engineering School of Ophthalmology and Optometry and Eye HospitalWenzhou Medical UniversityWenzhou 325011China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325000China Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China CAMS Key Laboratory of Genetics and Genomic Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China

This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival *** genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns.

关键词： esophageal squamous diagnosis

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二维任意倾斜地层的层速度计算结果分析

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长安大学学报(地球科学版) 1987年第2期 95-100页

作者：沈怡怡杜有成

本文主要介绍沙赫(Shan,P.M.)公式,对二维任意倾斜地层的层速度计算的应用效果。依据实际地层剖面Φ、V、Z参数的可能变化,设计18个较为复杂的地层模型进行了大量试算,并与Dix公式计算结果作了对比,表明对任意倾斜地层应采用沙赫公式提... 详细信息

本文主要介绍沙赫(Shan,P.M.)公式,对二维任意倾斜地层的层速度计算的应用效果。依据实际地层剖面Φ、V、Z参数的可能变化,设计18个较为复杂的地层模型进行了大量试算,并与Dix公式计算结果作了对比,表明对任意倾斜地层应采用沙赫公式提取层速度才是适宜的。

关键词：任意倾斜地层层速度波前曲率

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单线圈双调谐探头的电路分析

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分析仪器 1988年第3期 39-40页

作者：沙朝晨陈宣宣王熹江宣进中国科学院长春应用化学研究所

叙述一种单线圈双调谐探头的电路分析.单线圈双调谐探头同时提供两个不同信号源的发射和接收。探头使用同一个射频线圈进行核磁共振观察和场频联锁。应用二端网络原理对单线圈双调谐探头的电路进行分析,推导出计算探头参量的近似公式.... 详细信息

叙述一种单线圈双调谐探头的电路分析.单线圈双调谐探头同时提供两个不同信号源的发射和接收。探头使用同一个射频线圈进行核磁共振观察和场频联锁。应用二端网络原理对单线圈双调谐探头的电路进行分析,推导出计算探头参量的近似公式.依据公式设计了CH—100型付立叶变换核磁共振波谱仪的高质量探头电路。仪器性能:S/N为50:1在5毫米氢探头和1%乙基苯,并且40%乙醛得4.97×10-9的分辨率.

关键词：探头电路付立叶变换单线近似公式电路分析串联电路

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食管鳞状细胞癌中驱动基因的多组学关联分析

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医学研究杂志 2020年第1期49卷 100-103,107页

作者：席奕轶施新泽林霖郭文佳刘天媛王雨芊林东昕吴晨国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院/北京协和医学院肿瘤医院、分子肿瘤学国家重点实验室、病因及癌变研究室、癌发生及预防分子机理北京市重点实验室北京100021

目的探讨食管鳞癌驱动基因的体细胞突变、拷贝数改变、基因表达和DNA甲基化等多个分子层面的改变及其交互影响。方法从肿瘤基因组图谱计划(TCGA)下载95例食管鳞癌多组学数据,结合实验室前期91例患者测序结果进行分析;根据驱动基因突变... 详细信息

目的探讨食管鳞癌驱动基因的体细胞突变、拷贝数改变、基因表达和DNA甲基化等多个分子层面的改变及其交互影响。方法从肿瘤基因组图谱计划(TCGA)下载95例食管鳞癌多组学数据,结合实验室前期91例患者测序结果进行分析;根据驱动基因突变将患者分组,对两组患者的基因表达水平进行非配对t检验;通过Spearman秩相关进行拷贝数改变、DNA甲基化与驱动基因表达水平的关联分析;通过Log-Rank检验对突变组和非突变组患者生存曲线进行比较。结果多维度数据关联分析结果显示,驱动基因TP53、RB1、ZNF750和PTCH1的表达水平在突变组与非突变组间比较,差异有统计学意义(P=0.011,FC=1.43;P=0.045,FC=0.44;P=0.012,FC=2.20;P=0.011,FC=2.62);驱动基因CUL3、PIK3CA、RBPJ、FBXW7、CDKN2A、PTEN、RB1和CERBBP的表达水平与其拷贝数改变呈显著正相关;多个驱动基因表达受启动子和基因体甲基化的共同调控,并且在两部分数据中存在差异;驱动基因CREBBP(P=0.000)和FAT1(P=0.002)的突变与患者预后相关,可作为食管鳞癌潜在的预后标志物。结论通过对食管鳞癌多组学数据的整合分析,阐述了食管鳞癌中体细胞突变、拷贝数改变、DNA甲基化与20个驱动基因表达水平的关联,并发现CREBBP和FAT1的突变可能成为食管鳞癌患者潜在的预后标志物。这些结果为进一步探究驱动基因在食管鳞癌中的功能机制奠定了一定基础。

