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Heyingwuzi formulation alleviates diabetic retinopathy by promoting mitophagy via the HIF-1α/BNIP3/NIX axis

World Journal of Diabetes 2024年第6期15卷 1317-1339页

作者： Jia-Jun Wu Shu-Yan zhang Lin Mu Zhi-Guo Dong yin-jian zhang Department of Ophthalmology Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Ophthalmology Eye and ENT HospitalFudan UniversityShanghai 200031China

BACKGROUND Diabetic retinopathy(DR)is the primary cause of visual problems in patients with *** Heyingwuzi formulation(HYWZF)is effective against *** To determine the HYWZF prevention mechanisms,especially those underlying *** Human retinal capillary endothelial cells(HRCECs)were treated with high glucose(hg),HYWZF serum,PX-478,or Mdivi-1 in ***,cell counting kit-8,transwell,and tube formation assays were used to evaluate HRCEC proliferation,invasion,and tube formation,*** electron microscopy was used to assess mitochondrial morphology,and Western blotting was used to determine the protein *** cytometry was used to assess cell apoptosis,reactive oxygen species(ROS)production,and mitochondrial membrane ***,C57BL/6 mice were established in vivo using streptozotocin and treated with HYWZF for four *** glucose levels and body weight were monitored *** in retinal characteristics were evaluated using hematoxylin and eosin,tar violet,and periodic acid-Schiff *** levels in retinal tissues were determined via Western blotting,immunohistochemistry,and *** HYWZF inhibited excessive ROS production,apoptosis,tube formation,and invasion in hg-induced HRCECs via mitochondrial autophagy in *** increased the mRNA expression levels of BCL2-interacting protein 3(BNIP3),FUN14 domain-containing 1,BNIP3-like(BNIP3L,also known as NIX),PARKIN,PTEN-induced kinase 1,and hypoxia-inducible factor(HIF)-1α.Moreover,it downregulated the protein levels of vascular endothelial cell growth factor and increased the light chain 3-II/I ***,PX-478 and Mdivi-1 reversed these ***,PX-478 and Mdivi-1 rescued the effects of HYWZF by decreasing oxidative stress and apoptosis and increasing *** intervention improved the symptoms of diabetes,tissue damage,number of acellular capillaries,and oxidative stress in ***,in vivo

关键词： Diabetic retinopathy HIF-1α/BNIP3/NIX axis Mitophagy Heyingwuzi formulation Traditional Chinese medicine

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Effect of the traditional Chinese medicine fumigation combined with the meibomian gland squeezer for treatment of dry eye associated with meibomian gland dysfunction

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Integrative Medicine Discovery 2024年第15期8卷 1-5页

作者： Da-Hu Wang Lin Mu Xiao-Yu Wu yin-jian zhang Xin-Quan Liu Department of Ophthalmology Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Ophthalmology Eye&ENT Hospital of Fudan UniversityShanghai 200031China

Background:To observe the effect of traditional Chinese medicine fumigation combined with the meibomian gland squeezer for the treatment of dry eye associated with meibomian gland dysfunction(MGD).Methods:This is a randomized,controlled,non-masked,single-center ***-four cases(74 eyes)of dry eye associated with MGD were randomly divided into two ***-seven patients were chosen as the treatment group was treated by the traditional Chinese medicine fumigation 3 times a week combined with the meibomian gland squeezer once a week for one *** other 37 cases were sorted as the control group and only treated with the meibomian gland squeezer once a week for one *** groups received the primary treatment for 1 month,including Tobradex eye ointment once a day and 0.1%sodium hyaluronate eye drops 4-6 times *** were evaluated at baseline and 2-week and 1-month visits for the ocular symptom scores,international ocular surface disease index(OSDI),fluorescein tear break-up time(TBUT),corneal fluorescein staining test(CFS),Schirmer I test,meibum quality and meibum ***:Sixty-seven patients were followed in the study,and the mean age was 57(±12.6)***-three patients(11 males)in the treatment group and 34 patients(8 males)in the control group were followed in the study,and the mean age of the two groups was 45.36±15.02 years and 43.68±13.43 years,*** treatment,there was no significant difference between the two groups in gender,age,ocular symptom scores,OSDI,TBUT,CFS,Schirmer I test,meibum quality,and meibum expressibility(P>0.05).Compared with baseline,the 2 groups had different degrees of improvement in the ocular symptom scores,OSDI,TBUT,CFS,meibum quality,and meibum expressibility at the 2-week and 1-month visits(P<0.05),and the treatment group showed a more significant improvement in the ocular symptom scores,OSDI,TBUT,CFS,meibum quality and meibum expressibility compared with the control group(P

