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2D organic semiconductors, the future of green nanotechnology

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Nano Materials Science 2019年第4期1卷 246-259页

作者： Guru Prakash Neupane Wendi Ma Tanju Yildirim yilin tang Linglong Zhang Yuerui Lu Research School of Electrical Energy and Materials EngineeringCollege of Engineering and Computer ScienceThe Australian National UniversityCanberraACT2601Australia College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen518052GuangdongChina

The discovery of 2D organic semiconductors of atomically thin structures has attracted great attention due to their emerging optical, electronic, optoelectronic and mechatronic properties. Recent progress in such organic nanostructures has opened new opportunities for engineering material properties in many ways, such as, 0D/1D/2D nanoparticles hybridization, strain engineering, atomic doping etc. Moreover, 2D organic nanostructures exhibit a unique feature of bio–functionality and are highly sensitive to bio-analytes. Such peculiar behavior in 2D organics can be utilized to design highly-efficient bio-sensors. Also, a bio-molecular integrated electronic/optoelectronic device with enhanced performance can be attained. Furthermore, the bio-degradable, biocompatible, biometabolizable, non-toxic behaviour and natural origin of organic nanomaterials can address the current ecological concerns of increasing inorganic material based electronic waste. This review highlights the benefits of 2D organic semiconductors. Considering the importance of strategic techniques for growing thin 2D organic layers,this review summarizes progress towards this direction. The possible challenges for long-time stability and future research directions in 2D organic nano electronics/optoelectronics are also discussed. We believe that this review article provides immense research interests in organic 2D nanotechnology for exploiting green technologies in the future.

关键词： 2D organic semiconductor Green nanotechnology OTFTs OLEDs Photo-diodes Organic solar cell Optical wave guide

A prospective future towards bio/medical technology and bioelectronics based on 2D vdWs heterostructures

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Nano Research 2020年第1期13卷 1-17页

作者： Guru Prakash Neupane Linglong Zhang Tanju Yildirim Kai Zhou Bowen Wang yilin tang Wendi Ma Yunzhou Xue Yuerui Lu Research School of Electrical Energy and Materials EngineeringCollege of Engineering and Computer ScienceThe Australian National UniversityCanberraACT2601Australia College of Mechatronics and Control Engineering Shenzhen University Nan-hai Ave 3688Shenzhen518060China College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen518052China

Nano-biotechnology research has become extremely important due to the possibilities in manipulation and characterization of biological molecules through *** exhibit exciting electrical,optoelectronic,magnetic,mechanical and chemical properties that can be exploited to develop efficient biosensors or *** unique properties in nanomaterials can also be used in bioimaging and cancer therapeutics,where biomolecules influence the inherent properties in *** manipulation of nanomaterial properties can lead to many breakthroughs in nanotechnology ***,2D nanomaterials have emerged as viable materials for *** cross-section area and functional availability of 2D or 1D quantum limit in these nanomaterials allow greater flexibility and better nanodevice performance.2D nanomaterials enable advanced bioelectronics to be more easily integrated due to their atomic thickness,biocompatibility,mechanical flexibility and ***,with the development of 2D material heterostructures,enhanced material properties can be obtained which can directly influence bio-nanotechnology *** article firstly reviews the development of various types of 2D heterostructures in a wide variety of nano-biotechnology ***,future 2D heterostructure scopes in bioimaging,nanomedicine,bio-markers/therapy and bioelectronics are *** paper can be an avenue for providing a wide scope for 2D van der Waals(vdWs)heterostructures in bio-and medical fields.

关键词： hwo-dimensional(2D)nanomaterials heterostructures bioimaging nano-medicine nano-bio-electronics wearable 2D nanotechnology

Deep Clinical Phenotyping of Parkinson’s Disease: Towards a New Era of Research and Clinical Care

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Phenomics 2022年第5期2卷 349-361页

作者： Zhiheng Xu Bo Shen yilin tang Jianjun Wu Jian Wang Department of Neurology and National Research Center for Aging and Medicine&National Center for Neurological Disorders State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghai 200040China

Despite recent advances in technology,clinical phenotyping of Parkinson’s disease(PD)has remained relatively limited as current assessments are mainly based on empirical observation and subjective categorical judgment at the clinic.A lack of comprehensive,objective,and quantifiable clinical phenotyping data has hindered our capacity to diagnose,assess patients’conditions,discover pathogenesis,identify preclinical stages and clinical subtypes,and evaluate new ***,deep clinical phenotyping of PD patients is a necessary step towards understanding PD pathology and improving clinical *** this review,we present a growing community consensus and perspective on how to clinically phenotype this disease,that is,to phenotype the entire course of disease progression by integrating capacity,performance,and perception approaches with state-of-the-art *** also explore the most studied aspects of PD deep clinical phenotypes,namely,bradykinesia,tremor,dyskinesia and motor fluctuation,gait impairment,speech impairment,and non-motor phenotypes.

