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Selenopeptide nanomedicine ameliorates atherosclerosis by reducing monocyte adhesions and inflammations

Nano Research 2024年第7期17卷 6332-6341页

作者： Zhen Luo Yuxing Jiang Zimo Liu Lamei Guo Li Zhang Hongtao Rong Zhongyu duan Hongwen Liang Aili Zhang Lei Wang Yu yi Hao Wang CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)No.11 BeiyitiaoZhongguancunBeijing 100190China School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300130China Tianjin Medical University General Hospital Tianjin 300052China University of Chinese Academy of Sciences Beijing 100049China School of Environmental Science and Safety Engineering Tianjin University of TechnologyTianjin 300384China College of Pharmacy Chongqing Medical UniversityChongqing 400016China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Atherosclerosis is an inflammatory disease that may cause severe heart disease and *** pharmacotherapy for atherosclerosis shows limited *** the progression of atherosclerosis,monocyte adhesions and inflammatory macrophages play vital ***,precise regulations of inflammatory immune microenvironments in pathological tissues remain ***,we report an atherosclerotic plaque-targeted selenopeptide nanomedicine for inhibiting atherosclerosis progression by reducing monocyte adhesions and inflammation of *** targeted nanomedicine has 2.2-fold enhancement in atherosclerotic lesion *** oxidation-responsibility of selenopeptide enables eliminations of reactive oxygen species and specific release of anti-inflammatory drugs,thereby reducing inflammation responses of ***,we find the oxidative metabolite of selenopeptide,octadecyl selenite,can bind to P-selectin in a high affinity with a dissociation constant of 1.5μ*** in situ generated active seleno-species further inhibit monocyte adhesions for anti-inflammation in *** local regulations of monocyte adhesions and inflammations,the selenopeptide nanomedicine achieves 2.6-fold improvement in atherosclerotic plaque inhibition compared with simvastatin in the atherosclerosis mouse ***,the selenopeptide nanomedicine also displays excellent biological safety in both mice and rhesus *** study provides a safe and effective platform for regulating inflammatory immune microenvironments for inflammatory diseases such as atherosclerosis.

关键词： selenopeptide self-assembly atherosclerosis monocyte adhesion anti-inflammation

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Periodontitis exacerbates pulmonary hypertension by promoting IFNγ+T cell infiltration in mice

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International Journal of Oral Science 2024年第2期16卷 359-369页

作者： Xiaoqian Meng Linjuan Du shuo Xu Lujun Zhou Boyan Chen Yulin Li Chumao Chen Huilin Ye Jun Zhang Guocai Tian Xuebing Bai Ting Dong Wenzhen Lin Mengjun Sun Kecong Zhou Yan Liu Wuchang Zhang Shengzhong duan Department of Endodontics Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Laboratory of Oral Microbiota and Systemic Diseases Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina Hongqiao International Institute of Medicine Shanghai Tongren Hospital/Faculty of Basic MedicineKey Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationShanghai Jiao Tong University School of MedicineShanghaiChina Department of Orthodontics Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Department of Periodontology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhouChina

Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the prevention and treatment of the *** the current study,we showed that experimental periodontitis,which was established by ligation of molars followed by orally smearing subgingival plaques from patients with periodontitis,exacerbated hypoxia-induced pulmonary hypertension in ***,periodontitis dysregulated the pulmonary microbiota by promoting ectopic colonization and enrichment of oral bacteria in the lungs,contributing to pulmonary infiltration of interferon gamma positive(IFNγ^(+))T cells and aggravating the progression of pulmonary *** addition,we identified Prevotella zoogleoformans as the critical periodontitis-associated bacterium driving the exacerbation of pulmonary hypertension by periodontitis,and the exacerbation was potently ameliorated by both cervical lymph node excision and IFNγneutralizing *** study suggests a proof of concept that the combined prevention and treatment of periodontitis and pulmonary hypertension are necessary.

