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超声波强化硫酸洗涤单宁锗渣

矿冶 2024年第3期33卷 448-455页

作者：陆占清徐英杰裴启飞梁辰夏洪应昆明理工大学冶金与能源工程学院昆明650093 云南驰宏锌锗股份有限公司云南曲靖655011

锗具有特殊性能,已被许多国家划分为战略性资源,在多个领域具有不可替代的作用。在氧化锌烟尘浸出过程中,由于杂质金属与锗会一同进入溶液,并与单宁酸共同发生络合反应,导致煅烧后所获得的锗精矿品位低、杂质含量高,对于后续的氯化蒸馏... 详细信息

锗具有特殊性能,已被许多国家划分为战略性资源,在多个领域具有不可替代的作用。在氧化锌烟尘浸出过程中,由于杂质金属与锗会一同进入溶液,并与单宁酸共同发生络合反应,导致煅烧后所获得的锗精矿品位低、杂质含量高,对于后续的氯化蒸馏工艺十分不利。因此在单宁锗渣煅烧前,去除其中杂质金属对于锗资源化利用具有重要意义。本研究以单宁酸沉锗所得单宁锗渣为原料,以硫酸溶液为洗涤剂,通过引入超声波强化去除其中的主要杂质金属锌与铁,实现锗富集。通过单因素试验研究了酸洗过程中固液比、硫酸浓度、酸洗时间、酸洗温度以及超声波功率对锌与铁去除率的影响。结果表明,在最佳工艺条件:H_(2)SO_(4)浓度0.3 mol/L、固液比300 g/L、酸洗时间40 min、酸洗温度50℃、搅拌速度300 r/min、超声波功率300 W的条件下,锌与铁的去除率分别为86.74%与85.68%。对洗涤除杂后的单宁锗渣进行煅烧,结果表明超声波强化酸洗生产的锗精矿品位高达25.65%,与未洗涤以及常规酸洗相比,超声波强化酸洗生产的锗精矿品位分别提高了约22%、15%,绿色、高效地除去了单宁锗渣中的大部分杂质金属,显著提高了锗精矿的品位。

关键词：超声波单宁锗渣硫酸洗涤锗精矿锗富集煅烧

Data analysis of dose map verification for IMRT

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Nuclear Science and Techniques 2009年第5期20卷 297-301页

作者： xu yingjie DAI Jianrong FU Guishan ZHANG Yongqian ZHANG Ke CUI Weijie ZHANG Dandan JIANG Bo Department of Radiation Oncology Cancer Institute Chinese Academy of Medical Science Beijing 100021 China

In this paper we analyze the results of dose map verifications for patient’s IMRT (Intensity-modulated radiation therapy) plans and study the factors that may influence the accuracy of verification. MapCHECK, a two-dimensional diode array, was used to measure the dose maps for 1242 plans (14540 fields) from May 2004 to August 2008. The plans were designed with Pinnacle3 planning system. The passing rate of beams was determined when the acceptance criterion was 2%/2 mm, 3%/3 mm and 4%/4 mm. And the data with 3%/3 mm criteria was analyzed in more detail. The considered factors were beam modeling, optimization mode and treatment site. The median passing rate of total fields was 93.5%, 98.8%, and 100% when the acceptance criterion was 2%/2 mm, 3%/3 mm and 4%/4 mm, and the interquartile range were 11.1%, 3.8%, and 1.3%, respectively. The results of direct machine parameter optimization (DMPO) planning mode was better than those of multiple-step mode and beam modeling of new accelerators was better than that of old accelerators. These indicate that beam modeling is the key point of improving passing rate of IMRT verification and the influence of treatment site was little. The factors, the total number of segments, minimum area of segments and minimum monitor unit (MU) of segments, also influence the dosimetric accuracy of IMRT plan verification.

