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Prostate health index can stratify patients with Prostate Imaging Reporting and Data System score 3 lesions on magnetic resonance imaging to reduce prostate biopsies

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Asian Journal of Andrology 2024年第1期26卷 20-24页

作者： John Shung-Lai Leung Wai-Kit Ma Brian Sze-Ho Ho Stacia Tsun-Tsun Chun Rong Na Yongle Zhan Chi-Yuen Ng Chi-Ho Ip Ada Tsui-Lin Ng yiu-chung lam Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina Division of Urology Department of SurgeryPrincess Margaret HospitalHongKongChina

We aim to evaluate prostate health index as an additional risk-stratification tool in patients with Prostate Imaging Reporting and Data System score 3 lesions on multiparametric magnetic resonance *** with biochemical or clinical suspicion of having prostate cancer who underwent multiparametric magnetic resonance imaging in two tertiary centers(Queen Mary Hospital and Princess Margaret Hospital,Hong Kong,China)between January 2017 and June 2022 were ***-magnetic resonance imaging fusion biopsies were performed after prostate health index *** who only had Prostate Imaging Reporting and Data System score 3 lesions were further stratified into four prostate health index risk groups and the cancer detection rates were *** of the 747 patients,47.3%had Prostate Imaging Reporting and Data System score 3 lesions *** detection rate of clinically significant prostate cancer in this group was 15.0%.The cancer detection rates of clinically significant prostate cancer had statistically significant differences:5.3%in prostate health index<25.0,7.4%in prostate health index 25.0-34.9,17.9%in prostate health index 35.0-54.9,and 52.6%in prostate health index≥55.0(P<0.01).Among the patients,26.9%could have avoided a biopsy with a prostate health index<25.0,at the expense of a 5.3%risk of missing clinically significant prostate *** health index could be used as an additional risk stratification tool for patients with Prostate Imaging Reporting and Data System score 3 *** could be avoided in patients with low prostate health index,with a small risk of missing clinically significant prostate cancer.

关键词： biopsy fusion biopsy magnetic resonance imaging prostate cancer prostate health index

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Phase change memory

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Science China(Information Sciences) 2011年第5期54卷 1061-1072页

作者： lam chung IBM Research T.J. Watson Research Center Yorktown Heights New York 10598 USA

Phase change memory (PCM) is a non-volatile solid-state memory technology based on the large resistivity contrast between the amorphous and crystalline states in phase change materials. We present the physics behind this large resistivity contrast and describe how it is being exploited to create high density PCM. We address the challenges facing this technology, including the design of PCM cells, fabrication, device variability, thermal cross-talk and write disturb. We discuss the scalability, assess the performance, and examine the reliability of PCM including data retention, multi-bit storage and endurance.

关键词： solid state memory non-volatile DRAM flash phase change resistive memory data retention write endurance solid-state drive computer memory

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TRMT6 and TRMT61A facilitated acute pancreatitis severity via regulation of neutrophil function

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Science China Life Sciences 2025年

作者： Yuan Dong Li Su Sin Man lam Cen Yan Yalan Deng Guotao Lu Jinkui Yang Guanghou Shui Yingmei Feng Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Department of Science and Development Beijing Youan HospitalCapital Medical University Laboratory for Clinical Medicine Capital Medical University Neuroscience Research Institute Peking University Center of Medical and Health AnalysisPeking University State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences Pancreatic Center Department of GastroenterologyAffiliated Hospital of Yangzhou UniversityYangzhou University Beijing Key Laboratory of Diabetes Research and Care Department of EndocrinologyBeijing Tongren HospitalCapital Medical University

Dear Editor,Type 2 diabetes mellitus (T2DM) has been identified as a risk factor for increased severity in acute pancreatitis (AP)(Mikóet al,2018).However,to date,no studies have simultaneously included healthy individuals,T2DM patients,and AP patients to investigate which diabetes-associated metabolites are linked to AP severity.