关键词： hypertension prevention interferon

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Progress of GECAM Observation Research

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空间科学学报 2024年第4期44卷 668-673页

作者： WANG Chenwei ZHANG Yanqiu XIONG Shaolin LIU Jiacong TAN Wenjun XIAO shuo XIE Shenglun XUE Wangchen ZHAO Haisheng ZHAO yi ZHENG Chao Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049 University of Chinese Academy of Sciences Beijing 100049 Guizhou Normal University Guizhou 550025 Central China Normal University Wuhan 4300795 Dezhou University Dezhou 253023

Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)is a constellation with four instruments(launch date):GECAM-A/B(10 December 2020),GECAM-C(27 July 2022)and GECAM-D(13 March 2024),which are dedicated to monitoring gamma-ray transients in *** primary science objectives of GECAM include Gamma-Ray Bursts(GRBs),Soft Gamma-ray Repeaters(SGRs),high energy counterparts of Gravitation Wave(GW)and Fast Radio Burst(FRB),Solar Flares(SFLs),as well as Terrestrial Gamma-ray Flashes(TGFs)and Terrestrial Electron Beams(TEBs).A series of observations and research have been made since the launch of GECAM-A/*** observations provide new insights into these highenergy transients,demonstrating the unique role of GECAM in the“multi-wavelength,multi-messenger”era.

关键词： GECAM Gravitational wave electromagnetic counterpart High energy transients

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Achieving an ion-homogenizing and corrosion-resisting interface through nitro-coordination chemistry for stable zinc metal anodes

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Journal of Energy Chemistry 2024年第7期94卷 10-18页

作者： Jizhen Wang Long Jiao Qiaoyun Liu Wei Xin Yechen Lei Tian Zhang Leixin Yang Dengkun Shu shuo Yang Kaihua Li Chenyang Li Chao yi Hongyuan Bai Yuchao Ma Huan Li Wenjun Zhang Bowen'Cheng schoolof Light Industry Science and Engineering State Key Laboratory of Biobased Fiber Manufacturing TechnologyTianjin Key Laboratory of Pulp and PaperChina Light Industry Key Laboratory of Papermaking and BiorefineryTianjin University of Science&TechnologyTianjin 300457China Department of Materials Science and Engineering &Center of Super-Diamond and Advanced FilmsCity University of Hong Kong83 Tat Chee AvenueHong Kong 999077China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA 5005Australia

Suppression of uncontrollable dendrite growth and water-induced side reactions of Zn metal anodes is crucial for achieving long-lasting cycling stability and facilitating the practical implementations of aqueous Zn-metal *** address these challenges,we report in this study a functional nitro-cellulose interfacial layer(NCIL)on the surface of Zn anodes enlightened by a nitro-coordination chemistry *** NCIL exhibits strong zincophilicity and superior coordination capability with Zn^(2+)due to the highly electronegative and highly nucleophilic nature of the nitro functional *** characteristic facilitates a rapid Zn-ion desolvation process and homogeneous Zn plating,effectively preventing H_(2) evolution and dendrite ***,the negatively charged surface of NCIL acts as a shield,repelling SO_(4)^(2-)anions and inhibiting corrosive reactions on the Zn ***,reversible and stable Zn plating/stripping is achieved for over 5100 h at a current density of 1 mA cm^(-2),which is nearly 30 times longer than that of bare Zn ***,the Zn/V_(2)O_(5) full cells with the functional interface layer deliver a high-capacity retention of 80.3%for over 10,000 cycles at 5 A g^(-1).This research offers valuable insights for the rational development of advanced protective interface layers in order to achieve ultra-long-lifeZnmetal batteries.

