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Journal of Wuhan University of Technology(Materials Science) 2019年第6期34卷 1484-1494页

作者： HE Guanghua CAO Jilong WANG Cheng FAN Lihong yin yihua CAI Weiquan TAO Shengxiang School of Chemistry Chemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070China Department of Orthopedics Zhongnan Hospital of Wuhan UniversityWuhan 430070China

A simple strategy was developed to prepare a tough, self-healing, antibacterial and moldable hydrogel by introducing the natural polyphenolic compound tannic acid(TA) as a cross-linking center for hydrogen bonds. Polyvinyl alcohol(PVA)-TA hydrogel was prepared by physical mixing using PVA as a main component and TA as a cross-linker. There were two types of physical cross linking bonds in the PVA-TA hydrogel network, which were weaker hydrogen bonds between PVA molecular chains and stronger hydrogen bonds between PVA and TA molecules. The mechanical properties and self-healing ability could be adjusted by changing the contents of PVA and TA. The hydrogel possessed not only high mechanical strength(305 kPa tensile strength and 864 kPa compressive strength), moldability and excellent self-healing properties(95% selfhealing efficiency) but also good antibacterial abilities against S. aureus and E. coli. In addition, after soaking the dried hydrogel in 90 ℃ deionized water for 4 h, they could also regain their self-healing ability to a certain extent. The hydrogels have potential applications in the biomedical fields.

关键词： toughness self-healing moldability antibacterial swelling-resistant

Preparation and Properties of Poly(amidoamine) Dendrimer/Quaternary Ammonium Chitosan Hydrogels

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Journal of Wuhan University of Technology(Materials Science) 2018年第3期33卷 736-743页

作者：何广华 KONG Yahui 郑化 KE Wanwan CHEN Xiang yin yihua YI ying School of Chemistry Chemical Engineering and Life Sciences Wuhan University of Technology

A novel quaternary ammonium chitosan hydrogel modified by poly（amidoamine）（PAMAM） dendrimer was prepared by using glutaraldehyde as a cross-linker. The hydrogel was characterized by Fourier transform infrared spectroscopy（FTIR） and scanning electron microscopy（SEM）. The results confirmed its highly porous three-dimensional network structure. The swelling test of hydrogel proved that it had excellent swelling and p H-sensitive properties. The increasing PAMAM content or quaternization degree led to the increase in swelling properties. And the hydrogel with lower cross-linking agent concentration or quaternary ammonium chitosan concentration exhibited better swelling properties. The antibacterial results indicated that with the increase in the PAMAM content, quaternary ammonium chitosan concentration or cross-linking agent concentration, the hydrogels showed better antibacterial activities against both Staphylococcus aureus（S. aureus） and Escherichia coli（E. coli）. Thus, the hydrogel could serve as a promising antibacterial material in the future.

关键词： hydrogel quaternary ammonium chitosan poly(amidoamine) dendrimer antibacterial activity

Preparation, Swelling and Antibacterial Behaviors of N-Succinyl Chitosan-g-Poly(Acrylic Acid-co-Acrylamide) Superabsorbent Hydrogels

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Journal of Wuhan University of Technology(Materials Science) 2017年第4期32卷 963-970页

作者：何广华 ke wanwan liu liang li ya 郑化 yin yihua yi ying School of Chemistry Chemical Engineering and Life Sciences Wuhan University of Technology Wuhan 430070 China

Superabsorbent hydrogels were prepared successfully from N-succinyl chitosan grafted poly（acrylic acid-co-acrylamide）. The potassium persulfate（KPS）, N, N＇-methylenebisacrylamide（MBA） were used as the initiator and crosslinker, respectively. Fourier transform infrared spectroscopy（FTIR） and scanning electron microscopy（SEM） were used to confirm the porous network structure of superabsorbent hydrogel. The effects of reaction parameters on the swelling behaviors of the superabsorbent hydrogels were investigated. The results indicated that water absorbency increased first, and then decreased gradually with the increase in the contents of monomer（AA＋AM）, KPS, MBA or acrylamide. The product had excellent water absorbency of 1375 g/g in distilled water and 83 g/g in 0.9wt% NaCl solution. Simultaneously, the superabsorbent hydrogels were p H sensitive. The antibacterial activities of the hydrogels against Escherichia coli（E. coli） were improved effectively because of polyamidoamine（PAMAM） dendrimer absorbed in the hydrogels.

关键词： superabsorbent hydrogels N-succinyl chitosan water absorbency PAMAM dendrimer antibacterial activity

Synthesis and Evaluation of Novel Chitosan Derivatives for Gene Delivery

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Journal of Wuhan University of Technology(Materials Science) 2015年第4期30卷 852-858页

作者：付芳 LIU Xiong 吕波 QU Guoyi ZHENG Hua HUANG Zhijun XU Peihu XU Haixing yin yihua LIU Xia ZHANG Xueqiong School of Chemistry Chemical Engineering and Life Sciences Wuhan University of Technology Luo Tian Wan Mizhai Hospital

A series of novel water soluble chitosan derivatives as gene vectors was synthesized. The delivery systems were tested for their ability to form complexes with plasmid DNA by utilizing agarose gel electrophoresis, particle size analysis, zeta potential measurement and scanning electron microscopy. Furthermore, cytotoxicity of chitosan derivatives and transfection efficiency of polyplexes were evaluated in vitro. The experimental results showed that the novel chitosan derivatives had lower cytotoxicity, good DNA condensation, and higher transfection efficiencies compared to chitosan in both 293T and HeLa cell lines. It was indicated that these chitosan derivatives were promising candidates for non-viral gene vectors.