关键词： Parkinson’s disease Deep phenotyping Motor symptoms Non-motor symptoms

Preparation of highly stable diclofenac potassium pellet with microcrystalline cellulose by extrusionespheronization

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Asian Journal of Pharmaceutical Sciences 2013年第6期8卷 356-361页

作者： Yueqi Wang Hao Huang Chungang Zhang yilin tang Jinzhuo Li Xing tang Cuifang Cai Shenyang Pharmaceutical University No.103Wenhua RoadShenyang 110016China School of Materials Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China Department of Pharmaceutics College of PharmacyJilin UniversityChangchun 130021China

The main purpose of this study is to prepare highly stable diclofenac potassium(DP)pellet with microcrystalline cellulose(MCC)by *** MCC,DP pellets were prepared and the stability was *** compounds of DP pellets were analyzed by High Pressure Liquid Chromatography(HPLC).After stability test of 60℃/75%RH for 10 d,the values of two main related compounds were 0.94%and 2.17%,*** tests show that instability of DP was mainly caused by *** improve the stability of DP in presence of MCC,different kinds of stabilizers were *** addition of 1.5%(w/w)sodium hydroxide,the primary related compound of pellets was reduced to be 0.159%after stability test of 60℃/75%RH for 50 *** study demonstrated that MCC induced decomposition of DP upon exposure to moisture could be prohibited by addition of sodium *** mechanisms were discussed and residual hydroxyl free radicals in excipients were responsible for decomposition of ***,this formulation of DP is highly stable with sustained-release behavior.

关键词： Compatibility Microcrystalline cellulose Diclofenac potassium Pellets Stability

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战术互联网网络一体化关键技术研究

计算机工程 2006年第8期32卷 150-152,197页

作者：袁云权汤国建汤益林国防科学技术大学航天科学与材料工程学院长沙410073 第2炮兵装备研究院北京100085

根据战术互联网的一体化需求,对战术互联网路由协议体系,服务质量(QoS)控制和QoS路由问题展开研究。针对战术互联网的分布式体系结构,提出了基于链路反转的区域路由协议;根据服务质量控制中业务需求和网络资源同时动态变化的特点,引入... 详细信息

根据战术互联网的一体化需求,对战术互联网路由协议体系,服务质量(QoS)控制和QoS路由问题展开研究。针对战术互联网的分布式体系结构,提出了基于链路反转的区域路由协议;根据服务质量控制中业务需求和网络资源同时动态变化的特点,引入自适应控制模型,设计了自适应QoS控制的基本模型和实现框架;通过分析QoS路由面临的主要问题,结合链路反转和遗传算法的基本思想,提出了分布式遗传算法QoS路由协议。

关键词：战术互联网链路反转自适应 QoS控制分布式遗传算法

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基于模糊控制的脉冲功率源放电时序控制研究

火炮发射与控制学报 2021年第3期42卷 23-29页

作者：唐一林栗保明南京理工大学瞬态物理国家重点实验室江苏南京210094

为了实现多参数电源模块的脉冲成形网络输出电流的稳定性与可控性,设计了一种基于模糊控制的电源时序触发控制系统。根据发射过程中电枢状态的非线性特征,建立电磁发射系统电路模型和动力学模型,并设计模糊控制器与控制指令处理与分配... 详细信息

为了实现多参数电源模块的脉冲成形网络输出电流的稳定性与可控性,设计了一种基于模糊控制的电源时序触发控制系统。根据发射过程中电枢状态的非线性特征,建立电磁发射系统电路模型和动力学模型,并设计模糊控制器与控制指令处理与分配系统。建立一个由20个脉冲功率源模块组成的电磁发射系统仿真程序,验证上述系统的可行性。结果表明,模糊控制理论的引入可以准确控制脉冲功率源模块放电时序,使脉冲成形网络输出电流跟踪设定电流波形。