关键词： IMRT 最佳化二极管最小化

Prohibitin regulates mTOR pathway via interaction with FKBP8

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Frontiers of Medicine 2021年第3期15卷 448-459页

作者： Jiahui Zhang Yanan Yin Jiahui Wang Jingjing Zhang Hua Liu Weiwei Feng Wen Yang Bruce Zetter yingjie xu Department of Biochemistry and Molecular and Cell Biology Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Obstetrics and Gynecology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Vascular Biology Program Boston Children’s HospitalHarvard Medical SchoolBostonMA 02115USA

The ability of tumor cells to sustain continuous proliferation is one of the major characteristics of *** activation of oncogenes and the mutation or inactivation of tumor suppressor genes ensure the rapid proliferation of tumor *** PI3K-Akt-mTOR axis is one of the most frequently modified signaling pathways whose activation sustains cancer ***,it is also one of the most commonly attempted targets for cancer ***506 binding protein 8(FKBP8)is an intrinsic inhibitor of mTOR kinase that also exerts an anti-apoptotic *** aimed to explain these contradictory aspects of FKBP8 in cancer by identifying a“switch”type *** identified through immunoprecipitation--mass spectrometry-based proteomic analysis that the mitochondrial protein prohibitin 1(PHB1)specifically interacts with ***,the downregulation of PHB1 inhibited the proliferation of ovarian cancer cells and the mTOR signaling pathway,whereas the FKBP8 level in the mitochondria was substantially ***,concomitant with these changes,the interaction between FKBP8 and mTOR substantially increased in the absence of ***,our finding highlights PHB1 as a potential regulator of FKBP8 because of its subcellular localization and mTOR regulating role.

关键词： prohibitin 1 FKBP8 mTOR cell proliferation cancer

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法治守法九言联

书画世界 2024年第6期 62-62页

作者：徐盈杰杭州师范大学

徐盈杰创作感想。我的创作灵感来自黄庭坚草书。他的草书结构上的变化是改变了字与字之间不同的承接关系。从其草书作品中可以看到,黄庭坚对草书字形结构有许多有意改动,打破了大众对原有字的审美取向,将字拉长或缩小,精细塑造新的空间... 详细信息

徐盈杰创作感想。我的创作灵感来自黄庭坚草书。他的草书结构上的变化是改变了字与字之间不同的承接关系。从其草书作品中可以看到,黄庭坚对草书字形结构有许多有意改动,打破了大众对原有字的审美取向,将字拉长或缩小,精细塑造新的空间组合,形成和谐的整体感。这种字形结构上的处理使他的草书呈现雄肆多变的姿态,章法也常常化险为夷,跌宕起伏。在行笔上,他将速度放缓,并重组笔画,进而产生奇妙的视觉效果。他不断制造矛盾又化解冲突,在对立中创建新的视觉关系。

关键词：字形结构草书空间组合承接关系视觉关系黄庭坚视觉效果整体感

急性椎基底动脉闭塞血管内治疗后卒中相关性肺炎的危险因素及预后分析

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中国研究型医院 2024年第2期11卷 59-64页

作者：吴宗艺易继龙张盼胡淼淼许英杰徐国强孙文中山市中医院神经内科中山528400 荆门市中心医院神经内科荆门448000 中国科学技术大学附属第一医院神经内科合肥230022 永康市第一人民医院神经内科永康321300

目的探索急性椎基底动脉闭塞患者(VBAO)行血管内治疗后,卒中相关性肺炎(SAP的发生率、影响因素及预后情况。方法回顾性搜集2015年12月—2018年12月,中国21家卒中中心确诊为急性VBAO,并预计于闭塞24 h内接受血管内治疗的577例患者的临... 详细信息

