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A Novel Mutation of PRKAR1A Caused Carney Complex in a Chinese Patient

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Chinese Medical Journal 2017年第24期130卷 3009-3010页

作者： Xiao-Ling Cai Jing Wu ying-ying luo Ling Chen Xue-Yao Han Li-Nong Ji Department of Endocrinology and Metabolism Peking University People's Hospital Beijing 100044 China

Primary pigmented nodular adrenocortical disease （PPNAD） causes adrenocorticotropic hormone （ACTH）-independent Cushing＇s syndrome （CS）,which is the most frequent endocrine manifestation of Carney complex （CNC）.[1] In the disease process of PPNAD,both presadrenal glands are involved and feature small brown-black nodules separated by the atrophic adrenal cortex.

关键词： Carney Complex Chinese Mutation PRKAR1A Gene

Constructions of optimal binary locally repairable codes via intersection subspaces

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Science China(Information Sciences) 2024年第6期67卷 418-432页

作者： Wenqin ZHANG Deng TANG Chenhao ying Yuan luo School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University

Locally repairable codes（LRCs）, which can recover any symbol of a codeword by reading only a small number of other symbols, have been widely used in real-world distributed storage systems, such as Microsoft Azure Storage and Ceph Storage Cluster. Since binary linear LRCs can significantly reduce coding and decoding complexity, constructions of binary LRCs are of particular interest. The aim of this paper is to construct dimensional optimal binary LRCs with disjoint local repair groups. We introduce a method to connect intersection subspaces with binary LRCs and construct dimensional optimal binary linear LRCs with locality 2b（b 3） and minimum distance d 6 by employing intersection subspaces deduced from the direct sum. This method will sufficiently increase the number of possible repair groups of dimensional optimal LRCs, thus efficiently expanding the range of the construction parameters while keeping the largest code rates compared with all known binary linear LRCs with minimum distance d 6 and locality 2b.

关键词： locally repairable codes disjoint local repair groups distributed storage systems intersection subspaces direct sum

Hydroxysafflor yellow A induced ferroptosis of Osteosarcoma cancer cells by HIF-1α/HK2 and SLC7A11 pathway

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Oncology Research 2024年第5期32卷 899-910页

作者： YIWEN ZHU LIU YANG ying YU ying XIONG PING XIAO XIAO FU XIN luo Department of Rehabilitation Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang330006China Department of General Practice The Second Affiliated Hospital of Nanchang UniversityNanchang330006China

Osteosarcoma is a very serious primary bone cancer with a high death rate and a dismal *** there is no permanent therapy for this condition,it is necessary to develop a ***,this investigation was carried out to assess the impacts and biological functions of hydroxysafflor yellow A(HYSA)in osteosarcoma cell lines(MG63).In this investigational study,MG63 cells were *** experiments,quantitative polymerase chain reaction(qPCR),immunofluorescent staining,extracellular acidification rate(ECAR),oxygen consumption rate(OCR),glucose consumption,lactate production,and ATP levels,proliferation assay,5-Ethynyl-2′-deoxyuridine(EDU)staining,and Western blot were *** MG63 cells,HYSA lowered cell proliferation and metastasis rates,suppressed EDU cell number,and enhanced caspase-3/9 activity *** reduced the Warburg effect and induced ferroptosis(FPT)in MG63 *** ferroptosis diminished HYSA’s anti-cancer activities in MG63 *** stimulation of the HIF-1α/SLC7A11 pathway decreased HYSA’s anti-cancer activities in MG63 ***-1αis one target spot for HYSA in a model of osteosarcoma cancer(OC).HYSA altered HIF-1α’s thermophoretic activity;following binding with HYSA,HIF-1α’s melting point increased from~55°C to~60°*** significantly enhanced the thermal stability of exogenous WT HIF-1αwhile not affecting Mut HIF-1α,suggesting that ARG-311,GLY-312,GLN-347,and GLN-387 may be involved in the interaction between HIF-1αand ***,our study revealed that HYSA induced FPT and reduced the Warburg effect of OC through mitochondrial damage by HIF-1α/HK2/SLC7A11 *** is a possible therapeutic option for OC or other cancers.