关键词： Zinc metal anode Nitro-cellulose interfacial layer Coordination capability Dendrite-free deposition Long-term cycling

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社会信息加工对瞳孔大小的调节及其机制

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生物化学与生物物理进展 2024年第4期51卷 858-872页

作者：葛乙平李硕王莉蒋毅中国科学院心理研究所脑与认知科学国家重点实验室脑科学与智能技术卓越创新中心北京100101 中国科学院大学心理学系北京100049

瞳孔大小作为反映个体心理状态的窗口在社会互动中担任着重要的角色。除了非社会性信息(如刺激物理属性等因素)加工被发现影响瞳孔大小变化之外,越来越多的文献指出,瞳孔大小与个体社会信息加工之间也存在密切关系。基于此,本文系统综... 详细信息

瞳孔大小作为反映个体心理状态的窗口在社会互动中担任着重要的角色。除了非社会性信息(如刺激物理属性等因素)加工被发现影响瞳孔大小变化之外,越来越多的文献指出,瞳孔大小与个体社会信息加工之间也存在密切关系。基于此,本文系统综述了社会性刺激(如面孔和生物运动)本身以及社会性刺激含有的情绪信息对于瞳孔大小的影响,总结出瞳孔大小变化不仅可以反映个体对社会信息的感知,同样可以体现个体对更为复杂的社会互动情境的加工。这种社会性信息加工相关的瞳孔大小变化主要涉及个体的情绪唤醒和社会性注意过程。此外,对于自闭症谱系患者这一在社会互动中存在障碍的特殊群体,有关研究发现其对社会性刺激存在异常的瞳孔反应模式。这一特异性为进一步采用瞳孔指标对自闭症进行早期诊断提供了支持,具有重要的理论和实践意义。

关键词：瞳孔大小社会信息加工社会性刺激情绪自闭症

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Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes

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Chinese Journal of Integrative Medicine 2024年第3期30卷 222-229页

作者： ZHANG shuo LI Hong-jin YANG Chun-mei LIU Liu SUN Xiao-ying WANG Jiao CHEN Si-ting LU yi HU Man-qi YAN Ge ZHOU Ya-qiong MIAO Xiao LI Xin LI Bin Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai201203China Department of Integrated Traditional Chinese and Western Medicine Shanghai Skin Disease HospitalTongji University School of MedicineShanghai200443China

Objective:To determine the role of Tripterygium wilfordii multiglycoside(TGW) in the treatment of psoriatic dermatitis from a cellular immunological ***:Mouse models of psoriatic dermatitis were established by imiquimod(IMQ).Twelve male BALB/c mice were assigned to MQ or IMQ+TGW groups according to a random number *** changes in vivo were assessed by hematoxylin and eosin *** of immune cells and cytokines in mice,as well as PAM212 cell proliferation in vitro were assessed by flow ***-inflammatory cytokine expression was determined using reverse transcription quantitative polymerase chain ***:TGW significantly ameliorated the severity of IMQ-induced psoriasis-like mouse skin lesions and restrained the activation of CD45^(+)cells,neutrophils and T lymphocytes(all P<0.01).Moreover,TGW significantly attenuated keratinocytes(KCs) proliferation and downregulated the mRNA levels of inflammatory cytokines including interleukin(IL)-17A,IL-23,tumor necrosis factor α,and chemokine(C-X-C motif) ligand 1(P<0.01 or P<0.05).Furthermore,it reduced the number of γδ T17 cells in skin lesion of mice and draining lymph nodes(P<0.01).Conclusions:TGW improved psoriasis-like inflammation by inhibiting KCs proliferation,as well as the associated immune cells and cytokine *** inhibited IL-17 secretion from γδ T cells,which improved the immune-inflammatory microenvironment of psoriasis.

