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Rare Metals 2022年第6期41卷 2055-2062页

作者： Jing-Jing Chen Shuai Gu Rui Hao Zhen-Yu Wang Mu-Qing li zhi-Qiang li Kun liu Ke-Meng liao zhi-Qiang Wang He Huang ying-zhi li Kai-li Zhang Zhou-Guang Lu Department of Materials Science and Engineering Guangdong Provincial Key Laboratory of Energy Materials for Electric PowerShenzhen Key Laboratory of Interfacial Science and Engineering of MaterialsSouthern University of Science and TechnologyShenzhen 518055China Department of Mechanical Engineering City University of Hong KongHong Kong 999077China

Diminishing the size of active sites in catalysts is promis-ing to improve the kinetics of oxygen reduction reaction(ORR)and reduce the cost of metal-air ***,the facile preparation of high-performance catalysts with nanoscale active sites still suffers from great ***,we report a facile template-free strategy to fabri-cate Co single atoms and nanoparticles dispersed on porous N-doped carbon nanotube(Co-NCNT)by the pyrolysis of the composites of metal-organic complexes and porous carbon *** from the conventional strategy,the precursor metal-organic complexes in this work were prepared under mild conditions and used without complex purification *** with the pristine carbon nanotube,N-doped carbon nanotube with abundant meso-pores contribute to the formation of nanoscale Co sites.

关键词： nanoparticles composites carbon

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Enhancing whole yeast genome rearrangements through multiple LoxPsym sequences

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Science China life Sciences 2024年第9期67卷 2045-2047页

作者： Bing-zhi li ying-Jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education) School of Chemical Engineering and Technology Tianjin University Frontiers Research Institute for Synthetic Biology Tianjin University

Genomic rearrangements play a significant role in disease, evolution, and tumorigenesis(Mani and Chinnaiyan,2010). While single nucleotide polymorphisms(SNPs) and small insertions/deletions contribute substantially to...

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Enhanced photocatalytic performance by regulating the Ce^(3+)/Ce^(4+)ratio in cerium dioxide

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 75-87页

作者： zhi li Dongsheng Jia Wei Zhang ying li Mitang Wang Dongliang Zhang School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai200093China

Cerium dioxide(CeO_(2))photocatalysts are used in treating environmental pollution and addressing the energy crisis due to their excellent oxygen storage capacities and abundant oxygen *** this paper,CeO_(2)precursors were synthesized with different water-alcohol ratios via a solvothermal method,and CeO_(2)photocatalysts with different Ce^(3+)/Ce^(4+)ratios were obtained by changing the precursor calcination atmospheres(air,Ar)as well as the calcination *** effects of CeO_(2)with different Ce^(3+)/Ce^(4+)ratios in photocatalytic degradations of methylene blue under visible light were investigated.X-ray photoelectron spectroscopy results showed that the surfaces of the samples calcined under Ar had higher Ce^(3+)/Ce^(4+)ratios and oxygen vacancy concentrations,which reduced the band gaps of the catalysts and improved their utilization of visible *** addition,the many Ce^(3+)/Ce^(4+)redox centers and oxygen vacancies on the sample surfaces improved the separation and transfer efficiencies of the photogenerated *** sample C2-Ar calcined under Ar showed a high adsorption capacity and excellent photocatalytic activity by removing 96%of the methylene blue within 120 min,which was more than twice the degradation rate of the sample(C2-air)prepared via calcination under *** experiments showed that photogenerated holes played a key role in the photocatalytic *** addition,a synergistic photocatalytic mechanism for the Ce^(3+)/Ce^(4+)redox centers and oxygen vacancies was elucidated in detail,and the sensitization of cerium dioxide by dyes aided the degradation of methylene blue.

关键词： CeO_(2) oxygen vacancies Ce^(3+)/Ce^(4+)ratios photocatalytic dye-sensitization

Salidroside attenuates oxygen and glucose deprivation-induced neuronal injury by inhibiting ferroptosis

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Asian Pacific Journal of Tropical Biomedicine 2023年第2期13卷 70-79页

作者： ying-zhi li Ai-Ping Wu Dan-Dan Wang Pan-Pan Yang Bin Sheng Department of Rehabilitation Medicine Zhejiang HospitalHangzhou 310007ZhejiangChina Department of Emergency Medicine Zhejiang Provincial People’s HospitalHangzhou 310014ZhejiangChina

Objective: To evaluate the effect of salidroside on oxygen and glucose deprivation(OGD)-treated NT2 cells and its underlying mechanisms of ***: Retinoic acid was used to induce the differentiation of NT2 cells into neurons. The effects of salidroside on survival, apoptosis, inflammatory response, and oxidative stress of neurons undergoing OGD were evaluated. Using precursor cells as controls, the effect of salidroside on the differentiation progression of OGDtreated cells was evaluated. In addition, the effect of erastin, a ferroptosis inducer, on NT2 cells was examined to investigate the underlying mechanisms of neuroprotective action of ***: Salidroside alleviated the effects of OGD on neuronal survival, apoptosis, inflammation, and oxidative stress, and promoted NT2 cell differentiation. Moreover, salidroside prevented ferroptosis of OGD-treated cells, which was abolished following erastin treatment, indicating that ferroptosis mediated the regulatory pathway of ***: Salidroside attenuates OGD-induced neuronal injury by inhibiting ferroptosis and promotes neuronal differentiation.

