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The SKI proto-oncogene restrains the resident CD103^(+)CD8^(+) T cell response in viral clearance

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Cellular & Molecular Immunology 2021年第10期18卷 2410-2421页

作者： Bing Wu Ge Zhang Zengli Guo Gang wang Xiaojiang Xu Jian-liang Li Jason K.Whitmire Junnian Zheng yisong y.wan Lineberger Comprehensive Cancer Center School of MedicineUniversity of North Carolina at Chapel HillChapel HillNC 27599USA Department of Microbiology and Immunology School of MedicineUniversity of North Carolina at Chapel HillChapel HillNC 27599USA Department of Immunology College of Basic Medical ScienceDalian Medical UniversityDalianLiaoning 116044China Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Cancer InstituteXuzhou Medical UniversityXuzhouJiangsu221002China Integrative Bioinformatics National Institute of Environmental Health SciencesResearch Triangle ParkChapel HillNC 27709USA Department of Genetics School of MedicineUniversity of North Carolina at Chapel HillChapel HillNC 27599USA

Acute viral infection causes illness and *** addition,an infection often results in increased susceptibility to a secondary infection,but the mechanisms behind this susceptibility are poorly *** its initial identification as a marker for resident memory CD8^(+)T cells in barrier tissues,the function and regulation of CD103 integrin(encoded by ITGAE gene)have been extensively ***,the function and regulation of the resident CD103^(+)CD8^(+)T cell response to acute viral infection remain *** TGFβsignaling is essential for CD103 expression,the precise molecular mechanism behind this regulation is ***,we reveal a TGFβ–SKI–Smad4 pathway that critically and specifically directs resident CD103^(+)CD8^(+)T cell generation for protective immunity against primary and secondary viral *** found that resident CD103^(+)CD8^(+)T cells are abundant in both lymphoid and nonlymphoid tissues from uninfected ***103 acts as a costimulation signal to produce an optimal antigenic CD8^(+)T cell response to acute viral *** is a reduction in resident CD103^(+)CD8^(+)T cells following primary infection that results in increased susceptibility of the host to secondary ***,CD103 expression inversely and specifically correlates with SKI proto-oncogene(SKI)expression but not R-Smad2/3 *** expression of SKI restricts CD103 expression in CD8^(+)T cells in vitro and in vivo to hamper viral ***,SKI is recruited to the Itgae loci to directly suppress CD103 transcription by regulating histone acetylation in a Smad4-dependent *** study therefore reveals that resident CD103^(+)CD8^(+)T cells dictate protective immunity during primary and secondary *** with SKI function may amplify the resident CD103^(+)CD8^(+)T cell response to promote protective immunity.

关键词： CD103 TGFβ SKI Smad4 LCMV infection Histone acetylation

Regulatory T cells: immune suppression and beyond

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Cellular & Molecular Immunology 2010年第3期7卷 204-210页

作者： yisong y.wan Lineberger Comprehensive Cancer Center Department of Microbiology and ImmunologyThe University of North Carolina at Chapel HillSchool of MedicineNorth CarolinaNCUSA

Foxp3-expressing regulatory T cells(Tregs)were originally identified as critical in maintaining self-tolerance and immune *** immunosuppressive functions of Tregs are widely acknowledged and have been extensively *** studies have revealed many diverse roles of Tregs in shaping the immune system and the inflammatory *** review will discuss our efforts as well as the efforts of others towards understanding the multifaceted function of Tregs in immune regulation.

关键词： Foxp3 Treg immunosuppression and plasticity

An essential role for TAK1 in the contact hypersensitivity response

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Cellular & Molecular Immunology 2011年第4期8卷 315-324页

作者： yan G Zhao yunqi wang Weidong Hao yisong y.wan Department of Toxicology School of Public HealthPeking UniversityBeijingChina Department of Microbiology and Immunology Lineberger Comprehensive Cancer CenterUniversity of North Carolina at Chapel HillNCUSA

Contact hypersensitivity(CHS)is a delayed-type hypersensitivity that can be induced by haptens,such as 2,4-dinitrofluorobenzene(DNFB).Innate and adaptive immunities are both important for the development of *** treat CHS-related diseases,such as allergic contact dermatitis,a disease prevalent in industrialized countries,ways of interfering with improper immune function during CHS responses need to be *** growth factor-b-activated kinase-1(TAK1),a member of mitogen-activated protein kinase kinase kinase family,is important for both innate and adaptive *** thus hypothesized that the CHS response could be inhibited by interfering with TAK1 *** a mouse model in which TAK1 deletion can be locally induced,we observed that TAK deficiency led to an impaired CHS response and was associated with defective T-cell expansion,activation and interferon(IFN)-c *** addition,we investigated the effect of deleting TAK1 specifically in dendritic cells(DC)on the CHS *** found that when TAK1 is deficient in DC,the CHS response was abolished and hapten-elicited T-cell responses were ***,this study demonstrates an essential role of TAK1 in the induction of CHS and suggests that targeting TAK1 could be a viable approach to treat CHS.

