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Comprehensive evaluation of Actinidia arguta fruit based on the nutrition and taste:67 germplasm native to Northeast China

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Food Science and Human Wellness 2022年第2期11卷 393-404页

作者： Mengting Song Heran Xu Guang Xin Changjiang liu Xiaorong Sun Yinhong Zhi Bin Li yixiao Shen College of Food Science Shenyang Agricultural UniversityShenyang 110866China

Actinidia arguta is a berry fruit with high nutritional *** evaluate the comprehensive quality,the fruit weight,titratable acid(TAC),soluble solids(SSC),vitamin C,mineral elements,and taste value of67 accessions of *** were measured,and sensory attributes including olfactive intensity,juiciness,sweetness,sourness,and astringency were *** analysis was carried out based on mineral elements,and principal component analysis(PCA)was used for comprehensive score *** result demonstrated that fruit weight ranged from 3.5 g to 24.2 g,SSC ranged from 11.94%to 20.56%,TAC ranged from 0.15%to 1.20%,and vitamin C ranged from 3.51 g/kg to 230.76 g/kg(fresh weight)among the tested *** were significant differences in sourness,sweetness,bitterness,and umami among the 67 accessions based on electronic tongue analysis,and this result was rapidly and objectively characterized by the sensory *** dendrogram was obtained and clustered the accessions into two major clusters,and five principal components were extracted by ***,the information provided by this study identified the 10 best germplasm resources for fresh-eating and processing *** can provide theoretical reference for nutritional efficacy evaluation and food development of ***.

关键词： Actinidia arguta Electronic tongue analysis Cluster analysis Principal component analysis Comprehensive quality

头腹针结合颈通康对颈动脉狭窄脑血流低灌注模型大鼠干预机制研究

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针灸临床杂志 2022年第5期38卷 53-58页

作者：周海纯韩晓庆宋志强赵娜刘一潇王东岩邢学良黑龙江中医药大学第二临床医学院黑龙江哈尔滨150001 黑龙江中医药大学黑龙江哈尔滨150040 黑龙江省鸡西矿业集团总医院黑龙江鸡西158199

目的:分析头腹针疗法结合颈通康对颈动脉狭窄脑血流低灌注模型大鼠的作用机制。方法:健康雄性Wistar大鼠50只,采用“针控线栓法”进行颈动脉狭窄造模,成功后随机分为模型组、中药治疗组和针药治疗组,每组各15只模型大鼠,假手术组5只,不... 详细信息

目的:分析头腹针疗法结合颈通康对颈动脉狭窄脑血流低灌注模型大鼠的作用机制。方法:健康雄性Wistar大鼠50只,采用“针控线栓法”进行颈动脉狭窄造模,成功后随机分为模型组、中药治疗组和针药治疗组,每组各15只模型大鼠,假手术组5只,不操作。治疗前、7 d、14 d和21 d共4个时间点采用神经功能评分、行为学评估;3 d、7 d和14 d原位杂交检测NCAM、免疫荧光标记及激光共聚焦检测GFAP、NeuN。结果:神经功能评分、行为学评估7 d、14 d评分治疗组优于模型组,针药组优于中药组(P<0.05或P<0.01)。NCAM、GFAP和NeuN的阳性表达均在7 d达到高峰,在3 d、7 d和14 d治疗组均优于模型组,针药组优于中药组(P<0.05或P<0.01)。结论:头腹针疗法结合颈通康对颈动脉狭窄脑血流低灌注模型大鼠神经血管单元有干预作用。

关键词：头腹针疗法颈通康颈动脉狭窄神经血管单元

达原饮调控TLR/MAPK/NF-κB通路防治H1N1感染诱发急性肺损伤的作用机制

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中国实验方剂学杂志 2024年第18期30卷 52-60页

