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A Lower Bound for the Algebraic Connectivity of a Graph in Terms of the Domination Number

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Acta Mathematicae Applicatae Sinica 2018年第4期34卷 752-760页

作者： Yi-Zheng FAN ying-ying tan School of Mathematical Sciences Anhui University Hefei 230601 P. R. China School of Mathematics and Physics Anhui Jianzhu University Hefei 230601 China

We investigate how the algebraic connectivity of a graph changes by relocating a connected branch from one vertex to another vertex, and then minimize the algebraic connectivity among all connected graphs of order n with fixed domination number γ≤（n＋2）/3, and finally present a lower bound for the algebraic connectivity in terms of the domination number. We also characterize the minimum algebraic connectivity of graphs with domination number half their order.

关键词： graph algebraic connectivity domination number

Perfect State Transfer on Weighted Abelian Cayley Graphs

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Chinese Annals of Mathematics,Series B 2021年第4期42卷 625-642页

作者： Xiwang CAO Keqin FENG ying-ying tan Department of Mathematics Nanjing University of Aeronautics and Astronau-ticsNanjing 210016China Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China School of Mathematics and Physics Anhui Jianzhu UniversityHefei 230601China

Recently,there are extensive studies on perfect state transfer(PST for short)on graphs due to their significant applications in quantum information processing and quantum ***,there is not any general characterization of graphs that have PST in *** this paper,the authors present a depiction on weighted abelian Cayley graphs having *** give a unified approach to describe the periodicity and the existence of PST on some specific graphs.

关键词： Perfect state transfer Cayley graph Eigenvalues of a graph Weighted graph Random walk

The role of vascular endothelial growth factor in ossification

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International Journal of Oral Science 2012年第2期4卷 64-68页

作者： Yan-Qi Yang ying-ying tan Ricky Wong Alex Wenden Lin-Kun Zhang A bakr M Rabie Department of Orthodontics Faculty of Dentistry The University of Hong Kong Hong Kong China Unit Pakar Ortodontik Klinik Pergigian Poliklinik Komuniti Mak MandinMalaysia Department0fOrfhodonflcs Tlanj}nsfomafoI.gicalH.spJcaJ.iNankaiunIversityTianjinchinaand PrivatePracticeC0rrespondence:DrYQYang DepartmentDfOrthodonticsFacultyofDentIstryTheUnlversity硝HongKong34HospnalRoadHOngK0ngSARChinaE—maiJ=yan副anq@hkuhk

Osteogenesis and angiogenesis are two closely correlated processes during bone growth, development, remodelling and repair. Vascular endothelial growth factor （VEGF） is an essential mediator during the process of angiogenesis. Based on an extensive literature search, which was carried out using the PubMed database and the keywords of osteogenesis, VEGF, endochondral ossification and intramembranous ossification, this manuscript reviews the role of VEGF in ossification, with emphasis on its effect in endochondral and intramembranous ossification. Osteogenesis and angiogenesis are closely correlated processes. VEGF acts as an essential mediator durin~ these processes. It not only functions in bone an^io^enesis but also in various aspects of bone develooment.

关键词： endochondral ossification intramembranous ossification osteogenesis vascular endothelial growth factor

The Laplacian Spread of Bicyclic Graphs

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Journal of Mathematical Research and Exposition 2010年第1期30卷 17-28页

作者： Yi Zheng FAN Shuang Dong LI ying ying tan School of Mathematical Sciences Anhui University Anhui 230039 P. R. China Department of Mathematics & Physics Anhui University of Architecture Anhui 230022 P. R. China

The Laplacian spread of a graph is defined to be the difference between the largest eigenvalue and the second smallest eigenvalue of the Laplacian matrix of the graph. In our recent work, we have determined the graphs with maximal Laplacian spreads among all trees of fixed order and among all unicyclic graphs of fixed order, respectively. In this paper, we continue the work on Laplacian spread of graphs, and prove that there exist exactly two bicyclic graphs with maximal Laplacian spread among all bicyclic graphs of fixed order, which are obtained from a star by adding two incident edges and by adding two nonincident edges between the pendant vertices of the star, respectively.

关键词： bicyclic graph Laplacian matrix spread.

