Core-Corona Structure Formed by Hyaluronic Acid and Poly(L-lysine)via Kinetic Path

作     者：Wei Pan Dong-Xiao Yin Hai-Rong Jing Hao-Jing Chang Hao Wen De-Hai Liang Wei Pan;Dong-Xiao Yin;Hai-Rong Jing;Hao-Jing Chang;Hao Wen;De-Hai Liang

作者机构：Beijing National Laboratory for Molecular Sciences and Key Laboratory of Polymer Chemistry and Physics of Ministry of Education College of Chemistry and Molecular Engineering Peking University 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2019年第37卷第1期

页      面：36-42,1-2页

核心收录：

学科分类：07[理学] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：financially supported by the National Natural Science Foundation of China (No. 21574002) 

主　　题：Polyelectrolyte complex Core-corona structure Hyaluronic acid Poly(L-lysine) Laser light scattering 

摘      要：The structure and kinetics of the complex formed by hyaluronic acid(HA) and poly(L-lysine)(PLL) were studied by timeresolved laser light scattering, TEM, and AFM. Because HA has a hydrophilic backbone, the complexes formed by HA and PLL are different from those formed by oppositely charged polyelectrolytes both having hydrophobic backbones. Instead of forming strong aggregates and even precipitates, the complex in the presence of excess HA is stable in the studied time period. More importantly, the complex spontaneously forms core-corona structure by the rearrangement of HA chains. The core is composed of complex rich of PLL and the corona is mainly HA. Further analysis shows that the hydrogen bond formed by HA creates a barrier hindering the further relaxation of HA chains. The automatic formation of core-corona structure by PLL/HA is helpful not only to understand the relaxation of polyelectrolyte in complex, but also to develop drug carriers with desirable properties.