A novel phenotypic assay of hepatitis B virus polymerase with extensive site-specific mutagenesis

作     者：ya liu ying-ying luo xue-fei cai quan-xin long chun-yang gan liu-qing yang haitao guo ai-long huang wen-lu zhang jie-li hu 

作者机构：institute for viral hepatitiskey laboratory of molecular biology on infectious diseasesministry of educationthe second affiliated hospital of chongqing medical universityChongqing 400016China department of microbiology and immunologyindiana university school of medicine indianapolis46202 USA collaborative innovation center for diagnosis and treatment of infectious diseases(ccid)Hangzhou 310058China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2017年第32卷第2期

页      面：167-170页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：supported in part by grants from the National Natural Science Foundation of China(81671997) Chongqing Science&Technology Commission(cstc2015jcyj A10023) Chongqing Education Commission(CYB15099) the Program for Innovation Team of Higher Education in Chongqing(CXTDX 201601015) 

主　　题：In HBVDNA FSR A novel phenotypic assay of hepatitis B virus polymerase with extensive site-specific mutagenesis LAM 

摘      要：Dear Editor,A common reason for drug failure during long-term treatment of chronic hepatitis B with nucleot(s)ide analogues(NUCs)is the emergence of drug resistance(Das et al.,2001).Most primary NUCs-resistant mutations identified in clinical samples have been limited to a minority of amino acids(usually less