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Injectable bone cement with magnesium-containing microspheres enhances osteogenesis via anti-inflammatory immunoregulation

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Bioactive Materials 2021年第10期6卷 3411-3423页

作者： Shenglong Tan Yifan Wang yingying Du yin xiao Shengmin Zhang Advanced Biomaterials and Tissue Engineering Center Huazhong University of Science and TechnologyWuhan430074China Department of Biomedical Engineering Huazhong University of Science and TechnologyWuhan430074China Institute of Regulatory Science for Medical Devices Huazhong University of Science and TechnologyWuhan430074China Institute of Health and Biomedical Innovation Queensland University of TechnologyBrisbane60 Musk AveKelvin GroveBrisbaneQueensland4059Australia Australia-China Centre for Tissue Engineering and Regenerative Medicine Queensland University of Technology60 Musk AveKelvin GroveBrisbaneQueensland4059Australia

Injectable bone cement is especially useful in minimally invasive surgeries to repair small and irregular bone *** different kinds of injectable bone cements,bioactive calcium phosphate bone cement(CPC)has been widely studied due to its biological ***,its dense structure and poor biodegradability prevent the ingrowth of living tissue,which leads to undesirable bone regeneration and clinical *** address this issue,we prepared bone cement based on Magnesium-containing microspheres(MMSs)that can not only be cured into a 3D porous scaffold but also have controllable biodegradability that continuously provides space for desired tissue ***,magnesium ions released from MMSs cement(MMSC)trigger positive immunomodulation via upregulation of the anti-inflammatory genes IL-10 and M2 macrophage polarization with increased expression of CD206,which is beneficial to ***,the physicochemical properties of MMSC,including heat release,rheology and setting time,can be tuned to meet the requirements of injectable bone cement for clinical *** a rat model,we have demonstrated that MMSC promoted osteogenesis via mediation of tissue ingrowth and anti-inflammatory *** study provides a paradigm for the design and preparation of injectable bone cements with 3D porous structures,biodegradability and anti-inflammatory immunoregulation to efficiently promote osteogenesis.

关键词： Injectable bone cement microsphere Mg Immunomodulation Anti-inflammation Osteogenesis

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Mesoporous silica rods with cone shaped pores modulate inflammation and deliver BMP-2 for bone regeneration

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Nano Research 2020年第9期13卷 2323-2331页

作者： Chun Xu Lan xiao Yuxue Cao Yan He Chang Lei yin xiao Wujin Sun Samad Ahadian Xueting Zhou Ali Khademhosseini Qingsong Ye School of Dentistry The University of QueenslandHerstonQLD4006Australia Center for Minimally Invasive Therapeutics(C-MIT) University of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Department of Bioengineering University of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Institute of Health and Biomedical Innovation Queensland University of TechnologyKelvin Grove CampusBrisbane4006Australia School and Hospital of Stomatology Wenzhou Medical Universityy Wenzhou 325035China Department of Oral and Maxillofacial Surgery Massachusetts General Hospital and Harvard School of Dental MedicineBostonMA 02114USA Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQLD 4072t Australia Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Department of Chemical and Biomolecular Engineering University of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Department of Radiological Sciences University of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Terasaki Institute for Biomedical Innovation Los AngelesCA90095USA Present address:Center of Regenerative Medicine Renmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430060China

Biomaterials with suitable osteoimmunomodulation properties and ability to deliver osteoinductive biomolecules,such as bone morphogenetic proteins,are desired for bone ***,we report the development of mesoporous silica rods with large cone-shaped pores(MSR-CP)to load and deliver large protein *** is noted that those cone-shaped pores on the surface modulated the immune response and reduced the pro-inflammatory reaction of stimulated ***,bone morphogenetic proteins 2(BMP-2)loaded MSR-CP facilitated osteogenic differentiation and promoted osteogenesis of bone marrow stromal *** vivo tests confirmed BMP-2 loaded MSR-CP improved the bone regeneration *** study provides a potential strategy for the design of drug delivery systems for bone regeneration.