关键词： CHS DC 2,4-dinitrofluorobenzene(DNFB) TAK1

基于像素编码和空间注意力的多尺度医学图像分割方法

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生物医学工程学杂志 2024年第3期41卷 511-519页

作者：万雨龙周冬明王长城刘宜松白崇斌云南大学信息学院昆明650504 云南省红河州第二人民医院云南建水654300

针对医学图像分割中U型网络(U-Net)及其变体下采样过程中单尺度信息丢失、模型参数量较大的问题,本文提出了一种基于像素编码和空间注意力的多尺度医学图像分割方法。首先,通过重新设计变换器(Transformer)结构输入策略,提出了像素编码... 详细信息

针对医学图像分割中U型网络(U-Net)及其变体下采样过程中单尺度信息丢失、模型参数量较大的问题,本文提出了一种基于像素编码和空间注意力的多尺度医学图像分割方法。首先,通过重新设计变换器(Transformer)结构输入策略,提出了像素编码模块,使模型能够从多尺度图像特征中提取全局语义信息,获取更丰富的特征信息,同时在Transformer模块中引入可变形卷积,加快收敛速度的同时提升模块性能。其次,引入空间注意力模块并加入残差连接,使模型能够重点关注融合后特征图的前景信息。最后,通过消融实验实现网络轻量化并提升分割精度,加快模型收敛。本文所提算法在国际计算机医学图像辅助协会官方公开多器官分割公共数据集——突触(Synapse)数据库中得到令人满意的结果,戴斯相似性系数(DSC)和95%豪斯多夫距离系数(HD95)分别为77.65和18.34。实验结果表明,本文算法能够提高多器官分割结果,有望完善多尺度医学图像分割算法的空白,并为专业医师提供辅助诊断。

关键词：医学图像分割 U型网络变换器多尺度语义信息注意力模块

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小豆缺铁突变体分离群体叶色及产量性状分析

分子植物育种 2024年第2期22卷 503-511页

作者：晁兴晨顾忠珺万平杨凯曹劲宏赵波李奕松北京农学院植物科学技术学院北京农业应用新技术北京市重点实验室北京102206 北京农学院生物科学与工程学院农业部华北都市农业重点实验室北京102206 北京市怀柔区农业农村局北京101400

为了鉴定小豆铁吸收代谢突变体作图群体叶色性状的变异及其对产量的影响,本研究调查了‘河北801’(耐缺铁野生型)×FMy011(缺铁敏感突变体)和My076(耐缺铁突变体)×GM352(缺铁敏感资源)的F_(2)分离群体的叶色分离情况,测定了叶绿素SPAD... 详细信息

为了鉴定小豆铁吸收代谢突变体作图群体叶色性状的变异及其对产量的影响,本研究调查了‘河北801’(耐缺铁野生型)×FMy011(缺铁敏感突变体)和My076(耐缺铁突变体)×GM352(缺铁敏感资源)的F_(2)分离群体的叶色分离情况,测定了叶绿素SPAD值,并分析了其与单株产量及其他农艺性状的相关性。F_(2)群体分离出新叶黄化和正常单株,其叶绿素SPAD值差异极显著。相关性分析显示SPAD值与单株产量、单株荚数、百粒重呈极显著正相关,缺铁引起的新叶黄化会降低小豆产量。缺铁胁迫验证田间叶色分离表型,结果显示‘河北801’×FMy011群体的叶色表型与田间叶色分离符合度高,新叶黄化F_(2)单株的F_(2:3)家系全部黄化,新叶绿色F_(2)单株胁迫下其96.62%F_(2:3)家系表现正常绿叶或呈杂合叶色分离,3.38%新叶绿色F_(2)单株胁迫下其F_(2:3)家系新叶黄化,表型不符合。My076×GM352分离群体,田间正常叶色与缺铁胁迫鉴定的叶色一致,但田间新叶黄化F_(2)单株胁迫下仅有36.07%的F_(2:3)家系仍新叶黄化,60.66%新叶黄化F_(2)单株胁迫下其F_(2:3)家系表现为杂合叶色分离,3.28%新叶黄化F_(2)单株胁迫下其F_(2:3)家系叶色正常表型不符合。本研究为进一步定位克隆小豆中铁吸收代谢相关基因和铁生物强化育种提供了基础材料。

关键词：小豆(Vigna angularis L.) 叶色分离群体缺铁相关分析

The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation

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The TGF-β superfamily cytokine Activin-A is induced during ...

第十四届全国免疫学学术大会

作者： Bing Wu yisong wan UNC at Chapel hill 武汉大学

Th17 cells are known to exert pathogenic and non-pathogenic functions. Although the cytokine transforming growth factor b1(TGF-β1) is instrumental for Th17 cell differentiation, it is dispensable for generation of pathogenic Th17 cells. Here, we examined the T cell-intrinsic role of Activin-A, a TGF-β superfamily member closely related to TGF-β1, in pathogenic Th17 cell differentiation. Activin-A expression was increased in individuals with relapsing-remitting multiple sclerosis and in mice with experimental autoimmune encephalomyelitis. Stimulation with interleukin-6 and Activin-A induced a molecular program that mirrored that of pathogenic Th17 cells and was inhibited by blocking Activin-A signaling. Genetic disruption of Activin-A and its receptor ALK4 in T cells impaired pathogenic Th17 cell differentiation in vitro and in vivo. Mechanistically, extracellular-signal-regulated kinase(ERK) phosphorylation, which was essential for pathogenic Th17 cell differentiation, was suppressed by TGF-β1-ALK5 but not Activin-A-ALK4 signaling. Thus, Activin-A drives pathogenic Th17 cell differentiation, implicating the Activin-A-ALK4-ERK axis as a therapeutic target for Th17 cell-related diseases.

