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Triboelectric nanogenerators for self-powered neurostimulation

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Nano Research 2024年第10期17卷 8926-8941页

作者： Shumao xu Farid Manshaii xiao xiao Junyi yin Jun Chen Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA

The burgeoning field of soft bioelectronics heralds a new dawn in medical treatment for neurological and psychiatric conditions,presenting innovative methods for the stimulation,inhibition,and precise sensing of neuronal *** to these advancements is the challenge of power supply;devices dependent on traditional batteries face limitations regarding miniaturization and require invasive surgeries for battery *** nanogenerators(TENGs),which generate power from biomechanical movements,offer a promising solution for developing self-powered neurostimulation devices without the need for an external power *** review delves into recent progress in TENGs,with a focus on their application in selfpowered neurostimulation *** utility of TENGs across various nervous systems—including the center,autonomic,and somatic nervous systems—is explored and presented,highlighting the potential for these devices to facilitate neurological *** summarizing TENGs’operational details and the potential for clinical translation,this review also identifies challenges associated with the implantation and integration of neural electrodes and presents recent advances in solutions,aiming to reshape electric treatments for neurological diseases.

关键词： triboelectric nanogenerators neurostimulation self-powered soft bioelectronics biomechanical energy harvesting

Inactivation of the tumor suppressor Krüppel-like factor 6 (KLF6) by mutation or decreased expression in hepatocellular carcinomas

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第10期7卷 830-836页

作者： PAN Xiu-cheng CHEN Zhi CHEN Feng CHEN xiao-hong JIN Han-yin xu xiao-yan Institute of Infectious Disease the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Background and aim： The Krueppel-like transcription factor KLF6 is a novel tumor-suppressor gene. It was inactivated in human prostate cancer and other tumors tissue, as the result of frequent mutation and loss of heterozygosity （LOH）. However, there is no data reporting the levels of KLF6 both mRNA and protein in hepatocellular carcinomas （HCCs）. We therefore detected mutations and expression of KLF6 in HCC tissues and further observed the effect of it on cell growth in HCC cell lines. Methods： We analyzed the exon-2 ofKLF6 gene by direct DNA sequencing, and detected the expression of KLF6 by RT-PCR and Western blot in 23 HCC tissues and corresponding nontumorous tissues. Loss of growth suppressive effect of the HCC-derived KLF6 mutant was characterized by in vitro growth curves plotted, flow cytometry and Western blotting. Results： KLF6 mutations were found in 2 of 23 HCC tissues and one of mutations was missense. Expression ofKLF6 mRNA or protein was down-regulated in 8 （34.7%） or 9 （39.1%） of 23 HCC tissues. Wild-type KLF6 （wtKLF6） inhibited cellular proliferation and prolonged G1 -S transition by inducing the expression of p21WAF 1 following stable transfection into cultured HepG2 cells, but tumor-derived KLF6 mutant （mKLF6） had no effects. Conclusion： Our findings suggest that KLF6 may be involved in pathogenesis of HCC.

关键词： Tumor suppressor gene Krueppel-like factor 6 (KLF6) Mutation Gene expression Hepatocellular carcinoma

A Secure Cryptographic System Based on Steady-State Visual Evoked Potential Brain-Computer Interface Technology

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Journal of Systems Science and Information 2024年第3期12卷 423-432页

作者： xu xiao Feiyang ZHANG Wenhan yin Dezhi ZHENG College of Life and Environmental Science Minzu University of ChinaBeijing 100081China School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China Advanced Research Institute of Multidisciplinary Sciences Beijing Institute of TechnologyBeijing 100081China

Addressing the vulnerability of contact-based keyboard password systems to disclosure,this paper proposes and validates the feasibility of a non-contact secure password system based on brain-computer interface(BCI)technology that detects steady-state visual evoked potential(SSVEP)*** system first lets a testee look at a digital stimulus source flashing at a specific frequency,and uses a wearable dry electrode sensor to collect the SSVEP ***,a canonical correlation analysis method is applied to analyze the frequency of the stimulus source that the testee is looking at,and feeds back a code result through ***,after all password codes are input,the system makes a judgment and provides visual feedback to the *** were conducted to test the accuracy of the system,where twelve stimulus target frequencies between 10-16Hz were selected within the easily recognizable flicker frequency range of human brain,and each of them was tested for 12 *** results demonstrate that this SSVEP-BCI-based system is feasible,achieving an average accuracy rate of 97.2%,and exhibits promising applications in various domains such as financial transactions and identity recognition.