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A Uniformly Robust Staggered DG Method for the Unsteady Darcy-Forchheimer-Brinkman Problem

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Communications on Applied Mathematics and Computation 2022年第1期4卷 205-226页

作者： Lina Zhao Ming Fai lam Eric chung Department of Mathematics The Chinese University of Hong KongHong Kong SARChina

In this paper,we propose and analyze a uniformly robust staggered DG method for the unsteady Darcy-Forchheimer-Brinkman *** formulation is based on velocity gradient-velocity-pressure and the resulting scheme can be flexibly applied to fairly general polygonal *** relax the tangential continuity for velocity,which is the key ingredi-ent in achieving the uniform *** present well-posedness and error analysis for both the semi-discrete scheme and the fully discrete scheme,and the theories indicate that the error estimates for velocity are independent of *** numerical experiments are presented to confirm the theoretical findings.

关键词： Staggered DG method Brinkman-Forchheimer General meshes Uniformly stable

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Solitary seminal vesicle metastasis from ileal adenocarcinoma presenting with hematospermia:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6775-6780页

作者： Xiao-Bao Cheng Zhen-Quan Lu Wayne lam Ming-Kwong yiu Ji-Shi Li Department of Surgery The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina Division of Urology Department of SurgeryQueen Mary HospitalThe University of Hong KongHong KongChina Department of Oncology The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina

BACKGROUND Although metastatic adenocarcinoma of the ileum is not uncommon,solitary metastasis to the seminal vesicle has not been *** report a patient with recurrent hematospermia diagnosed with metastasis to the seminal vesicle following ileal adenocarcinoma resection,his subsequent management and *** SUMMARY A 46-year-old man presented with recurrent episodes of painless *** was not associated with any lower urinary tract *** had a past medical history of ileal tumor at the terminal ileum with solitary mesenteric lymph node metastasis on presentation,and underwent partial ileectomy and lymphadenectomy 4 years *** investigations included positronemission tomography and computed tomography imaging confirmed the very unusual diagnosis of a solitary tumor at the left seminal *** leftsided vesiculectomy was carried *** analysis with immunohistochemistry showed that CDX-2 was positive and CK7 was negative,and the appearance was consistent with the diagnosis of recurrent metastatic adenocarcinoma of his previously treated intestine *** patient had an uneventful post-operative *** received adjuvant chemoradiotherapy following *** remained asymptomatic until he developed multiple bone and pulmonary metastases one year after *** Clinicians should be aware of hematospermia as the first symptom of metastatic recurrence in patients with a history of ileal adenocarcinoma.

关键词： Seminal vesicle Metastasis Ileal adenocarcinoma Hematospermia Laparoscopic vesiculectomy Case report

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Fabrication of La,Ce co-doped ZnO nanorods for improving photodegradation of methylene blue

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Journal of Rare Earths 2024年第1期42卷 76-83,I0003页

作者： Erfan Hakim Azmal Zaid Jin-chung Sin Sze-Mun lam Abdul Rahman Mohamed School of Chemical Engineering Universiti Sains Malaysia(USM)14300Nibong TebalPenangMalaysia College of Environmental Science and Engineering Guilin University of TechnologyGuilin541004China Guangxi Key Laboratory of Theory and Technology for Environmental Pollution Control Guilin University of TechnologyGuilin541004China Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area Guilin University of TechnologyGuilin541004China Faculty of Engineering and Green Technology Universiti Tunku Abdul RahmanJalan UniversitiBandar Barat31900KamparPerakMalaysia

La,Ce co-doped ZnO nanorods(ZnLC)were synthesized through a one-step solvothermal *** photocatalysts were characterized by X-ray diffraction,Raman spectroscopy,field-emission scanning electron microscopy,energy dispersive X-ray,transmission electron microscopy,UV-vis diffuse reflectance spectroscopy and photo luminescence *** La and Ce doping enhanced the visible light absorption ability of ZnLC and a red shift was detected for *** simulated solar light irradiation,the ZnO doped with 3 at%La and 1 at%Ce(ZnLC1)degrades methylene blue(MB)more effectively than those of pure ZnO,La-doped ZnO(ZnL)and commercially available *** improved photocatalytic performance of ZnLC1 can be attributed to the high charge separation efficiency as demonstrated by the photoluminescence ***,the photocatalytic experiments reveal that several parameters have their own impact on the MB *** a variety of radical scavengers,it is discovered that superoxide anion radical plays a crucial role in the degradation of *** ZnLC1 is also reused several times without noticeable decrease of photoactivity,indicating that it has a substantial potential for environmental remediation applications.

