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Chinese Medical Journal 2020年第17期133卷 2098-2103页

作者： yi-xuan liao Ya-Hong Chen Department of Pulmonary and Critical Care Medicine Peking University Third HospitalBeijing 100191China Department of Pulmonary and Critical Care Medicine Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

The Global Initiative for Chronic Obstructive Lung Disease(GOLD)has been changing for nearly 20 *** has moved from single assessment using spirometry to a more comprehensive assessment of chronic obstructive pulmonary disease using spirometry,symptoms and exacerbation *** subsequently,a new assessment system for chronic obstructive pulmonary disease separated spirometric grades from the old assessment system,and classified patients only according to their symptoms and history of *** distribution,clinical characteristics,treatment,and prognosis of the new subgroups were different from the old *** this review,we will present a brief profile of changes made to the disease assessment method of GOLD,based on the relevant existing literature.

关键词： Chronic obstructive pulmonary disease Global Initiative for Chronic Obstructive Lung Disease Disease assessment method

Systemic lupus erythematosus combined with primary hyperfibrinolysis and protein C and protein S deficiency:A case report

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World Journal of Clinical Cases 2021年第8期9卷 2008-2014页

作者： yi-xuan liao Yan-Fei Guo Yu-Xia Wang Ai-Hua Liu Chun-Li Zhang Department of Pulmonary and Critical Care Medicine Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Department of Rheumatology and Immunology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Department of Hematology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by systemic involvement and multiple autoantibodies in the *** with protein C(PC)and protein S(PS)deficiency are prone to *** contrast,patients with primary hyperfibrino-lysis tend to *** SUMMARY A 52-year-old female patient with bilateral pleural effusion was diagnosed with"tuberculous pleurisy"and treated with anti-tuberculosis drugs and *** coagulation-related laboratory results showed decreased fibrinogen,PC activity,PS activity,and antithrombinШ*** immune-related laboratory results showed positive antinuclear antibody,anti-Smith antibody,anticardiolipin antibody(ACL),anti-β2-glycoprotein I antibody(aβ2GPI)and direct Coomb’s test and decreased complement 3 and complement *** was performed and bloody pleural fluid was *** of the pleural biopsy showed lymphocytes,plasma cells,and a few eosinophils in adipose and fibrous connective *** of whole exome sequencing of blood showed no genetic mutations suggesting the presence of hereditary hematological *** patient was finally diagnosed with SLE and primary hyperfibrinolysis,and was treated with prednisolone,hydroxychloroquine,and compound *** PC and PS deficiency in SLE might be related to ACL and aβ*** and primary hyperfibrinolysis can coexist in one patient,with both a risk of thrombosis and a risk of bleeding.

关键词： Systemic lupus erythematosus Primary hyperfibrinolysis Antiphospholipid antibody Protein C deficiency Protein S deficiency Case report

Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury

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World Journal of Gastroenterology 2021年第22期27卷 2944-2962页

作者： Dan-Dan Zhu Xue-Mei Tan Li-Qing Lu Si-Jia Yu Ru-Li Jian Xin-Fang Liang yi-xuan liao Wei Fan LucíiaBarbier-Torres Austin Yang He-Ping Yang Ting Liu Department of Gastroenterology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Key Laboratory of Cancer proteomics of Chinese Ministry of Health Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Medicine Division of Digestive and Liver DiseasesCedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biology East Los Angeles CollegeLos AngelesCA 91008United States

Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2 is a global pandemic and poses a major threat to human health *** addition to respiratory symptoms,COVID-19 is usually accompanied by systemic inflammation and liver damage in moderate and severe *** factor erythroid 2-related factor 2(NRF2)is a transcription factor that regulates the expression of antioxidant proteins,participating in COVID-19-mediated inflammation and liver ***,we show the novel reciprocal regulation between NRF2 and inflammatory mediators associated with COVID-19-related liver ***,we describe some mechanisms and treatment strategies.