关键词： brain computer interface steady-state visual evoked potential password system

Bioinspired nanomaterials for wearable sensing and human–machine interfacing

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Nano Research 2024年第2期17卷 445-461页

作者： Vishesh Kashyap Junyi yin xiao xiao Jun Chen Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Mechanical and Aerospace Engineering University of CaliforniaLos AngelesLos AngelesCA 90095USA

The inculcation of bioinspiration in sensing and human–machine interface(HMI)technologies can lead to distinctive characteristics such as conformability,low power consumption,high sensitivity,and unique properties like self-healing,self-cleaning,and *** sensing and HMI are fields rife with opportunities for the application of bioinspired nanomaterials,particularly when it comes to wearable sensory systems where biocompatibility is an additional *** review discusses recent development in bioinspired nanomaterials for wearable sensing and HMIs,with a specific focus on state-of-the-art bioinspired capacitive sensors,piezoresistive sensors,piezoelectric sensors,triboelectric sensors,magnetoelastic sensors,and electrochemical *** also present a comprehensive overview of the challenges that have hindered the scientific advancement in academia and commercialization in the industry.

关键词： bioinspired nanomaterials human–machine interface wearable sensors wearable bioelectronics

Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior:Synthesis,Characterization and Biological Applications

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Chinese Journal of Polymer Science 2024年第6期42卷 826-837页

作者： Feng-Ming yin Li-Li Wu Shu-Sheng Li xiao-Na Pan xiao-Li Zhu xu-Bao Jiang Xiang Zheng Kong College of Chemistry and Chemical Engineering University of JinanJinan250022China Shandong Institute for Product Quality Inspection Jinan250102China College of Chemical Engineering Tianjin UniversityTianjin300072China

Non-aromatic fluorescent and multi-responsive materials,exhibiting inherent fluorescence emission and controlled phase change,have garnered significant attention in recent ***,the underlying interaction between their fluorescent properties and phase transition remains *** this study,we synthesized a series of catalyst-free aza-Michael addition-based polyethyleneimine(RFPEI)materials by reacting polyethyleneimine(PEI)with N-isopropyl acrylamide(NIPAM).The resulting RFPEI was comprehensively characterized,and demonstrated dual-phase transition behavior(LCST and UCST)in water,which could be finely tuned by adjusting its composition or external factors such as ***,upon UV irradiation(365 nm),RFPEI exhibited strong fluorescence *** further investigated the effects of NIPAM grafting percentage to PEI,polymer concentration,and pH on the LCST/UCST and fluorescent properties of RFPEI aqueous ***,we showcased the great potential of RFPEI as a versatile tool for physiological cell imaging,trace detection,and controlled release of *** study presents a novel class of stimuli-responsive fluorescent materials with promising applications in the field of biomedicine.

关键词： Polyethyleneimine Multi-responsiveness Intrinsic fluorescence emission Cell imaging Controlled drug release

Surface Polarization Effects on Collapse Transition of Polyelectrolyte Brushes

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Chinese Journal of Polymer Science 2024年第9期42卷 1313-1320,I0006页

作者： xiao-Fei xu State Key Laboratory of Chemical Engineering and School of Chemical Engineering East China University of Science and TechnologyShanghai200237China

Polyelectrolyte brushes(PEBs)are commonly used to modify surface that have attracted great research *** dielectric permittivity of the grafted surface is typically significantly different from that of solution,which results in surface polarization(SP)effect with a jump of electric *** is thus important to study how SP alters the PEB’s structure and *** this work,the SP effects on PEB structure was studied using a statistical thermodynamic *** free energy functional to describe SP effect was constructed by using the image-charge ***,the electrostatic potential was solved from a modified Poisson-Boltzmann equation taking the ion solvation effect into *** the absence of SP,the thickness of PEB exhibited a continuous collapse transition when decreasing the solvent *** the presence of SP,the collapse became a jump-like *** energy analysis showed that the long-range Coulombic interaction dominated the transition because of the enhanced counterion condensation in the presence of *** theory provides an effective tool to study SP effect on PEBs,and the results explain the underlying physics in PEB collapse transition.

