检索结果-南通市图书馆

Global and Blow-up Solutions to a p-Laplace Equation with Nonlocal Source and Nonlocal Boundary Condition

在线全文

学校读者我要写书评

暂无评论

Communications in Mathematical Research 2010年第3期26卷 280-288页

作者： GUO BIN WEI ying-jie gao WEN-jie Institute of Mathematics Jilin University Changchun 130012

This paper deals with an evolution p-Laplace equation with nonlocal source subject to weighted nonlocal Dirichlet boundary conditions. We give sufficient conditions for the existence of global and non-global solutions.

关键词： nonlocal boundary condition evolution p-Laplace nonlocal source blow-up

Numerical simulation of the effect of waves on cavity dynamics for oblique water entry of a cylinder

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2020年第6期32卷 1178-1190页

作者： Gui-yong Zhang Zhao Hou Tie-zhi Sun Hai-peng Wei Ning Li Bo Zhou ying-jie gao School of Naval Architecture Liaoning Engineering Laboratory for Deep-Sea Floating StructuresDalian University of TechnologyDalian 116024China State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian 116024China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration Shanghai 200240China Beijing Institute of Astronautical Systems Engineering Beijing 100076China Marine Design and Research Institute of China Shanghai 200011China

The water entry process associated with complicated unsteady structures,with consideration of the influence of the waves,is not well *** the present work,the oblique water entry of a cylinder under different regular waves is numerically *** volume of fluid(VOF)method and the sub-grid scale(SGS)stress model based on the large eddy simulation(LES)method are adopted for the 3-D simulation with six degrees of *** present numerical model is based on a wave model,and as shown by the previous work that the predicted cavity evolution in the calm water agrees well with the experimental *** present model is validated and it is shown that it could be used to predict the correct wave periods and *** cavity evolution mechanism,the dynamic characteristics and the vortex structures are *** cavity of the water entry with waves closes more quickly than in the calm water ***,several parametric studies of the water entry with different wave heights and water entry locations are carried *** results provide insights into the effects of the waves on the cavity dynamics for oblique water entry problems.

关键词： Large eddy simulation(LES) wave oblique water entry cavity dynamics

A Quasilinear Parabolic System with Nonlocal Boundary Conditions and Localized Sources

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Mathematical Research 2011年第4期27卷 315-330页

作者： HAN YU-ZHU WEI ying-jie gao WEN-jie Institute of Mathematics Jilin University Changchun 130012

This paper investigates the properties of solutions to a quasilinear parabolic system with nonlocal boundary conditions and localized sources. Conditions for the existence of global or blow-up solutions are given. Glo... 详细信息

关键词： global existence finite time blow-up localized source nonlocal bound-ary global blow-up blow-up rate

Highly Efficient and Recyclable Catalyst HBF_4·SiO_2 Catalyzed Synthesis of β-Enamino Compounds Under Solvent-free Conditions

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2011年第5期27卷 792-794页

作者： gao Han JIA Xu-dong DUAN Hai-feng LIN ying-jie gao Jun-gang LIANG Da-peng WU Mao-cheng Department of Organic Chemistry College of Chemistry dilin University Changchun 130012 l~ R. China

Fluoroboric acid adsorbed on silica-gel（HBF4·SiO2） has been found to be an extremely efficient and recyclable catalyst for the preparation of β-enaminones and β-enamino esters under solvent-free conditions.

关键词： β-Enaminone β-Enamino ester HBF4·SiO2 Solvent-free condition

Interaction between enteric epithelial cells and Peyer's patch lymphocytes in response to Shigella lipopolysaccharide: Effect on nitric oxide and IL-6 release

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第24期12卷 3895-3900页

作者： jie Chen Chuen-Pei Ng Dewi K Rowlands Peng-Hui Xu jie-ying gao Yiu-Wa Chung Hsiao-Chang Chan Epithelial Cell Biology Research Center Department of Physiology Faculty of Medicine Chinese University of Hong Kong Hong Kong China Department of Immunology Institute of Microbiology and Epidemiology Academy of Military Medical Sciences Beijing 100071 China Department of Biology Faculty of Medicine ShanxiMedical University Taiyuan 030001 Shanxi Province China