关键词： meibomian gland squeezer traditional Chinese medicine dry eye disease meibomian gland dysfunction

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FPGA implementation of 500-MHz high-count-rate high-time-resolution real-time digital neutron-gamma discrimination for fast liquid detectors

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Nuclear Science and Techniques 2024年第8期35卷 101-113页

作者： Hui‑yin Shen Jing‑Long zhang Jie zhang jian‑Hang Zhou College of Nuclear Technology and Automation Engineering Chengdu University of TechnologyChengdu 610059China Southwestern Institute of Physics P.O.Box 432Chengdu 610041China

Fast neutron flux measurements with high count rates and high time resolution have important applications in equipment such as *** this study,real-time neutron and gamma discrimination was implemented on a self-developed 500-Msps,12-bit digitizer,and the neutron and gamma spectra were calculated directly on an FPGA.A fast neutron flux measurement system with BC-501A and EJ-309 liquid scintillator detectors was developed and a fast neutron measurement experiment was successfully performed on the HL-2 M tokamak at the Southwestern Institute of Physics,*** experimental results demonstrated that the system obtained the neutron and gamma spectra with a time accuracy of 1 *** count rates of up to 1 Mcps,the figure of merit was greater than 1.05 for energies between 50 keV and 2.8 MeV.

关键词： Neutron-gamma discrimination Liquid scintillation detector Real-time spectrum analyzer

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Attaining synergetic equilibrium of electrical conductivity and tensile strength in GQDs@GN/Cu composites through multi-scale intragranular and intergranular reinforcements

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Rare Metals 2024年第1期43卷 366-379页

作者： Shuang-yin zhang Liang Liu Rui Bao jian-Hong Yi Sheng-Da Guo Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China Key Laboratory of Advanced Materials of Yunnan Province Kunming University of Science and TechnologyKunming 650093China Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China

The configuration and quality of reinforcements, as well as the robustness of interfacial bonding,holding a critical significance in determining the concurrence between electrical conductivity and mechanical strength in metal matrix composites. In this study, citric acid was employed as the precursor for synthesizing multiscale carbon nanomaterials(graphene quantum dots and graphene, abbreviated as GQDs and GN). The GQDs@GN/Cu composites were fabricated through a segmented ball milling process in conjunction with subsequent spark plasma sintering(SPS). The intragranular GQDs and intergranular GQDs@GN had synergistically reinforced Cu composites through Orowan strengthening, load transfer strengthening and refinement strengthening. Furthermore,the robust interface bonding between GQDs@GN and Cu effectively mitigated interfacial impedance stemming from electron-boundary scattering. The yield strength and ultimate tensile strength of the GQDs@GN/Cu composites were recorded as 270 and 314 MPa, respectively, representing an improvement of 92 and 28% over pure Cu, while maintaining electrical conductivity at a level comparable to that of pure Cu. This study advances the understanding of the possibility of realizing a synergistic compatibility between electrical conductivity and mechanical strength in Cu composites.