作者：李承泽褚福浩李园刘运泽郑浩呈王思慈顾益枭朱万鸿张若诗宋行健盖聪丁霞北京中医药大学中医学院北京100102 北京中医药大学中药学院北京100102 北京中医药大学国家中医体质与治未病研究院北京100102 北京中医药大学东直门医院北京101121

目的:探究达原饮对H1N1感染诱发的急性肺损伤的药效及其潜在机制。方法:使用超高效液相色谱-四级杆静电场轨道阱质谱仪对达原饮水煎液进行药物成分分析。将48只雌性BALB/c小鼠随机分为正常组、模型组、奥司他韦组(19.5 mg·kg^(-1))、... 详细信息

目的:探究达原饮对H1N1感染诱发的急性肺损伤的药效及其潜在机制。方法:使用超高效液相色谱-四级杆静电场轨道阱质谱仪对达原饮水煎液进行药物成分分析。将48只雌性BALB/c小鼠随机分为正常组、模型组、奥司他韦组(19.5 mg·kg^(-1))、达原饮低、中、高剂量组(2.73、5.46、10.92 g·kg^(-1))。正常组和模型组给予去离子水灌胃,其他各组给予对应药物灌胃。给药第3天,正常组给予生理盐水滴鼻,其他各组在鼻内接种A/RP/8/34(H1N1)构建流感病毒感染的动物模型。连续给药7 d,每日称体质量。末次给药12 h后进行取材,肺组织称重,计算肺指数;苏木素-伊红(HE)染色观察肺组织及支气管病理形态学变化;微球免疫分析系统(CBA)检测血清中的γ干扰素(IFN-γ)、趋化因子(C-X-C基序)配体1(CXCL1)、肿瘤坏死因子-α(TNF-α)、趋化因子配体2(CCL2)、白细胞介素-12p70(IL-12p70)、趋化因子配体5(CCL5)、白细胞介素-1β(IL-1β)、趋化因子(C-X-C基序)配体10(CXCL10)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)、白细胞介素-10(IL-10)、干扰素-β(IFN-β)、干扰素-α(IFN-α)、白细胞介素-6(IL-6)。基于质谱结果联合网络药理学,分析达原饮防治甲流病毒引起的急性肺损伤的作用机制。通过蛋白免疫印迹法(Western bolt)检测肺组织中的细胞外信号调节激酶1/2(ERK1/2)、p38丝裂原活化蛋白激酶(p38 MAPK)、核转录因子-κB(NF-κB),及其磷酸化蛋白的表达;实时荧光定量聚合酶链式反应(Real-time PCR)检测肺组织中的髓样分化因子88(MyD88)、Toll样受体3(TLR3)、Toll样受体7(TLR7)、Toll样受体8(TLR8)的mRNA表达。结果:质谱分析确定达原饮水煎液中含有芍药苷、黄芩素等57种化合物。与正常组比较,模型组小鼠体质量下降(P<0.01),肺部水肿和出血,肺指数升高(P<0.01),IFN-γ、IL-12p70、CCL5、IL-1β、CXCL10、GM-CSF、IFN-β、IL-6显著升高(P<0.01)。与模型组比较,达原饮治疗组小鼠肺泡壁增厚、毛细血管充血和免疫细胞浸润的病理变化明显减轻,体质量和肺指数改变减轻(P<0.01),IFN-γ、IL-12p70、CCL5、IL-1β、CXCL10、GM-CSF、IFN-β、IL-6蛋白表达量显著下降(P<0.01);网络药理学分析共获得57个关键基因,其中MAPK信号通路为主要的靶向信号通路。与正常组比较,模型组小鼠肺组织的p-ERK1/2、p-p38MAPK、p-NF-κB表达上升(P<0.01),TLR7、TLR8、MyD88、TLR3的mRNA表达上升(P<0.05,P<0.01)。与模型组比较,达原饮治疗组表现出剂量依赖性地抑制ERK1/2、p38 MAPK和NF-κB p65的磷酸化水平(P<0.01),同时能够下调TLR3、TLR7、TLR8、MyD88的mRNA表达(P<0.01)。结论:达原饮能够通过抑制TLR/MAPK/NF-κB信号通路,有效防治H1N1感染诱发的急性肺损伤。