AIM： TO investigate the effect of interaction between enteric epithelial cells and lymphocytes of Peyer＇s patch on the release of nitric oxide （NO） and IL-6 in response to Shigella lipopolysaccharide （LPS）. METHODS： Human colonic epithelial cells （Caco-2） were mixed cocultured with lymphocytes of Peyer＇s patch from wild-type （C57 mice） and inducible NO synthase knockout mice, and challenged with Shigella F2a-12 LPS. Release of NO and raiL-6 was measured by Griess colorimetric assay and enzyme-linked immunosorbent assay （ELISA）, respectively. RESULTS： In the absence of LPS challenge, NO was detected in the culture medium of Caco-2 epithelial cells but not in lymphocytes of Peyer＇s patch, and the NO release was further up-regulated in both cocultures with lymphocytes from either the wild-type or iNOS knockout mice, with a significantly higher level observed in the coculture with iNOS knockout lymphocytes. After Shigella F2a-12 LPS challenge for 24-h, NO production was significantly increased in both Caco-2 alone and the coculture with lymphocytes of Peyer＇s patch from the wild-type mice but not from iNOS knockout mice. LPS was found to stimulate the release of mIL-6 from lymphocytes, which was suppressed by coculture with Caco-2 epithelial cells. The LPS-induced mIL-6 production in lymphocytes from iNOS knockout mice was significantly greater than that from the wild-type mice. CONCLUSION： Lymphocytes of Peyer＇s patch maintain a constitutive basal level of NO production from the enteric epithelial cell Caco-2. LPS-induced mIL-6 release from lymphocytes of Peyer＇s patch is suppressed by the cocultured epithelial cells. While no changes are detectable in NO production in lymphocytes from both wild-type and iNOS knockout mice before and after LPS challenge, NO from lymphocytes appears to play an inhibitory role in epithelial NO release and their own mIL-6 release in response to LPS.

关键词： Shigella F2a-12 LPS Colon epithelial cells(Caco-2) Peyer's patch lymphocyte Coculture Nitricoxide Interleukin-6

Interplay between creeping fat and gut microbiota: A brand-new perspective on fecal microbiota transplantation in Crohn's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第2期31卷 138-143页

作者： ying Wang jie Liu Department of Life Sciences and Medicine South District of Endoscopic CenterThe First Affiliated Hospital of University of Science and Technology of ChinaUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastroenterology The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina

Inflammatory bowel disease,particularly Crohn's disease(CD),has been linked to modifications in mesenteric adipose tissue(MAT)and the phenomenon known as"creeping fat"(CrF).The presence of CrF is believed to serve as a predictor for early clinical recurrence following surgical intervention in patients with ***,the incorporation of the mesentery during ileocolic resection for CD has been correlated with a decrease in surgical recurrence,indicating the significant role of MAT in the pathogenesis of *** numerous studies have indicated that dysbiosis of the gut microbiota is a critical factor in the development of CD,the functional implications of translocated microbiota within the MAT of CD patients remain *** manuscript commentary discusses a recent basic research conducted by Wu et *** their study,intestinal bacteria from individuals were transplanted into CD model mice,revealing that fecal microbiota trans-plantation(FMT)from healthy donors alleviated CD symptoms,whereas FMT from CD patients exacerbated these ***,FMT was found to affect intestinal permeability,barrier function,and the levels of proinflammatory factors and ***,these findings suggest that targeting MAT and CrF may hold therapeutic potential for patients with ***,the study did not evaluate the composition of the intestinal microbiota of the donors or the subsequent alterations in the gut ***,the gut microbiota plays a crucial role in the histopathology of CD,and thus,targeting MAT and CrF may represent a promising avenue for treatment in this patient population.

