Two New Alkaloids from Fusarium tricinctum SYPF 7082,an Endophyte from the Root of Panax notoginseng
作者机构：State Key Laboratory of Phytochemistry and Plant Resources in West ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Shenyang Pharmaceutical UniversityShenyang 110016People’s Republic of China Yunnan Key Laboratory of Natural Medicinal ChemistryKunming Institute of BotanyChinese Academy of SciencesKunmingPeople’s Republic of China
出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)
年 卷 期：2018年第8卷第5期
页 面：391-396页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by the Major Science and Technique Programs in Yunnan Province(2016ZF001-001,2017IB038) the Science and Technology Planning Project of Yunnan Province(2013FC008,2015IC017) the National Science and Technology Major Project of China(2018ZX09735001-002-002)
主 题：Fusarium tricinctum SYPF 7082 Endophytic fungus Alkaloids Panax notoginseng Inhibition on NO production
摘 要：Panax notoginseng(Araliaceae)is a famous traditional Chinese medicine mainly cultivated in Yunnan and Guangxi provinces of *** new alkaloids,rigidiusculamide E(1)and[-(a-oxyisohexanoyl-N-methyl-leucyl)2-](2),together with two known ones,(-)-oxysporidinone(3)and(-)-4,60-anhydrooxysporidinone(4)were isolated from the mycelia culture of Fusarium tricinctum SYPF 7082,an endophytic fungus obtained from the healthy root of *** structures were determined on the basis of extensive spectroscopic *** 1-4 were tested for their inhibitory effects against NO production on Murine macrophage cell line,and the new compound 2 showed significant inhibitory activity on NO production with the IC_(50)value of 18.10±0.16μM.
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