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Promising application of a new ulnar nerve compound muscle action potential measurement montage in amyotrophic lateral sclerosis:a prospective cross-sectional study

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Neural Regeneration Research 2023年第4期18卷 908-912页

作者： yi-xuan zhang Jing-Yue Ma Xiang-yi Liu Shuo zhang Zhou Yu Dong-Sheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Previous studies have shown that ulnar nerve compound muscle action potential recorded by the conventional“belly-tendon”montage does not accurately and completely reflect the action potential of the ulnar nerve dominating the abductor digiti minimi muscle due to the effects of far-field potentials of intrinsic hand muscles.A new method of ulnar nerve compound muscle action potential measurement was developed in 2020,which adjusts the E2 electrode from the distal tendon of the abductor digitorum to the middle of the back of the proximal *** new method may reduce the influence of the reference electrode and better reflect the actual ulnar nerve compound muscle action *** this prospective cross-sectional study,we included 64 patients with amyotrophic lateral sclerosis and 64 age-and sex-matched controls who underwent conventional and novel ulnar nerve compound muscle action potential measurement between April 2020 and May 2021 in Peking University Third *** compound muscle action potential waveforms recorded by the new montage were unimodal and more uniform than those recorded by traditional *** the controls,no significant difference in the compound muscle action potential waveforms was found between the traditional montage and new montage *** amyotrophic lateral sclerosis patients presenting with abductor digiti minimi spontaneous activity and muscular atrophy,the amplitude of compound muscle action potential-pE2 was significantly lower than that of compound muscle action potential-dE2(P<0.01).Using the new method,damaged axons were more likely to exhibit more severe amplitude decreases than those measured with the traditional method,in particular for patients in early stage amyotrophic lateral *** addition,the decline in compound muscle action potential amplitude measured by the new method was correlated with a decrease in Revised Amyotrophic Lateral Sclerosis Functional Rating Scale *** findings suggest tha

关键词： amyotrophic lateral sclerosis axonal degeneration biomarker compound muscle action potential distal E2 electrode early diagnosis far field potential nerve electrophysiology prognosis evaluation proximal E2 electrode ulnar motor nerve conduction

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Allelochemicals of Panax notoginseng and their effects on various plants and rhizosphere microorganisms

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Plant Diversity 2020年第5期42卷 323-333页

作者： yi-Jun Qiao Cheng-Zhen Gu Hong-Tao Zhu Dong Wang Meng-Yue zhang yi-xuan zhang Chong-Ren Yang ying-Jun zhang State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming650204China University of Chinese Academy of Sciences Beijing100049China Fujian Agriculture and Forestry University Fuzhou350002China School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang110016China Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming Institute of BotanyChinese Academy of SciencesKunming650201China

Panax notoginseng(Araliaceae)is an important ginseng herb with various health benefits and a history of cultivation in southwestern China over 400 *** recent years?.notoginseng has faced serious continuous-cropping obstacles due to its large-scale *** this study,we aim to explore the allelochemicals of *** and their interactions with various plants and rhizosphere *** chemical constituents of the soil cultivated with 3-year-old *** were studied by column chromatography,spectroscopic and GC-MS *** identified 13 volatile components and isolated six triterpenes(1-4,6-7)and one anthraquinone(5).Compounds 1-7 were tested for their effects on seed germination and root elongation in ***,corn,wheat,turnip,water spinach and Arabidopsis *** also examined the effect of compounds 1-7on the growth of ten rhizosphere microorganisms of *** a concentration of 1.0 ug mL',compounds 3 and 5-7 caused the death of *** root cells and compounds 2,6 and 7 induced the death of root cells of *** 1-5and 7 inhibited elongation of *** root tip cells at a concentration of 10.0μg mL^-***,at a concentration of 0.1 mg mL^-1,compounds 3,4,6 and 7 inhibited the growth of probiotics and promoted the growth of pathogens of *** results suggest that these isolated ursane-type triterpenoid acids and anthraquinone are potential allelochemicals that contribute to continuous-cropping obstacles of ***.

