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Lacticaseibacillus rhamnosus Fmb14 ameliorates hyperuricemia-induced hepatocyte pyroptosis via NLRP3 inflammasome cascade inhibition

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Food Science and Human Wellness 2024年第4期13卷 2174-2186页

作者： Hongyuan Zhao Xiaoyu Chen Li Zhang Fanqiang Meng Libang Zhou Zhaoxin lu yingjian lu College of Food Science&Technology Nanjing Agricultural UniversityNanjing 210095China Institute of Vegetable Gansu Academy of Agricultural SciencesLanzhou 730070China College of Food Science&Engineering Nanjing University of Finance and EconomicsNanjing 210023China

Hyperuricemia is a high-risk factor for the development of gout and renal fibrosis,but the adverse effects of hyperuricemia on the liver have been seriously *** research investigated the ameliorating effect of Lacticaseibacillus rhamnosus Fmb14 on hyperuricemia induced liver dysfunction both in vitro and in *** free extracts of high dose *** Fmb14 treatment reduced the death rate of HepG2 cell lines from 24.1%to 14.9%by inhibiting NLRP3 recruitment,which was mainly activated by reactive oxygen species release and mitochondrial membrane potential *** purine dietary induced hyperuricemia(PDIH)mice model,liver oedema and pyroptosis were ameliorated after *** Fmb14 administration through downregulating the expression levels of NLRP3,caspase-1 and gasdermin-D from 1.61 to 0.86,3.15 to 1.01 and 5.63 to 2.02,*** Fmb14 administration restored mitochondrial inner membrane protein(MPV17)and connexin 43 from 2.83 and 0.73 to 0.80 and 0.98 respectively in PDIH mice,indicating that dysbiosis of mitochondrial membrane potential was restored in ***,PDIH pyroptosis stimulates the process of apoptosis,which leads to severe leakage of hepatocytes,and both of pyroptosis and apoptosis were decreased after *** Fmb14 ***,*** Fmb14 is a promising biological resource to maintain homeostasis of the liver in hyperuricemia and the prevention of subsequent complications.

关键词： Lacticaseibacillus rhamnosus Fmb14 Hyperuricemia Pyroptosis NLRP3 pathway

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Surfactin alleviated hyperglycaemia in mice with type 2 diabetes induced by a high-fat diet and streptozotocin

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Food Science and Human Wellness 2023年第6期12卷 2095-2110页

作者： Xiaoyu Chen Hongyuan Zhao Fanqiang Meng Libang Zhou Zhaoxin lu yingjian lu College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China College of Food Science and Engineering Nanjing University of Finance and EconomicsNanjing 210023China

Type 2 diabetes mellitus(T2DM)is associated with liver dysfunction and intestinal *** peptides(BAPs)have been reported to ameliorate T2DM by preventing oxidative damage to the *** amyloliquefaciens fmb50 produces the lipopeptide surfactin with a wide range of biological *** effects of surfactin on T2DM,on the other hand,have not been *** the present study,80 mg/kg body weight surfactin supplementation lowered fasting blood glucose(FBG)levels by 21.05%and insulin resistance(IR)by 18.18%compared with those in the T2DM group,reduced inflammation,and increased antioxidant activity in mice with T2DM induced by a high-fat diet(HFD)and streptozotocin(STZ).According to further research,surfactin administration reduced Firmicutes-to-Bacteroidetes ratios while increasing Bifi dobacterium abundance by 20 times and the level of the tight junction protein Occludin by 18.38%and ZO-1 by 66.60%.Furthermore,surfactin also improved hepatic glucose metabolism by activating the adenosine monophosphate-activated protein kinase(AMPK)signalling pathway,increasing glycogen synthesis and glucose transporter 2(GluT2)protein expression while reducing glucose-6-phosphatase(G6Pase)protein *** addition,the increased Bifi dobacterium abundance indirectly reduced the liver burden of the metabolic products indole,cresol and amine produced by saprophytic *** of these findings revealed that surfactin not only ameliorated HFD/STZ-induced gut dysbiosis and preserved intestinal barrier integrity but also enhanced hepatic glucose metabolism and detoxifi cation function in T2DM *** gut microbiota appeared to be important in controlling glucose metabolism,IR,fat accumulation,inflammation and antioxidation,according to Spearman’s correlation coeffi *** data indicated that surfactin alleviated hyperglycaemia in mice with T2DM induced by HFD/STZ.