关键词： gene vector transfection efficiency chitosan non-viral vector

NETWORK　CROWN　ETHER　POLYMERS　WITH　CENTRIC　FUNCTIONAL　GROUPS．Ⅱ．SYNTHESIS　OF　NETWORK　CROWN　ETHER　POLYMER　WITH　PENDANT　SULFIDE　SIDE　CHAIN　AND　ITS　PLATINUM　COMPLEX

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Chinese Journal of Reactive Polymers 1995年第1期4卷 53-60页

作者： CHEN Yuanyin MENG Lingzhi yin yihua Department of Chemistry Wuhan University Wuhan 430072

Network crewn ether polymer with pendant sulfide side ohain in the networkstructure units has been synthesized via ring- opening copolymerization of β-ethylthioethyl glycidyl ether and diethylene glycol bisglycidyl ether. A kind of active catalyst suitable for this reaction was suggested. The title polymer was found tobe a good ligand for platinous chloride, and the platinous complex could catalyze thehydrosilylation of olefins with triethoxysilane efficiently.

关键词： Crown ether Polymeric crown ether Sulfide platinum complex Hydrosilylation catalyst Platinum

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后处理工艺对聚苯硫醚滤料清灰性能的影响

纺织学报 2016年第8期37卷 16-20页

作者：殷依华于斌韩建浙江理工大学材料与纺织学院产业用纺织材料制备技术浙江省重点实验室

为研究滤料清灰性能的不同影响因素,选取4种聚苯硫醚(PPS)纤维滤料,即未经后处理、烧毛、聚四氟乙烯(PTFE)乳液浸渍和PTFE微孔膜覆膜处理的滤料为试样,采用滤料动态过滤性能测试仪测试了4种聚苯硫醚纤维滤料的清灰性能,通过扫描电镜观... 详细信息

为研究滤料清灰性能的不同影响因素,选取4种聚苯硫醚(PPS)纤维滤料,即未经后处理、烧毛、聚四氟乙烯(PTFE)乳液浸渍和PTFE微孔膜覆膜处理的滤料为试样,采用滤料动态过滤性能测试仪测试了4种聚苯硫醚纤维滤料的清灰性能,通过扫描电镜观察了过滤前后滤料的表观形貌。测试结果表明:在试验周期内,这4种滤料中,覆膜滤料经粉尘过滤后剩余压差最低,清灰周期最长,清灰性能最为优异;未经处理滤料清灰性能次之;PTFE乳液浸渍滤料由于表面纤维间充满着PTFE乳液固状物,其清灰性能较差;烧毛处理滤料表面留有面积较大的PPS纤维烧焦物质,其清灰性能最差。

关键词：聚苯硫醚滤料滤料后处理粉尘过滤清灰性能

泌尿生殖道标本解脲脲原体和人型支原体检测及抗菌药物敏感性试验结果分析

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中国感染与化疗杂志 2021年第2期21卷 201-204页

作者：殷怡华张贤华同济大学附属上海市第一妇婴保健院妇科上海201204 同济大学附属上海市第一妇婴保健院检验科上海201204

目的了解泌尿生殖道标本解脲脲原体和人型支原体对常用抗菌药物敏感性,为临床抗菌药物选择提供客观依据。方法采用商品化的支原体培养及药敏试验试剂盒,对2016—2018年连续3年同济大学附属上海市第一妇婴保健院泌尿生殖道标本进行支原... 详细信息

目的了解泌尿生殖道标本解脲脲原体和人型支原体对常用抗菌药物敏感性,为临床抗菌药物选择提供客观依据。方法采用商品化的支原体培养及药敏试验试剂盒,对2016—2018年连续3年同济大学附属上海市第一妇婴保健院泌尿生殖道标本进行支原体检测及药敏测定。结果3年间共采集泌尿生殖道标本35006份,12572份(35.9%)标本检出解脲脲原体,1073份(3.1%)标本同时检出解脲脲原体与人型支原体,15份(0.04%)标本仅检出人型支原体。解脲脲原体、人型支原体对四环素、多西环素、克拉霉素和交沙霉素敏感率高(≥93.3%);但解脲脲原体与人型支原体混合体,仅对多西环素、米诺环素、交沙霉素保持有较高敏感率(≥70.4%)。生殖道支原体对喹诺酮类药物敏感率低(≤46.7%)。结论泌尿生殖道支原体以解脲脲原体多见;对喹诺酮类耐药性高,应根据培养及药敏结果选择抗菌药物。

