Bioinspired therapeutic platform based on extracellular vesicles for prevention of arterial wall remodeling in hypertension

作     者：Chen Wang Changyang Xing Zhelong Li Yunnan Liu Qiaoying Li Yixiao Wang Jiao Hu Lijun Yuan Guodong Yang 

作者机构：Department of Ultrasound DiagnosticsTangdu HospitalFourth Military Medical UniversityXi’an710038People’s Republic of China State Key Laboratory of Cancer BiologyFourth Military Medical UniversityXi’an710032People’s Republic of China Department of Biochemistry and Molecular BiologyFourth Military Medical UniversityXi’an710032People’s Republic of China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第2期

页      面：494-504页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：funded by NSFC 31771507 and 81970737 to Yang GD NSFC 81871357 and 81671690 to Yuan LJ NSFC 81901751 to Xing CY Provincial Scientific Foundation of Shaan’Xi(2020TD-038) Innovative Development Fund of Tangdu Hospital(2018QYTS007) Clinical Trial Fund of Tangdu Hospital(2021LCYJ006)to Yuan LJ funded by MOST(2016YFA0102100) 

主　　题：Hypertension Extracellular vesicles Endothelial cell Smooth muscle cell Phenotype switch microRNA 

摘      要：Arterial stiffness due to the vessel remodeling is closely linked to raised blood pressure,and its physiopathologic mechanism is still not fully *** here aimed to explore whether extracellular vesicle(EV)mediated intercellular communication between endothelium and smooth muscle cell contribute to the blood vessel remodeling under *** here revealed that the arterial endothelial cells robustly secreted EV,which in turn could be circulated and/or directly taken up by the subendothelial smooth muscle cells(SMC).Under hypertension,the EV secretion increased and the miRNA profile changed significantly mainly due to the raised mechanical force and subsequent enhanced reactive oxygen species *** the miRNA cargos in the EV,miR-320d/423-5p were found increased most *** vivo delivery of miR-320d/423-5p mimics via engineered EV increased their expression in arterial vessels,recapitulating the phenotype in *** contrast,therapeutic delivery of miR-320d/423-5p inhibitors via engineered EV alleviated the phenotype in spontaneous hypertension rat ***,we have found that the injured endothelium due to the raised mechanical force in hypertension contributes to the arterial wall remodeling via the secreted *** study has not only provided novel insights on the mechanism of hypertension associated blood vessel wall remodeling,but also shed light on therapeutic intervention of hypertension associated vascular diseases.