关键词： Crohn's disease Mesenteric adipose tissue Creeping fat Fecal microbiota transplantation Gut microbiota

The analgesic, anti-inflammatory, and anti-infection effects of Chai Ge fever relief oral liquid

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Drug Combination Therapy 2020年第2期2卷 45-53页

作者： Shan-Shan Guo Ya-Xin Wang ying-jie gao Sai-Wei Lu Xiao-Lan Cui Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100029China Suzhou Youseen New Drug R&D Co. Ltd.SuzhouJiangsu 215001China

Backgroud:To explore the analgesic,anti-inflammatory,and anti-infective effects of Chai Ge fever relief oral liquid and provide evidence for clinical application of Chai Ge fever relief oral ***:In this study,four groups of experiments were designed:analgesic,anti-inflammatory,antiviral,and *** the mouse pain model,the analgesic effect of Chai Ge fever relief oral liquid was studied by the writhing method and pain threshold;the anti-inflammatory effect by measuring the level of capillary permeability in the abdominal cavity of mice in different dose groups and the weight of cotton ball granuloma formation in rats;the antiviral effect by measuring the lung index of a pneumonia model of mouse infected with influenza virus;and the antibacterial effect by comparing the difference in the death protection ratio between each dose group and the model group ***:In the analgesic experiment,the high and medium dose of Chai Ge fever relief oral liquid could significantly reduce the number of writhing in mice caused by acetic acid,and the pain threshold of mice in the high-and medium-dose groups was significantly increased for 1–3 *** the anti-inflammatory experiment,the medium-dose group could significantly inhibit the increase of capillary permeability in the abdominal cavity of mice caused by acetic acid,and the low-dose group could significantly reduce the weight of rat cotton ball *** the antiviral experiment,the high-and medium-doses of Chai Ge fever relief oral liquid could significantly reduce the lung index of normal mouse pneumonia model of influenza virus infection and achieve a higher inhibition *** the anti-infective experiment,the death protection rate of the high-dose group was significantly different from that of the model control *** three dose groups could significantly prolong the survival days of infected ***:These experimental results prove that in addition to its antipyretic effect,Chai

关键词： Chai Ge fever relief oral liquid Analgesia Anti-inflammatory Antiviral Antibacterial

The antipyretic effects of Chai Ge fever relief oral liquid

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Drug Combination Therapy 2020年第3期2卷 104-113页

作者： Shan-Shan Guo Ya-Xin Wang ying-jie gao Sai-Wei Lu Xiao-Lan Cui Institute of Chinese Mateia Medica China Academy of Chinese Medical Sciences Beijing China Suzhou Yusen New Drug R&D Co. Ltd.Suzhou 215001China

Backgroud:To verify the antipyretic effect and mechanism of Chai Ge fever relief oral liquid,and to provide evidence for the clinical application of Chai Ge fever relief oral ***:By designing three groups of experimental models of yeast-induced rat fever model,endotoxin-induced rabbit fever model,and para-influenza virus-induced rabbit fever model,the antipyretic effect and mechanism of Chai Ge fever relief oral liquid were studied by measuring body temperature before and after treatment and the expressions of protein kinase A(PKA),protein kinase C,arginine vasopressin(AVP),prostaglandin E2 and cyclic adenosine monophosphate(cAMP)in hypothalamus after ***:In the yeast-induced fever model of rats,the body temperature and PKA expression levels in different dose groups of Chai Ge fever relief oral liquid were significantly different from those of the model group 1–3 h after *** the rabbit fever model induced by endotoxin,different dosage groups of Chai Ge fever relief oral liquid have obvious antipyretic effect on 1–3 h after the model is established,and can significantly reduce the expression of AVP and cAMP in *** the para-influenza virus-induced rabbit fever model,each dose group of Chai Ge fever relief oral liquid has obvious antipyretic effect on 1–2 h after the model is ***:Chai Ge fever relief oral liquid has good antipyretic effect on fever models induced by yeast,endotoxin and parainfluenza by regulating the expression of PKA,AVP,and cAMP.

关键词： Chai Ge fever relief oral liquid Yeast Endotoxin Parainfluenza virus Antipyretic effect Fever model

A discontinuous collocated-grid implementation for high-order finite-difference modeling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A discontinuous collocated-grid implementation for high-orde...