关键词： Cu matrix composites Interface bonding Mechanical property Graphene quantum dots(GQDs) Electrical conductivity

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Harnessing data using symbolic regression methods for discovering novel paradigms in physics

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 1-11页

作者： jianyang Guo Wan-jian yin College of Energy Soochow Institute for Energy and Materials Innovations(SIEMIS)Jiangsu Provincial Key Laboratory for Advanced Carbon Materials and Wearable Energy TechnologiesSoochow UniversitySuzhou 215006China Shanghai Qi Zhi Institute Shanghai 200232China Light Industry Institute of Electrochemical Power Sources Soochow UniversitySuzhou 215006China

In recent years,machine-learning methods have profoundly impacted research in the interdisciplinary fields of ***,most machine-learning models lack interpretability,and physicists doubt the credibility of their conclusions because they cannot be combined with prior physical ***,this review focuses on symbolic regression,which is an interpretable machine-learning ***,the relevant concepts of machine learning are introduced in conjunction with ***,we provide an overview of symbolic regression ***,the recent directions for the application of symbolic regression methods in different subfields of physics are outlined,and an overview of the ways in which the applications of symbolic regression have evolved in the realm of physics is *** major aim of this review is to introduce the basic principles of symbolic regression and explain its applications in the field of physics.

关键词： machine learning genetic programming symbolic regression

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Synthesis strategies of hard carbon anodes for sodium-ion batteries

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Materials Reports(Energy) 2024年第2期4卷 1-22页

作者： jian yin Ye Shui zhang Hanfeng Liang Wenli zhang Yunpei Zhu Laboratory of Environmental Sciences and Technology Xinjiang Technical Institute of Physics&ChemistryChinese Academy of SciencesUrumqi830011China Materials Science and Engineering Physical Science and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal23955-6900Saudi Arabia School of Engineering University of AberdeenAberdeenAB243UEUK State Key Laboratory of Physical Chemistry of Solid Surfaces Tan Kah Kee Innovation Laboratory(IKKEM)College of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Jieyang515200China Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light IndustryGuangdong University of Technology(GDUT)Panyu DistrictGuangzhou510006China School of Advanced Manufacturing Guangdong University of Technology(GDUT)Jieyang522000China

Sodium-ion battery(SIB)is an ideal candidate for large-scale energy storage due to high abundant sodium sources,relatively high energy density,and potentially low *** carbons,as one of the most promising anodes,could deliver high plateau capacities at low potentials,which boosts the energy densities of *** slope capacities have been demonstrated from the defect adsorption of sodium ions,while the plateau capacity depends highly on intercalation and pore ***,the specific structures of sodium ions stored in hard carbons have not been clarified,namely active sites of adsorption,intercalation,and pore-filling ***,delicate synthesis methods are required to prepare hard carbons with controllable specific structures,along with elucidating the precise active sites for enhancing the Na-ion storage *** offer databases for future designs,we summarized the synthesis strategies of hard carbon anodes for constructing active sites of plateau *** methods were highlighted with corresponding influences on the meticulous structures of hard carbons and Na-ion storage *** but not least,perspectives were proposed for developing hard carbon anodes from the points of research and practical applications.

关键词： Hard carbon anodeCarbon synthesisSodium-ion batteryStructure-function relationship

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Industrial Carbon Emission Distribution and Regional Joint Emission Reduction:A Case Study of Cities in the Pearl River Basin,China

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Chinese Geographical Science 2024年第2期34卷 210-229页

作者： jianG Hongtao yin jian zhang Bin WEI Danqi LUO Xinyuan DING Yi XIA Ruici Center for Western China Modernization Guizhou University of Finance and EconomicsGuiyang 550025China College of Big Data Application and Economic Guizhou University of Finance and EconomicsGuiyang 550025China Key Laboratory of Green Fintech Guizhou University of Finance and EconomicsGuiyang 550025China