关键词： COVID-19-related liver injury Nuclear factor erythroid 2-related factor 2 Inflammatory mediator Oxidative stress Therapeutic targets

Impact of obstructive sleep apnea on pulmonary hypertension in patients with chronic obstructive pulmonary disease

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Chinese Medical Journal 2019年第11期132卷 1272-1282页

作者： Wan-Lu Sun Jian-Li Wang Guo-Hua Jia Wen-Jun Mi yi-xuan liao Yong-Wei Huang Zheng Hu Li-Qiang Zhang Ya-Hong Chen Departm ent of Pulmonary and Critical Care Medicine Peking University Third Hospital Peking University Beijing 100191 China Department of Respiratory Medicine Cixi People's Hospital Cixi Zhejiang 315300 China

Background:Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) syndrome are highly prevalent respiratory conditions. Their coexistence is referred to as the overlap syndrome. They are both related to pulmonary hypertension (PH) development. This study investigated the effects of OSA on PH in patients with COPD and the associated factors. Methods: Consecutive patients with stable COPD were recruited for an observational cross-sectional study from September 2016 to May 2018 at Peking University Third Hospital. In total, 106 patients with COPD were enrolled and performed home portable monitoring and echocardiography. OSA was defined by an apnea hypopnea index (AHI)>10 events/h. Based on OSA absence or presence, patients were divided into the COPD with OSA and COPD without OSA groups. Factors affecting pulmonary artery pressure (PAP) and PH were identified using univariate analysis and logistic regression models. Results: In the 106 patients with COPD, the mean age was 69.52 years, 91.5% were men, and the mean forced expiratory volume in 1 s (FEV!) percentage of predicted was 56.15%. Fifty-six (52.8%) patients with COPD were diagnosed with OSA, and 24 (22.6%) patients with COPD were diagnosed as PH. Compared with COPD without OSA group, the median PAP in COPD with severe OSA group increased by 5 mmHg (36.00 [26.00-50.00] mmHg vs. 31.00 [24.00-34.00] mmHg, P = 0.036). COPD with percent of night-time spent with oxygen saturation below 90%(T90)> 10% group had higher PAP than COPD with T90 < 1 % group (36.00 [29.00-50.00)] mmHg vs. 29.00 [25.50-34.00] mmHg, F = 7.889, P = 0.007). Univariate analysis revealed age, FEVi% predicted, T90, and Charlson index had statistically significant effects on PH. Multiple regression analysis showed a significant and independent effect of both FEVj% predicted (odds ratio [OR]= 3.46;95% confidence interval [Cl]: 1.15-10.46;P = 0.028) and AHI (OR = 3.20;95% Cl: 1.09-19.35;P = 0.034) on PH. Conclusions: Patients with

关键词： Chronic obstructive pulmonary disease Echocardiography Obstructive sleep apnea Pulmonary hypertension

Homologous CoS2 interface with directed electron transfer and strong chloridion repulsion for efficient seawater oxidation

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Science China Chemistry 2025年

作者： Yuan Tian Jiang-Bo Chen Jie ying Ge Tian Yu-xuan Xiao yi Lu Si-Ming Wu Wei Geng Ling Shen Xiao-Yu Yang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and Engineering and Shenzhen Research Institute & Laoshan Laboratory Wuhan University of Technology School of Chemical Engineering and Technology Sun Yat-Sen University National Energy Key Laboratory for New Hydrogen-Ammonia Energy Technologies Foshan Xianhu Laboratory