关键词： Salidroside Rhodiola rosea Ferroptosis Oxygen and glucose deprivation Neuronal differentiation Ischemic stroke

Arthroscopic surgery for synovial chondroma of the subacromial bursa with non-traumatic shoulder subluxation complications:Two case reports

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World Journal of Clinical Cases 2022年第5期10卷 1645-1653页

作者： Xiong-Feng Tang Yan-Guo Qin Xian-Yue Shen Bo Chen ying-zhi li Orthpoeadic Medical Center Jilin University Second HospitalChangchun 130041Jilin ProvinceChina

BACKGROUND Synovial chondromatosis is a disease originating from the synovium and characterized by the presence of metaplastic cartilaginous nodules in synovial *** exact prevalence of synovial chondromatosis remains unknown,and the involvement of the shoulder joint is very *** chondromatosis accompanied by subluxation of the humeral head without a history of trauma is rarely encountered,and to our knowledge,no published reports describe this *** SUMMARY We present two cases of synovial chondromatosis in the shoulder joint,accompanied by subluxation of the humeral head,in two arthroscopically managed adult *** performed arthroscopic labrum fixation and removal of the loose body from the shoulder *** identify primary and secondary categories,pathological analysis was *** and radiographic evaluations at the 1-mo follow-up were *** The biomechanical function of the shoulder joint requires attention,especially following the detection of loose bodies,as observed with synovial chondroma occurring in rare *** management is successful in patients with synovial chondromatosis combined with shoulder subluxation.

关键词： Synovial chondromatosis Shoulder Subluxation Arthroscopic surgery Case report

Paroxysmal Kinesigenic Dyskinesia:Genetics and Pathophysiological Mechanisms

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Neuroscience Bulletin 2024年第7期40卷 952-962页

作者： Jiao-Jiao Xu Hong-Fu li zhi-ying Wu Department of Medical Genetics and Center for Rare Diseases The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Neurology in the Second Affiliated Hospital Key Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310009China

Paroxysmal kinesigenic dyskinesia(PKD),the most common type of paroxysmal movement disorder,is characterized by sudden and brief attacks of choreoathetosis or dystonia triggered by sudden voluntary *** is mainly caused by mutations in the PRRT2 or TMEM151A *** exact pathophysiological mechanisms of PKD remain unclear,although the function of PRRT2 protein has been well characterized in the last *** on abnormal ion channels and disturbed synaptic transmission in the absence of PRRT2,PKD may be channelopathy or synaptopathy,or *** addition,the cerebellum is regarded as the key pathogenic *** depolarization in the cerebellum is tightly associated with dyskinetic ***,in PKD,other than the cerebellum,the role of the cerebrum including the cortex and thalamus needs to be further investigated.

关键词： Paroxysmal kinesigenic dyskinesia PRRT2 TMEM151A Genetics Pathophysiological mechanisms

Constructing a 3D multichannel structure to enhance performance of Ni–Co–Mn hydroxide electrodes for flexible supercapacitors

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Rare Metals 2024年第1期43卷 148-163页

作者： zhi-Hui Xu Shi-Shuai Sun Xue-Lei li zhi-Hui Zhang Hai-ying li Shuang-Ting Ruan Shou-Gen Yin Key Laboratory of Display Materials and Photoelectric Devices(Ministry of Education)and Tianjin Key Laboratory for Photoelectric Materials and Devices School of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China College of Science Tianjin University of TechnologyTianjin 300384China School of Materials Science and Engineering Inner Mongolia University of TechnologyHohhot 010051China

The balancing of the electrochemical performance,mechanical stability,and processing technology for applying supercapacitors to flexible and wearable electronics continues to encounter severe ***,we prepare Ni-Co-Mn hydroxide electrodes with a threedimensional multichannel structure via a simple hydrothermal *** are constructed using vertically contiguous nano sheets with a uniform thickness and rough *** electrodes can provide numerous electroactive sites and accelerate the transmission of electrolyte *** relationship between the structure and electrochemical performances is verified by experiments and theoretical ***-dimensional(2D)planar and one-dimensional(1D)fiber electrodes are prepared using a flexible carbon cloth(CC)and carbon fiber(CF),respectively,as *** assembled quasi-solid-state flexible asymmetric supercapacitor(FASC)with a twodimensional sandwich structure using NiCoMn-OH/CC as the electrode achieves a remarkable energy density of73.8 Wh·kg^(-1)at a power density of 1.03 kW·kg^(-1).The quasi-solid-state FASC with a 1D linear structure using NiCoMn-OH/CF as the electrode also attains a high energy density(12.9 Wh·kg^(-1)at a power density of0.75 W·kg^(-1)).Moreover,the electrochemical performances of the NiCoMn/CC//AC/CC and NiCoMn/CF//AC/CF FASCs are not disturbed at different bending angles(0°,45°,90°,135°and 180°),This indicates the superior flexibility of the *** also assemble a self-powered energy-harvesting storage system by integrating FASCs and commercial solar cells to verify its *** displays sustainable development potential for energy storage.