关键词： Surfactin Type 2 diabetes mellitus(T2DM) Insulin resistance Gut microbiota Glucose metabolism

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Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice

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Food Science and Human Wellness 2022年第5期11卷 1428-1439页

作者： Chao Tang Weiwei Zhou Mengyuan Shan Zhaoxin lu yingjian lu College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China College of Food Science and Engineering Nanjing University of Finance and EconomicsNanjing 210023China

Accumulating evidence revealed that some probiotics regulated lipid metabolism and alleviated diet-induced non-alcoholic fatty liver disease(NAFLD).This study mainly explored whether yogurt-derived Lactobacillus plantarum Q16 modulated lipid and energy metabolism,and suppressed microbial dysbiosis in high-fat diet(HFD)-fed *** showed that oral administration of *** Q16 improved serum and hepatic lipid *** analysis showed that *** Q16 could reduce hepatic lipid content by reducing the expression of FAS,ACC,SCD-1,Srebp-lc and ATGL,but increasing expression levels of CPT-1α,PPAR-αand ***,*** Q16 also improved hepatic energy metabolism by regulating FGF21/adiponectin/AMPKα/PGC-1αsignaling *** analysis also discovered that *** Q16 increased species diversity and richness of intestinal microbiota,promoted proliferation of beneficial commensals and suppressed the growth of endotoxin-producing microorganisms in the colon of HFD-fed ***,*** Q16 protected against HFD-induced NAFLD by improving hepatic profile and regulating colonic microbiota composition.

关键词： Lactobacillus plantarum Q16 Non-alcoholic fatty acid liver disease Lipid metabolism Energy metabolism Colonic microbiota

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杆菌霉素D和壳聚糖复合抑菌作用及其对砂糖橘保鲜效果

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食品工业科技 2024年第17期45卷 372-379页

作者：孙静刘玉娟罗晓娇张莫然黄俊凯戴永进陆颖健南京财经大学食品科学与工程学院/江苏省现代粮食流通与安全协同创新中心江苏南京210023

目的:基于杆菌霉素D(BD)和壳聚糖(CTS)对柑橘绿霉的抑菌作用,探究BD和CTS复配对砂糖橘采后病害的防治作用及保鲜效果。方法:以砂糖橘为研究对象,在发霉的砂糖橘中筛选出霉菌菌种进行鉴定,并通过棋盘微稀释法确定BD和CTS对柑橘绿霉的最... 详细信息

目的:基于杆菌霉素D(BD)和壳聚糖(CTS)对柑橘绿霉的抑菌作用,探究BD和CTS复配对砂糖橘采后病害的防治作用及保鲜效果。方法:以砂糖橘为研究对象,在发霉的砂糖橘中筛选出霉菌菌种进行鉴定,并通过棋盘微稀释法确定BD和CTS对柑橘绿霉的最小抑菌浓度和FIC指数,最后采用BD和CTS处理过的砂糖橘在28℃、相对湿度90%条件下贮藏保鲜,测定发病率、失重率、硬度、可溶性固形物、酶活等指标的变化。结果:对霉腐砂糖橘上分离纯化的菌种进行鉴定,为柑橘绿霉菌,并命名为Penicillium digitatum strain L6。BD和CTS对柑橘绿霉的最小抑菌浓度分别为42.19和62.5 mg/L,FIC指数为0.75,表明BD和CTS对柑橘绿霉的抑制为累加作用。贮藏保鲜结果表明,贮藏15 d后,BD、CTS和BD+CTS处理的砂糖橘失重率分别为0.99%、1.62%和1.09%,与对照组相比,分别降低了66.44%、45.08%和63.05%。另外,可滴定酸度、可溶性固形物、抗坏血酸以及植物相关酶活性的变化等结果也表明BD、CTS和BD+CTS复合处理的砂糖橘保鲜效果良好,其中BD+CTS复合处理组的整体效果最好。结论:BD和CTS均对柑橘绿霉菌具有显著的抑制效果,可用于砂糖橘的贮藏保鲜,延长货架期。两者复合使用不仅可以增强保鲜效果,而且CTS的价格低,可以减少BD的使用,降低成本。

关键词：杆菌霉素D 壳聚糖砂糖橘抑菌保鲜

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Ameliorative effect of Lacticaseibacillus rhamnosus Fmb14 from Chinese yogurt on hyperuricemia

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Food Science and Human Wellness 2023年第4期12卷 1379-1390页