关键词： Hydroxysafflor yellow A Osteosarcoma HIF-1α FPT

Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting

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Chinese Journal of Polymer Science 2024年第8期42卷 1067-1076页

作者： Chun-Peng Zhang Si-Jia Gao ying luo Lei Zou Yong-Jun Zhang State Key Laboratory of Separation Membranes and Membrane Processes School of Material Science and EngineeringTiangong UniversityTianjin 300387China State Key Laboratory of Separation Membranes and Membrane Processes School of Pharmaceutical SciencesTiangong UniversityTianjin 300387China Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Institute of Hepatobiliary DiseaseNankai University Affiliated Third Center HospitalTianjin 300170China Cangzhou Institute of Tiangong University Cangzhou 061000China

Glucose-sensitive membrane has potential application in self-regulating insulin *** acid(PBA)is a well-known glucose ***,most PBA-based glucose-sensitive materials are expansion-type,which are not suitable as chemical valves in membrane pores for self-regulating insulin *** to a new glucose-sensitive mechanism,we synthesized PBA-based contraction-type glucose-sensitive liner polymer and ***,a glucose-sensitive membrane was prepared by grafting PBA-based contraction-type glucose-sensitive linear polymer on the membrane *** adjusting the chain length and chain density,the glucose-sensitivity of the membrane was *** membrane can reversibly regulate insulin release at physiologically relevant glucose concentrations in simulates body fluids and fetal bovine *** membrane also has good stability,anti-fouling and biocom *** has potential application in selfregulating insulin release.

关键词： Phenylboronic acid Glucose-sensitive Membrane Surface grafting Insulin

Role of inflammatory lipid and fatty acid metabolic abnormalities induced by plastic additives exposure in childhood asthma

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Journal of Environmental Sciences 2024年第3期137卷 172-180页

作者： Zhiyu Chen Fang Li Lei Fu Yu Xia ying luo Ang Guo Xiaona Zhu Huifang Zhong Qian luo Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Rheumatology&Immunology Department of Shenzhen Children’s Hospital Shenzhen 518038China Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances Institute of Environment and HealthJianghan UniversityWuhan 430056China

Lipid metabolism play an essential role in occurrence and development of asthma,and it can be disturbed by phthalate esters(PAEs)and organophosphate fame retardants(OPFRs).As a chronic infammatory respiratory disease,the occurrence risk of childhood asthma is increased by PAEs and OPFRs exposure,but it remains not entirely clear how PAEs and OPFRs contribute the onset and progress of the *** have profiled the serum levels of PAEs and OPFRs congeners by liquid chromatography coupled with mass spectrometry,and its relationships with the dysregulation of lipid metabolism in asthmatic,bronchitic(acute infammation)and healthy(non-infammation)*** PAEs and nine OPFRs congeners were found in the serum of children(1–5 years old)from Shenzhen,and their total median levels were 615.16 ng/m L and 17.06 ng/m L,***,the serum levels of mono-methyl phthalate(MMP),tri-propyl phosphate(TPP)and tri-n-butyl phosphate(TNBP)were significant higher in asthmatic children than in healthy and bronchitic children as ***-one characteristic lipids and fatty acids of asthma were screened by machine-learning random forest model based on serum lipidome data,and the alterations of infammatory characteristic lipids and fatty acids including palmitic acids,12,13-Di HODE,14,21-Di HDHA,prostaglandin D2 and Lyso PA(18:2)showed significant correlated with high serum levels of MMP,TPP and *** results imply PAEs and OPFRs promote the occurrence of childhood asthma via disrupting infammatory lipid and fatty acid metabolism,and provide a novel sight for better understanding the effects of plastic additives on childhood asthma.

关键词： Phthalate esters Organophosphate fame retardants Childhood asthma Lipid and fatty acid metabolism Machine-learning random forest model Chronic airway infammation

Facet effects on bimetallic ZnSn hydroxide microcrystals for selective electrochemical CO2 reduction

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Green Energy & Environment 2024年第8期9卷 1314-1320页

作者： Liu Han Cheng-wei Wang Shan-shan luo ying-tang Zhou Bing Li Ming Liu School of Chemistry and Chemical Engineering Harbin Institute of Technology National Engineering Research Center for Marine Aquaculture Marine Science and Technology CollegeZhejiang Ocean University

Employing crystal facets to regulate the catalytic properties in electrocatalytic carbon dioxide reduction reaction（eCO2RR） has been well demonstrated on electrocatalysts containing single metals but rarely explored for bimetallic systems. Here, we synthesize Zn Sn（OH）6（ZSO）microcrystals（MCs） with distinct facets and investigate the facet effects in eCO2RR. Electrochemical studies and in situ Fourier Transform Infrared Spectroscopy（in situ-FTIR） reveal that ZSO MCs produce mainly C1 products of HCOOH and CO. The {111} facet of the ZSO MCS exhibits higher selectivity and faradaic efficiency（FE） than that of the {100} facet over a wide range of potentials（-0.9 V ～-1.3 V versus RHE）. Density Functional Theory（DFT） calculations elucidate that the {111} facet is favorable to the adsorption/activation of CO2molecules,the formation of intermediate in the rate-determining step, and the desorption of C1 products of CO and HCOOH molecules.

