An essential role for TAK1 in the contact hypersensitivity response
作者机构：Department of ToxicologySchool of Public HealthPeking UniversityBeijingChina Department of Microbiology and ImmunologyLineberger Comprehensive Cancer CenterUniversity of North Carolina at Chapel HillNCUSA
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2011年第8卷第4期
页 面：315-324页
核心收录：
学科分类：0710[理学-生物学] 071001[理学-植物学] 07[理学]
基 金：the National Institutes of Health(R00AI072956 to YYW) the Beijing Natural Science Foundation(7082054) the National Science and Technology Major Specific Project of the People’s Republic of China(2009ZX09301-010 to WH)and the China Scholarship Council(YGZ)
主 题：CHS DC 2,4-dinitrofluorobenzene(DNFB) TAK1
摘 要：Contact hypersensitivity(CHS)is a delayed-type hypersensitivity that can be induced by haptens,such as 2,4-dinitrofluorobenzene(DNFB).Innate and adaptive immunities are both important for the development of *** treat CHS-related diseases,such as allergic contact dermatitis,a disease prevalent in industrialized countries,ways of interfering with improper immune function during CHS responses need to be *** growth factor-b-activated kinase-1(TAK1),a member of mitogen-activated protein kinase kinase kinase family,is important for both innate and adaptive *** thus hypothesized that the CHS response could be inhibited by interfering with TAK1 *** a mouse model in which TAK1 deletion can be locally induced,we observed that TAK deficiency led to an impaired CHS response and was associated with defective T-cell expansion,activation and interferon(IFN)-c *** addition,we investigated the effect of deleting TAK1 specifically in dendritic cells(DC)on the CHS *** found that when TAK1 is deficient in DC,the CHS response was abolished and hapten-elicited T-cell responses were ***,this study demonstrates an essential role of TAK1 in the induction of CHS and suggests that targeting TAK1 could be a viable approach to treat CHS.
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