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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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负责任的社会科学数据治理的内涵、特征与层次

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现代情报 2025年第1期45卷 124-134页

作者：王英卢国强湖北大学历史文化学院湖北武汉430062 吉林大学商学与管理学院吉林长春130012

[目的/意义]“十四五”国家哲学社会科学发展规划的背景下,负责任的数据治理成为促进社会科学数据开放共享、推进社会科学研究与创新的重要驱动力,亟须探索负责任的社会科学数据治理的基础理论。[方法/过程]运用主题分析法,探寻负责任... 详细信息

[目的/意义]“十四五”国家哲学社会科学发展规划的背景下,负责任的数据治理成为促进社会科学数据开放共享、推进社会科学研究与创新的重要驱动力,亟须探索负责任的社会科学数据治理的基础理论。[方法/过程]运用主题分析法,探寻负责任的数据治理的概念要素及维度,按照国际标准ISO704:2009的概念关系,结合社会科学数据的特性,阐释负责任的社会科学数据治理的内涵及其与相关概念的关系、特征、层次与内容,旨在构建一个较为全面且系统的概念体系。[结果/结论]负责任的社会科学数据治理是多元主体在现有的数据治理环境之下,运用相应的治理机制和手段,将负责任的研究与创新的理念和原则融入社会科学数据全生命周期,以确保所有涉及社会科学数据的流程和成果的责任性的过程,具有责任性、反思性、前瞻性、开放性和工具性特征,可划分为战略层、数据层和活动层。

关键词：社会科学数据负责任的数据治理数据治理

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng E Qian He Nanyang Wang Hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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AI 预测天然染料在丝绸上的最佳染色工艺与色牢度研究

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丝绸 2025年第1期62卷 40页

作者：刘莹陈杰南宁师范大学美术与设计学院武汉大学物理科学与技术学院

随着环境问题的日益严峻，为了提高实验效率、节约成本，推动可持续发展战略在染料与纺织品领域的应用，文章首先对天然染料染色的数据进行了收集与预处理，然后采用Xgboost集成学习算法构建AI模型并进行了模型训练与验证，评估了模型... 详细信息

随着环境问题的日益严峻，为了提高实验效率、节约成本，推动可持续发展战略在染料与纺织品领域的应用，文章首先对天然染料染色的数据进行了收集与预处理，然后采用Xgboost集成学习算法构建AI模型并进行了模型训练与验证，评估了模型的有效性和预测精度。该模型实现了天然染料在丝绸上染色工艺与效果的高效模拟与预测，从而显著缩短了实验时间并降低了资源损耗。这一方法提高了研究效率和经济效益。研究表明，该模型在预测反应最佳酸碱度(pH值)、水洗色牢度(CFW)和摩擦色牢度(CFR)方面具有较高的准确率，在验证集中三者的预测准确率高达94.12%、93.75%、100%,在真实的测试集上分别拥有87.50%、94.12%、82.35%的准确率，同时具备有效性与可迁移性。集成学习的方法通过极小的部署成本和极短的耗时为天然染料染色性能的探索给出了极具价值的指导，也为AI机器学习与纺织染色的学科的交叉应用拓展了可能性。

关键词： AI预测 Xgboost 天然染料丝绸色牢度

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Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

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World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na Li Yue-Yue Ren ying Tang Qi Yang Tian-Tian Meng Song Li Jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

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基于系统耦合理论的高校“劳动教育+思政教育”协同育人机制研究

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兵团教育学院学报 2025年第1期35卷 20-25,30页

作者：裴莹西安思源学院教育学院陕西西安710038

推进劳动教育与思政教育同向同行、协同育人是落实高质量教育教学改革实践的重要课题。在分析“劳动教育+思政教育”协同育人模式构建的逻辑机理的基础上,从系统耦合理论的视角出发,提出劳动教育教学系统与思政教育教学系统的“三维”... 详细信息

推进劳动教育与思政教育同向同行、协同育人是落实高质量教育教学改革实践的重要课题。在分析“劳动教育+思政教育”协同育人模式构建的逻辑机理的基础上,从系统耦合理论的视角出发,提出劳动教育教学系统与思政教育教学系统的“三维”立体耦合分析模型,构建了提升劳动教育与思政教育教学系统主体层面协同“能力源”,搭建劳动教育与思政教育教学系统环体层面协同“共享链”,拓展劳动教育与思政教育教学系统介体层面协同“空间域”三个层面的协同育人实践路径,以期完善劳动教育与思政教育的协同育人教育理念与实践。

关键词：劳动教育思政教育协同育人系统耦合

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马克思的“机器体系”:基于资本逻辑的技术批判路径

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河北大学学报（哲学社会科学版） 2025年第1期50卷 63-73页

作者：夏莹四川美术学院重庆400053 清华大学哲学系北京100084

马克思在《资本论》及其手稿的准备阶段以劳动为诠释资本逻辑的核心要素,提出“机器体系”的概念,作为资本生产三要素之一的劳动工具。该概念彰显出被资本主义生产关系所左右的机器,在其自动化的迭代中转变为可以左右人的活劳动形式的... 详细信息

马克思在《资本论》及其手稿的准备阶段以劳动为诠释资本逻辑的核心要素,提出“机器体系”的概念,作为资本生产三要素之一的劳动工具。该概念彰显出被资本主义生产关系所左右的机器,在其自动化的迭代中转变为可以左右人的活劳动形式的“体系”。劳动者,一方面沦为站在机器体系旁边的智能器官,另一方面却也作为推进资本增殖的酵母而左右着机器体系可能迭代的速度与方向,机器体系本质上仍然是人的产物。由此决定了机器体系的诞生固然依赖于资本主义生产方式,但却因作为人的产物,具有了逃离资本的可能性方式。马克思在《1857—1858年经济手稿》中,借助于机器体系的生产对人类社会财富之本质规定的变革,提出机器体系为人的解放所提供的自由时间的增加,以及对劳动价值论的瓦解,从而瓦解资本逻辑的全部可能性,为今天处于激进迭代的技术批判提供了一种基于资本逻辑所特有的批判视角。

关键词：机器体系资本逻辑劳动财富

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临沧市土司文化研究

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保山学院学报 2025年第01期44卷 29-36页

作者：梅英滇西科技师范学院

土司文化是西南民族地区元、明时期较为盛行的特色文化。在史料及实地考证基础上，对临沧市现辖区域临翔区、凤庆县、云县、双江拉祜族佤族布朗族傣族自治县、沧源佤族自治县、耿马傣族佤族自治县以及永德县的土司文化进行了简要梳理，... 详细信息

土司文化是西南民族地区元、明时期较为盛行的特色文化。在史料及实地考证基础上，对临沧市现辖区域临翔区、凤庆县、云县、双江拉祜族佤族布朗族傣族自治县、沧源佤族自治县、耿马傣族佤族自治县以及永德县的土司文化进行了简要梳理，并对其后续挖掘方向做了建议。

关键词：临沧市土司文化民族文化

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Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-ying Chen Fa Shen Chang Cheng Yu-Han Wang Wen-Chao Cheng De-Zhi Yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

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