关键词：达原饮流感病毒急性肺损伤炎症 Toll样受体(TLR)/丝裂原活化蛋白激酶(MAPK)/核转录因子-κB(NF-κB)信号通路

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水中溶解氧对低锡中铌锆合金氧化膜显微组织和电化学性能的影响

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机械工程材料 2024年第6期48卷 11-17页

作者：王旭彤李九霄于一笑赵志伟郑锋欣曾奇锋刘庆冬上海工程技术大学材料科学与工程学院上海201620 上海交通大学材料科学与工程学院上海200240 上海大学材料科学与工程学院上海200444 上海交通大学核科学与工程学院上海200240

在含溶解氧(质量浓度分别为300,1 000μg·L^(-1))环境中对Zr-0.4Sn-0.7Nb-0.3Fe-0.1Cr-0.15Mo-0.12O新型低锡中铌锆合金进行了长达300 d的堆外高压釜腐蚀试验,研究了腐蚀过程中合金表面氧化膜微观结构的变化,并结合离位电化学检测表征... 详细信息

在含溶解氧(质量浓度分别为300,1 000μg·L^(-1))环境中对Zr-0.4Sn-0.7Nb-0.3Fe-0.1Cr-0.15Mo-0.12O新型低锡中铌锆合金进行了长达300 d的堆外高压釜腐蚀试验,研究了腐蚀过程中合金表面氧化膜微观结构的变化,并结合离位电化学检测表征了腐蚀后合金的电化学性能,分析了溶解氧对电化学性能的影响。结果表明:在含溶解氧环境中腐蚀时,合金表面氧化膜的厚度随时间呈线性增加,氧化膜内裂纹增多,氧化膜/基体界面起伏加剧;当溶解氧含量较高时,合金的腐蚀质量增加较大,表面氧化膜内裂纹较多。在含溶解氧环境中腐蚀130 d时,合金的自腐蚀电位和极化电阻最小,自腐蚀电流密度最大,其耐腐蚀性不仅与表面氧化膜厚度有关,还受氧化膜内缺陷影响;腐蚀300 d时,合金的阻抗谱呈多容抗弧特征,较高溶解氧含量下的容抗弧数量较多。

关键词：锆合金高温高压腐蚀氧化膜溶解氧电化学检测

Engineering Pt heterogeneous catalysts for accelerated liquid–solid redox conversion in Li-S batteries

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Journal of Energy Chemistry 2022年第6期31卷 490-496,I0014页

作者： Qinhua Gu Yujie Qi Wuxing Hua Tongxin Shang Junnan Chen Luozhen Jiang Lina Li Ming Lu yixiao Zhang Xi liu Ying Wan Bingsen Zhang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016LiaoningChina Key Laboratory of Preparation and Application of Environmental Friendly Materials of the Ministry of Education The Joint Laboratory of MXene MaterialsKey Laboratory of Functional Materials Physics and Chemistry of the Ministry of EducationJilin Normal UniversityChangchun 130103JilinChina Nanoyang Group State Key Laboratory of Chemical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Key Laboratory of Resource Chemistry of Ministry of Education Shanghai Key Laboratory of Rare Earth Functional Materialsand Department of ChemistryShanghai Normal UniversityShanghai 200234China School of Chemistry and Chemical Engineering In-situ Center for Physical ScienceShanghai Jiao Tong UniversityShanghai 200240China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China