关键词： ZnSn(OH) 6 Crystal facets Electrochemical carbon dioxide reduction C1 product Density functional theory

Recent advances in heterogeneous catalysis of solar-driven carbon dioxide conversion

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Journal of Environmental Sciences 2024年第6期140卷 165-182页

作者： Jun Xu Farzaneh Arabpour Roghabadi ying luo Vahid Ahmadi Qian Wang Zheng Wang Hong He State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Chemistry and Chemical Engineering Henan Polytechnic UniversityJiaozuoHenan 454000China Department of Process Engineering Faculty of Chemical EngineeringTarbiat Modares UniversityTehranIran Optoelectronics and Nanophotonics Research Group Faculty of Electrical and Computer EngineeringTarbiat Modares UniversityTehranIran Graduate School of Engineering Nagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan

Solar-driven carbon dioxide(CO_(2))conversion including photocatalytic(PC),photoelectrochemical(PEC),photovoltaic plus electrochemical(PV/EC)systems,offers a renewable and scalable way to produce fuels and high-value chemicals for environment and energy *** review summarizes the basic fundament and the recent advances in the field of solar-driven CO_(2)*** the visible-light absorption is an important strategy to improve solar energy conversion *** separation and migration of photogenerated charges carriers to surface sites and the surface catalytic processes also determine the photocatalytic *** engineering including co-catalyst loading,defect engineering,morphology control,surface modification,surface phase junction,and Z-scheme photocatalytic system construction,have become fundamental strategies to obtain high-efficiency *** to photocatalysis,these strategies have been applied to improve the conversion efficiency and Faradaic efficiency of typical PEC *** PV/EC systems,the electrode surface structure and morphology,electrolyte effects,and mass transport conditions affect the activity and selectivity of electrochemical CO_(2)***,the challenges and prospects are addressed for the development of solar-driven CO_(2)conversion system with high energy conversion efficiency,high product selectivity and stability.

关键词： Solar-driven CO_(2)reduction Photocatalytic system Photoelectrochemical system Photovoltaic plus electrochemical system Surface/interface engineering

Single-atomic activation on ZnIn_(2)S_(4)basal planes boosts photocatalytic hydrogen evolution

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Nano Research 2024年第7期17卷 5949-5955页

作者： Jianpeng Cui ying Wang Luxue Lin Xiaotian Yang Xuyu luo Shiying Guo Xiaoyong Xu College of Physics Science and Technology and Center for Interdisciplinary ResearchYangzhou UniversityYangzhou 225002China

The use of single-atom cocatalysts plays a crucial role in enhancing artificial photocatalysis,where the precise construction of stable and efficient single-atom configuration is essential but remains ***,we report a simple one-step hydrothermal method for preparing single-atomic Mo modified ZnIn_(2)S_(4)(Mo-ZIS)nanosheets as a highly active photocatalytic hydrogen evolution(PHE)*** Mo substituting for portion of In atoms in ZIS nanosheets induces the spatial charge redistribution,which not only promotes the separation of photogenerated charge carriers but also optimizes the Gibbs free energy of adsorbing H*on S atoms at basal *** a result,Mo-ZIS exhibits an impressive PHE rate as high as 6.71 mmol·g^(−1)·h^(−1),over 10 times that of the pristine ZIS,with an apparent quantum efficiency(AQE)up to 38.8%at 420 *** study gains insights into the coordination configuration and electronic modulation resulting from single-atomic decoration,providing mechanistic cognitions for the development of advanced photocatalysts via non-precious metal atomic modification.

关键词： photocatalytic hydrogen evolution ZnIn_(2)S_(4) single-atom activation Gibbs free energy

A novel phenotypic assay of hepatitis B virus polymerase with extensive site-specific mutagenesis

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Virologica Sinica 2017年第2期32卷 167-170页

作者： ya liu ying-ying luo xue-fei cai quan-xin long chun-yang gan liu-qing yang haitao guo ai-long huang wen-lu zhang jie-li hu institute for viral hepatitis key laboratory of molecular biology on infectious diseasesministry of educationthe second affiliated hospital of chongqing medical universityChongqing 400016China department of microbiology and immunology indiana university school of medicine indianapolis46202 USA collaborative innovation center for diagnosis and treatment of infectious diseases(ccid) Hangzhou 310058China

Dear Editor,A common reason for drug failure during long-term treatment of chronic hepatitis B with nucleot(s)ide analogues(NUCs)is the emergence of drug resistance(Das et al.,2001).Most primary NUCs-resistant mutatio... 详细信息

关键词： In HBVDNA FSR A novel phenotypic assay of hepatitis B virus polymerase with extensive site-specific mutagenesis LAM