关键词： ZnO Lanthanum Cerium Co-doping Photodegradation Rare earths

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Dipyridyl Azo Compound 4,4'-Azopyridine as a Potential Coating Material for Toilet Sanitizer

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Chemical Research in Chinese Universities 2023年第6期39卷 864-869页

作者： WANG Qiwei JIANG Lu lam Pik-Ling CHUI chung-Hin WONG Wai-Yeung Antibiotics Research and Reevaluation Key Laboratory of Sichuan Province Sichuan Industrial Institute of AntibioticsChengdu UniversityChengdu 610052P.R.China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomHong KongP.R.China Research and Development Division One Health International LimitedHong KongP.R.China

Good toilet hygiene can reduce the risk of pathogenic *** flushing,pathogenic bacteria can be spread by the water droplets,especially in the toilet *** coli(***)is one of the frequently occurring Gram-negative bacterial pathogens found in the toilet *** this study,we investigated the potential *** activity of some azobenzene *** them,compound 2,with the heterocyclic nitrogen in both phenyl rings,showed the strongest antibacterial effect on ***,with the minimum inhibitory concentration of 80μg/mL and the minimum bactericidal concentration of 320μg/*** 2 displayed a comparative zone of clearance[(14.50±2.29)mm]to that of ampicillin[(13.17±1.76)mm].The reactive oxygen species(ROS)assay suggested that compound 2 might induce the loss of bacteria via the oxidative stress by eliciting the generation of intracellular *** further examined the potential cytotoxicity of compound 2 to the human skin HaCaT *** 2-treated skin cells showed a good maintenance of cellular morphology and a clear definition of cell nuclei,with a satisfactory cell viability(ca.90%)at 80μg/***,compound 2 would be a possible antibacterial coating agent for the surface sanitizer of the toilet seats to inhibit the growth of ***.

关键词： Antibacterial Azobenzene Escherichia coli Skin cytotoxicity Toilet seat

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A cross-sectional study on compliance with topical glaucoma medication and its associated socioeconomic burden for a Chinese population

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 293-299页

作者： Man-Hin Lui Jason Chun Ho lam Yi Lee Kwong Tak Siu Wong Pak Long Cheung Sherri Shun Yan Lai Pak Lun Yuen Wai yiu lam Ho Yan Chan yiu Fai Wong Jimmy Shiu Ming Lai Kendrick Co Shih Li Ka Shing Faculty of Medicine the University of Hong KongPokfulamHong KongChina Department of Ophthalmology Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHongKongChina Department of Ophthalmology Queen Mary HospitalPokfulamHong KongChina

AIM： To estimate the overall drug compliance for local Chinese glaucoma patients on long-term topical ***： This was a retrospective cross-sectional ***-seven primary glaucoma patients from the subspecialty clinic of a publicly-funded tertiary care hospital in Hong Kong completed a questionnaire on compliance with topical glaucoma medication,attitude towards glaucoma and therapy and vision related quality of *** was defined as reporting missing more than or equal to 10% of the prescribed topical glaucoma medication during the 2wk immediately prior to the *** between noncompliance and demographics,attitude,disease and treatment status was *** was estimated with quality of life and direct medical cost involved with *** logistic regression on noncompliance was performed on selected ***： Compliance was calculated as 75%（95% CI： 64%-87%） among 57 subjects（mean age 69 y,female 51%）.No statistical significant relationship was established between noncompliance and any single factors or ***（P=0.048） and forgetfulness（P=0.064） were found to be marginally significant predictive factors on noncompliance in multivariable logistic *** might be related（P=0.130） to poorer self-rated vision-associated quality of *** societal cost of noncompliance was estimated to be over 2510 life-years and US$ 3.7 million ***： The compliance of Chinese glaucoma patients in Hong Kong is comparable to other parts in the world,and carries detrimental impacts on individual and societal *** and forgetfulness are two possible independent predictors for noncompliance.