关键词：食管鳞状细胞癌驱动基因多组学预后

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RHA2b-mediated MYB30 degradation facilitates MYB75-regulated,sucrose-induced anthocyanin biosynthesis in Arabidopsis seedlings

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Plant Communications 2024年第3期5卷 62-76页

作者： Huapeng Zhou Jiaxian He yiyi Zhang Hongyun Zhao xia Sun xi Chen xinrui Liu Yuan Zheng Honghui Lin Key Laboratory of Bio-resource and Eco-environment of the Ministry of Education College of Life SciencesSichuan UniversityChengdu 610064China Innovative Center of Molecular Genetics and Evolution School of Life SciencesGuangzhou UniversityGuangzhou 510642China State Key Laboratory of Cotton Biology Department of BiologyHenan UniversityKaifeng 475004China

Anthocyanins play diverse roles in plant physiology and stress *** Arabidopsis,the MYB–bHLH–WD40(MBW)complex has a crucial role in the regulation of anthocyanin ***,we report that the R2R3-MYB transcription factor MYB30 and the ubiquitin E3 ligase RHA2b participate in anthocyanin biosynthesis through regulation of the MBW ***30 was found to negatively regulate sucrose-induced anthocyanin biosynthesis in Arabidopsis *** of multiple genes involved inflavo-noid or anthocyanin biosynthesis was affected in the myb30 mutant,and MYB30 directly repressed the expression of MYB75,which encodes a core component of the MBW complex,by binding to its ***,MYB30 physically interacted with MYB75 to inhibit its activity by repressing MBW complex *** addition,sucrose treatment signicantly promoted MYB30 degradation via the action of *** ubiquitination and degradation of MYB30 were signicantly attenuated in the rha2b mutant un-der high-sucrose treatment,and further analysis showed that MYB75 directly promoted RHA2b expression in response to high *** work thus reveals an anthocyanin biosynthetic regulatory module,RHA2b–MYB30,that controls the function of the MBW complex via *** repression of MYB75 by MYB30 is released by MYB75-induced RHA2b expression,thus ensuring the self-activation of MYB75 when anthocy-anin synthesis is needed.

关键词： anthocyanin biosynthesis high sucrose MBW complex MYB30 MYB75 RHA2b

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Extraordinarily stable and wide-temperature range sodium/potassium-ion batteries based on 1D SnSe2-SePAN composite nanofibers

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InfoMat 2023年第9期5卷 38-50页

作者： yiyi Wang Fuyu xiao xi Chen Peixun xiong Chuyuan Lin Hong-En Wang Mingdeng Wei Qingrong Qian Qinghua Chen Lingxing Zeng Engineering Research Center of Polymer Green Recycling of Ministry of Education College of Carbon Neutral Modern IndustryFujian Normal UniversityFuzhouthe People's Republic of China Universitéde Picardie Jules Verne Laboratoire de Réactivitéet Chimie des Solides(LRCS)AmiensFrance Inorganic Chemistry I Technische Universität DresdenDresdenGermany College of Physics and Electronics Information Yunnan Key Laboratory of Optoelectronic Information TechnologyYunnan Normal UniversityKunmingthe People's Republic of China Fujian Provincial Key Laboratory of Electrochemical Energy Storage Materials Fuzhou UniversityFuzhouthe People's Republic of China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjinthe People's Republic of China

Developing electrodes with long lifespan and wide-temperature adaptability is crucial important to achieve high-performance sodium/potassium-ion batteries(SIBs/PIBs).Herein,the SnSe2-SePAN composite was fabricated for extraordinarily stable and wide-temperature range SIBs/PIBs through a coupling strategy between controllable electrospinning and selenylation,in which SnSe2 nanoparticles were uniformly encapsulated in the SePAN *** unique structure of SnSe2-SePAN not only relieves drastic volume variation but also guarantees the structural integrity of the composite,endowing SnSe2-SePAN with excellent sodium/potassium storage ***,SnSe2-SePAN displays a high sodium storage capacity and excellent feasibility in a wide working temperature range(-15 to 60℃:300 mAh g^(-1)/700 cycles/-15℃;352 mAh g^(-1)/100 cycles/60℃at 0.5 A g^(-1)).At room temperature,it delivers a record-ultralong cycling life of 192 mAh g^(-1)that exceeds 66000 cycles even at 15 A g^(-1).It exhibits extremely superb electrochemical performance in PIBs(157 mAh g^(-1)exceeding 15000 cycles at 5 A g^(-1)).The ex situ XRD and TEM results attest the conversion-alloy mechanism of ***,computational calculations verify that SePAN takes an important role in intensifying the electrochemical performance of SnSe2-SePAN ***,this study breaks new ground on solving the polyselenide dissolution issue and improving the wide temperature workable performance of sodium/potassium storage.

