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Au/FeO_x-TiO_2 as an efficient catalyst for the selective hydrogenation of phthalic anhydride to phthalide

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Chinese Chemical Letters 2010年第11期21卷 1322-1325页

作者： ying xin liu Tie Feng xing Yi Ming Luo Xiao Nian Li Wei Yan Research and Development Base of Catalytic Hydrogenation Zhejiang University of Technology Hangzhou 310032 China State Key Laboratory Breeding Base of Green Chemistry Synthesis Technology Zhejiang University of Technology Hangzhou 310032 China

Au/FeOx-TiO2,prepared by deposition-precipitation method,is an efficient and stable catalyst for the liquid phase selective hydrogenation of phthalic anhydride to phthalide under mild reaction conditions.

关键词： Au/FeOx-TiO2 catalyst Phthalic anhydride Liquid phase hydrogenation Phthalide

Mesomorphous structure change by tail chain number in ionic liquid crystalline complexes of linear polymer and amphiphiles

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Chinese Chemical Letters 2011年第11期22卷 1375-1378页

作者： Zhi Yu Cheng Bi Ye Ren Shu ying He xin xing liu Zhen Tong Research Institute of Materials Science South China University of Technology Guangzhou 510640 China

Three polymer-amphiphile complexes were prepared by combining poly（allylamine hydrochloride）（PAH） with the potassium salt of mono-,di-,and trisubstituted benzoic acid dendrons（4-octyloxybenzoic acid,3,5-dioctyloxybenzoic acid,and 3,4,5- trioctyloxybenzoic acid）.The solid structure and properties were monitored with FT-IR,XRD,TG,DSC,and polarized optical microscope（POM）.Difference in the tail chain number of the dendritic amphiphile induced two different mesomorphous structures： lamella for the mono-,disubstituted dendron containing complexes and hexagonal column for the trisubstituted dendron containing *** corresponded to the ionic thermotropic liquid crystal SmA andΦ_h phases,*** finding is significant for design of functional nanostructures based on the ionic complexation of polymers and amphiphiles.

关键词： Polymer-amphiphile complex Poly(allylamine hydrochloride) Dendritic amphiphile Ionic thermotropic liquid crystal

The Effect of Neodymia on the Activityof Hydrocarbon Synthesis Catalysts from Carbon Dioxide

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Chinese Chemical Letters 1999年第11期10卷 965-966页

作者： xin ying liu Guo Cai DENG Yun Ti CHEN(Department of Chemistry, Nankai University, Tianjin 300071) Department of Chemistry Nankai University Tianjin 300071 China

In this paper, neodymia was added into hydrocarbon synthesis catalysts by solid-mixing method to improve the activity of hydrocarbon synthesis catalyst from carbon dioxide. 0.1% Nd2O3 can improve the carbon dioxide co... 详细信息

关键词： neodymia hydrocarbon synthesis carbon dioxide hydrogenation

Involvement of CD4^＋CD25^＋ regulatory T cells in the pathogenesis of polycythaemia vera

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Chinese Medical Journal 2008年第18期 1781-1786页

作者： ZHAO Wen-bo LI ying liu xin ZHANG Ling-yan WANG xin Department of Hematology Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China

Background Regulatory T cells （mreg） have been shown to play an important role in the regulation of hematopoietic activity. However, there is no information about the effect of Treg cells in the pathogenesis of polycythaemia vera （PV）. Methods In this study, we investigated the percentage and function of Treg cells in the peripheral blood of 21 PV patients and 25 healthy donors, mreg cells were identified and characterized as CD4^＋CD25^＋FOXP3^＋ by flow cytometry. The suppressive activity of CD4^＋CD25^＋ Treg cells was assessed by the proliferation and cytokine secretion of the co-cultured CD4^＋CD25^- fractions. Results The results showed that the percentage of Treg cells in the peripheral blood of PV patients significantly increased compared to healthy controls （（10.93±4.02）% vs （5.86±1.99）%, P 〈0.05）. Moreover, the mRNA and protein expression of FOXP3 was higher in CD4^＋CD25^＋ Treg cells. Coordinately, when co-cultured with the activated CD4^＋CD25^- cells, the CD4^＋CD25^＋ Treg cells showed enhanced suppressive function in PV. Yet, the underlying mechanism for the increased frequency and function of CD4^＋CD25^＋ Treg cells is still to be clarified. Conclusion Treg cells expansion might account for the abnormal T cell immunity in PV patients and thus contribute to the pathogenesis of PV.

