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妊娠晚期抗病毒治疗预防乙型肝炎病毒母婴传播：利还是弊？

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中华妇产科杂志 2017年第2期52卷 82-85页

作者：周乙华胡娅莉南京大学医学院附属鼓楼医院感染病科 210008 南京大学医学院附属鼓楼医院妇产科 210008

预防乙型肝炎病毒（hepatitis B virus,HBV）母婴传播是控制慢性乙型肝炎的关键.目前,我国对所有新生儿均免费接种乙型肝炎疫苗,并对HBsAg阳性孕妇分娩的新生儿在出生12 h内免费注射100 U乙型肝炎免疫球蛋白（hepatitis B immunoglobuli... 详细信息

预防乙型肝炎病毒（hepatitis B virus,HBV）母婴传播是控制慢性乙型肝炎的关键.目前,我国对所有新生儿均免费接种乙型肝炎疫苗,并对HBsAg阳性孕妇分娩的新生儿在出生12 h内免费注射100 U乙型肝炎免疫球蛋白（hepatitis B immunoglobulin, HBIG）[1],但仍存在着预防失败,主要原因是母体高病毒载量,即HBV DNA≥106拷贝/ml.最近,孕晚期口服抗HBV药物以减少母婴传播成为研究热点,现对相关问题论述如下.

关键词：乙型肝炎病毒母婴传播抗病毒治疗预防妊娠晚期 HBsAg阳性孕妇乙型肝炎免疫球蛋白抗HBV药物

Phenylpropanoid Derivatives Are Essential Components of Sporopollenin in Vascular Plants

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Molecular Plant 2020年第11期13卷 1644-1653页

作者： Jinp-Shi Xue Baocai Zhang HuaDong Zhan Yong-Lin Lv Xin-Lei Jia TianHua Wang Nai-Ying Yang Yu-Xia Lou Zai-Bao Zhang Wen-Jing Hu Jinshan Gui Jianguo Cao Ping Xu yihua zhou Jin-Feng Hu Laigeng Li Zhong-Nan Yang Shanghai Key Laboratory of Plant Molecular Sciences College of Life SciencesShanghai Normal UniversityShanghai 200234China National Key Laboratory of Plant Molecular Genetics&CAS Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and EcologyChinese Academy of SciencesBeijing 200032China State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Crop Genetics and Germplasm Enhancement College of AgricultureNanjing Agricultural UniversityNanjing 210095China College of Life Science Xinyang Normal UniversityXinyangHenan 464000China Department of Natural Products Chemistry School of PharmacyFudan UniversityNo.826 Zhangheng RoadShanghai201203China

The outer wall of pollen and spores,namely the exine,is composed of sporopollenin,which is highly resistant to chemical reagents and *** this study,we demonstrated that phenylpropanoid pathway derivatives are essential components of sporopollenin in seed *** analyses showed that the autofluorescence of Lilium and Arabidopsis sporopollenin is similar to that of *** and NMR analyses of pollen from Lilium and Cryptomeria further revealed that the sporopollenin of seed plants contains phenylpropanoid derivatives,including p-hydroxybenzoate(p-BA),p-coumarate(p-CA),ferulate(FA),and lignin guaiacyl(G)*** phenylpropanoid pathway is expressed in the tapetum in Arabidopsis,consistent with the fact that the sporopollenin precursor originates from the *** germination and comet assays showed that this pathway plays an important role in protection of pollen against UV *** the pteridophyte plant species Ophioglossum vulgatum and Lycopodium clavata,phenylpropanoid derivatives including p-BA and p-CA were also detected,but G units were *** together,our results indicate that phenylpropanoid derivatives are essential for sporopollenin synthesis in vascular *** addition,sporopollenin autofluorescence spectra of bryophytes,such as Physcomitrella and Haplocladium,exhibit distinct characteristics compared with those of vascular plants,indicating the diversity of sporopollenin among land plants.

关键词： sporopollenin pollen cell wall phenylpropanoid pathway

如何根据特异性IgM和IgG评价新型冠状病毒宫内垂直传播

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中华围产医学杂志 2020年第4期23卷 217-219页

作者：王晨周乙华杨慧霞北京大学第一医院妇产科 100034 南京大学医学院附属鼓楼医院感染疾病科 210008

新型冠状病毒能否通过宫内垂直传播感染胎儿是关注的焦点,而如何正确评价新型冠状病毒是否存在宫内垂直传播,更是问题的关键所在。病毒学和血清学证据对诊断病毒宫内垂直传播都有价值。单纯将血清学结果用于确定新型冠状病毒宫内传播时... 详细信息

新型冠状病毒能否通过宫内垂直传播感染胎儿是关注的焦点,而如何正确评价新型冠状病毒是否存在宫内垂直传播,更是问题的关键所在。病毒学和血清学证据对诊断病毒宫内垂直传播都有价值。单纯将血清学结果用于确定新型冠状病毒宫内传播时,应至少对新生儿随访3~6个月,动态观察IgM和IgG滴度变化,同时随访其母亲,与母亲特异性抗体的滴度进行比较。