关键词： Panax notoginseng Continuous cropping obstacle Allelochemical Triterpenes Anthraquinone

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Pulmonary hypertension,nephrotic syndrome,and polymyositis due to hepatitis C virus infection:A case report

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World Journal of Gastroenterology 2023年第19期29卷 3040-3047页

作者： Ya-Nan Zhao Guo-Hui Liu Chang Wang yi-xuan zhang Ping Yang Ming Yu Department of Cardiology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

BACKGROUND Hepatitis C infection not only damages the liver but also often accompanies many extrahepatic *** of pulmonary hypertension(PH)caused by hepatitis C are rare,and incidences of concurrent nephrotic syndrome and polymyositis are even *** SUMMARY Herein we describe the case of a 57-year-old woman who was admitted to our department for intermittent chest tightness upon exertion for 5 years,aggravated with dyspnea for 10 *** relevant examinations she was diagnosed with PH,nephrotic syndrome,and polymyositis due to chronic hepatitis C infection.A multi-disciplinary recommendation was that the patient should be treated with sildenafil and macitentan in combination and *** treatment autoimmune symptoms,liver function,hepatitis C RNA levels,and cardiac parameters of right heart catheterization were monitored *** patient showed significant improvement in 6-min walking distance from 100 to 300 m at 3-mo follow-up and pulmonary artery pressure drops to 50 ***-term follow-up is needed to confirm further efficacy and *** Increasing evidence supports a relationship between hepatitis C infection and diverse extrahepatic manifestations,but it is very rare to have PH,nephrotic syndrome,and polymyositis in a single *** conducted a literature review on the management of several specific extrahepatic manifestations of hepatitis C.

关键词： Hepatitis C Nephrotic syndrome Polymyositis Pulmonary hypertension Case report

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Lactobacillus plantarum and quercetin synergistically ameliorate hyperuricemia through targeting multiple pathways

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Food Science and Human Wellness 2024年

作者： Lin-Yan Zhu Meng-Yue zhang Juan-Cheng yi-xuan zhang School of Life Science and Biopharmaceutics， Shenyang Pharmaceutical University

Hyperuricemia is a prevalent metabolic disorder resulting from dysregulation of purine metabolism， often accompanied by inflammation. It is characterized by an abnormal elevation in uric acid levels. In our investigation， the combined treatment with Lactobacillus plantarum DY1 and quercetin suppressed the activity of xanthine oxidase and adenosine deaminase， decreased the levels of uric acid， TNF-α and IL-β， downregulated gene expression of URAT1 and GLUT9， and upregulated OAT1 and ABCG2. The combination increased the abundance of Lactobacillus and decreased the abundance of norank＿f＿norank＿o＿Clostridia＿UCG-014 and Roseburia. Metabolomics analysis revealed that the combination of probiotics and quercetin exhibited distinct metabolic pathways compared to their individual administrations. When compared to probiotics alone， the combination led to alterations in glutathione metabolism (oxidized glutathione and glutathione) as well as sphingolipid metabolism (sphingosine and sphinganine). When compared to quercetin alone， the combination resulted in variations in tryptophan metabolism (indole-3-acetamide， 5-hydroxy-L-tryptophan， indoleacetaldehyde， 3-(3-Indolyl)-2-oxopropanoic acid， 3-indoleacetic acid and 3-methylindole) along with purine metabolism (UA， xanthosine， cAMP， ADP and adenosine monophosphate). The subsequent fecal microbiota transplantation proved that the effect of the combination on reducing uric acid levels was mediated by the gut microbiota. Therefore， this new combination can be considered a promising adjuvant therapy capable of synergistically alleviating hyperuricemia.

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Striatal CDK5 Regulates Cholinergic Neuron Activation and Dyskinesia-like Behaviors through BK Channels

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Research 2023年第4期2023卷 739-753页

作者： Chu Tong Peng-Xiang Min Qian zhang Ru-Xin Gu Yao-Hai Wen yi Shi Yu-Huan Bao Xiang Chen yi-xuan zhang Xing-Feng Mao Hao-Yang Yuan Xiu-Xiu Liu Takuya Sasaki Li zhang Feng Han ying-Mei Lu Department of Physiology School of Basic Medical SciencesNanjing Medical UniversityNanjing211166China International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical UniversityNanjing211166China Department of Geriatrics Nanjing Brain Hospital Affiliated to Nanjing Medical UniversityNanjing210029China Institute of Pharmacology and Toxicology College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Gusu School Nanjing Medical UniversitySuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou215002China Department of Pharmacology Graduate School of Pharmaceutical SciencesTohoku UniversitySendai980-8578Japan Institute of Brain Science the Affiliated Brain Hospital of Nanjing Medical UniversityNanjing211166China.