关键词： polycythaemia vera regulatory T cells pathogenesis

Lineal DNA logic gate for microRNA diagnostics with strand displacement and fluorescence resonance energy transfer

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Chinese Chemical Letters 2015年第9期26卷 1179-1182页

作者： Tian-Tian Meng ying-xin liu Meng-Tan liu Jiao-Bao Long Qing-Feng Cao Shu-Ya Yan Xiang-Xian Meng College of Biology The High School Attach to Hunan University Hunan University School of Life Science Xiamen University

Designing molecular logic gates to operate programmably for molecular diagnostics in molecular computing still remains ***,we designed a novel linear DNA logic gates for microRNA analysis based on strand displacement and fluorescence resonance energy transfer（FRET）.Two labeled strands closed each other produce to FRET through hybridization with a complementary strand to form a basic work unit of logic *** indicators of heart failure（microRNA-195 and microRNA-21） were selected as the logic inputs and the fluorescence mode was used as the logic *** have demonstrated that the molecular logic gate mechanism worked well with the construction of YES and AND gates.

关键词： Molecular logic gate Strand displacement Fluorescence resonance energy transfer

Sensitive and enzyme-free detection for single nucleotide polymorphism using microbead-assisted toehold-mediated strand displacement reaction

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Chinese Chemical Letters 2015年第8期26卷 1031-1035页

作者： Jia-Bao Long ying-xin liu Qing-Feng Cao Qiu-Ping Guo Shu-Ya Yan Xiang-Xian Meng College of Biology State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan University Department of Bioengineering and Environment Science Changsha University

This report described a free-enzyme, convenient and inexpensive genotyping biosensor capable of detecting single nucleotide polymorphism at normal temperature based on the combination of toeholdmediated strand displacement reaction（toehold-SDR） and microbead-capture technique. The biosensor consists of a pre-hybridized strand formed by a reporter probe and a capture probe. In the presence of a mutant sequence, there is no toehold-mediated strand displacement and the reporter probe cannot be released from the pre-hybridized strand. Microbeads capture the fluorescent pre-hybridized strand through biotin–streptavidin interaction, so microbeads give out significant fluorescence signal, while there is no fluorescence in the solution. However, in the presence of a matched target, the strand displacement is effectively initiated and the reporter probe is released from pre-hybridized strand. After adding microbeads, the solution produces bright fluorescence, while microbeads have no obvious *** are identified conveniently according to the fluorescence intensity of the solution. The method provides a simple and inexpensive strategy to detect point mutation. Moreover, this biosensor shows the linear relationship in the range of 1–40 nmol/L and reaches a detection limit of 0.3 nmol/L.？ 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical *** by Elsevier B.V. All rights reserved.

关键词： strand capture biosensor convenient detecting capable inexpensive reporter bright matched

Anti-epileptic and Neuroprotective Effects of Ultra-low Dose NADPH Oxidase Inhibitor Dextromethorphan on Kainic Acid-induced Chronic Temporal Lobe Epilepsy in Rats

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Neuroscience Bulletin 2024年第5期40卷 577-593页

作者： Jing-Jing Yang ying-xin liu Yan-Fang Wang Bi-ying Ge ying Wang Qing-Shan Wang Sheng Li Jian-Jie Zhang Ling-Ling Jin Jau-Shyong Hong Sheng-Ming Yin Jie Zhao College of Basic Medical Sciences Dalian Medical UniversityDalian116044China Department of Neurology The First Affiliated Hospital of Dalian Medical UniversityDalian116011China National and Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases Dalian116044China School of Public Health Dalian Medical UniversityDalian116044China Neurobiology Laboratory National Institute of Environmental Health SciencesNational Institutes of HealthResearch Triangle ParkDurhamNC27709USA

Neuroinflammation mediated by microglia and oxidative stress play pivotal roles in the development of chronic temporal lobe epilepsy(TLE).We postulated that kainic acid(KA)-Induced status epilepticus triggers microglia-dependent inflammation,leading to neuronal damage,a lowered seizure threshold,and the emergence of spontaneous recurrent seizures(SRS).Extensive evidence from our laboratory suggests that dextromethorphan(DM),even in ultra-low doses,has anti-inflammatory and neuroprotective effects in many animal models of neurodegenerative *** results showed that administration of DM(10 ng/kg per day;subcutaneously via osmotic minipump for 4 weeks)significantly mitigated the residual effects of KA,including the frequency of SRS and seizure *** addition,DM-treated rats showed improved cognitive function and reduced hippocampal neuronal *** found suppressed microglial activation-mediated neuroinflammation and decreased expression of hippocampal gp91^(phox) and p47^(phox) proteins in KA-induced chronic TLE ***,even after discontinuation of DM treatment,ultra-low doses of DM continued to confer long-term anti-seizure and neuroprotective effects,which were attributed to the inhibition of microglial NADPH oxidase 2 as revealed by mechanistic studies.

关键词： Temporal lobe epilepsy Dextromethorphan NADPH oxidase Ultra-low dose

Study on Chemical Cross-linking Modification of Hyaluronan and the Biocompatibility of its Derivatives

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Chinese Journal of Biomedical Engineering(English Edition) 2006年第4期15卷 139-150页

作者： HU Guo-ying liu xin GU Han-qing The Second Hospital of Tianjin Medical University 300211 TianjinChina The Second Hospital of Tianjin Medical University300211 TianjinChina The Second Hospital of Tianjin Medical University300211 TianjinChina

Objective: Prepare cross-linked HA gels with higher mechanical stability, lower degradation velocity and desirable biocompatibility,so as to extend the usage of ***:*** molecular weight of HA (Mr_ HA ) by viscosimetry;*** cross-linked HA gels by DVS, GTA, DEC;*** the cross-linking and degradation procedure;*** the biocompatibility of the best HA gels. Results:The mechanical stability and durability to degradation of HA-DVS gels are superior to those of other gels, and when HA:DVS = 40:1(g/g), at 35℃ and in 0.2 M NaOH solution, the HA-DVS gel shows the best mechanical stability, and its cytotoxicity reaches class I, hemolysis ratio is lower than 5%. Conclusion:Our HA-DVS gel can be used to prepare biologic scaffolds.

关键词： Hyaluronic acid (Hyaluronan) Cross-linking Divinyl sulfone Diepoxy compound Glutaraldehyde Biocompatibility In vitro degradation

SYNTHESIS，　COMPLEXATION　PROPERTIES　AND　CRYSTAL　STRUCTURE　OF　NEW　DIOXOCYCLAM　BEARING　8－METHYL　QUINOLINE　AS　FUNCTIONAL　PENDANT（S）

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Chinese Chemical Letters 1994年第12期5卷 1027-1030页

作者： Dao Li AN Xian lle BU xin ying liu Yu liu and Yun Ti CHEN (Department of Chemistry, Nankai University, Tianjin 300071)

Two new dioxo tetraamine ligands L1 and L2 have been synthesized and characterized by 1H NMR, IR, MS and elemental analysis,Their protonation eonstants and complex formation constants with Cu2+have been determined by ... 详细信息

关键词： AS FUNCTIONAL QUINOLINE METHYL PENDANT AND BEARING