关键词：电磁轨道炮脉冲成形网络脉冲功率源模糊控制时序控制

MicroRNA 29 familyand Parkinson’s disease

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MicroRNA 29 familyand Parkinson’s disease

长三角地区神经科学论坛2016暨第八次会员代表大会

作者： Xiaochen Bai yilin tang Mei Yu Lei Wu Fengtao Liu Zishan Wang Jinghui Wang Jian Wang 黄芳 The State Key Laboratory of Medical Neurobiology and the Institutes of Brain Science Shanghai Medical College Fudan University Department of Neurology Huashan Hospital Fudan University

＜正＞Parkinson’s disease is the second most common neurodegenerative disease,characterized by the progressive loss of dopaminergic neurons in the substantia nigra of the *** is still a lack of effective diagnosis and treatments for *** RNAs have been proved to play an important role in PD *** RNA29 family（mi R-29s）is including two gene clusters:mi R-29a/b1 and mi R-29b2/c,which

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基于MDA架构的软件开发方法研究

科技广场 2008年第7期 160-162页

作者：唐伊林长沙南方职业学院湖南长沙410208

传统的软件产业存在着许多问题。其表现为开发效率不高,常常会因为各种问题而使项目超期,经过长时间开发出来的信息系统也存在的质量问题,通常需要耗费大量的人力去进行后期的维护。由于这些原因,所以软件开发成本也往往是大大超出预期... 详细信息

传统的软件产业存在着许多问题。其表现为开发效率不高,常常会因为各种问题而使项目超期,经过长时间开发出来的信息系统也存在的质量问题,通常需要耗费大量的人力去进行后期的维护。由于这些原因,所以软件开发成本也往往是大大超出预期,很多情况下公司不得不放弃那些最终成本代价过高的项目,或者是减弱其原先设计的功能来节约成本。虽然目前软件业经过几次软件危机之后,先后提出了基于软件工程的开发方法和许多被验证为成功的设计模式和框架。然而这些并没有从根本上解决现今软件业面临的问题。模型驱动架构(model driven architecture)就是在这样的大背景下被提出的一种新型软件开发方法。本文将结合具体的应用对MDA开发方法进行探讨。

关键词：软件危机设计模式 MDA

低强度超声联合骨髓间充质干细胞缩短大鼠皮肤愈合增殖期的研究

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中国超声医学杂志 2022年第4期38卷 449-453页

作者：许豪鹏唐义林夏怡唐文韬王嫣重庆医科大学生物医学工程学院超声医学工程国家重点实验室

目的探究低强度超声（LIUS）联合骨髓间充质干细胞（BMSCs）对大鼠皮肤创伤增殖期的作用及机制。方法在大鼠背部剪出直径为2 cm的圆形伤口建立全层皮肤切除模型，设置LIUS组（0.2 W/cm;, 20 min/d, 7 d）、BMSCs组、LIUS+BMSCs组和对... 详细信息

目的探究低强度超声（LIUS）联合骨髓间充质干细胞（BMSCs）对大鼠皮肤创伤增殖期的作用及机制。方法在大鼠背部剪出直径为2 cm的圆形伤口建立全层皮肤切除模型，设置LIUS组（0.2 W/cm;, 20 min/d, 7 d）、BMSCs组、LIUS+BMSCs组和对照组。观察大鼠皮肤创伤愈合情况并通过Image J计算皮肤创伤愈合率；HE染色观察3 d和7 d大鼠皮肤创面组织病理变化情况；ELISA检测大鼠血清0、3、7、14和28 d基质细胞衍生因子（SDF-1）、肿瘤坏死因子（TNF-α）、血小板衍生生长因子（PDGF）的含量。结果与其他组相比，LIUS+BMSCs组能够提高大鼠皮肤创伤愈合速度；3 d时可见肉芽组织开始形成，7 d时LIUS+BMSCs组肉芽组织中新生血管明显，有统计学意义（P<0.05）;大鼠血清中TNF-α和PDGF含量呈先上升后下降趋势，SDF-1含量呈下降趋势，与其他组相比，LIUS+BMSCs组在第3天和第7天都存在统计学意义（P<0.05）。结论 LIUS联合BMSCs能够缩短大鼠皮肤愈合增殖期，其机制可能是影响了皮肤愈合有关的细胞因子分泌和合成。

关键词：低强度超声骨髓间充质干细胞皮肤创伤愈合细胞因子