关键词： mesoporous silica rod bone regeneration cone shaped pores morphogenetic proteins 2(BMP-2)delivery osteoimmunomodulation

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Tectonic-thermal history and hydrocarbon potential of the Pearl River Mouth Basin,northern South China Sea:Insights from borehole apatite fission-track thermochronology

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China Geology 2023年第3期6卷 429-442页

作者： xiao-yin Tang Shu-chun Yang Sheng-biao Hu Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China Key Laboratory of Petroleum Geomechanics China Geological SurveyBeijing 100081China Key Laboratory of Paleomagnetism and Tectonic Reconstruction Ministry of Natural ResourcesBeijing 100081China CNOOC Research Institute Beijing 100028China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China

The Pearl River Mouth Basin(PRMB)is one of the most petroliferous basins on the northern margin of the South China *** of the thermal history of the PRMB is significant for understanding its tectonic evolution and for unraveling its poorly studied source-rock maturation *** investigations in this study are based on apatite fission-track(AFT)thermochronology analysis of 12 cutting samples from 4 *** AFT ages and length data suggested that the PRMB has experienced quite complicated thermal *** history modeling results unraveled four successive events of heating separated by three stages of cooling since the early Middle *** cooling events occurred approximately in the Late Eocene,early Oligocene,and the Late Miocene,possibly attributed to the Zhuqiong II Event,Nanhai Event,and Dongsha Event,*** erosion amount during the first cooling stage is roughly estimated to be about 455-712 m,with an erosion rate of 0.08-0.12 mm/*** second erosion-driven cooling is stronger than the first one,with an erosion amount of about 747-814 m and an erosion rate between about 0.13-0.21 mm/*** erosion amount calculated related to the third cooling event varies from 800 m to 3419 m,which is speculative due to the possible influence of the magmatic activity.

关键词： Oil and gas Hydrocarbon potential Apatite fission-track Tectonic-thermal evolution Thermal history modeling Cooling event Heating event Marine geological survey engineering Erosion amount and rate Oil-gas exploration engineering Pearl River Mouth Basin The South China Sea

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An efficient parallel algorithm of variational nodal method for heterogeneous neutron transport problems

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Nuclear Science and Techniques 2024年第4期35卷 29-45页

作者： Han yin xiao-Jing Liu Teng-Fei Zhang School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 2002040China

The heterogeneous variational nodal method(HVNM)has emerged as a potential approach for solving high-fidelity neutron transport ***,achieving accurate results with HVNM in large-scale problems using high-fidelity models has been challenging due to the prohibitive computational *** paper presents an efficient parallel algorithm tailored for HVNM based on the Message Passing Interface *** algorithm evenly distributes the response matrix sets among processors during the matrix formation process,thus enabling independent construction without *** the formation tasks are completed,a collective operation merges and shares the matrix sets among the *** the solution process,the problem domain is decomposed into subdomains assigned to specific processors,and the red-black Gauss-Seidel iteration is employed within each subdomain to solve the response matrix ***-to-point communication is conducted between adjacent subdomains to exchange data along the *** accuracy and efficiency of the parallel algorithm are verified using the KAIST and JRR-3 test *** results obtained with multiple processors agree well with those obtained from Monte Carlo *** parallelization of HVNM results in eigenvalue errors of 31 pcm/-90 pcm and fission rate RMS errors of 1.22%/0.66%,respectively,for the 3D KAIST problem and the 3D JRR-3 *** addition,the parallel algorithm significantly reduces computation time,with an efficiency of 68.51% using 36 processors in the KAIST problem and 77.14% using 144 processors in the JRR-3 problem.

关键词： Neutron transport Variational nodal method Parallelization KAIST JRR-3

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Hydrothermal Synthesis, Characterization and Photoluminescence Properties of GdOHCO3 Rhombic Microcrystals

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Chemical Research in Chinese Universities 2013年第5期29卷 841-844页

作者： ZHANG You-jin XU Zhen-yu yin xiao-bin HE Hong-mei Department of Chemistry University of Science and Technology of China Hefei 230026 P. R. China

GdOHCO3 rhombic microcrystals were synthesized by hydrothermal method with urea used as the preci- pitator. Experimental parameters, such as the molar ratio of the starting reagents, reaction temperature and reaction time were examined. The as-obtained product was characterized by powder X-ray diffraction（XRD）, field-emission scanning electron microscopy（FESEM）, X-ray photoelectron spectroscopy（XPS）, Fourier transform infrared spec- troscopy（FTIR） and spectrofluorometry. The main reactions to form GdOHCO3 were proposed. In addition, the pho- toluminescence（PL） properties of GdOHCO3 rhombic microcrystals were discussed. The broad band located between 350 nm and 600 nm in the emission spectrum can be attributed to the self-trapped exciton luminescence.