关键词：泌尿生殖道解脲脲原体人型支原体药物敏感性

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GIS软件共享CAD图块的关键技术

计算机辅助设计与图形学学报 2006年第9期18卷 1460-1464页

作者：陶陶尹轶华陶以欣重庆大学建筑城规学院重庆400045

CAD数据作为GIS的一种主要数据源,转换为GIS格式后将出现图块信息丢失或点要素性质改变等问题.通过解决CAD数据的语义转换、图块库与通用地图符号库的交互以及地图符号多平台显示等关键技术,实现了CAD数据向GIS数据转换过程中图块符号... 详细信息

CAD数据作为GIS的一种主要数据源,转换为GIS格式后将出现图块信息丢失或点要素性质改变等问题.通过解决CAD数据的语义转换、图块库与通用地图符号库的交互以及地图符号多平台显示等关键技术,实现了CAD数据向GIS数据转换过程中图块符号信息的同步迁移和共享.

关键词：图块共享语义转换通用地图符号库地图符号多平台显示

病原宏基因组二代测序在宫颈相关疾病研究中的应用价值探索

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中华微生物学和免疫学杂志 2024年第4期44卷 336-345页

作者：黄佳玲殷怡华徐晓刚复旦大学附属华山医院抗生素研究所上海200040 同济大学附属第一妇婴保健院妇科上海201204

目的探索病原宏基因组二代测序(metagenomic next-generation sequencing,mNGS)在HPV感染、宫颈癌等宫颈相关疾病研究中的潜在价值。方法从6例宫颈癌或癌前病变患者中采集宫颈拭子标本;提取DNA后,分别进行病原mNGS和ⅡB型限制性内切酶相... 详细信息

目的探索病原宏基因组二代测序(metagenomic next-generation sequencing,mNGS)在HPV感染、宫颈癌等宫颈相关疾病研究中的潜在价值。方法从6例宫颈癌或癌前病变患者中采集宫颈拭子标本;提取DNA后,分别进行病原mNGS和ⅡB型限制性内切酶相关DNA位点(2bRAD)测序,比较2种方法的微生物物种定量注释结果、高丰度物种检测能力及14种高危型HPV的检测能力,从而评估病原mNGS的宫颈微生态评价能力。对病原mNGS的宿主基因组数据进行染色体拷贝数变异(copy number variation,CNV)分析,比较临床病理结果与mNGS-CNV结果的一致性。为进一步探究病原mNGS的检测能力,在23例无宫颈疾病和存在不同等级宫颈病变的患者样本中进行初步验证。结果微生物定量注释结果显示,mNGS和2bRAD对于高丰度细菌物种的检出基本一致。对与宫颈癌高度相关的14种高危型HPV的分析结果显示,mNGS获得了与临床微生物实验室常规检测完全一致的结果。对mNGS的人源核酸数据进行CNV分析显示,3例宫颈癌中有1例存在CNV异常。此外,利用病原mNGS对存在宫颈病变和无宫颈病变患者的宫颈拭子进行分析显示,卷曲乳杆菌丰度、CNV阳性率和高危型HPV阳性率在两组患者之间存在差异,普雷沃菌属的某些物种可能与发生高级别病变和宫颈癌的高风险相关。结论病原mNGS作为一种无创且高效的病原微生物检测技术,能通过一次检查同时得到菌群微生态、HPV感染状态及宿主染色体稳定性3方面的信息,从而对健康和宫颈疾病患者进行鉴别,因此有望为HPV感染和宫颈癌筛查和诊断开辟新途径。

关键词：宏基因组二代测序拷贝数变异宫颈癌人乳头瘤病毒

Poly(N-isopropylacrylamide), Poly(methacrylic acid) and Their Copolymers for Oral Colon-specific Drug Delivery

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Journal of Wuhan University of Technology(Materials Science) 2009年第4期24卷 571-574页

作者：高玉香 School of Chemical Engineering Wuhan University of Technology

A series of cross-linked gels of Poly（N-isopropylacrylamide） [P（NIPAAm）] and Poly（methacr-ylic acid）[P（MAA）] homopolymers and P（NIPAAm-co-MAA） random copolymers were synthesized based on NIPAAm and MAA using 4,4-Bis-（methacryloylamino） azobenzene （BMAAB） as a cross-linker. The swelling behavior of these hydrogels in different pH buffer solutions was studied. The influential factors of the gels including composition of NIPAAm and MAA, pH and temperature upon swelling behavior were investigated. The obtained gels not only hold pH and thermometrical sensitivity, but also take on enzymatic sensitivity due to the cross-linker could be degraded by enzymes of colon. Swelling equilibrium degree of copolymers was very low in acidic medium, which could avoid drug releasing due to biggish swelling of carder in stomach. Hydrogels would partly swell owing to higher pH value in small intestine. When arrived in colon, hydrogels completely swelled, meanwhile, azoenzymes located would degrade azo-bonds of polymeric network and then drug released in colon.

关键词： pH sensitivity therrnometrical sensitivity colon-specific