目的探索急性椎基底动脉闭塞患者(VBAO)行血管内治疗后,卒中相关性肺炎(SAP的发生率、影响因素及预后情况。方法回顾性搜集2015年12月—2018年12月,中国21家卒中中心确诊为急性VBAO,并预计于闭塞24 h内接受血管内治疗的577例患者的临床及影像资料。根据患者是否发生SAP分为SAP组368例,非SAP组209例,比较两组患者的卒中相关病史、卒中分型、美国国立卫生研究院卒中量表(NIHSS)评分、格拉斯哥昏迷量表(GCS)评分、后循环阿尔伯塔卒中项目早期CT评分、颅内血管侧支循环分级、麻醉方式、预计闭塞至穿刺时间、穿刺至再通时间、成功再通及症状性颅内出血情况,分析SAP的相关影响因素,结合90 d随访数据,进一步分析其对临床预后的影响。两组符合正态分布的计量资料以x±s表示、采用独立样本t检验,非正态分布的计量资料以M(Q_(1),Q_(3))表示、采用Mann-Whitney U检验;计数资料以例数(%)表示,采用χ^(2)检验;单因素分析中P0.05)。多因素logistic回归分析结果显示,GCS评分(OR:0.908,95%CI:0.860~0.960,P=0.001)、全身麻醉(OR:2.507,95%CI:1.519~4.138,P<0.001)、穿刺至再通时间长(OR:1.003,95%CI:1.000~1.006,P=0.033)是SAP的独立危险因素。预后相关分析显示,SAP与90 d良好预后呈显著负相关(OR:0.605,95%CI:0.386~0.948,P=0.028)。结论 VBAO血管内治疗患者发生SAP的独立危险因素是GCS评分较低,全身麻醉及较长的穿刺至再通时间,合并SAP的患者预后更差。

关键词：卒中脑缺血椎基底动脉闭塞肺炎血管内治疗

NSUN2-mediated mRNA m^(5)C Modification Regulates the Progression of Hepatocellular Carcinoma

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Genomics, Proteomics & Bioinformatics 2023年第4期21卷 823-833页

作者： Dan Song Ke An Wenlong Zhai Luyao Feng yingjie xu Ran Sun Yueqin Wang Yun-Gui Yang Quancheng Kan Xin Tian Department of Pharmacy the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Henan Key Laboratory of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhou 450052China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Digestive Organ Transplantation of Henan Province Zhengzhou UniversityZhengzhou 450052China

RNA modifications affect many biological processes and physiological *** 5-methylcytosine(m^(5)C)modification regulates the progression of multiple ***,its characteristics and functions in hepatocellular carcinoma(HCC)remain largely ***,we found that HCC tissues had a higher m^(5)C methylation level than the adjacent normal *** analysis revealed that the hypermethylated genes mainly participated in the phosphokinase signaling pathways,such as the Ras and PI3K-Akt *** m^(5)C methyltransferase NSUN2 was highly expressed in HCC ***,the expression of many genes was positively correlated with the expression of NSUN2,including GRB2,RNF115,AATF,ADAM15,RTN3,and ***-time PCR assays further revealed that the expression of the mRNAs of GRB2,RNF115,and AATF decreased significantly with the down-regulation of NSUN2 expression in HCC ***,NSUN2 could regulate the cellular sensitivity of HCC cells to sorafenib via modulating the Ras signaling ***,knocking down NSUN2 caused cell cycle *** together,our study demonstrates the vital role of NSUN2 in the progression of HCC.

关键词： 5-methylcytosine Hepatocellular carcinoma NSUN2 Ras pathway Sorafenib

Multi-Physics Coupled Acoustic-Mechanics Analysis and Synergetic Optimization for a Twin-Fluid Atomization Nozzle

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 204-223页

作者： Wenying Li Yanying Li yingjie Lu Jinhuan xu Bo Chen Li Zhang Yanbiao Li College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China School of Materials Science and Engineering Northwestern Polytechnical UniversityXian 710072China Guizhou Anda Aviation Forging Co. Ltd.Anshun 561005China