Seawater electrolysis is a highly promising method to produce high energy density hydrogen,especially in dry areas that have scarce freshwater ***,application of seawater electrolysis is confronted by two major problems associated with catalysts employed for the anodic oxygen evolution reaction （OER） including the competitive hypochlorite evolution reaction（HCER） and strong chloridion （Cl–） triggered *** studies aimed at overcoming these problems,a facile method has been developed to synthesize a homologous CoS2heterojunction as an OER *** to a difference in work functions at the interface and increased electron density,this material has directed electron transfer and strong chloridion repulsion properties,*** have shown that CoS2achieves low overpotentials of 289 and 322 mV at 10 mA cm-2current density in respective alkaline （1 M KOH） and alkaline simulated seawater ***,the outstanding stability of CoS2is reflected in a negligible decline in activity during promotion of the OER for 100 *** of density functional theory calculations reveal that the homologous CoS2heterojunction promotes directed electron transport for optimizing adsorption/desorption of reactive species and heightens the Cl-adsorption energy for strongly repulsing Cl-,phenomena that enhance OER performance in alkaline simulated seawater.

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Response of fine particulate matter to reductions in anthropogenic emissions in Beijing during the 2014 Asia–Pacific Economic Cooperation summit

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Atmospheric and Oceanic Science Letters 2016年第6期9卷 411-419页

作者： GU yi-xuan liao Hong State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of Sciences College of Earth Science University of Chinese Academy of Sciences School of Environmental Science and Engineering Nanjing University of Information Science &Technology

The nested-grid capability of the global chemical transport model GEOS-Chem, with a horizontal resolution of 1/4°× 5/16° （latitude x longitude）, was used to identify the chemical species whose reductions made the largest contributions to decreases in PM2.s concentrations （fine particulate matter, diameter 〈 2.5μm, defined in this study as the sum of sulfate, nitrate, ammonium, black carbon, and organic carbon aerosols） in Beijing during the 2014 Asia-Pacific Economic Cooperation （APEC） summit. A number of numerical experiments were carried out for the period 15 October-29 November 2014. The model reproduced the observed daily variations of concentrations of PM2.s and gas-phase species （carbon monoxide, nitrogen dioxide, and sulfur dioxide）. Simulated PM2.s concentrations decreased by 55.9%-58.5% during the APEC period, compared to other periods in October and November 2014, which agreed closely with measurements. Sensitivity results showed that emissions control measures regarding nitrogen oxides and organic carbon over North China led to the largest reductions in PM2.s concentrations in Beijing during the APEC summit, which led to overall reductions in the PM2.5 concentration of Beijing by 5.7% and 4.6%, respectively. The control of ammonia emissions was found to be able to greatly reduce PM2.5 concentrations in the whole of North China during the APEC meeting.

关键词： Fine particulate matter emissions reduction Asia-Pacifc EconomicCooperation Beijing GEOS-Chem

从句子图到篇章图——基于抽象语义表示的篇章级共指标注体系研究

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外语学刊 2025年第1期 19-28页

作者：张艺璇李斌许智星南京师范大学文学院南京210097 南京师范大学语言大数据与计算人文研究中心南京210097

篇章级共指关系是语言学和计算语言学的研究难点之一。本文在梳理共指理论研究与趋势的基础上,回顾共指语料库的构建与自动解析方法,指出共指语料的构建主要存在以下两个问题:共指关系的标注较为粗疏,也基本不考虑与句子语义结构本身的... 详细信息

篇章级共指关系是语言学和计算语言学的研究难点之一。本文在梳理共指理论研究与趋势的基础上,回顾共指语料库的构建与自动解析方法,指出共指语料的构建主要存在以下两个问题:共指关系的标注较为粗疏,也基本不考虑与句子语义结构本身的关系。本文在句子级语义标注体系(中文抽象语义表示)的基础上,设计篇章共指的标注体系,以“概念同一性”为基本原则,从词形的异同和概念的表述角度区分9种篇章共指关系,标注了500个篇章的共指信息。与已完整标注的52种句内语义关系相结合,构建出带有篇章共指信息的篇章抽象语义图库。该语料库选自CTB新闻语料,体裁涵盖经济、体育及生活类,规模为6237句,16万词例。该语料库的构建为篇章级语义分析提供了新框架与数据资源。