关键词： GdOHCO3 Hydrothermal method Crystal growth Rhombic microcrystal Photoluminescence

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Core-Corona Structure Formed by Hyaluronic Acid and Poly(L-lysine)via Kinetic Path

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Chinese Journal of Polymer Science 2019年第1期37卷 36-42,1-2页

作者： Wei Pan Dong-xiao yin Hai-Rong Jing Hao-Jing Chang Hao Wen De-Hai Liang Beijing National Laboratory for Molecular Sciences and Key Laboratory of Polymer Chemistry and Physics of Ministry of Education College of Chemistry and Molecular Engineering Peking University

The structure and kinetics of the complex formed by hyaluronic acid(HA) and poly(L-lysine)(PLL) were studied by timeresolved laser light scattering, TEM, and AFM. Because HA has a hydrophilic backbone, the complexes formed by HA and PLL are different from those formed by oppositely charged polyelectrolytes both having hydrophobic backbones. Instead of forming strong aggregates and even precipitates, the complex in the presence of excess HA is stable in the studied time period. More importantly, the complex spontaneously forms core-corona structure by the rearrangement of HA chains. The core is composed of complex rich of PLL and the corona is mainly HA. Further analysis shows that the hydrogen bond formed by HA creates a barrier hindering the further relaxation of HA chains. The automatic formation of core-corona structure by PLL/HA is helpful not only to understand the relaxation of polyelectrolyte in complex, but also to develop drug carriers with desirable properties.

关键词： Polyelectrolyte complex Core-corona structure Hyaluronic acid Poly(L-lysine) Laser light scattering

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Analysis of S-SEED’s characteristics in optical switch

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The Journal of China Universities of Posts and Telecommunications 2008年第4期15卷 91-94页

作者： CAO Yong-sheng yin xiao-li XIN Xiang-jun YU Chong-xiu Key Laboratory of Optical Communication and Lightwave Technologies Beijing University of Posts and Telecommunications Ministry of Education Beijing 100876 China

This article introduces the basic structure of a symmetric self-electrooptic effect device （S-SEED）, and applies the Kirchoff＇ s current law and a purely equivalent capacitive model, to analyze S-SEED＇s switch characteristics. Linear approximation and N-segment approximation are utilized to obtain S-SEED＇s voltage-time （V-T） and characteristics. Theoretical analysis is verified by simulations, and the results demonstrate that the precision of S-SEED＇s switch time can satisfy the requirement in applications with linear approximation. Moreover, the simulations compare S-SEED＇s switch characteristics with different input powers and input contrast ratios, which reveal that increasing input contrast ratio is an effective way to improve S-SEED＇s switch characteristics.

关键词： symmetry S-SEED optical switch V-T characteristics characteristic simulations

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Three-dimensional bioprinting collagen/silk fibroin scaffold combined with neural stem cells promotes nerve regeneration after spinal cord injury

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Neural Regeneration Research 2020年第5期15卷 959-968页

作者： Ji-Peng Jiang xiao-yin Liu Fei Zhao Xiang Zhu xiao-yin Li Xue-Gang Niu Zi-Tong Yao Chen Dai Hui-You Xu Ke Ma Xu-Yi Chen Sai Zhang Department of Thoracic Surgery General Hospital of People’s Liberation Army (PLA)BeijingChina Tianjin Key Laboratory of Neurotrauma Repair Institute of Traumatic Brain Injury and NeuroscienceCenter for Neurology and Neurosurgery of Chinese People’s Armed Police Force (PAP) Medical CenterTianjinChina Tianjin Medical University TianjinChina Department of Neurology Luoyang First Hospital of Traditional Chinese MedicineLuoyangHenan ProvinceChina Department of Neurosurgery Fourth Central Hospital of TianjinTianjinChina