The shuttle effect caused by soluble lithium polysulfides (LiPSs) deteriorates multiphase transformation reaction kinetics of sulfur species,and gives rise to an unserviceable lithium-sulfur (Li-S) ***,as a process optimization approach,offers an option to eliminate the intrinsic ***,exploring and understanding the role of catalysts on electrode reaction remains critical bottlenecks,particularly as they are prone to continuous evolution under complex dynamic ***,platinum nanoparticles loaded on MXene nanosheets,as sulfur host,and the action of catalysts on the reaction process are investigated via ex-situ monitors upon solid–liquid–solid chemical transformation of sulfur *** traces confirm that the high performance originates from electron transfer between catalysts and LiPSs,which lowers the nucleation barrier from liquid LiPSs to solid Li_(2)S/Li_(2)S_(2).Further,the accelerated liquid–solid conversion can alleviate the accumulation of LiPSs,and boost the reaction kinetics in Li-S *** findings corroborate the electronic modulation between catalysts and LiPSs,which is a generalizable strategy to optimize energy conversion efficiency of Li-S batteries.

关键词： Lithium-sulfur batteries MXene Catalysis Shuttle effect Pt

Bioinspired therapeutic platform based on extracellular vesicles for prevention of arterial wall remodeling in hypertension

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Bioactive Materials 2022年第2期7卷 494-504页

作者： Chen Wang Changyang Xing Zhelong Li Yunnan liu Qiaoying Li yixiao Wang Jiao Hu Lijun Yuan Guodong Yang Department of Ultrasound Diagnostics Tangdu HospitalFourth Military Medical UniversityXi’an710038People’s Republic of China State Key Laboratory of Cancer Biology Fourth Military Medical UniversityXi’an710032People’s Republic of China Department of Biochemistry and Molecular Biology Fourth Military Medical UniversityXi’an710032People’s Republic of China

Arterial stiffness due to the vessel remodeling is closely linked to raised blood pressure,and its physiopathologic mechanism is still not fully *** here aimed to explore whether extracellular vesicle(EV)mediated intercellular communication between endothelium and smooth muscle cell contribute to the blood vessel remodeling under *** here revealed that the arterial endothelial cells robustly secreted EV,which in turn could be circulated and/or directly taken up by the subendothelial smooth muscle cells(SMC).Under hypertension,the EV secretion increased and the miRNA profile changed significantly mainly due to the raised mechanical force and subsequent enhanced reactive oxygen species *** the miRNA cargos in the EV,miR-320d/423-5p were found increased most *** vivo delivery of miR-320d/423-5p mimics via engineered EV increased their expression in arterial vessels,recapitulating the phenotype in *** contrast,therapeutic delivery of miR-320d/423-5p inhibitors via engineered EV alleviated the phenotype in spontaneous hypertension rat ***,we have found that the injured endothelium due to the raised mechanical force in hypertension contributes to the arterial wall remodeling via the secreted *** study has not only provided novel insights on the mechanism of hypertension associated blood vessel wall remodeling,but also shed light on therapeutic intervention of hypertension associated vascular diseases.

关键词： Hypertension Extracellular vesicles Endothelial cell Smooth muscle cell Phenotype switch microRNA

小麦组蛋白TaHis3.2的克隆及盐胁迫下的表达分析

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山西农业科学 2022年第8期50卷 1197-1203页

作者：吴丹萌梁丹刘丹张欣胡子全王志强梁晨刘一晓潘萍萍王从磊袁卉馥王建贺河北北方学院河北张家口075000 天津市农业科学院农作物研究所/天津市农作物遗传育种重点实验室天津300384 界首市农业技术推广中心安徽界首236500 天津市宝坻区农业发展服务中心天津301800 天津市农业发展服务中心天津300061

为了研究组蛋白编码基因的表达是否受到渗透胁迫的诱导及探讨利用组蛋白编码基因开发分子标记,辅助耐盐育种的可能,以小麦(Triticum aestivum L.)为研究对象,通过NaCl渗透胁迫,从根叶组织的RNA-seq挖掘到一个表达受到盐胁迫影响的组蛋... 详细信息