关键词： glaucoma eye drop compliance quality of life

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Blockchain for Education:Verification and Management of Lifelong Learning Data

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Computer Systems Science & Engineering 2022年第11期43卷 591-604页

作者： Ba-lam Do Van-Thanh Nguyen Hoang-Nam Dinh Thanh-chung Dao BinhMinh Nguyen School of Information and Communication Technology Hanoi University of Science and TechnologyHanoiVietnam

In recent years,blockchain technology has been applied in the educational domain because of its salient advantages,i.e.,transparency,decentralization,and *** systems typically use public blockchain networks such as Ethereum and Bitcoin to store learning ***,the cost of writing data on these networks is significant,making educational institutions limit data sent to the target network,typically containing only hash codes of the issued *** this paper,we present a system based on a private blockchain network for lifelong learning data authentication and management named B4E(Blockchain For Education).B4E stores not only certificates but also learners’training data such as transcripts and educational programs in order to create a complete record of the lifelong education of each user and verify certificates that they have *** a result,B4E can address two types of fake certificates,i.e.,certificates printed by unlawful organizations and certificates issued by educational institutions for learners who have not met the training *** addition,B4E is designed to allow all participants to easily deploy software packages to manage,share,and check stored information without depending on a single point of *** such,the system enhances the transparency and reliability of the stored *** experiments show that B4E meets expectations for deployment in reality.

关键词： Training data certificate verification and management private blockchain

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Virtual reality based multiple life skill training for intellectual disability:A multicenter randomized controlled trial

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Engineered Regeneration 2022年第2期3卷 121-130页

作者： James chung-Wai Cheung Ming Ni Andy yiu-Chau Tam Tim Tin-Chun Chan Alyssa Ka-Yan Cheung Ocean Yu-Hong Tsang Chi-Bun Yip Wing-Kai lam Duo Wai-Chi Wong Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Research Institute for Smart Ageing The Hong Kong Polytechnic UniversityHong Kong 999077China Jockey Club Smart Ageing Hub Department of Biomedical EngineeringFaculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Department of Orthopaedics Pudong New Area People’s Hospital Affiliated to Shanghai Jiaotong UniversityShanghai 201299China Social Service Department Yan Chai HospitalHong Kong 999077China C2 Innovations and Research Limited Hong Kong 999077China Department of Kinesiology Shenyang Sport UniversityShenyang 110102China Sports Information and External Affairs Centre Hong Kong Sports InstituteHong Kong 999077China

Life skill-based training is essential for intellectual disabled individuals to regain autonomy and social *** reality(VR)could deliver a nascent application that is more engaging and *** objective of this study was to evaluate the training effects of the VR-based multiple life skill training program on life skill perfor-mance,self-efficacy,memory,cognitive and behavioral functions via a multicenter randomized controlled trial.A total of 145 intellectual disabled participants were recruited for a randomized controlled trial with three in-tervention arms:VR(n=42);traditional(n=53);and control(n=50).The life skill tasks for the interventions included 1)grocery shopping,2)cooking,and 3)kitchen *** measures were performance scores for the three tasks,self-efficacy scale,digit span score,and Frontal Assessment Battery score,graded by blinded ***-after effects of each group were evaluated using separated Wilcoxon Signed-rank *** sig-nificantly improved cooking,cleaning performance,and memory span,while traditional training significantly improved shopping,cooking,and cleaning *** generalized estimating equation evaluated effects between groups adjusted for age,gender and intelligence quotient(IQ).VR had significantly larger improvement effects in cooking and cleaning than the control group and memory span compared to traditional training and controls *** appeared to be a significant confounder on the training *** work may consider developing artificial intelligence to customize programs depending on IQ level.

关键词： Mental retardation Intellectual development X-reality Immersive rehabilitation Metaverse

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