关键词： psoriasis Tripterygium wilfordii multiglycoside γδT cells inflammation Chinese medicine

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Plasma metabolites and risk of myocardial infarction:a bidirectional Mendelian randomization study

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Journal of Geriatric Cardiology 2024年第2期21卷 219-231页

作者： Dong-Hua LI Qiang WU Jing-Sheng LAN shuo CHEN You-yi HUANG Lan-Jin WU Zhi-Qing QIN ying HUANG Wan-Zhong HUANG Ting ZENG Xin HAO Hua-Bin SU Qiang SU Department of Cardiovascular Medicine Minzu Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Library of Graduate School Chinese PLA General HospitalBeijingChina Department of Cardiology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Health Management Institute the Second Medical CenterChinese PLA General HospitalBeijingChina

BACKGROUND Myocardial infarction(MI)is a critical cardiovascular event with multifaceted etiology,involving several genetic and environmental *** is essential to understand the function of plasma metabolites in the development of MI and unravel its complex *** This study employed a bidirectional Mendelian randomization(MR)approach to investigate the causal relationships between plasma metabolites and MI *** used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice *** addition,the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite(1400 metabolites)and MI(20,917 individuals with MI and 440,906 individuals without MI)*** variance weighted was the primary method for estimating causal *** estimates are expressed as beta coefficients or odds ratio(OR)with 95%*** We identified 14 plasma metabolites associated with the occurrence of MI(P<0.05),among which 8 plasma metabolites[propionylglycine levels(OR=0.922,95%CI:0.881–0.965,P<0.001),gamma-glutamylglycine levels(OR=0.903,95%CI:0.861–0.948,P<0.001),hexadecanedioate(C16-DC)levels(OR=0.941,95%CI:0.911–0.973,P<0.001),pentose acid levels(OR=0.923,95%CI:0.877–0.972,P=0.002),X-24546 levels(OR=0.936,95%CI:0.902–0.971,P<0.001),glycine levels(OR=0.936,95%CI:0.909–0.964,P<0.001),glycine to serine ratio(OR=0.930,95%CI:0.888–0.974,P=0.002),and mannose to trans-4-hydroxyproline ratio(OR=0.912,95%CI:0.869–0.958,P<0.001)]were correlated with a decreased risk of MI,whereas the remaining 6 plasma metabolites[1-palmitoyl-2-arachidonoyl-GPE(16:0/20:4)levels(OR=1.051,95%CI:1.018–1.084,P=0.002),behenoyl dihydrosphingomyelin(d18:0/22:0)levels(OR=1.076,95%CI:1.027–1.128,P=0.002),1-stearoyl-2-docosahexaenoyl-GPE(18:0/22:6)levels(OR=1.067,95%CI:1.027–1.109,P=0.001),alpha-ketobutyrate levels(OR=1.108,95%

关键词： infarction alterations diagnosis

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国外公共文化数字化转型：研究主题、框架与前瞻

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中国图书馆学报 2024年第3期50卷 117-129页

作者：李秋实陈一段若阳华中师范大学信息管理学院武汉大学信息管理学院

以大数据、人工智能为代表的数字化技术推动了世界范围内的公共文化数字化转型，对国外相关研究进行梳理，有助于掌握国际公共文化数字化转型发展全貌，为我国相关领域的实践和研究提供参考。本文选取新世纪以来国外公共文化数字化转型... 详细信息

以大数据、人工智能为代表的数字化技术推动了世界范围内的公共文化数字化转型，对国外相关研究进行梳理，有助于掌握国际公共文化数字化转型发展全貌，为我国相关领域的实践和研究提供参考。本文选取新世纪以来国外公共文化数字化转型研究的代表性文献，运用系统性综述方法，凝练研究热点主题，从系统论和复杂性视角构建整合性研究框架，前瞻未来研究方向。研究发现，当前研究主题主要集中在公共文化数字化转型内涵、转型前因条件、转型过程机制和转型影响成效四个方面。公共文化数字化转型具有注重用户需求、技术驱动、机构合作融合的特征；外部环境、信息技术和组织管理是转型的前因条件；通过资源融合、众包交互、合作协同的转型过程机制，公共文化机构优化用户体验，提升服务效能，增进社会福祉。在此基础上，本文进一步提出公共文化数字化转型研究的未来方向，以期为我国公共文化机构平稳转型、高质量发展提供有益参考。图1。参考文献48。

关键词：公共文化数字化转型整合性研究框架

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基于辐射传输模型探究机载高光谱激光雷达的植被垂直生化组分探测能力