关键词： anode energy storage SnSe2-SePAN composite sodium/potassium-ion batteries widetemperature range

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Boosting the adsorption and removal of dye from water by COOH-functionalized carbon nanotubes

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Green Chemical Engineering 2023年第1期4卷 88-98页

作者： Binran Zhao yiyi Zhao Peng Liu Yu-Long Men Yun-xiang Pan School of Chemical Engineering Northwest UniversityXi'an710069China Department of Chemical Engineering School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai200240China

Water pollution caused by dye is a serious ***,we use a novel discharge process to functionalize carbon nanotube(CNT)by COOH groups to form CNT30 for removing methyl red(MR)from *** pristine CNT,75%MR is removed in 60 min,with an adsorption capacity of 68.44 mg *** CNT30,85%MR is fast removed in only 5 min,and the removal efficiency reaches to 95%after 30 min,with an adsorption capacity of80.33 mg ***,a higher MR removal efficiency is achieved in a much shorter time on ***,CNT30 has an outstanding reusability,with the MR removal efficiency decreasing by only 7%after ten *** COOH groups on CNT30 improve the hydrophilicity of CNT30,thus promoting the interaction of MR in water with *** hydrogen bonding and electrostatic interaction of MR with the COOH groups on CNT30 could be the force to drive MR adsorption on *** higher COOH content could be the origin for the better performance of CNT30 in removing dye from *** discharge process developed herein is operated in O2,without using harmful substances,and the COOH content on CNT can be efficiently tuned by simply changing discharge *** is different from the chemical modification widely used to functionalize CNT by strong oxidants,e.g.,HNO_(3).The present work is of great significance to realize green construction of materials for more efficiently removing dye from water.

关键词： Carbon nanotube Oxygen-containing functional group Dye Water pollution Discharge process

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Bubble-like Fe-encapsulated N,S-codoped carbon nanofibers as efficient bifunctional oxygen electrocatalysts for robust Zn-air batteries

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Nano Research 2020年第8期13卷 2175-2182页

作者： yiyi She Jin Liu Hongkang Wang Li Li Jinsong Zhou Michael K.H.Leung Ability R&D Energy Research Centre School of Energy and EnvironmentCity University of Hong KongHong KongChina Center of Nanomaterials for Renewable Energy(CNRE) State Key Lab of Electrical Insulation and Power EquipmentSchool of Electrical EngineeringXi’an Jiaotong UniversityXi’an710049China School of Automotive and Traffic Engineering Jiangsu University of TechnologyChangzhou213001China

Nano Research volume 13,pages2175–2182(2020)Cite this article 208 Accesses 1 Altmetric Metrics details Abstract Efficient,robust and cost-effective bifunctional oxygen electrocatalysts for oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)are of vital importance to the widespread utilization of Zn-air *** we report the fabrication of a bubble-like N,S-codoped porous carbon nanofibers with encapsulated fine Fe/Fe5C2 nanocrystals(∼10 nm)(FeNSCs)by a facile one-pot pyrolysis *** novel FeNSC nanostructures with high Fe content(37.3 wt.%),and synergetic N and S doping demonstrate remarkable ORR and OER catalytic activities in alkaline *** for ORR,the optimal FeNSC catalyst exhibits superior performance in terms of current density and durability in both alkaline and acidic ***,as catalysts on the air electrodes of Zn-air batteries,the optimal FeNSCs show a high peak power density of 59.6 mW/cm^2 and extraordinary discharge-charge cycling performance for 200 h with negligible voltage gap change of only 8%at current density of 20 mA/cm,surpassing its noble metal counterpart(***).The impressive battery stability can be attributed to favorable electron transfer resulting from appropriate graphitization of the bubble-like carbon nanofibers and thorough protection of Fe/Fe5C2 nanoparticles by carbon wrapping to prevent oxidation,agglomeration and dissolution of Fe nanoparticles during battery *** present FeNSC catalyst,which is highly active,robust yet affordable,shows promising prospects in large-scale applications,such as metal-air batteries and fuel cells.

关键词： bifunctional catalyst heteroatom doping FeNSC catalyst oxygen reduction reaction oxygen evolution reaction

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