Disturbance of the cholinergic system plays a crucial role in the pathological progression of neurological diseases that cause dyskinesia-like ***,the molecular mechanisms underlying this disturbance remain ***,we showed that cyclin-dependent kinase 5(Cdk5)was reduced in cholinergic neurons of midbrain according to the single-nucleus RNA sequencing *** levels of CDK5 also decreased in patients with Parkinson’s disease accompanied by motor ***,Cdk5 deficiency in cholinergic neurons triggered paw tremors,abnormal motor coordination,and motor balance deficits in *** symptoms occurred along with cholinergic neuron hyperexcitability and increases in the current density of large-conductance Ca2+-activated K+channels(BK channels).Pharmacological inhibition of BK channels restrained the excessive intrinsic excitability of striatal cholinergic neurons in Cdk5-deficient ***,CDK5 interacted with BK channels and negatively regulated BK channel activity via phosphorylation of *** of CDK5 expression in striatal cholinergic neurons reduced dyskinesia-like behaviors in ChAT-Cre;Cdk5f/f ***,these findings indicate that CDK5-induced phosphorylation of BK channels involves in cholinergic-neuronmediated motor function,providing a potential new therapeutic target for treating dyskinesia-like behaviors arising from neurological diseases.

关键词： Cdk5 Neuron CDK5

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Effect of two surgical approaches on the lung function and prognosis of patients with combined esophagogastric cancer

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World Journal of Gastrointestinal Surgery 2023年第9期15卷 1986-1994页

作者： Chong-Bing Sun Xiao-Qing Han Hao Wang yi-xuan zhang Meng-Chun Wang Yong-Ning Liu Department of General Surgery Weifang People's HospitalWeifang 261041Shandong ProvinceChina Department of Spinal Surgery Weifang People's HospitalWeifang 261041Shandong ProvinceChina Department of Medical Weifang People's HospitalWeifang 261041Shandong ProvinceChina

BACKGROUND Adenocarcinoma of the esophagogastric junction has a center of origin within 5 cm of the esophagogastric *** resection remains the main treatment.A transthoracic approach is recommended for Siewert I adenocarcinoma of the esophagogastric junction and a transabdominal approach is recommended for Siewert III adenocarcinoma of the esophagogastric ***,there is a need to determine the optimal surgical approach for Siewert II adenocarcinoma of the esophagogastric junction to improve lung function and the prognosis of *** To investigate and compare the surgical effects,postoperative changes in pulmonary function,and prognoses of two approaches to treating combined esophagogastric *** One hundred and thirty-eight patients with combined esophagogastric cancer treated by general and thoracic surgeries in our hospital were *** were divided into group A comprising 70 patients(transabdominal approach)and group B comprising 68 patients(transthoracic approach)based on the surgical *** indexes related to surgical trauma,number of removed lymph nodes,indexes of lung function before and after surgery,survival rate,and survival duration of the two groups were compared 3 years after *** The duration of surgery,length of hospital stay,and postoperative drainage duration of the patients in group A were shorter than those of the patients in group B,and the volume of blood loss caused by surgery was lower for group A than for group B(P<0.05).At the one-month postoperative review,the first second,maximum ventilation volume,forceful lung volume,and lung volume values were higher for group A than for group B(P<0.05).Preoperatively,the QLQ-OES18 scale scores of the patients in group A were higher than those in group B on re-evaluation at 3 mo postoperatively(P<0.05).The surgical complication rate of the patients in group A was 10.00%,which was lower than that of patients in group B,which was 23.53%(P<0.05)

关键词： Transabdominal approach Transthoracic approach Esophagogastric Junction cancer Pulmonary function Prognosis Adenocarcinoma

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Two New Alkaloids from Fusarium tricinctum SYPF 7082,an Endophyte from the Root of Panax notoginseng

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Natural Products and Bioprospecting 2018年第5期8卷 391-396页

作者： Wen-Jie Sun Hong-Tao Zhu Tian-Yuan zhang Meng-Yue zhang Dong Wang Chong-Ren Yang yi-xuan zhang ying-Jun zhang State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Shenyang Pharmaceutical University Shenyang 110016People’s Republic of China Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming Institute of BotanyChinese Academy of SciencesKunmingPeople’s Republic of China

Panax notoginseng(Araliaceae)is a famous traditional Chinese medicine mainly cultivated in Yunnan and Guangxi provinces of *** new alkaloids,rigidiusculamide E(1)and[-(a-oxyisohexanoyl-N-methyl-leucyl)2-](2),together with two known ones,(-)-oxysporidinone(3)and(-)-4,60-anhydrooxysporidinone(4)were isolated from the mycelia culture of Fusarium tricinctum SYPF 7082,an endophytic fungus obtained from the healthy root of *** structures were determined on the basis of extensive spectroscopic *** 1-4 were tested for their inhibitory effects against NO production on Murine macrophage cell line,and the new compound 2 showed significant inhibitory activity on NO production with the IC_(50)value of 18.10±0.16μM.

