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Treadmill exercise exerts a synergistic effect with bone marrow mesenchymal stem cell-derived exosomes on neuronal apoptosis and synaptic-axonal remodeling

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Neural Regeneration Research 2023年第6期18卷 1293-1299页

作者： Xin-Hong Jiang Hang-Feng Li Man-Li Chen Yi-Xian Zhang Hong-Bin Chen Rong-Hua Chen ying-chun xiao Nan Liu Department of Rehabilitation Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Institute of Cerebrovascular Disease FuzhouFujian ProvinceChina Key Laboratory of Brain Aging and Neurodegenerative Diseases Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Longyan First Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Treadmill exercise and mesenchymal stem cell transplantation are both practical and effective methods for the treatment of cerebral ***,whether there is a synergistic effect between the two remains *** this study,we established rat models of ischemia/reperfusion injury by occlusion of the middle cerebral artery for 2 hours and reperfusion for 24 *** models were perfused with bone marrow mesenchymal stem cell-derived exosomes(MSC-exos)via the tail vein and underwent 14 successive days of treadmill *** assessment,histopathology,and immunohistochemistry results revealed decreased neuronal apoptosis and cerebral infarct volume,evident synaptic formation and axonal regeneration,and remarkably recovered neurological function in rats subjected to treadmill exercise and MSC-exos *** effects were superior to those in rats subjected to treadmill exercise or MSC-exos treatment ***,further investigation revealed that the activation of JNK1/c-Jun signaling pathways regulated neuronal apoptosis and synaptic-axonal *** findings suggest that treadmill exercise may exhibit a synergistic effect with MSC-exos treatment,which may be related to activation of the JNK1/c-Jun signaling *** study provides novel theoretical evidence for the clinical application of treadmill exercise combined with MSC-exos treatment for ischemic cerebrovascular disease.

关键词： apoptosis axonal regeneration c-Jun exosomes functional remodeling ischemic stroke JNK1 mesenchymal stem cells synaptic formation treadmill exercise

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Small interfering RNA targeting of keratin 17 reduces inflammation in imiquimod-induced psoriasis-like dermatitis

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Chinese Medical Journal 2020年第24期133卷 2910-2918页

作者： chun-ying xiao Zhen-Lai Zhu Chen Zhang Meng Fu Hong-Jiang Qiao Gang Wang Er-Le Dang Department of Dermatology Xijing HospitalFourth Military Medical UniversityXi’anShaanxi 710032China

Background:Psoriasis is a common chronic inflammatory skin disease with 2%to 3%prevalence worldwide and a heavy social-psychological burden for patients and their *** the exact pathogenesis of psoriasis is still unknown,the current treatment is far from ***,there is an urgent need to find a more effective therapy for this *** 17(K17),a type I intermediate filament,is overexpressed in the psoriatic epidermis and plays a critical pathogenic role by stimulating T cells in ***,we hypothesized that inhibiting K17 may be a potential therapeutic approach for *** study aimed to investigate the therapeutic effect of K17-specific small interfering RNA(siRNA)on mice with imiquimod(IMQ)-induced psoriasis-like ***:Eight-week-old female BALB/c mice were administered a 5%IMQ cream on both ears to produce psoriatic *** day 3,K17 siRNA was mixed with an emulsion matrix and applied topically to the left ears of the mice after IMQ application every day for 7 *** right ears of the mice were treated in parallel with negative control(NC)*** was evaluated by gross ear thickness,histopathology,the infiltration of inflammatory cells(CD3+T cells and neutrophils)using immunofluorescence,and the expression of cytokine production using real-time quantitative polymerase chain *** obtained data were statistically evaluated by unpaired t-tests and a one-way analysis of ***:The severity of IMQ-induced dermatitis on K17 siRNA-treated mice ears was significantly lower than that on NC siRNA-treated mice ears,as evidenced by the alleviated ear inflammation phenotype,including decreased ear thickness,infiltration of inflammatory cells(CD3+T cells and neutrophils),and inflammatory cytokine/chemokine expression levels(interleukin 17[IL-17],IL-22,IL-23,C-X-C motif chemokine ligand 1,and C-C motif chemokine ligand 20)(P<0.05 *** Blank or NC siRNA groups).Compared to the NC siRNA

关键词： Psoriasis Keratin 17 Small interfering RNA Imiquimod Inflammation

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Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang ying Zhu Pu Chen Tong Zhou Zhe-Yi Han Jun xiao Jian-Feng Ma Wen Ma Peng Zang ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

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乌司他丁对ICU脓毒症患者凝血功能障碍的影响

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中国药房 2015年第29期26卷 4094-4096页

