Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice

作     者：Chao Tang Weiwei Zhou Mengyuan Shan Zhaoxin Lu Yingjian Lu Chao Tang;Weiwei Zhou;Mengyuan Shan;Zhaoxin Lu;Yingjian Lu

作者机构：College of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China College of Food Science and EngineeringNanjing University of Finance and EconomicsNanjing 210023China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2022年第11卷第5期

页      面：1428-1439页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083203[工学-农产品加工及贮藏工程] 

基　　金：the financial support for this work provided by the National Natural Science Foundation of China(31771948&32072182) 

主　　题：Lactobacillus plantarum Q16 Non-alcoholic fatty acid liver disease Lipid metabolism Energy metabolism Colonic microbiota 

摘      要：Accumulating evidence revealed that some probiotics regulated lipid metabolism and alleviated diet-induced non-alcoholic fatty liver disease(NAFLD).This study mainly explored whether yogurt-derived Lactobacillus plantarum Q16 modulated lipid and energy metabolism,and suppressed microbial dysbiosis in high-fat diet(HFD)-fed *** showed that oral administration of *** Q16 improved serum and hepatic lipid *** analysis showed that *** Q16 could reduce hepatic lipid content by reducing the expression of FAS,ACC,SCD-1,Srebp-lc and ATGL,but increasing expression levels of CPT-1α,PPAR-αand ***,*** Q16 also improved hepatic energy metabolism by regulating FGF21/adiponectin/AMPKα/PGC-1αsignaling *** analysis also discovered that *** Q16 increased species diversity and richness of intestinal microbiota,promoted proliferation of beneficial commensals and suppressed the growth of endotoxin-producing microorganisms in the colon of HFD-fed ***,*** Q16 protected against HFD-induced NAFLD by improving hepatic profile and regulating colonic microbiota composition.