作者： Hongyuan Zhao Xiaoyu Chen Fanqiang Meng Libang Zhou Xinyi Pang Zhaoxin lu yingjian lu College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China College of Food Science and Engineering Nanjing University of Finance and EconomicsNanjing 210023China

Hyperuricemia is a critical threat to human health,and a high inosine diet can increase the prevalence of *** rhamnosus Fmb14 was isolated from traditional fermented Chinese yogurt,and its inosine degradation rate reached 36.3%at 109 CFU/mL for 24 ***-MS analysis revealed that high concentrations of inosine could activate compensatory metabolic pathways of *** Fmb14 to catalyse inosine as an energy source and produce intracellular folic acid and *** contents of folic acid and riboflavin were 6.0 and 4.3 fold increased after inosine treatment in the cell-free extracts(CFE).*** Fmb14 CFE treatment ameliorates hyperuricemia through xanthine oxidase(XOD)inhibition and ATP-binding cassette subfamily G member 2(ABCG2)promotion,both of which are responsible for uric acid(UA)synthesis and secretion in HepG2 and Caco2 cells,*** in vivo results showed that the serum UA level decreased from 236.28 to 149.28μmol/L after 8 weeks of oral administration of *** Fmb14 in inosine-induced hyperuricemia model *** results revealed that *** Fmb14 has a potential as a biological therapeutic agent in hyperuricemia prevention.

关键词： Lacticaseibacillus rhamnosus Fmb14 Hyperuricemia Inosine degradation Uric acid metabolism

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Neomycin biosynthesis is regulated positively by AfsA-g and NeoR in Streptomyces fradiae CGMCC 4.7387

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Science China(Life Sciences) 2017年第9期60卷 980-991页

作者： Xiangxi Meng Wenzhao Wang Zhoujie Xie Pengwei Li Yue Li Zhengyan Guo yingjian lu Jie Yang Kaile Guan Zhaoxin lu Huarong Tan Yihua Chen State Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China Department of Nutrition and Food Science University of Maryland College Park MD 20742 USA College of Food Science and Technology Nanjing Agricultural University Nanjing 210095 China

Neomycins are a group of aminoglycoside antibiotics with both clinical and agricultural *** elucidate the regulatory mechanism of neomycin biosynthesis,we completed draft genome sequencing of a neomycin producer Streptomyces fradiae CGMCC 4.7387 from marine sediments,and the neomycin biosynthesis gene cluster was *** of the afsA-g gene encoding a γ-butyrolactone(GBL) synthase in *** CGMCC 4.7387 resulted in a significant decrease of neomycin *** RT-PCR analysis revealed that the transcriptional level of neoR and the aphA-neoGH operon were reduced in the afsA-g::aac(3)Ⅳ ***,a conserved binding site of AdpA,a key activator in the GBL regulatory cascade,was discovered upstream of neoR,a putative regulatory gene encoding a protein with an ATPase domain and a tetratricopeptide repeat *** neoR was inactivated,the neomycin production was reduced about 40%in comparison with the WT *** RT-PCR analysis revealed that the transcriptional levels of genes in the aphA-neoGH operon were reduced clearly in the neoR::aac(3)Ⅳ ***,the titers of neomycin were improved considerably by overexpression of qfsA-gand neoR in *** CGMCC 4.7387.

关键词： neomycin regulation γ-butyrolactone Streptomyces

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基于产业学院的产教融合人才培养模式研究——以粮食工程专业为例

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农产品加工 2024年第8期 118-121,125页

作者：庞心怡丁超李向菲孙静陆颖健南京财经大学食品科学与工程学院江苏南京210023

粮食产业关系国际民生和健康中国战略的实施,关系乡村振兴和双循环的发展格局。高校面临着培养适应我国粮食产业转型升级的高层次复合型人才的挑战。立足国家“人才兴粮”“科技兴粮”的战略,以南京财经大学现代粮食工程与营养健康产业... 详细信息

粮食产业关系国际民生和健康中国战略的实施,关系乡村振兴和双循环的发展格局。高校面临着培养适应我国粮食产业转型升级的高层次复合型人才的挑战。立足国家“人才兴粮”“科技兴粮”的战略,以南京财经大学现代粮食工程与营养健康产业学院为例,结合粮食行业人才现状及需求,针对产教融合存在的突出问题,重点围绕产业学院模式下的粮食工程专业人才培养目标、课程体系、实践体系、师资队伍及评价体系进行探讨,以期为我国粮食行业人才培养探索可行的路径和创新模式。

