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An update on electrostatic powder coating for pharmaceuticals

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Particuology 2017年第2期15卷 1-7页

作者： Qingliang Yang yingliang ma Jesse Zhu Kwok Chow Kaiqi Shi Particle Technology Research Centre Department of Chemical and Biochemical Engineering University of Western Ontario London Ontario N6A 589 Canada Powder Pharma Coatings Mississauga Ontario LSR 2Y9 Canada Ningbo Weston Powder Pharma Coatings Co. Ltd. Ningbo Zhejiang 315042 China

Derived from dry powder coating of metals, electrostatic powder coating for pharmaceuticals is a technology for coating drug solid dosage forms. In this technology, coating powders, containing coating polymers, pigments, and other excipients, are directly sprayed onto the surface of the solid dosage forms through an electrostatic gun without using any organic solvent or water. The deposited coating powders are further cured to form a coating film. Electrostatic powder coating technology has many advantages compared to other pharmaceutical coating methods. It can eliminate the limitations caused by the organic solvent in solvent coating such as environmental issues and health problems. And electrostatic powder coating technology also surpasses aqueous coating due to its shorter processing time and less energy consumption, leading to a lower overall cost. Furthermore, the utilization of electrical attraction can promote the movement of coating powders towards the substrate, leading to an enhanced coating powder adhesion and coating efficiency, which make it more promising compared to other dry coating technologies. The objective of this review is to summarize the coating principles, apparatus, and formulations of different electrostatic powder coating technologies, giving their advantages and limitations and also analyzing the future application in the industry for each technology

关键词： Electrostatic powder coating Solid dosage forms Plasticizers Powder adhesion Film formation Curing

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一种点云模型的内蕴对称检测算法

系统仿真学报 2014年第10期26卷 2430-2433,2441页

作者：谢东来马颖亮中国人民解放军93199部队中国人民解放军63680部队

三维几何模型的对称检测在几何处理领域具有重要意义,点云模型由于通常包含噪声及数据缺失,其内蕴对称检测非常困难。基于非负矩阵分解和模型骨架,提出1种点云模型的内蕴对称检测算法,对于给定的点云模型,提取其曲线骨架,以选举方法获... 详细信息

三维几何模型的对称检测在几何处理领域具有重要意义,点云模型由于通常包含噪声及数据缺失,其内蕴对称检测非常困难。基于非负矩阵分解和模型骨架,提出1种点云模型的内蕴对称检测算法,对于给定的点云模型,提取其曲线骨架,以选举方法获取反映模型表面点间对称性的骨架点对,构造包含模型对称属性的对称对应关系矩阵,利用非负矩阵分解分析对称对应关系矩阵,通过聚类的方法获取点云模型上的对称区域。实验表明,可以有效地检测点云模型的内蕴对称属性。

关键词：非负矩阵分解内蕴对称点云模型对称对应关系矩阵

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NURBS曲线曲面间最短距离的计算

计算机辅助设计与图形学学报 2010年第8期22卷 1344-1351页

作者：贺平张彩明周景博马颖亮山东大学计算机科学与技术学院济南250101

针对现有的大多数计算几何形状间最短距离的算法都需要进行大量的多边形检测,且有时计算出的最短距离不够精确的问题,提出一种计算NURBS曲线与曲线、曲线与曲面和曲面与曲面间最短距离的算法.首先将2个NURBS形状分解成分段B啨zier表示的... 详细信息

针对现有的大多数计算几何形状间最短距离的算法都需要进行大量的多边形检测,且有时计算出的最短距离不够精确的问题,提出一种计算NURBS曲线与曲线、曲线与曲面和曲面与曲面间最短距离的算法.首先将2个NURBS形状分解成分段B啨zier表示的2个集合,给出一种计算2个集合的边界包围球的简单快速算法;然后分别在2个集合中选择包含最短距离的B啨zier表示对形成候选集.该算法采用边界包围球和"四点条件"约束提高计算效率,用多维Newton-Raphson迭代计算所有候选对间的局部最短距离,由此求出全局的最短距离.实验结果表明,文中算法具有速度快、精度高和鲁棒性好的特点,可实时计算2个NURBS曲线曲面间的最短距离.

关键词：最短距离控制多边形 NURBS曲线曲面 Newton-Raphson方法

Elasticity meets topology

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National Science Review 2024年第6期11卷 84-85页

作者： Guancong ma Department of Physics Hong Kong Baptist University

We are surrounded by environments and items that are made from solid materials in our daily life. Any physical contact with any items is a mechanical disturbance that produces mechanical *** underlines the crucial role that such vibrations play in our daily interactions,highlighting the need for a deeper understanding and improved manipulation of these fundamental phenomena.

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舰空导弹作战过程建模研究

计算机工程与应用 2013年第4期49卷 249-253页

作者：马颖亮黄定东王保乳海军航空工程学院研究生管理大队中国人民解放军91640部队

应用DoDAF对舰空导弹作战过程进行描述,基于排队论理论对作战效果进行分析,比较了平台中心作战与网络中心作战的目标分配方式和作战效率。研究表明,随着网络服务时间的增长,其服务效率将大幅下降,在到达一定时间后将劣于平台中心作战效率。

关键词： DoDAF 排队论作战效能

Uniform decomposition of velocity gradient tensor

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Journal of Hydrodynamics 2024年第1期36卷 24-34页

作者： Chenxi ma Chaoqun Liu Department of mathematics University of Texas at ArlingtonArlingtonTXUSA

In this paper,the principal decomposition of the velocity gradient tensor[∇v]is discussed in 3 cases based on the discriminant∆:∆0 with 3 distinct real eigen values,and∆=0 with 1 or 2 distinct real eigen *** velocity gradient tensor can also be classified as rotation point,which can be decomposed into three parts,i.e.,rotation[R],shear[S]and stretching/compression[SC],and non-rotation point,we defined a new resistance term[L],and the tensor can be decomposed into three parts,i.e.,resistance[L],shear[S]and stretching/compression[SC].Example matric are also displayed to demonstrate the new *** of principal decomposition between 3 different cases,and between Resistance and Liutex will also be discussed.

