The analgesic, anti-inflammatory, and anti-infection effects of Chai Ge fever relief oral liquid

作     者：Shan-Shan Guo Ya-Xin Wang Ying-Jie Gao Sai-Wei Lu Xiao-Lan Cui 

作者机构：Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100029China Suzhou Youseen New Drug R&D Co.Ltd.SuzhouJiangsu 215001China 

出 版 物：《Drug Combination Therapy》 (药物联合治疗)

年 卷 期：2020年第2卷第2期

页      面：45-53页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：This study was supported by National Natural Science Foundation of China(81773977) 

主　　题：Chai Ge fever relief oral liquid Analgesia Anti-inflammatory Antiviral Antibacterial 

摘      要：Backgroud:To explore the analgesic,anti-inflammatory,and anti-infective effects of Chai Ge fever relief oral liquid and provide evidence for clinical application of Chai Ge fever relief oral ***:In this study,four groups of experiments were designed:analgesic,anti-inflammatory,antiviral,and *** the mouse pain model,the analgesic effect of Chai Ge fever relief oral liquid was studied by the writhing method and pain threshold;the anti-inflammatory effect by measuring the level of capillary permeability in the abdominal cavity of mice in different dose groups and the weight of cotton ball granuloma formation in rats;the antiviral effect by measuring the lung index of a pneumonia model of mouse infected with influenza virus;and the antibacterial effect by comparing the difference in the death protection ratio between each dose group and the model group ***:In the analgesic experiment,the high and medium dose of Chai Ge fever relief oral liquid could significantly reduce the number of writhing in mice caused by acetic acid,and the pain threshold of mice in the high-and medium-dose groups was significantly increased for 1–3 *** the anti-inflammatory experiment,the medium-dose group could significantly inhibit the increase of capillary permeability in the abdominal cavity of mice caused by acetic acid,and the low-dose group could significantly reduce the weight of rat cotton ball *** the antiviral experiment,the high-and medium-doses of Chai Ge fever relief oral liquid could significantly reduce the lung index of normal mouse pneumonia model of influenza virus infection and achieve a higher inhibition *** the anti-infective experiment,the death protection rate of the high-dose group was significantly different from that of the model control *** three dose groups could significantly prolong the survival days of infected ***:These experimental results prove that in addition to its antipyretic effect,Chai