关键词：冠状病毒感染传染性疾病传播,垂直免疫球蛋白M 免疫球蛋白G

对中国乙型肝炎病毒母婴传播防治指南(2019年版)的商榷

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中华肝脏病杂志 2020年第1期28卷 24-26页

作者：周乙华李彤庄辉南京大学医学院附属鼓楼医院感染科南京210008 北京大学基础医学院病原生物学系和感染病研究中心北京100191

中华医学会感染病学分会和GRADE中国中心最近发布了《中国乙型肝炎病毒母婴传播防治指南(2019年版)》。该指南存在参考文献引用不当,对预防乙型肝炎病毒母婴传播的部分关键策略缺乏推荐意见,部分推荐意见证据不足或缺乏证据等问题。本... 详细信息

中华医学会感染病学分会和GRADE中国中心最近发布了《中国乙型肝炎病毒母婴传播防治指南(2019年版)》。该指南存在参考文献引用不当,对预防乙型肝炎病毒母婴传播的部分关键策略缺乏推荐意见,部分推荐意见证据不足或缺乏证据等问题。本着学术争鸣原则,现对该指南提出一些管见,愿与作者和读者商榷。

关键词：肝炎病毒,乙型肝炎疫苗,乙型抗病毒药母婴传播阻断乙型肝炎免疫球蛋白

ATAT1 deficiency enhances microglia/macrophage-mediated erythrophagocytosis and hematoma absorption following intracerebral hemorrhage

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Neural Regeneration Research 2024年第5期19卷 1072-1077页

作者： yihua Zhang Ping Huang Min Cao Yi Chen Xinhu Zhao Xuzhi He Lunshan Xu Department of Neurosurgery Daping HospitalArmy Medical UniversityChongqingChina

MIcroglia/macrophage-mediated erythrophagocytosis plays a crucial role in hematoma clearance after intracerebral *** cytoskeletal changes accompany ***,whether and how these changes are associated with microglia/macrophage-mediated erythrophagocytosis remain *** this study,we investigated the function of acetylatedα-tubulin,a stabilized microtubule form,in microglia/macrophage erythrophagocytosis after intracerebral hemorrhage both in vitro and in *** first assessed the function of acetylatedα-tubulin in erythrophagocytosis using primary DiO GFP-labeled red blood cells co-cultured with the BV2 microglia or RAW264.7 macrophage cell ***α-tubulin expression was significantly decreased in BV2 and RAW264.7 cells during ***,silencingα-tubulin acetyltransferase 1(ATAT1),a newly discoveredα-tubulin acetyltransferase,decreased Ac-α-tub levels and enhanced the erythrophagocytosis by BV2 and RAW264.7 *** with these findings,in ATAT1-/-mice,we observed increased ionized calcium binding adapter molecule 1(Iba1)and Perls-positive microglia/macrophage phagocytes of red blood cells in peri-hematoma and reduced hematoma volume in mice with intracerebral ***,knocking out ATAT1 alleviated neuronal apoptosis and pro-inflammatory cytokines and increased anti-inflammatory cytokines around the hematoma,ultimately improving neurological recovery of mice after intracerebral *** findings suggest that ATAT1 deficiency accelerates erythrophagocytosis by microglia/macrophages and hematoma absorption after intracerebral *** results provide novel insights into the mechanisms of hematoma clearance and suggest ATAT1 as a potential target for the treatment of intracerebral hemorrhage.

关键词： acetylatedα-tubulin α-tubulin acetyltransferase 1(ATAT1) erythrophagocytosis hematoma absorption intracerebral hemorrhage macrophage microglia

Lightweight Intrusion Detection Using Reservoir Computing

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Computers, Materials & Continua 2024年第1期78卷 1345-1361页

作者： Jiarui Deng Wuqiang Shen yihua Feng Guosheng Lu Guiquan Shen Lei Cui Shanxiang Lyu Joint Laboratory on Cyberspace Security China Southern Power GridGuangzhou510080China College of Cyber Security Jinan UniversityGuangzhou510632China Guangdong Power Grid Company Limited Guangzhou510663China School of Computer Science and Technology Guangdong University of TechnologyGuangzhou510006China China Southern Power Grid Extra High Voltage Transmission CompanyGuangzhouChina

The blockchain-empowered Internet of Vehicles(IoV)enables various services and achieves data security and privacy,significantly advancing modern vehicle ***,the increased frequency of data transmission and complex network connections among nodes also make them more susceptible to adversarial *** a result,an efficient intrusion detection system(IDS)becomes crucial for securing the IoV *** IDSs based on convolutional neural networks(CNN)often suffer from high training time and storage *** this paper,we propose a lightweight IDS solution to protect IoV against both intra-vehicle and external *** approach achieves superior performance,as demonstrated by key metrics such as accuracy and ***,our method achieves accuracy rates ranging from 99.08% to 100% on the Car-Hacking dataset,with a remarkably short training time.