为了研究组蛋白编码基因的表达是否受到渗透胁迫的诱导及探讨利用组蛋白编码基因开发分子标记,辅助耐盐育种的可能,以小麦(Triticum aestivum L.)为研究对象,通过NaCl渗透胁迫,从根叶组织的RNA-seq挖掘到一个表达受到盐胁迫影响的组蛋白编码基因His3.2出发,利用同源克隆法从小麦中获得His3.2基因,通过生物信息学方法分析其蛋白序列特征,使用HMMER软件、PF00125结构域进行全家族调取,并利用FPKM算法分析其组织表达特异性以及盐胁迫响应模式。结果表明,共得到2种TaHis3.2序列,开放阅读框长411 bp,存在8个SNP,编码同一种氨基酸;氨基酸结构域预测发现,TaHis3.2包含Histon保守结构域PF00125;小麦中该家族共398个成员,在各个染色体上均有分布,且主要分布在染色体的两端。表达分析显示,TaHis3.2主要在根部表达,盐胁迫抑制该基因的表达。自然群体序列分析发现,在D基因组该基因高度保守,未发现品种间存在序列差异。

关键词：小麦盐胁迫组蛋白基因表达生物信息学方法

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Development of digital organ-on-a-chip to assess hepatotoxicity and extracellular vesicle-based anti-liver cancer immunotherapy

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Bio-Design and Manufacturing 2022年第3期5卷 437-450页

作者： Guohua Wu Jianguo Wu Zihan Li Shengyu Shi Di Wu Xuanbo Wang Han Xu Hui liu yixiao Huang Rending Wang Jia Shen Zhihong Dong Shuqi Wang The First Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310029China Institute for Translational Medicine Zhejiang UniversityHangzhou 310029China Department of Chemical Engineering University of Waterloo200 University Avenue WestWaterlooON N2L 3G1Canada Department of Building Environment and Energy Engineering Xi’an Jiaotong UniversityXi’an 710049China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065China Clinical Research Center for Respiratory Disease West China HospitalSichuan UniversityChengdu 610065China Kidney Disease Center The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310029China School of Mechanical Engineering Chengdu UniversityChengdu 610106China Institute for Advanced Study Chengdu UniversityChengdu 610106China

Organ-on-a-chip systems have been increasingly recognized as attractive platforms to assess toxicity and to develop new therapeutic ***,current organ-on-a-chip platforms are limited by a“single pot”design,which inevitably requires holistic analysis and limits parallel ***,we developed a digital organ-on-a-chip by combining a microwell array with cellular microspheres,which significantly increased the parallelism over traditional organ-on-a-chip for drug *** to 127 uniform liver cancer microspheres in this digital organ-on-a-chip format served as individual analytical units,allowing for analysis with high consistency and quick *** platform displayed evident anti-cancer efficacy at a concentration of 10μM for sorafenib,and had greater alignment than the“single pot”organ-on-a-chip with a previous in vivo *** addition,this digital organ-on-a-chip demonstrated the treatment efficacy of natural killer cell-derived extracellular vesicles for liver cancer at 50μg/*** successful development of this digital organ-on-a-chip platform provides high-parallelism and a low-variability analytical tool for toxicity assessment and the exploration of new anticancer modalities,thereby accelerating the joint endeavor to combat cancer.

关键词： Digital Organ-on-a-chip Microwell array Microspheres Extracellular vesicles

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按照规范完善直流电源系统的设计

石油化工自动化 2006年第3期 1-3页

作者：宁学典徐野刘一笑中国石化集团洛阳石化工程公司仪电室中国石化集团物资装备公司设备处

结合标准规范,阐述了仪表直流电源系统的风险及风险降低方案,从标准的角度出发结合实际应用,介绍了电源系统的基本方案,并对各个方案的安全性做了对比,供工程设计和实际应用参考。

关键词：风险直流稳压电源负载平衡功能冗余双回路交流供电