关键词： Surface polarization Polyelectrolyte brush Image charge Ion solvation Polyelectrolyte collapse transition

Identification of Key Blood Biomarkers Linking Di(2-ethylhexyl)Phthalate and Autoimmune Diseases in Adolescents Mice

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Biomedical and Environmental Sciences 2024年第5期37卷 521-525页

作者： xu xiao Mei LI xiao Lu HU Die CAI xiao Yue LI Qi Meng ZHENG Yuan Zhuo CAI Yang QI yin yin xu Tao ZHAO Ling Li NING Xia Department of Infectious Diseases Anhui Provincial Children’s HospitalHefei 231000AnhuiChina Department of Toxicology School of Public HealthKey Laboratory of Environmental Toxicology of Anhui Higher Education InstitutesAnhui Medical UniversityHefei 231000AnhuiChina School of Biology Food and EnvironmentHefei UniversityHefei 230601AnhuiChina

Di(2-ethylhexyl)phthalate(DEHP)is a widely used plasticizer known for its reproductive developmental and immune system toxicity,mainly through esophagal,dermal,and respiratory exposure^([1-3]).Maternal exposure to DEHP during pregnancy can lead to adverse birth outcomes in offspring,including impacts on the thyroid system of adolescent offspring^([2-4]).

关键词： Blood respiratory pregnancy

An efficient parallel algorithm of variational nodal method for heterogeneous neutron transport problems

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Nuclear Science and Techniques 2024年第4期35卷 29-45页

作者： Han yin xiao-Jing Liu Teng-Fei Zhang School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 2002040China

The heterogeneous variational nodal method(HVNM)has emerged as a potential approach for solving high-fidelity neutron transport ***,achieving accurate results with HVNM in large-scale problems using high-fidelity models has been challenging due to the prohibitive computational *** paper presents an efficient parallel algorithm tailored for HVNM based on the Message Passing Interface *** algorithm evenly distributes the response matrix sets among processors during the matrix formation process,thus enabling independent construction without *** the formation tasks are completed,a collective operation merges and shares the matrix sets among the *** the solution process,the problem domain is decomposed into subdomains assigned to specific processors,and the red-black Gauss-Seidel iteration is employed within each subdomain to solve the response matrix ***-to-point communication is conducted between adjacent subdomains to exchange data along the *** accuracy and efficiency of the parallel algorithm are verified using the KAIST and JRR-3 test *** results obtained with multiple processors agree well with those obtained from Monte Carlo *** parallelization of HVNM results in eigenvalue errors of 31 pcm/-90 pcm and fission rate RMS errors of 1.22%/0.66%,respectively,for the 3D KAIST problem and the 3D JRR-3 *** addition,the parallel algorithm significantly reduces computation time,with an efficiency of 68.51% using 36 processors in the KAIST problem and 77.14% using 144 processors in the JRR-3 problem.

关键词： Neutron transport Variational nodal method Parallelization KAIST JRR-3

High-performance grinding of ceramic matrix composites

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NANOTECHNOLOGY AND PRECISION ENGINEERING 2024年第3期7卷 45-55页

作者： yin, Jingfei xu, Jiuhua Su, Honghua Nanjing Univ Aeronaut & Astronaut Coll Mech & Elect Engn Nanjing 210016 Peoples R China AECC Shenyang Liming Aeroengine Co Ltd Dept Technol Ctr Shenyang 110043 Peoples R China

Ceramic matrix composites (CMCs) are highly promising materials for the next generation of aero-engines. However, machining of CMCs suffers from low efficiency and poor surface finish, which presents an obstacle to their wider application. To overcome these problems, this study investigates high-efficiency deep grinding of CMCs, focusing on the effects of grinding depth. The results show that both the surface roughness and the depth of subsurface damage (SSD) are insensitive to grinding depth. The material removal rate can be increased sixfold by increasing the grinding depth, while the surface roughness and SSD depth increase by only about 10%. Moreover, it is found that the behavior of material removal is strongly dependent on grinding depth. As the grinding depth is increased, fibers are removed in smaller sizes, with the fiber length in chips being reduced by about 34%. However, too large a grinding depth will result in blockage by chip powder, which leads to a dramatic increase in the ratio of tangential to normal grinding forces. This study demonstrates that increasing the depth of cut is an effective approach to improve the machining efficiency of CMCs, while maintaining a good surface finish. It provides the basis for the further development of high-performance grinding methods for CMCs, which should facilitate their wider application.

关键词： Ceramic matrix composite Grinding Surface finish Subsurface damage Fiber breakage C/SIC COMPOSITES MECHANISM SILICON