关键词： Velocity gradient Liutex resistance fluid kinematics

VOC emitted by biopharmaceutical industries:Source profiles,health risks,and secondary pollution

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Journal of Environmental Sciences 2024年第1期135卷 570-584页

作者： Jiawei ma Lin Li State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China National Engineering Laboratory for VOCs Pollution Control material&Technology University of Chinese Academy of SciencesBeijing 101408China

The biopharmaceutical industry contributes substantially to volatile organic compounds(VOCs)emissions,causing growing concerns and social developmental *** study conducted an on-site investigation of the process-based emission of VOCs from three biopharmaceutical *** the workshops of the three enterprises,26 VOCs were detected,which could be sorted into 4 classes:hydrocarbons,aromatic hydrocarbons,oxygen-containing compounds,and nitrogen-containing *** were the main components of waste gases,accounting for 44.13%-77.85%of the overall ***-based source profiles were compiled for each process unit,with the fermentation and extraction units of tiamulin fumarate being the main source of VOC *** heptanone,vinyl acetate,diethylamine,propylene glycol methyl ether(PGME),and benzene were screened as priority pollutants through a fuzzy comprehensive evaluation *** level concentration simulation results of the Gauss plume diffusion model demonstrated that the diffusivity of VOCs in the atmosphere was relatively high,indicating potential non-carcinogenic and carcinogenic risks 1.5-2 km ***,the process-based formation potentials of ozone and secondary organic aerosols(SOAs)were determined and indicated that N-methyl-2-pyrrolidone,dimethyl heptanone,and PGME should be preferentially controlled to reduce the ozone formation potential,whereas the control of benzene and chlorobenzene should be prioritized to reduce the generation of *** results provide a basis for understanding the characteristics of VOC emission by biopharmaceutical industries and their diffusion,potentially allowing the development of measures to reduce health risks and secondary pollution.

关键词： Biopharmaceutical Volatile organic compound Priority pollutant Exposure risk Secondary pollution

Deterministic and Robust Volt-var Control Methods of Power System Based on Convex Deep Learning

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 719-729页

作者： Qing ma Changhong Deng the School of Electrical Engineering and Automation Wuhan UniversityWuhanChina

Volt-var control(VVC)is essentially a non-convex optimization problem due to the non-convexity of power flow(PF)constraints,resulting in the difficulty in obtaining the optimum without convexity *** existing second-order cone method for the convexity conversion often leads to a sharp increase in PF constraints and optimization variables,which in turn increases the optimization difficulty or even leads to optimization *** paper first proposes a deterministic VVC method based on convex deep learning power flow(DLPF).This method uses the input convex neural network(ICNN)to establish a single convex mapping between state parameters and node voltage to complete the convexity conversion while the optimization variables only correspond to reactive power equipment,which can ensure the global optimum with extremely fast computation *** cope with the impact brought by the uncertainty of distributed energy and omit the additional worst scenario search of traditional robust VVC,this paper proposes robust VVC method based on convex deep learning interval power flow(DLIPF),which continues to adopt ICNN to establish another convex mapping between state parameters and node voltage *** DLIPF with DLPF,this method decreases the modeling and optimization difficulty of robust VVC *** results on 30-bus,118-bus,and 200-bus systems prove the correctness and rapidity of the proposed methods.

关键词： Volt-var control convexity conversion convex deep learning power flow

Copper slag assisted coke reduction of phosphogypsum for sulphur dioxide preparation

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Chinese Journal of Chemical Engineering 2024年第1期65卷 43-53页

作者： Dong ma Qinhui Wang State Key Laboratory of Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou 310027China

The reduction of phosphogypsum(PG)to lime slag and SO_(2)using coke can effectively alleviate the environmental problems caused by ***,the PG decomposition temperature remains high and the product yield remains *** adding additives,the decomposition temperature can be further reduced and PG decomposition rate and product yield can be ***,the use of current additives such as Fe_(2)O_(3)and SiO_(2)brings the problem of increasing economic ***,it is proposed to use solid waste copper slag(CS)as a new additive to reduce PG to prepare SO2,which can reduce the cost and meet the environmental benefits at the same *** effects of proportion,temperature and thermostatic time on PG decomposition are investigated by experimental and kinetic analysis combined with FactSage thermodynamic calculations to optimize the roasting ***,the reaction mechanism is *** is found that adding CS to the coke and PG system can increase the rate of PG decomposition and SO_(2)yield while lowering the PG decomposition *** example,when the CS/PG mass ratio increases from 0 to 1,PG decomposition rate increases from 83.38%to 99.35%,SO_(2)yield increases from 78.62%to 96.81%,and PG decomposition temperature decreases from 992.4℃to 949.6℃.The optimal reaction parameters are CS/PG mass ratio of 1,Coke/PG mass ratio of 0.06 at 1100℃for 20 min with 99.35%PG decomposition rate and 96.81%SO_(2) *** process proceeds according to the following reactions:2CaSO_(4)+ 0.7C + 0.8Fe_(2)SiO_(4)→0.8Ca_(2)SiO_(4)+ 0.2Ca_(2)Fe_(2)O_(5)+ 0.4Fe_(3)O_(4)+2SO_(2)+ 0.7CO_(2)Finally,a process for decomposing PG with coke and CS is proposed.

关键词： Phosphogypsum Sulfur dioxide Copper slag Fluidized-bed Reduction Waste treatment