China’s low-carbon development path will make significant contributions to achieving global sustainable development *** to the diverse natural and economic conditions across different regions in China,there exists an imbalance in the distribution of car-bon ***,regional cooperation serves as an effective means to attain low-carbon *** study examined the pattern of carbon emissions and proposed a potential joint emission reduction strategy by utilizing the industrial carbon emission intens-ity(ICEI)as a crucial *** utilized social network analysis and Local Indicators of Spatial Association(LISA)space-time trans-ition matrix to investigate the spatiotemporal connections and discrepancies of ICEI in the cities of the Pearl River Basin(PRB),China from 2010 to *** primary drivers of the ICEI were determined through geographical detectors and multi-scale geographically weighted *** results were as follows:1)the overall ICEI in the Pearl River Basin is showing a downward trend,and there is a significant spatial imbalance.2)There are numerous network connections between cities regarding the ICEI,but the network structure is relatively fragile and unstable.3)Economically developed cities such as Guangzhou,Foshan,and Dongguan are in the center of the network while playing an intermediary role.4)Energy consumption,industrialization,per capita GDP,urbanization,science and techno-logy,and productivity are found to be the most influential variables in the spatial differentiation of ICEI,and their combination in-creased the explanatory power of the geographic variation of ***,through the analysis of differences and connections in urban carbon emissions under different economic levels and ICEI,the study suggests joint carbon reduction strategies,which are centered on carbon transfer,financial support,and technological assistance among cities.

关键词： industrial carbon emission intensity carbon emission social network analysis Location Indicators of Spatial Association(LISA) geographical detector multi-scale geographically weighted regression Pearl River Basin(PRB),China

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Multi-surrogate framework with an adaptive selection mechanism for production optimization

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Petroleum Science 2024年第1期21卷 366-383页

作者： Jia-Lin Wang Li-Ming zhang Kai zhang jian Wang jian-Ping Zhou Wen-Feng Peng Fa-Liang yin Chao Zhong Xia Yan Pi-Yang Liu Hua-Qing zhang Yong-Fei Yang Hai Sun School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Qingdao University of Technology Qingdao266580ShandongChina College of Science China University of PetroleumQingdao266580ShandongChina Zepu Oil and Gas Development Department PetroChina Tarim Oilfield CompanyKorla841000XinjiangChina Hainan Branch of CNOOC Ltd Haikou70311HainanChina

Data-driven surrogate models that assist with efficient evolutionary algorithms to find the optimal development scheme have been widely used to solve reservoir production optimization ***,existing research suggests that the effectiveness of a surrogate model can vary depending on the complexity of the design problem.A surrogate model that has demonstrated success in one scenario may not perform as well in *** the absence of prior knowledge,finding a promising surrogate model that performs well for an unknown reservoir is ***,the optimization process often relies on a single evolutionary algorithm,which can yield varying results across different *** address these limitations,this paper introduces a novel approach called the multi-surrogate framework with an adaptive selection mechanism(MSFASM)to tackle production optimization *** consists of two *** the first stage,a reduced-dimensional broad learning system(BLS)is used to adaptively select the evolutionary algorithm with the best performance during the current optimization *** the second stage,the multi-objective algorithm,non-dominated sorting genetic algorithm II(NSGA-II),is used as an optimizer to find a set of Pareto solutions with good performance on multiple surrogate models.A novel optimal point criterion is utilized in this stage to select the Pareto solutions,thereby obtaining the desired development schemes without increasing the computational load of the numerical *** two stages are combined using sequential transfer *** the two most important perspectives of an evolutionary algorithm and a surrogate model,the proposed method improves adaptability to optimization problems of various reservoir *** verify the effectiveness of the proposed method,four 100-dimensional benchmark functions and two reservoir models are tested,and the results are compared with those obtained by six other surrogate-model-based *** res

关键词： Production optimization Multi-surrogate models Multi-evolutionary algorithms Dimension reduction Broad learning system

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Low-latitude hydroclimate changes related to paleomagnetic variations during the Holocene in coastal southern China