关键词： Supercapacitors Flexible Ni–Co–Mn hydroxide 3D multichannel structure High performances

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Influence of friction-lubrication characteristics varying with rolling speed on instability of chatter and slip in cold tandem rolling process

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Journal of Iron and Steel Research International 2024年第4期31卷 894-908页

作者： Yan-li Xin zhi-ying Gao Bo Tian Qing-dong Zhang School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China

In the high-speed cold tandem rolling process of thin plate,chatter or slip instability gives rise to the deterioration of equipment and product *** instability behavior is closely related to interfacial friction-lubrication con-dition which is generally characterized by the friction ***,with higher and higher speed requirements,the commonly used model of friction coefficient is no longer applicable and accurate.A novel approach is suggested to calculate the speed-dependent friction coefficient,in which the viscosity-pressure-temperature effects of the lubricant,surface roughness states of work rolls and rolled piece are comprehensively involved and the mixed flm lubrication theory is ***,the influences of friction coefficient on the instability of slip and chatter are investigated for a five-stand cold tandem rolling *** one side,the critical friction coefficient for each stand is determined by calculating the corresponding slip factor;on the other hand,the friction coefficient varying with rolling speed is combined with the model of theoretical critical rolling speed presented under constant friction coefficient,so that the speed threshold is ***,the stable and unstable regions corresponding to the rear three stands are individually discussed,and the technical strategies are proposed to suppress both slip and chatter frequently occurring in the actual rolling process.

关键词： Cold tandem rolling:Oil film thickness Speed-dependent friction coefficient-Slip:Chatter

Transcriptome-based analysis of key signaling pathways affecting the formation of primordial germ cell in chickens

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Journal of Integrative Agriculture 2024年第5期23卷 1644-1657页

作者： ying Ding Qiong zhi Qisheng Zuo Kai Jin Wei Han Bichun li Key Laboratory of Animal Genetics Breeding and Molecular Design of Jiangsu ProvinceCollege of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China Yangzhou UniversityYangzhou225009China Poultry Research Institute Chinese Academy of Agricultural Sciences/Jiangsu Institute of Poultry ScienceYangzhou 225009China

Bone morphogenetic protein 4(BMP4)can induce the formation of chicken primordial germ cells(PGCs)in vitro;however,its regulatory mechanism in poultry remains *** study aimed to use RNA-seq to analyze PGCs in chicken embryos and iPGCs induced by BMP4 in vitro,clarify the internal regulatory factors of PGCs,analyze the mechanism of the formation of PGCs,and lay a theoretical foundation for the further optimization of PGCs induction *** stem cells(ESCs),PGCs and iPGCs induced by BMP4 in vitro were *** transcriptional maps of the three cell types were studied using *** results showed 6,142 genes differentially expressed between PGCs and iPGCs,of which 2,728 were upregulated in iPGCs and 3,414 were downregulated in *** to that in ESCs,BMP4 was significantly upregulated in PGCs and *** results showed that both the TGF-βand Wnt signaling pathways were activated during the formation of PGCs in vitro and in vivo,and the activation was more significant during iPGCs induced by *** expression of Nodal,an inhibitory factor of TGF-βsignaling,was significantly decreased in PGCs and iPGCs,but was not expressed in iPGCs,which further supports our ***,the Lysosome and PI3K-AKT signaling pathways were significantly enriched in PGCs and iPGCs,***,transmission electron microscopy(TEM)results showed that the number of autolysosomes was significantly higher after the addition of BMP4,which is consistent with the KEGG ***,the number of PGCs was significantly reduced after ATG14 was interfered in vivo and in *** conclusion,this study screened out the key signaling pathways during the formation of PGCs,aiming to provide help for enriching the mechanism network regulating PGCs formation in chicken and laying a theoretical foundation for further improving the efficiency of inducing PGCs in vitro.

关键词： RNA-seq BMP4 PGCs ATG14 chicken

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Gene therapy for monogenic disorders: challenges, strategies, and perspectives

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Journal of Genetics and Genomics 2024年第2期51卷 133-143页

作者： Yi Zhang zhi-ying Wu Department of Medical Genetics and Center for Rare Diseases Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Key Laboratory of Medical Neurobiology of Zhejiang Province HangzhouZhejiang 310009China

Monogenic disorders refer to a group of human diseases caused by mutations in single genes. While disease-modifying therapies have offered some relief from symptoms and delayed progression for some monogenic diseases, most of these diseases still lack effective treatments. In recent decades, gene therapy has emerged as a promising therapeutic strategy for genetic disorders. Researchers have developed various gene manipulation tools and gene delivery systems to treat monogenic diseases. Despite this progress, concerns about inefficient delivery, persistent expression, immunogenicity, toxicity, capacity limitation, genomic integration, and limited tissue specificity still need to be addressed. This review gives an overview of commonly used gene therapy and delivery tools, along with the challenges they face and potential strategies to counter them.

关键词： Gene therapy Monogenic diseases Geneediting Genedelivery Challenges