关键词： Echo state network intrusion detection system Internet of Vehicles reservoir computing

The Cellulose Synthases Are Cargo of the TPLATE Adaptor Complex

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Molecular Plant 2018年第2期11卷 346-349页

作者： Clara Sanchez-Rodriguez Yanyun Shi Christopher Kesten Dongmei Zhang Gloria Sancho-Andres Alexander Ivakov Edwin R. Lampugnani Kamil Sklodowski Masaru Fujimoto Akihiko Nakano Antony Bacic Ian S. Wallace Takashi Ueda Daniel Van Damme yihua zhou Staffan Persson Max-Planck-lnstitute for Molecular Plant Physiology Am Muehlenberg 1 14476 Potsdam Germany Department of Biology ETH Zurich 8092 Zurich Switzerland State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China School of Biosciences University of Melbourne Parkvine 3010 VIC Australia ARC Centre of Excellence for Translational Photosynthesis Research School of Biology Australian National University GPO Box 475 Canberra ACT 2601 Australia Department of Biological Sciences Graduate School of Science The University of Tokyo Hongo Bunkyo-ku Tokyo 113-0033 Japan Live Cell Super-resolution Imaging Research Team RIKEN Center for Advances Photonics Hirosawa Wako Saitama 351-0198 Japan ARC Centre of Excellence in Plant Cell Walls School of Biosciences University of Melbourne Parkville 3010 VIC Australia Department of Biochemistry and Molecular Biology University of Nevada Reno NV 89557 USA Division of Cellular Dynamics National Institute for Basic Biology Okazaki Aichi 444-8585 Japan Department of Plant Biotechnology and Bioinformatics Ghent University 9052 Gent Belgium Center for Plant Systems Biology VIB Technologiepark 927 9052 Gent Belgium present address: Laboratory of Plant Molecular Genetics Graduate School of Agricultural and Life Sciences The University of Tokyo 1-1-1 Yayoi Bunkyo-ku Tokyo 113-8657 Japan

Dear Editor Clathrin-mediated endocytosis （CME） is an evolutionary conserved mechanism by which plasma membrane （PM）-based cargo proteins are recognized by adaptor protein complexes and internalized. Apart from the canonical adaptor complex, AP-2, plant cells rely on the TPLATE complex （TPC） to execute CME （Gadeyne et al., 2014）. FT160100218, DP110100410）, the Ministry of Education, Culture, Sports, Science, and Technology of Japan （24114003, 15H04382, and 17K19412）, the European Research Council （ERC grant 682436）, the IRRTF-RNC （no. 501892） and a USA National Science Foundation CAREER Award.

关键词： CLATHRIN-MEDIATED ENDOCYTOSIS ARABIDOPSIS MEMBRANE

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反安装凸轮对综框运动规律的影响

天津纺织工学院学报 1998年第4期17卷 70-73,103页

作者：周贻华南通市职业大学

本文对无梭织机开口凸轮反安装后从动件运动规律进行了理论分析．文中指出这种安装方式对织机织造性能、机械性能所产生的影响。

关键词：凸轮反安装运动规律无梭织机综框运动

Introduction of pokeweed antiviral protein cDNA into Brassica napus and acquisition of transgenic plants resistant to viruses

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Chinese Science Bulletin 1999年第8期44卷 701-704页

作者： ZHANG Haiyan , TIAN Yingchuan , zhou yihua , DANG Benyuan LAN Haiyan , SONG Guiying , WANG Lanlan , LIU Guizhen , ZHANG Lihua and CHEN ZhenghuaInstitute of Genetics , Chinese Academy of Sciences , Beijing 100101, China Institute of Microbiology , Chinese Academy of Sciences , Beijing 100080, China Institute of Genetics Chinese Academy of Sciences Beijing China Institute of Microbiology Chinese Academy of Sciences Beijing China

Using cotyledonary petioles as explants, the PAP cDNA controlled by wound-in-ducible promoter has been introduced into Brassica napus by coculture with Agrobacterium tumefaciens and laser microbeam puncture respectively. Regenerated plants resistant to gen-tamycin have been selected out. PCR amplification and Southern blotting analysis indicated that PAP cDNA together with wound-inducible promoter had been integrated into Brassica genome with transformation frequencies of 2.0% and 1.7% for two transformation methods respectively. The test of virus challenge showed that these transgenic Brassica plants were resistant in different degrees to mechanically inoculated TuMV.

关键词： pokeweed antiviral protein cDNA wound-inducible promoter Agrobacterium tumefaciens laser microbeam puncture.