关键词：产教融合粮食工程产业学院人才培养

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萝卜硫素在神经系统疾病领域的研究进展

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食品科学 2023年第10期44卷 332-340页

作者：宋小叶庞心怡陆颖健南京财经大学食品科学与工程学院江苏南京210023

萝卜硫素是一种具有抗氧化和抗炎效果的天然产物,广泛存在于十字花科植物中。神经系统疾病发病原因复杂,但许多神经系统疾病的发生都与炎症和氧化应激有关,萝卜硫素在这些疾病的预防和治疗中有巨大的应用潜力。本文概述了萝卜硫素的来... 详细信息

萝卜硫素是一种具有抗氧化和抗炎效果的天然产物,广泛存在于十字花科植物中。神经系统疾病发病原因复杂,但许多神经系统疾病的发生都与炎症和氧化应激有关,萝卜硫素在这些疾病的预防和治疗中有巨大的应用潜力。本文概述了萝卜硫素的来源、生物合成途径及代谢途径,综述了萝卜硫素在神经保护方面的作用机制,总结了近年来萝卜硫素在阿尔茨海默病、自闭症谱系障碍、脑卒中等多种神经系统疾病防治领域的研究成果,讨论了目前研究的局限性并对未来研究的方向提出展望。

关键词：萝卜硫素神经保护阿尔茨海默病自闭症谱系障碍脑卒中

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解淀粉芽孢杆菌中脂肽的生物合成、抑菌机理及应用的研究进展

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食品工业科技 2022年第19期43卷 462-470页

作者：罗晓娇孙静陆颖健南京财经大学食品科学与工程学院江苏南京210023

解淀粉芽孢杆菌常作为有益菌广泛应用于食品的生物防治,其中主要的抗菌物质为脂肽类。这些抗菌脂肽具有抗菌、抗肿瘤、抗病毒等生物活性,同时具有安全、广谱、高效、无毒、在体内易分解等优点。因此,解淀粉芽孢杆菌及其脂肽类代谢产物... 详细信息

解淀粉芽孢杆菌常作为有益菌广泛应用于食品的生物防治,其中主要的抗菌物质为脂肽类。这些抗菌脂肽具有抗菌、抗肿瘤、抗病毒等生物活性,同时具有安全、广谱、高效、无毒、在体内易分解等优点。因此,解淀粉芽孢杆菌及其脂肽类代谢产物可广泛应用于农作物的生物防治、瓜果蔬菜的保鲜防腐以及采后的微生物防治等,具有巨大的开发应用前景。本文主要从解淀粉芽孢杆菌中脂肽类物质的类型、生物合成、抑菌机制及其应用前景等方面进行论述。

关键词：解淀粉芽孢杆菌脂肽生物合成抑菌机理

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探索“守望精神”的一把东方之钥——塞林格与吠檀多哲学

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山东社会科学 2024年第4期 101-107页

作者：吕威郭英剑中国人民大学外国语学院牡丹江师范学院西方语言学院

自成名作《麦田里的守望者》起,塞林格作品中所展现的东方色彩愈发浓烈,这种变化显然与他接触并参习中国的禅道思想和印度的吠檀多哲学有着密切的联系。但颇为遗憾的是,学界虽然注意到了塞林格创作的东方转向,却往往只将其与禅道相联系... 详细信息

自成名作《麦田里的守望者》起,塞林格作品中所展现的东方色彩愈发浓烈,这种变化显然与他接触并参习中国的禅道思想和印度的吠檀多哲学有着密切的联系。但颇为遗憾的是,学界虽然注意到了塞林格创作的东方转向,却往往只将其与禅道相联系,而甚少关注同属东方文化脉络的吠檀多哲学。诚然,禅宗所倡导的“见性”说与道家所尊崇的“自然”观,的确契合塞林格笔下人物对本真的“守望”,但这些人物在灵性成长过程中的行动准则、婚姻导向及生死态度等方面,却明显流露出吠檀多思想的痕迹。从吠檀多哲学这一全新角度重释塞林格作品,不仅可以探究作者创作思想的多重维度,还能窥见塞林格借印度智慧给予读者的种种灵性启悟,亦可进一步挖掘其笔下“守望精神”的丰富内涵。

关键词：塞林格吠檀多灵性 “梵”

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