Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury

作     者：Dan-Dan Zhu Xue-Mei Tan Li-Qing Lu Si-Jia Yu Ru-Li Jian Xin-Fang Liang Yi-Xuan Liao Wei Fan LucíiaBarbier-Torres Austin Yang He-Ping Yang Ting Liu 

作者机构：Department of GastroenterologyXiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Key Laboratory of Cancer proteomics of Chinese Ministry of HealthXiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of MedicineDivision of Digestive and Liver DiseasesCedars-Sinai Medical CenterLos AngelesCA 90048United States Department of BiologyEast Los Angeles CollegeLos AngelesCA 91008United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2021年第27卷第22期

页      面：2944-2962页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by National Natural Science Foundation of China No.82070632 

主　　题：COVID-19-related liver injury Nuclear factor erythroid 2-related factor 2 Inflammatory mediator Oxidative stress Therapeutic targets 

摘      要：Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2 is a global pandemic and poses a major threat to human health *** addition to respiratory symptoms,COVID-19 is usually accompanied by systemic inflammation and liver damage in moderate and severe *** factor erythroid 2-related factor 2(NRF2)is a transcription factor that regulates the expression of antioxidant proteins,participating in COVID-19-mediated inflammation and liver ***,we show the novel reciprocal regulation between NRF2 and inflammatory mediators associated with COVID-19-related liver ***,we describe some mechanisms and treatment strategies.