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Frontiers of Earth Science 2024年第2期18卷 324-335页

作者： Tingwei zhang Xiaoqiang YANG jian yin Qiong CHEN jianfang HU Lu WANG Mengshan JU Qiangqiang WANG School of Earth Science and Engineering/Guangdong Provincial Key Laboratory of Geodynamics and Geohazards/Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Sun Yat-sen UniversityGuangzhou 510275China Institute of Cultural Heritage Shandong UniversityQingdao 266237China State Key Laboratory of Organic Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China College of Urban and Environmental Sciences Peking UniversityBeijing 100871China Institute of Oceanology Chinese Academy of SciencesQingdao 266071China

The variations in precipitation have displayed a complex pattern in different regions since the *** formation processes may have a significant impact on precipitation,especially during the tropical marine processes and summer monsoon which convey abundant water vapor to coastal southern China and inland ***,we use two 7500 year sedimentary records from the Pearl River Delta and the closed Maar Lake,respectively,in coastal southern China to reconstruct the mid-to-late-Holocene humidity variability and explore its possible relationship with cloud cover modulated by the Earth’s magnetic fields(EMF).Our proxy records document an apparent increase in wetness in coastal southern China between 3.0 and 1.8 kyr *** apparent increase in humidity appears to be consistent with the lower virtual axial dipole moments and,in turn,with a lower *** correlation suggests that the EMF might have been superimposed on the weakened monsoon to regulate the mid-to-late-Holocene hydroclimate in coastal southern China through the medium of galactic cosmic rays,aerosols,and cloud ***,further investigations are needed to verify this interaction.

关键词： hydroclimate variations Earth’s magnetic field coastal southern China the Holocene epoch

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Elaborate Design of Two Novel Fluorescent Zinc-based Metal-Organic Frameworks for Highly Efficient Tetracycline Antibiotics Detection

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Chemical Research in Chinese Universities 2024年第3期40卷 499-507页

作者： TAO He JI Chengshan zhang jian yin Yuanyuan JIA Wenwen jianG Xin XU Jie YANG Yulin MIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001P.R.China

The abuse of tetracycline antibiotics has caused great harm to human health and *** inexpensive,convenient and sensitive methods for the detection of tetracycline antibiotics is highly ***,based on the H_(4)ddp ligand[H_(4)ddp=3-(3,5-dicarboxyphenyl)pyridine-2,6-dicarboxylic acid],two novel zinc-based metal-organic frameworks(MOFs){[Zn_(3)(ddp)_(2)(H_(2)O)_(4)]·3H_(2)O}n(Zn1-ddp)and{[Zn_(3)(ddp)_(2)(H_(2)O)_(4)]·3H_(2)O}n(Zn2-ddp)were successfully designed by delicate structural *** Zn1-ddp and Zn2-ddp exhibited excellent water and chemical stability and showed excellent fluorescence quenching performance for tetracycline ***,the more advanced framework structure and better fluorescent performance make Zn1-ddp more sensitive than Zn2-ddp in fluorescent detection with a detection limit of 0.29µmol/L for tetracycline(TC),0.09µmol/L for doxycycline(DOX),0.10µmol/L for minocycline(MIN)and metacycline(MEL),0.19µmol/L for chlortetracycline(CTC),and 0.67µmol/L for oxytetracycline(OTC)among tetracycline *** fluorescence quenching mechanism of Zn1-ddp and Zn2-ddp for tetracycline antibiotics detection was deeply *** reasons for the superior detection performance of Zn1-ddp over Zn2-ddp were also analyzed in depth through Fourier transform infrared spectrophotometry(FTIR),X-ray photoelectron spectroscopy(XPS)analysis and framework structure *** developed method opens up a new perspective for antibiotics detection based on zinc-based MOFs.

关键词： Water system Metal-organic framework Fluorescent detection Tetracycline antibiotic

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