Palladium-Catalyzed Desulfinative Cross-Coupling of Polyhalogenated Aryl Triflates with Aryl Sulfinate Salts:Inversion of Traditional Chemoselectivity
作者机构：State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityKowloonHong KongChina Henan Key Laboratory of Function-Oriented Porous MaterialsCollege of Chemistry and Chemical EngineeringLuoyang Normal UniversityLuoyangHenan471934 China The Hong Kong Polytechnic University Shenzhen Research InstituteShenzhenGuangdong518057 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2023年第41卷第8期
页 面：909-914页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：the Research Grants Council of the Hong Kong Special Administrative Region,China(PolyU 15302821,15300220,and 25301819) the National Natural Science Foundation of China(21972122)for their financial support
主 题：Palladium Phosphane ligands IChemoselectivity Desulfurization Polyhalogenated aryl triflates
摘 要：Comprehensive Summary This paper presents the first general examples of palladium-catalyzed desulfinative cross-coupling reaction of polyhalogenated aryl triflates with aryl sulfinate salts showing an inversion of the conventional reactivity order of C-BrC-Cl*** catalyst system,comprising of Pd(OAc)_(2)and tBuPhSelectPhos,exhibited excellent catalytic reactivity and chemoselectivity toward this *** reaction had a wide range of substrate scopes and provided a simple and efficient method for the construction of functionalized biaryl ***,the C-H···Pd interaction from the methine hydrogen of the C2-cyclohexyl group of the indolyl phosphine ligand with the Pd center may contribute a key factor in reactivity and *** with density functional theory(DFT)calculations,the results revealed that the oxidative addition step in this reaction was a controlling-chemoselectivity step.
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