Fine particulate matter produced during the rapid industrialization over the past decades can cause significant harm to human ***-fluid atomization technology is an effective means of controlling fine particulate matter *** this paper,the influences of the main parameters on the droplet size,effective atomization range and sound pressure level(SPL)of a twin-fluid nozzle(TFN)are investigated,and in order to improve the atomization performance,a multi-objective synergetic optimization algorithm is presented.A multi-physics coupled acousticmechanics model based on the discrete phase model(DPM),large eddy simulation(LES)model,and Ffowcs Williams-Hawkings(FW-H)model is established,and the numerical simulation results of the multi-physics coupled acoustic-mechanics method are verified via experimental *** on the analysis of the multi-physics coupled acoustic-mechanics numerical simulation results,the effects of the water flow on the characteristics of the atomization flow distribution were obtained.A multi-physics coupled acoustic-mechanics numerical simulation result was employed to establish an orthogonal test database,and a multi-objective synergetic optimization algorithm was adopted to optimize the key parameters of the *** optimal parameters are as follows:A gas flow of 0.94 m^(3)/h,water flow of 0.0237 m^(3)/h,orifice diameter of the self-excited vibrating cavity(SVC)of 1.19 mm,SVC orifice depth of 0.53 mm,distance between SVC and the outlet of nozzle of 5.11 mm,and a nozzle outlet diameter of 3.15 *** droplet particle size in the atomization flow field was significantly reduced,the spray distance improved by 71.56%,and the SPL data at each corresponding measurement point decreased by an average of 38.96%.The conclusions of this study offer a references for future TFN research.

关键词： Twin-fluid nozzle BP neural network Multi-objective optimization Multi-physics coupled Acousticmechanics analysis Genetic algorithm

Correlation of ^1H NMR Chemical Shift for Aqueous Solutions by Statistical Associating Fluid Theory Association Model

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Chinese Journal of Chemical Engineering 2005年第2期13卷 280-284页

作者：许波李浩然王从敏许映杰韩世钧 Department of Chemistry Zhejiang University Hangzhou 310027China

1H NMR chemical shifts of binary aqueous mixtures of acylamide, alcohol, dimethyl sulphoxide (DMSO), and acetone are correlated by statistical associating fluid theory (SAFT) association model. The comparison between SAPT association model and Wilson equation shows that the former is better for dealing with aqueous solutions. Finally, the specialties of both models are discussed.

关键词： Statistical associating fluid theory (SAFT) association model NMR chemical shift aqueous solution

Antibody-platinum(IV)prodrugs conjugates for targeted treatment of cutaneous squamous cell carcinoma

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Journal of Pharmaceutical Analysis 2024年第3期14卷 389-400页

作者： Xiangye Yin yingjie Zhuang Haiqin Song Yujian xu Fan Zhang Jianxin Cui Lei Zhao yingjie Yu Qixu Zhang Jun Ye Youbai Chen Yan Han Department of Plastic and Reconstructive Surgery The First Medical CenterChinese PLA General HospitalBeijing100853China Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200023China State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing100029China Department of Plastic Surgery University of Texas MD Anderson Cancer CenterHoustonTX77030USA State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China

Antibody-drug conjugates(ADCs)are a new type of targeting antibodies that conjugate with highly toxic anticancer drugs via chemical linkers to exert high specificity and efficient killing of tumor cells,thereby attracting considerable attention in precise oncology ***(Cet)is a typical antibody that offers the benefits of good targeting and safety for individuals with advanced and inoperable cutaneous squamous cell carcinoma(cSCC);however,its anti-tumor activity is limited to a single ***(CisPt)shows good curative effects;however,its adverse effects and non-tumor-targeting ability are major *** this study,we designed and developed a new ADC based on a new cytotoxic platinum(IV)prodrug(C8Pt(IV))and *** so-called antibody-platinum(IV)prodrugs conjugates,named Cet-C8Pt(IV),showed excellent tumor targeting in ***,it accurately delivered C8Pt(IV)into tumor cells to exert the combined anti-tumor effect of Cet and ***,metabolomic analysis showed that Cet-C8Pt(IV)promoted cellular apoptosis and increased DNA damage in cSCC cells by affecting the vitamin B6 metabolic pathway in tumor cells,thereby further enhancing the tumor-killing ability and providing a new strategy for clinical cancer treatment using antibody-platinum(IV)prodrugs conjugates.

关键词： Antibody drug conjugate Cutaneous squamous cell carcinoma DNA damage Platinum drug Targeted therapy