Many studies have shown that bio-scaffolds have important value for promoting axonal regeneration of injured spinal ***,cell transplantation and bio-scaffold implantation are considered to be effective methods for neural *** study was designed to fabricate a type of three-dimensional collagen/silk fibroin scaffold (3D-CF) with cavities that simulate the anatomy of normal spinal *** scaffold allows cell growth in vitro and in *** observe the effects of combined transplantation of neural stem cells (NSCs) and 3D-CF on the repair of spinal cord *** Sprague-Dawley rats were divided into four groups: sham (only laminectomy was performed),spinal cord injury (transection injury of T10 spinal cord without any transplantation),3D-CF (3D scaffold was transplanted into the local injured cavity),and 3D-CF + NSCs (3D scaffold co-cultured with NSCs was transplanted into the local injured ***,imaging,hematoxylin-eosin staining,argentaffin staining,immunofluorescence staining,and western blot assay were *** from the sham group,neurological scores were significantly higher in the 3D-CF + NSCs group compared with other ***,latency of the 3D-CF + NSCs group was significantly reduced,while the amplitude was significantly increased in motor evoked potential *** results of magnetic resonance imaging and diffusion tensor imaging showed that both spinal cord continuity and the filling of injury cavity were the best in the 3D-CF + NSCs ***,regenerative axons were abundant and glial scarring was reduced in the 3D-CF + NSCs group compared with other *** results confirm that implantation of 3D-CF combined with NSCs can promote the repair of injured spinal *** study was approved by the Institutional Animal Care and Use Committee of People’s Armed Police Force Medical Center in 2017 (approval No.2017-0007.2).

关键词： 3D bioprinting collagen diffusion tensor imaging functional recovery magnetic resonance imaging nerve regeneration neural regeneration neural stem cell scaffold silk fibroin spinal cord injury

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当代教学的价值偏差及其调整

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教学研究 2024年第1期47卷 33-39页

作者：张鹏飞李雪庆尹小霞西北师范大学教育科学学院甘肃兰州730070 山东师范大学教育学部山东济南250014 山东大学外国语学院山东济南250100

教学既要指向学生人格的发展和完善,也要教授学生适应和改造外部世界的知识和技能,所以教学的价值主要体现在本体性价值和工具性价值辩证统一的动态平衡当中。然而,当代教学对工具性价值的过度张扬导致了本体性价值的迷失,主要表现为:... 详细信息

教学既要指向学生人格的发展和完善,也要教授学生适应和改造外部世界的知识和技能,所以教学的价值主要体现在本体性价值和工具性价值辩证统一的动态平衡当中。然而,当代教学对工具性价值的过度张扬导致了本体性价值的迷失,主要表现为:在教学目标层面,对功利的追逐侵占了伦理性的精神家园;在教学内容层面,对科学事实的推崇导致了人类意义世界的异化;在教学实施层面,对差异的过度关注动摇了共性的中坚地位;在教学评价层面,对个体遭遇的偏重压缩了公共关怀的空间。在市场化日渐加剧的时代,扭转教学工具性价值过度张扬的局面、重拾教学的育人功能具有重要的理论和现实意义,对教师而言,则要深化教学的价值认知,重塑教学的价值结构,并在此基础上激发教学的价值自觉。

关键词：教学价值工具理性价值自觉

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The Non-Singularity and Regularity of GP-Vˊ-Rings

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Journal of Mathematical Research and Exposition 2011年第6期31卷 1003-1008页

作者： xiao Bin yin Rui WANG xiao Long LI College of Mathematics and Computer Science Anhui Normal UniversityAnhui 241000P.R.China

In this paper,we introduce a non-trivial generalization of ZI-rings-quasi ZI-rings.A ring R is called a quasi ZI-ring,if for any non-zero elements a,b ∈ R,ab = 0 implies that there exists a positive integer n such that an = 0 and anRbn = *** non-singularity and regularity of quasi ZI,GP-Vˊ-rings are *** new characterizations of strong regular rings are *** effectively extend some known results.

关键词： GP-Vˊ-rings quasi ZI-rings MELT(MERT)rings weakly regular rings generalized regular rings.

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