Poly(N-isopropylacrylamide), Poly(methacrylic acid) and Their Copolymers for Oral Colon-specific Drug Delivery

作     者：高玉香 GAO Yuxiang1,JI Xingmin2,YIN Yihua1,DONG Hui1,ZHENG Hua1 (1. School of Chemical Engineering,Wuhan University of Technology,Wuhan 430070,China;2. Department of Pharmaceutical Engineering,Wuhan University of Technology Huaxia College,Wuhan 430223,China)

作者机构：School of Chemical EngineeringWuhan University of Technology 

出 版 物：《Journal of Wuhan University of Technology(Materials Science)》 (武汉理工大学学报（材料科学英文版）)

年 卷 期：2009年第24卷第4期

页      面：571-574页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

主　　题：pH sensitivity therrnometrical sensitivity colon-specific 

摘      要：A series of cross-linked gels of Poly（N-isopropylacrylamide） [P（NIPAAm）] and Poly（methacr-ylic acid）[P（MAA）] homopolymers and P（NIPAAm-co-MAA） random copolymers were synthesized based on NIPAAm and MAA using 4,4-Bis-（methacryloylamino） azobenzene （BMAAB） as a cross-linker. The swelling behavior of these hydrogels in different pH buffer solutions was studied. The influential factors of the gels including composition of NIPAAm and MAA, pH and temperature upon swelling behavior were investigated. The obtained gels not only hold pH and thermometrical sensitivity, but also take on enzymatic sensitivity due to the cross-linker could be degraded by enzymes of colon. Swelling equilibrium degree of copolymers was very low in acidic medium, which could avoid drug releasing due to biggish swelling of carder in stomach. Hydrogels would partly swell owing to higher pH value in small intestine. When arrived in colon, hydrogels completely swelled, meanwhile, azoenzymes located would degrade azo-bonds of polymeric network and then drug released in colon.