Investigating the Potential Mechanism of Huazhi Rougan Granules Against Alcoholic Liver Disease by Network Pharmacology and Experiment

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 191-203页

作者： ying-ying tan ying-ying Liu Yi-Yan Zhai Yi-Xuan Wang Zhi-Shan Wu Antony Stalin Guo-Liang Cheng Bing Li Chao Wu Zhi-Hong Huang Shan Lu Xiao-Tian Fan Zheng Zhao Jia-Rui Wu Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijingChina Department of Bioinformatics Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengduChina Department of Traditional Chinese Medicine State Key Laboratory of Generic Manufacture Technology of Chinese Traditional MedicineLinyiChina Department of Clinical Medicine Beijing Zest Bridge Medical Technology Inc.BeijingChina

Objective: Huazhi Rougan granules(HRGs) are a promising drug to improve alcoholic liver disease(ALD), but its mechanism remains unclear. Materials and Methods: Network pharmacology, molecular docking, and animal experiments were used to reveal the potential mechanism of HRG against ALD. Results: A total of 245 potential targets of HRG against ALD were obtained. Functional enrichment analysis suggests that HRG could synergistically regulate various biological pathways to exert therapeutic effects on ALD. Molecular docking showed that the key targets exhibited the good binding ability with the key compounds. The in vivo experiments showed that HRG can effectively alleviate pathological changes in liver tissue, improve blood lipid levels, antioxidant stress ability, and liver function, and reduce the release of inflammatory cytokines in the liver. Conclusions: This study reflects that HRG is an effective strategy for treating ALD, providing a basis for revealing the prevention and treatment mechanisms of ALD.

关键词： Alcoholic liver disease Huazhi Rougan granules inflammatory response network pharmacology

Elucidation of Immune Regulation Mechanism of Renshen Guben Oral Liquid by Network Pharmacology and Molecular Docking

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World Journal of Traditional Chinese Medicine 2023年第4期9卷 419-429页

作者： ying-ying tan ying-ying Liu Jing-Yuan Zhang Jia-Lin Li Pei-Zhi Ye Antony Stalin Xiao-Tian Fan Zhi-Hong Huang Bing Li Chao Wu Shan Lu Zhi-Shan Wu Xiao-Meng Zhang Guo-Liang Cheng Jia-Rui Wu Yan-Fang Mou Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijingChina Traditional Chinese Medicine Department Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Bioinformatics Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengduChina Department of Traditional Chinese Medicine State Key Laboratory of Generic Manufacture Technology of Chinese Traditional MedicineLinyiChina

Objective:To investigate the mechanism of Renshen Guben oral liquid(RSGB)enhancing immune *** and Methods:Network pharmacology and molecular docking were used to intuitively demonstrate the mechanism of immune regulation of ***:A total of 112 active compounds of RSGB were found,and 501 targets were ***,2974 immune targets were obtained from UniProt and NCBI Gene databases,and 111 common targets of RSGB and immunity were *** them,interleukin(IL)6,tumor necrosis factor,AKT1,VEGFA,STAT3,MAPK1,SRC,EGFR,IL1B,and PTGS2 might be the key targets for RSGB to improve *** and Kyoto Encyclopedia of Genes and Genomes analysis showed that the immunoregulatory mechanism of RSGB may find a relation with the B cell receptor signaling pathway and T cell receptor signaling ***,this study preliminarily explored the mechanism of RSGB improving menopausal syndrome,polycystic ovary syndrome,and cancer-related fatigue by enhancing ***:RSGB can improve the body's immunity through multicomponent,multitarget,and *** addition,RSGB can also improve the immune capacity of the body to assist in the treatment of diseases,which has great potential as an immunomodulator.

关键词： Immunity molecular docking network pharmacology Renshen Guben oral liquid

Nanostructured ZnO/BiVO_(4)I-scheme heterojunctions for piezocatalytic degradation of organic dyes via harvesting ultrasonic vibration energy

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 488-497页

作者： Yiling Li Xiaoyao Yu yingjie Zhou Yao Lin ying Wu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China

BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active ***,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

关键词： piezoelectric catalytic heterojunction dye degradation ultrasonic vibration

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由可分组设计构造对称设计

数学学报（中文版） 2023年第3期66卷 589-598页

作者：谭莹莹夏田田梁晓晔冯荣权安徽建筑大学数理学院合肥230601 安徽建筑大学运筹学与数据科学实验室合肥230601 北京大学数学科学学院北京100871

本文提出了由一类可分组设计构造出对称设计的方法.注意到这类可分组设计的关联图对应着5类结合方案的关系图.本文利用该5类结合方案的商结合方案,由这类可分组设计构造对称设计,并举例说明了构造的具体过程.此外,提出了一种利用阵列由... 详细信息

本文提出了由一类可分组设计构造出对称设计的方法.注意到这类可分组设计的关联图对应着5类结合方案的关系图.本文利用该5类结合方案的商结合方案,由这类可分组设计构造对称设计,并举例说明了构造的具体过程.此外,提出了一种利用阵列由对称设计构造可分组设计的方法.在此基础上,证明了两个有对偶性质的可分组设计GDDDP(2,11;5;0,1)和GDDDP(2,16;6;0,1)不存在.

关键词：对称设计可分组设计商结合方案关联图

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： ying Wang Xiang Zhang Henrik Biverstål Nicolas GBazan Shuai tan Nailin Li Makiko Ohshima Marianne Schultzberg Xiaofei Li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator