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Identification and Gene Mapping of a Novel Mutant supernumerary lodicules(snl) in Rice

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Journal of Integrative Plant Biology 2010年第3期52卷 265-272页

作者： Nan Wang Xian-Chun Sang Yun-Feng Li zheng-Lin Yang Fang-ming Zhao ying-Hua Ling zheng-Sheng Zhang Guang-Hua He Rice Research Institute Key Laboratory of Biotechnology and Crop Quality Improvement Ministry of Agriculture Southwest University Chongqing 400715 China

In order to gain a better understanding of rice flower development, a rice flower mutant supernumerary Iodicules （snl）, which was identified from ethyl methane sulfonate （EMS）-treated Jinhui10 （Oryza sativa L. ssp. indica） was used in the present study. In the snl mutant, the palea obtained lemma identity, additional glume-like organs formed, Iodicules increased and elongated, stamens decreased, and a few aberrant carpels formed. These phenotypes suggest that SNL is involved in the entire rice flower development. SNL was mapped between two simple sequence repeat markers RM3512 and RM1342 on chromosome 2, an approximate 800 kb region, and it co-segregated with SSR215. We conclude that SNL is a novel gene involved in flower development in rice. The present study will be useful for further cloning of the SNL gene, which will contribute to the elucidation of rice flower development.

关键词： GENE mapping RICE ETHYL methanesulfonate STAMEN CARPEL

Effect of photodynamic therapy with(17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt on pancreatic cancer cells in vitro and in vivo

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World Journal of Gastroenterology 2018年第46期24卷 5246-5258页

作者： Yu-Jie Shen Jia Cao Fang Sun Xiao-Lei Cai ming-ming Li Nan-Nan zheng Chun-ying Qu Yi Zhang Feng Shen Min Zhou ying-Wei Chen Lei-ming Xu Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

AIM To investigate the antitumor effects and underlying mechanisms of(17 R,18 R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt(YLG-1)-induced photodynamic therapy(PDT) on pancreatic cancer in vitro and in *** YLG-1 is a novel photosensitizer extracted from spirulina. Its phototoxicity, cellular uptake and localization, as well as its effect on reactive oxygen species(ROS) production, apoptosis, and expression of apoptosis-associated proteins were detected in vitro. An in vivo imaging system(IVIS), the Lumina K imaging system, and mouse models of subcutaneous Panc-1-bearing tumors were exploited to evaluate the drug delivery pathway and pancreatic cancer growth in *** YLG-1 was localized to the mitochondria, and the appropriate incubation time was 6 h. Under 650 nm light irradiation, YLG-1-PDT exerted a potent cytotoxic effect on pancreatic cancer cells in vitro, which could be abolished by the ROS scavenger N-acetyl-L-cysteine(NAC). The death mode caused by YLG-1-PDT was apoptosis, accompanied by upregulated Bax and cleaved Caspase-3 and decreased Bcl-2 expression. The results from the IVIS images suggested that the optimal administration route was intratumoral(IT) injection and that the best time to conduct YLG-1-PDT was 2 h post-IT injection. Consistent with the results in vitro, YLG-1-PDT showed great growth inhibition effects on pancreatic cancer cells in a mouse *** YLG-1 is a potential photosensitizer for pancreatic cancer PDT via IT injection, the mechanisms of which are associated with inducing ROS and promoting apoptosis.

关键词： Photodynamic therapy Pancreatic neoplasm (17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt Antitumor effect

Palladium-Catalyzed Desulfinative Cross-Coupling of Polyhalogenated Aryl Triflates with Aryl Sulfinate Salts:Inversion of Traditional Chemoselectivity

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Chinese Journal of Chemistry 2023年第8期41卷 909-914页

作者： Miao Wang On ying Yuen Chau ming So State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityKowloonHong KongChina Henan Key Laboratory of Function-Oriented Porous Materials College of Chemistry and Chemical EngineeringLuoyang Normal UniversityLuoyangHenan471934 China The Hong Kong Polytechnic University Shenzhen Research Institute ShenzhenGuangdong518057 China

Comprehensive Summary This paper presents the first general examples of palladium-catalyzed desulfinative cross-coupling reaction of polyhalogenated aryl triflates with aryl sulfinate salts showing an inversion of the conventional reactivity order of C-Br>C-Cl>*** catalyst system,comprising of Pd(OAc)_(2)and tBuPhSelectPhos,exhibited excellent catalytic reactivity and chemoselectivity toward this *** reaction had a wide range of substrate scopes and provided a simple and efficient method for the construction of functionalized biaryl ***,the C-H···Pd interaction from the methine hydrogen of the C2-cyclohexyl group of the indolyl phosphine ligand with the Pd center may contribute a key factor in reactivity and *** with density functional theory(DFT)calculations,the results revealed that the oxidative addition step in this reaction was a controlling-chemoselectivity step.

关键词： Palladium Phosphane ligands IChemoselectivity Desulfurization Polyhalogenated aryl triflates

Recent advancements in single-cell metabolic analysis for pharmacological research

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Journal of Pharmaceutical Analysis 2023年第10期13卷 1102-1116页

作者： ying Hou Hongren Yao Jin-ming Lin Beijing Key Laboratory of Microanalytical Methods and Instrumentation Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education)Department of ChemistryTsinghua UniversityBeijing100084China

Cellular heterogeneity is crucial for understanding tissue biology and disease *** research is being advanced by single-cell metabolic analysis,which offers a technique to identify variations in RNA,proteins,metabolites,and drug molecules in *** this review,the recent advancement of single-cell metabolic analysis techniques and their applications in drug metabolism and drug response are ***-precision and controlled single-cell isolation and manipulation are provided by microfluidics-based methods,such as droplet microfluidics,microchamber,open microfluidic probe,and digital *** are used in tandem with variety of detection techniques,including optical imaging,Raman spectroscopy,electrochemical detection,RNA sequencing,and mass spectrometry,to evaluate single-cell metabolic changes in response to drug *** advantages and disadvantages of different techniques are discussed along with the challenges and future directions for single-cell *** techniques are employed in pharmaceutical analysis for studying drug response and resistance pathway,therapeutic targets discovery,and in vitro disease model evaluation.

关键词： Single-cell Metabolism Pharmacology Drug response Microfluidics

Molecular recognition and biological application of modified β-cyclodextrins

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Science China Chemistry 2019年第5期62卷 549-560页

作者： ying-ming Zhang Qiao-Yan Xu Yu Liu College of Chemistry State Key Laboratory of Elemento-Organic ChemistryNankai University Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The molecular recognition based on cyclodextrins(CDs) has become a focus of interest in modern supramolecular *** are known to encapsulate various ions and organic/inorganic molecules in their hydrophobic cavities and form stable inclusion complexes through cooperative noncovalent interactions. During the past few decades, a large variety of modified CDs have been elaborately designed and synthesized, which significantly promotes our molecular-level understanding of the structure–function relationship in many supramolecular systems. Through the accurate analysis on the molecular binding behaviors, one can create a library of CD-based nanoassemblies with controlled physicochemical properties. In this review, we will focus on the stability constant-directed molecular recognition and the biological activities of β-CDs toward some representative bioactive substrates, including metal ions, steroids, porphyrins, amino acids and oligopeptides, as well as drug molecules, with the final goal of promoting their practical applications in the biomedical field.

关键词： Host-guest chemistry molecular recognition cyclodextrin biological function

Effect of CuO Particle Size on the Microstructure Evolution of Al_2O_(3P)/Al Composites Prepared Via Displacement Reactions in the Al/CuO System

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Acta Metallurgica Sinica(English Letters) 2015年第6期28卷 699-706页

作者： Ge Zhao Zhi-ming Shi Rui-ying Zhang School of Materials Science and Engineering Inner Mongolia University of Technology

An A1203p/A1 composite was successfully synthesized using a displacement reaction between 80 wt% A1 and 20 wt% CuO powders at a heating rate of 5 ℃/min. Two different sizes CuO particles were used, and all the experiments were conducted under an argon atmosphere. To analyze the microstructural evolution during synthesis, the A1-20 wt% CuO samples were heated to the temperatures selected according to the differential scanning calorimetry curve and then immediately quenched with water. The phase composites and microstructure of the water-quenching samples were in- vestigated using X-ray diffraction, optical microscopy, scanning electron microscopy and energy-dispersive spectrometry. The results indicate that the CuO particle size has a significant effect on the microstructural evolution of the samples during the heating stage and on the microstructure of synthesized composites. Smaller CuO particles can decrease the reaction temperature, narrow the reaction temperature range at the different reaction stages during the heating stage and make the size and distribution of in situ A1203 particles more uniform. The reaction between A1 and CuO can be complete as the temperature rises to 900 ℃. The size of the in situ A1203 particles is approximately 5 μm when the size of the CuO particles is less than 6 μm. This sample has a relatively high Rockwell hardness of 60 HRB.