作者：王淑颖应春晓何许伟张剑丽水市人民医院重症医学科浙江丽水323000

目的:探讨乌司他丁对重症监护病房(ICU)脓毒症患者凝血功能障碍的影响及其机制。方法:选择64例ICU脓毒症患者,按随机数字表法分成治疗组和对照组,各32例。对照组患者采用常规治疗,治疗组患者在对照组治疗的基础上加用乌司他丁注射液,每... 详细信息

目的:探讨乌司他丁对重症监护病房(ICU)脓毒症患者凝血功能障碍的影响及其机制。方法:选择64例ICU脓毒症患者,按随机数字表法分成治疗组和对照组,各32例。对照组患者采用常规治疗,治疗组患者在对照组治疗的基础上加用乌司他丁注射液,每次取10万单位溶于500 ml 15%葡萄糖注射液或氯化钠注射液中静脉滴注,每日3次,连用7 d。统计两组患者的机械通气时间、ICU住院时间和30 d生存率;检测患者治疗前与治疗后第1、3、7天的血小板计数(PLT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)、白细胞计数(WBC)和白细胞介素-6(IL-6)水平。结果:治疗后,治疗组患者的机械通气时间、ICU住院时间显著短于对照组,生存率显著高于对照组,差异有统计学意义(P<0.05);治疗组外周血中的WBC和IL-6水平显著低于对照组,差异有统计学意义(P<0.05);治疗组治疗后第7天的各凝血指标水平与治疗前和治疗后对照组比较,差异均有统计学意义(P<0.05),各项凝血指标在治疗后7 d恢复至正常水平。结论:乌司他丁可改善ICU脓毒症患者的凝血功能,其作用机制可能与乌司他丁抑制炎性因子的释放及相应的凝血因子功能有关。

关键词：乌司他丁凝血功能障碍脓毒症重症监护病房

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Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie Liu Changqing Xu Da-Jian Wu ying Cheng xiao-Jun Liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

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浙江省瑞安市中青年体检人群高血压前期流行现状调查研究

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中国预防医学杂志 2019年第8期20卷 707-711页

作者：蔡云余谢海波应晓春瑞安市人民医院红十字分院

目的在瑞安市中青年体检人群中进行高血压前期流行病学现状的调查。方法纳入2016年1月~2016年12月在瑞安市人民医院体检中心体检的2000例35~59岁中青年体检人群作为调查对象。调查内容包括:调查对象的性别,年龄,体质量指数(BMI,Body Mas... 详细信息

目的在瑞安市中青年体检人群中进行高血压前期流行病学现状的调查。方法纳入2016年1月~2016年12月在瑞安市人民医院体检中心体检的2000例35~59岁中青年体检人群作为调查对象。调查内容包括:调查对象的性别,年龄,体质量指数(BMI,Body Mass Index),高血压家族史,不良嗜好(烟、酒),体检结果中的血压、血糖(Glu)、血脂指标(TC,TG)。考察高血压前期[血压在(120~139)/(80~89)mmHg)]患病率;采用Logistic回归法对高血压前期人群的相关危险因素进行分析。结果(1)2000例青年人群中,高血压前期人群检出率高于高血压人群的患病率,其中45~54岁年龄段中青年中高血压前期检出率更高,χ^2=41.960,P=0.000,<0.05。(2)组间差异比较显示高血压前期组和健康人群组的年龄、BMI、高血压家族史、嗜烟、血液TG、TC和血糖水平差异有统计学意义(均P<0.05)。(3)经logistic回归分析发现,45~54岁年龄(P=0.011,OR=1.150,95%CI=1.042-1.213)、高BMI(P=0.003,OR=1.583,95%CI=1.331-1.986)、有高血压家族史(P=0.005,OR=2.004,95%CI=1.424-2.599)、嗜烟(P=0.012,OR=1.142,95%CI=1.038-1.257)、高血脂指标TC(P=0.006,OR=2.038,=95%CI=1.554-2.614)、TG(P=0.001,OR=1.872,95%CI=1.619-2.188)因素均与高血压前期患病率有明显的相关性(均P<0.05)。结论瑞安市中青年人群中高血压前期的患病率较高,尤其在嗜好抽烟、超重、高血脂、具有高血压家族史等高危人群中,建议临床对高血压前期人群加强健康宣教以防控高血压患病率及可能出现的心、脑血管等靶器官损害。

关键词：中青年高血压前期检出率体检

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产学研用视角下高校审计人才培养模式改革与实践研究——以应用型本科为例

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黑龙江纺织 2019年第1期 27-28,31页

作者：陈慧玲应晓春宁波财经学院浙江宁波315175

从产学研用视角下,研究应用型本科审计专业人才培养模式,针对应用型本科审计人才培养问题展开讨论,希望提高应用型本科审计专业的教学质量,解决当前应用型本科审计专业人才培养。