关键词：篇章共指抽象语义表示概念同一性篇章语义结构语料库中文信息处理

Incompressible Limit of the Compressible Q-tensor System of Liquid Crystals

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Acta Mathematicae Applicatae Sinica 2023年第1期39卷 179-201页

作者： yi-xuan WANG University of Pittsburgh PA 15260USA

We study the connection between the compressible Navier-Stokes equations coupled by the Qtensor equation for liquid crystals with the incompressible system in the periodic case, when the Mach number is low. To be more specific, the convergence of the weak solutions of the compressible nematic liquid crystal model to the incompressible one is proved as the Mach number approaches zero, and we also obtain the similar results in the stochastic setting when the equations are driven by a stochastic force. Our approach is based on the uniform estimates of the weak solutions and the martingale solutions, then we justify the limits using various compactness criteria.

关键词： compressible liquid crystal system Q-tensor weak solutions martingale solution stochastic compactness Mach number incompressible limit

From blocker to booster:Harnessing garnet surface chemistry for advanced solid-state electrolytes

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Nano Research 2025年第1期18卷 323-331页

作者： Jun Cheng xuan Zhou Hongqiang Zhang Zhen Zeng Yuanyuan Li Yulong Zhu yingsheng liao Lijie Ci Deping Li State Key Laboratory of Precision Welding and Joining of Materials and Structures School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China

Garnet electrolytes with high ionic conductivity and electrochemical stability are widely used as fillers to fabricate composite solid electrolytes(CPEs)within polymer ***,the performance of CPEs is significantly influenced by the surface characteristics of the garnet ***,the impact of garnet surface characteristics on CPEs was systematically investigated and a conversion from a typically unstable and Lewis basic surface to a more stable Lewis acidic surface was realized,which is shown to be more conductive to the improved performance of *** simultaneously removing the Li_(2)CO_(3)layer and applying a Li-Al-O coating,the influence of surface characteristics on CPEs was *** Lewis acid Li-Al-O surface coating not only promotes lithium salt dissociation,improving the ionic conductivity and ionic transfer number,but also prevents the reformation of the passive Lewis basic Li_(2)CO_(3)*** to garnet with a Lewis basic Li_(2)CO_(3)surface,the garnet modified with a Lewis acid Li-Al-O coating enhances CPEs,which exhibit an improved critical current density of 1.0 mA·cm^(-2)and highly stable lithium symmetric cell cycling for 400 h at 0.2 mA·cm^(-2).This research highlights the importance of surface chemistry in the design of high-performance solid-state batteries and presents a strategic modification approach for garnetbased CPEs.

关键词： garnet electrolyte composite solid electrolyte surface chemistry all-solid-state batteries

Design and tailoring of patterned ZnO nanostructures for perovskite light absorption modulation

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 855-861页

作者： Haonan Si xuan Zhao Qingliang liao Yue Zhang Academy for Advanced Interdisciplinary Science and Technology Beijing Advanced Innovation Center for Materials Genome EngineeringUniversity of Science and Technology BeijingBeijing 100083China Key Laboratory of Advanced Materials and Devices for Post-Moore Chips Ministry of EducationBeijing Key Laboratory for Advanced Energy Materials and TechnologiesSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Lithography is a pivotal micro/nanomanufacturing technique,facilitating performance enhancements in an extensive array of devices,encompassing sensors,transistors,and photovoltaic *** key to creating highly precise,multiscale-distributed patterned structures is the precise control of the lithography ***,high-quality patterned ZnO nanostructures are constructed by systematically tuning the exposure and development times during *** optimizing these parameters,ZnO nanorod arrays with line/hole arrangements are successfully *** ZnO nanostructures with highly controllable morphology and structure possess discrete three-dimensional space structure,enlarged surface area,and improved light capture ability,which achieve highly efficient energy conversion in perovskite solar *** lithography process management for these patterned ZnO nanostructures provides important guidance for the design and construction of complex nanostructures and devices with excellent performance.

关键词： lithography patterned ZnO nanorod arrays light absorption perovskite solar cell