关键词： AI203p/AI composite Displacement reaction CuO particles Particle size Microstructureevolution

The J_2 invariant relative configuration of spaceborne SAR interferometer for digital elevation measurement

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Acta Mechanica Sinica 2010年第4期26卷 643-651页

作者： ming Xu ying-Hong Jia Shi-Jie Xu Department of System Engineering DFH Satellite Co. Ltd. EO. Box 5616 Beijing 100094 China

A 3-craft formation configuration is proposed to perform the digital elevation model （DEM） for the distributed spacebome interferometric synthetic aperture radar （InSAR）, and it is optimized by the modified ant colony algorithm to have the best compatibility with J2 invariant orbits created by differential correction algorithm. The configuration has succeeded in assigning the across-track baseline to vary periodically and with its mean value equal to the optimal baseline determined by the relative height measurement accuracy. The required relationship between crafts＇ magnitudes and phases is formulated for the general case of interferometry measure from non-orthographic and non-lateral view. The J2 invariant configurations created by differential correction algorithm are employed to investigate their compatibility with the required configuration. The colony algorithm is applied to search the optimal configuration holding the near-constant across-track baseline under the J2 perturbation, and the absolute height measurement accuracy is preferable as expected.

关键词： InSAR Digital elevation model (DEM) J2 invariant orbit Differential correction algorithm Formation flying

ZnO/PANI nanoflake arrays sensor for ultra-low concentration and rapid detection of NO_(2)at room temperature

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Rare Metals 2023年第2期42卷 536-544页

作者： Qiu-Yue zheng Meng Yang Xin Dong Xian-Fa Zhang Xiao-Li Cheng Li-Hua Huo Zoltán Major ying-ming Xu Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin150080China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education School of Chemistryand State Key Laboratory of Optoelectronic Materials and TechnologiesSun Yat-Senen UniversityGuangzhou510275China Institute of Polymer Product Engineering Johannes Kepler University Linz124040LinzAustria

With the development of environmental monitoring,it is urgent to establish NO_(2)sensor with good sensing *** with the traditional NO_(2)sensors made of metal oxides,NO_(2)sensors made of n-p heterostructure nanocomposites have good sensing performance in detection limit and operating *** nanoflake arrays with polyaniline film grown on the surface were prepared on ceramic tubes by hydrothermal and vapor diffusion *** gas-phase diffusion method can control the heterostructure by adjusting the diffusion *** room temperature(25℃),the construction of rich n-p heterogeneous interface enables the sensor prepared by the nanocomposite to respond to NO_(2),showing the sensing performance with the response value of 28.00 to10.00×10^(-6)NO_(2);the detection limit improved to0.01×10^(-6)and the recovery time of 18 *** this work,the sensing mechanism of NO_(2)at heterogeneous interface is analyzed,which provides a promising material for the detection of low concentration NO_(2)at room temperature.

关键词： ZnO/polyaniline(PANI)nanoflake arrays n-p heterostructure Ultra-low concentration NO_(2)gas sensor Rapid detection

A New Approach to Ethyl 1-Aroyl/Aroylmethyl-5-methyl-3- methylthiopyrazole-4-carboxylates: High Regioselectivity in Alkylation and Acylation Reactions between N-1 and N-2 of a Pyrazole Derivative

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Chinese Chemical Letters 2005年第9期16卷 1161-1164页

作者： Li Rong WEN Gui Long ZHAO ming LI Wen ying QI Xiu Li ZHANG Hua zheng YANG College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 State Key Laboratory of Elemento-organic Chemistry Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071 Ocean Food and Drug Institute Ocean University of China Qingdao 266003

Two series, totalizing twelve, of new compounds, ethyl 1-aroyl/aroylmethyl-5-methyl-3- methylthiopyrazole-4-carboxylates 5/6, have been synthesized via highly regioselective acylation and alkylation of ethyl 3-methyl-5-methylthio-1H- pyrazole-4-carboxylate 2a with aroyl chloride 3 and alpha-tosyloxysubstitutedacetophenones 4. Unexpected structures of the product have been unambiguously determined by both X-ray crystallographic analysis and 2D NMR.

关键词： Pyrazole regioselectivity X-ray crystallographic analysis 2D NMR