关键词：产学研用人才培养教学改革

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一种基于多底物混合共代谢定向产酸发酵研究

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哈尔滨商业大学学报（自然科学版） 2017年第5期33卷 581-587页

作者：李春颖李晓燕哈尔滨商业大学能源建筑与工程学院哈尔滨150028

以牛粪、水稻秸秆、糖蜜废水的三种底物混合共代谢发酵作为CSTR的产酸相,联合IC产甲烷相进行两相厌氧发酵,其中研究的重点是提高产酸相的产酸量.通过pH值、ORP值、VFAs、TOC、TN、可溶性COD质量浓度的测定以及红外光谱(FTIR)观察水稻秸... 详细信息

以牛粪、水稻秸秆、糖蜜废水的三种底物混合共代谢发酵作为CSTR的产酸相,联合IC产甲烷相进行两相厌氧发酵,其中研究的重点是提高产酸相的产酸量.通过pH值、ORP值、VFAs、TOC、TN、可溶性COD质量浓度的测定以及红外光谱(FTIR)观察水稻秸秆的降解情况.通过PCR-DGGE来观察产酸相优势种群的变化,来调节最适共代谢发酵底物,以进入产甲烷相来提高产甲烷量.结果表明,厌氧CSTR反应器发酵前30 d,反应器内pH值、ORP值均呈下降趋势,此后,反应器内pH值比较稳定,在6.2~6.5之间上下浮动,ORP值在-250^-400 m V之间浮动.反应器运行30 d,TOC、TN含量大量增加,可溶COD质量浓度上升.反应60 d时,仍能满足C/N比为27∶1,此时TOC、TN、可溶COD质量浓度含量趋于稳定,进入共代谢产酸发酵的稳定期.乙酸、丙酸、丁酸、戊酸的含量均随着时间的变化先增加后下降.随着反应进行60 d,丙酸迅速下降,没有出现酸积累现象,反应器内以乙酸为主.通过FTIR观察,发现水稻秸秆得到有效的降解.本文利用PCR-DGGE技术解析产酸相,以Clostridium bifermentans、Firmicutes bacterium、Pseudomonas aeruginosa为优势菌群.

关键词：多底物共代谢混合发酵 PCR-DGGE

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起挑流量与终挑流量计算

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吉林水利 2003年第1期 8-11页

作者：马春英杨晓龙吉林省水利水电勘测设计研究院吉林长春130012

本文分别就坎前接陡坡、正坡、有平台段的和有扩散的几种情况给出起挑和终挑流的计算方法。

关键词：起挑流量终挑流量计算界坎陡坡逆坎水跃

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Electrochemical conversion of methane to bridge the gap in the artificial carbon cycle

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Journal of Energy Chemistry 2025年第1期100卷 286-308页

作者： Yuhao Peng Yuefeng Song Ihar Razanau Juanxiu xiao Wei xiao Di Hu Guoxiong Wang College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Dalian Institute of Chemical Physics Chinese Academy of Sciences Laboratory of Physical-Chemical Technologies SSPA Scientific and Practical Materials Research Centre of NAS of Belarus State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University Department of Chemical and Environmental Engineering University of Nottingham Ningbo China

Methane, an abundant one-carbon（C1） resource, is extensively used in the industrial production of vital fuels and value-added chemicals. However, current industrial methane conversion technologies are energy-and carbon-intensive, mainly due to the high activation energy required to break the inert C–H bond, low selectivity, and problematic side reactions, including CO2emissions and coke deposition. Electrochemical conversion of methane（ECM） using intermittent renewable energy offers an attractive solution, due to its modular reactor design and operational flexibility across a broad spectrum of temperatures and pressures. This review emphasizes conversion pathways of methane in various reaction systems, highlighting the significance and advantages of ECM in facilitating a sustainable artificial carbon cycle. This work provides a comprehensive overview of conventional methane activation mechanisms and delineates the complete pathways of methane conversion in electrolysis contexts. Based on surface/interface chemistry, this work systematically analyzes proposed reaction pathways and corresponding strategies to enhance ECM efficiency towards various target products, including syngas, hydrocarbons, oxygenates, and advanced carbon materials. The discussion also encompasses opportunities and challenges for the ECM process, including insights into ECM pathways, rational electrocatalyst design, establishment of benchmarking protocols, electrolyte engineering, enhancement of CH4conversion rates, and minimization of CO2emission.

关键词： Methane Electrochemical conversion Reaction mechanism Catalyst design Electrode Electrocatalysis

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