关键词： Fusarium tricinctum SYPF 7082 Endophytic fungus Alkaloids Panax notoginseng Inhibition on NO production

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A case of type I Kounis syndrome caused by double allergens

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Chinese Medical Journal 2020年第6期133卷 735-737页

作者： yi-xuan zhang Lu Liu Li-Ping Liu Hui Xu Yu-Mei Li Research Center of Stem Cell and Regenerative Medicine Affiliated Hospital of Jiangsu UniversityZhenjiangJiangsu 212001China Department of Dermatology Affiliated Hospital of Jiangsu UniversityZhenjiangJiangsu 212001China Department of Emergency Medicine The Fourth Affiliated Hospital of Jiangsu UniversityZhenjiangJiangsu 212001China

To the Editor:A 42-year-old Chinese man presented with head trauma caused by a brief loss of consciousness and fell after a bee sting on his nasal root while cycling *** being rushed to the emergency room,he developed sweats,dizziness,headaches,bosom frowsty,shortness of breath,and urinary *** pressure was 74/47 mmHg,blood oxygen saturation was 81%,and pulse rate was 149 beats/*** examination revealed mental confusion,bilateral pupil diameter at 3 mm,slightly pupil insensitivity to light reflection,and rigid abdomen.25 mg promethazine and 10 mg dexamethasone were administered immediately.

关键词： Blood cycling slightly

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MLOCA瞬态堆芯水位监测有效性分析

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核动力工程 2017年第3期38卷 115-118页

作者：姜夏岚刘泰丽刘仪章旋中广核(北京)仿真技术有限公司广东深圳518115

为了验证中国改进型百万千瓦级(CPR1000)核电站在一回路中等破口失水事故(MLOCA)工况下堆芯冷却监视系统(CCMS)测量的有效性,及定量分析控制系统中反应堆冷却剂泵(简称:主泵)状态的2种判定方法导致的水位计算差异,对CCMS测量原理进行了... 详细信息

为了验证中国改进型百万千瓦级(CPR1000)核电站在一回路中等破口失水事故(MLOCA)工况下堆芯冷却监视系统(CCMS)测量的有效性,及定量分析控制系统中反应堆冷却剂泵(简称:主泵)状态的2种判定方法导致的水位计算差异,对CCMS测量原理进行了分析。以RELAP5-3D程序对CPR1000机组进行热工水力建模、使用虚拟数字化控制系统(DCS)模拟其控制逻辑,定量计算了在这2种主泵状态判定方法中CCMS输出水位及其误差,并分析了误差产生的原因。结果表明:2种方案都会引入较大的水位误差,结合状态导向法事故处理程序(SOP)分析,可能使操纵员对堆芯水位判断产生一定的误导。

关键词：堆芯水位堆芯冷却监视系统(CCMS) 中等破口失水事故(MLOCA) 主泵状态全范围模拟机(FSS)

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Universal design of three-dimensional porous graphene-iron based promotors for kinetically rationalized lithium-sulfur chemistry

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Journal of Energy Chemistry 2025年第1期100卷 192-200页

作者： Hua Gao Yunfeng zhang Menglei Wang Ruoxuan Yang Shuai Feng xuan Cao Yaping zhang Zhongyuan Lu yingze Song State Key Laboratory of Environment-Friendly Energy Materials School of Materials and Chemistry Southwest University of Science and Technology School of Material Science and Engineering Henan University of Technology College of Chemistry and Chemical Engineering Taishan University

Lithium-sulfur （Li-S） batteries are widely deemed to be one of the most potential candidates for future secondary batteries because of their remarkable energy ***,notorious polysulfide shuttling and retarded sulfur reaction kinetics pose significant obstacles to the further application of Li-S *** rationally designed highly active electrocatalysts can facilitate polysulfide conversion,the universal and scalable synthesis strategies need to be ***,a universal synthetic strategy to construct a series of three-dimensional （3D） porous graphene-iron （3DGr-Fe） based electrocatalysts involving 3DGr-FeP,3DGr-Fe3C,and 3DGr-Fe3Se4is exploited for manipulating the Li-S redox *** has been observed that the implementation of a 3D porous Gr architecture leads to the well-designed conductive networks,while the uniformly dispersed iron nanoparticles introduce an abundance of active sites,fostering the lithium polysulfide conversion,thereby bolstering the overall electrochemical *** Li-S battery with the 3DGr-Fe based electrocatalyst exhibits remarkable capacity retention of 94.8%upon 100 times at 0.2 ***,the soft-packaged Li-S pouch cell based on such a 3DGr-Fe electrocatalyst delivers superior capacity of 1060.71 mA h g-1and guarantees for the continuous 30 min work of fan *** investigation gives comprehensive insights into the design,synthesis,and mechanism of 3DGr-Fe based electrocatalysts with high activity toward efficient and durable Li-S batteries.

关键词： Redox reactions

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