关键词： autoimmune disease multiple sclerosis EAE pathogenic Th17 cells Activin-A ALK4 TGF-β1 ALK5 ERK1/2

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中国转基因水稻的研究进展及产业化问题分析

生物技术通报 2010年第12期26卷 1-6页

作者：孙国庆金芜军宛煜嵩林敏中国农业科学院生物技术研究所北京100081

水稻在我国粮食生产和消费中占有重要地位,也是世界上最重要的粮食作物之一。水稻转基因研究已成为当前国内外植物分子生物学和作物育种研究的热点。目前我国转基因水稻研究处于国际领先水平,有望成为转基因抗虫棉之后又一个进入产业化... 详细信息

水稻在我国粮食生产和消费中占有重要地位,也是世界上最重要的粮食作物之一。水稻转基因研究已成为当前国内外植物分子生物学和作物育种研究的热点。目前我国转基因水稻研究处于国际领先水平,有望成为转基因抗虫棉之后又一个进入产业化的转基因粮食作物,这可能将在确保我国粮食安全中发挥重要贡献。从国内外转基因水稻研发概况、我国Bt抗虫水稻生物安全评价两方面综述了我国转基因水稻产业化的前景,并在此基础上对产业化提出相关建议与对策。

关键词：转基因水稻产业化

城市再生视野下的规划实践与思考——以新江湾城规划为例

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城市规划学刊 2005年第4期 93-98页

作者：徐毅松王颖禾范宇上海城投置地(集团)有限公司上海市城市规划管理局上海市城市规划管理局总工程师办公室总工程师高级工程师副总工程师工程师

新江湾城是原江湾军用机场搬迁后的土地再开发区域。随着时代的发展,对该项目的规划经历了一个与时俱进的过程。重新定位后的新江湾城规划强调城区、生态、人文观念,以一种开放而具有多目标性的规划实践,体现了对城市再生这一主题的探... 详细信息

新江湾城是原江湾军用机场搬迁后的土地再开发区域。随着时代的发展,对该项目的规划经历了一个与时俱进的过程。重新定位后的新江湾城规划强调城区、生态、人文观念,以一种开放而具有多目标性的规划实践,体现了对城市再生这一主题的探索和思考。

关键词：新江湾城规划城市再生

全踝关节镜下免打结锚钉修复距腓前韧带的疗效分析

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中国骨伤 2023年第8期36卷 777-781页

作者：王成林杨俊忠雷宜松万玲玲武汉市协和江南医院江夏区第一人民医院骨科湖北武汉430200

目的:探讨全踝关节镜下采用免打结锚钉修复距腓前韧带治疗慢性踝关节外侧不稳的临床疗效。方法:自2018年4月至2021年8月,对24例采用全踝关节镜下免打结锚钉修复距腓前韧带治疗的慢性踝关节外侧不稳患者进行回顾性分析,其中男16例,女8例... 详细信息

目的:探讨全踝关节镜下采用免打结锚钉修复距腓前韧带治疗慢性踝关节外侧不稳的临床疗效。方法:自2018年4月至2021年8月,对24例采用全踝关节镜下免打结锚钉修复距腓前韧带治疗的慢性踝关节外侧不稳患者进行回顾性分析,其中男16例,女8例;年龄22~42(28.6±5.8)岁;受伤至手术时间6~10(7.7±1.3)个月。比较手术前后美国踝与足关节协会(American Orhopaedic Foot and Ankle Society,AOFAS)踝与后足功能评分、视觉模拟疼痛评分(visual analogue scale,VAS)、距骨倾斜角及距骨前移距离变化情况。结果:所有患者获得随访,时间8~12(10.20±1.14)个月。伤口均Ⅰ期愈合,未出现伤口感染,神经损伤及踝关节外侧不稳等其他并发症。AOFAS评分由术前(52.79±8.96)分提高到术后6个月(93.00±4.01)分,其中优23例,良1例;VAS由术前(5.50±0.98)分下降到术后6个月(1.04±0.80)分(P<0.05);距骨倾斜角由术前(9.16±2.09)°下降到术后3个月(3.10±1.72)°(P<0.05);距骨前移距离由术前(8.80±2.55)mm下降到术后3个月(2.98±1.97)mm(P<0.05)。末次随访24例患者行踝关节抽屉试验及内翻试验均为阴性。结论:全踝关节镜下采用免打结锚钉技术修复距腓前韧带治疗慢性踝关节外侧不稳创伤小,并发症少,安全可靠,踝关节功能恢复好。

关键词：慢性踝关节不稳踝关节镜免打结锚钉