Deep Clinical Phenotyping of Parkinson’s Disease: Towards a New Era of Research and Clinical Care
作者机构：Department of Neurology and National Research Center for Aging and Medicine&National Center for Neurological DisordersState Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghai 200040China
出 版 物：《Phenomics》 (表型组学（英文）)
年 卷 期：2022年第2卷第5期
页 面：349-361页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：JW received research funding from Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01,and 21S31902200) ZJ Lab,Shanghai Center for Brain Science and Brain-Inspired Technology,and the National Nature Science Foundation of China(grant numbers:82171421,91949118 and 81771372)
主 题：Parkinson’s disease Deep phenotyping Motor symptoms Non-motor symptoms
摘 要：Despite recent advances in technology,clinical phenotyping of Parkinson’s disease(PD)has remained relatively limited as current assessments are mainly based on empirical observation and subjective categorical judgment at the clinic.A lack of comprehensive,objective,and quantifiable clinical phenotyping data has hindered our capacity to diagnose,assess patients’conditions,discover pathogenesis,identify preclinical stages and clinical subtypes,and evaluate new ***,deep clinical phenotyping of PD patients is a necessary step towards understanding PD pathology and improving clinical *** this review,we present a growing community consensus and perspective on how to clinically phenotype this disease,that is,to phenotype the entire course of disease progression by integrating capacity,performance,and perception approaches with state-of-the-art *** also explore the most studied aspects of PD deep clinical phenotypes,namely,bradykinesia,tremor,dyskinesia and motor fluctuation,gait impairment,speech impairment,and non-motor phenotypes.
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