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光谱学与光谱分析 2024年第7期44卷 2083-2092页

作者：郝一硕牛沂芳王力毕恺艺中国科学院空天信息创新研究院遥感与数字地球重点实验室(中国科学院)北京100101 中国科学院大学北京100049

自然环境下的植被群落,由于各种群之间以及种群与环境间的竞争与选择,常呈现出一定的垂直结构,对于同一植株的不同生长阶段,在垂直方向也有着不同的生理生化参数。对这种三维立体分布特征进行探测,能够进行生态环境立体化定量评价,对森... 详细信息

自然环境下的植被群落,由于各种群之间以及种群与环境间的竞争与选择,常呈现出一定的垂直结构,对于同一植株的不同生长阶段,在垂直方向也有着不同的生理生化参数。对这种三维立体分布特征进行探测,能够进行生态环境立体化定量评价,对森林碳储量估算和生物多样性保护等具有重要意义。传统的被动光学遥感以及激光雷达在植被生化参数垂直探测方面有较大的局限性,而高光谱激光雷达(Hyperspectral LiDAR,HSL)这一新型探测仪器的出现为探测植被生理生化参数垂直分布提供了新的手段。但由于受到硬件方面的限制,HSL在机载平台下对森林复杂立体场景的适用性尚未得到充分研究。故首先基于HSL原型样机在实验室开展小尺度的室内测量,以火炬花植株为目标,验证其对空间信息和光谱信息的一体化提取能力;随后进一步使用三维辐射传输模型构建具有垂直异质性特征的森林场景,模拟机载HSL设备实现森林的高光谱三维点云提取,结合植被指数和随机森林模型对场景中三种不同植被冠层的叶绿素浓度和类胡萝卜素浓度进行反演。结果表明:室内实验证实了HSL回波信息可以有效区分植株不同高度处光谱曲线的差异,火炬花上部红色叶片和下部绿色叶片的归一化植被指数分别小于和大于0.5;基于三维辐射传输模型成功构建了虚拟森林场景的机载HSL高光谱三维点云,在得到的24组植被指数中,有17组指数表现出良好的探测精度(平均绝对百分比误差MAPE<13%);植被叶绿素反演模型R^(2)达到0.93,上层、中层和下层的平均绝对误差MAE分别为6.26、3.40和2.81;类胡萝卜素反演模型R^(2)为0.91,上层、中层和下层的MAE分别为1.59、2.58和0.39。该研究显示出HSL设备是一种立体化提取植被光谱信息的有效手段,在探测森林等复杂植被场景的生化组分垂直分布方面具有巨大的应用潜力。

关键词：森林立体场景机载高光谱激光雷达三维辐射传输模型植被生化组分

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In situ forming injectable MSC-loaded GelMA hydrogels combined with PD for vascularized sweat gland regeneration

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Military Medical Research 2024年第1期11卷 152-155页

作者： Enhe Jirigala Bin Yao Zhao Li yi-Jie Zhang Chao Zhang Li-Ting Liang Fan-Liang Zhang Xing-Yu Yuan Xian-Lan duan Wei Song Meng-De Zhang yi Kong Xiao-Bing Fu Sha Huang Research Center for Tissue Repair and Regeneration Medical Innovation Research DepartmentChinese PLA General Hospital and PLA Medical CollegeBeijing 100048China Institute of Basic Medical Research Inner Mongolia Medical UniversityHohhot 010110China Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China School of Medicine Nankai UniversityTianjin 300071China

Dear Editor,Three dimensional(3D)bioprinted extracellular matrix(ECM)can be used to provide both biochemical and biophysical cues to direct mesenchymal stem cells(MSCs)differentiation,and then differentiated cells were isolated for implantation in vivo using surgical ***,the reduced cell activity after cell isolation from 3D constructs and low cell retention in injured sites limit its application[1].Methacrylated gelatin(GelMA)hydrogel has the advantage of fast crosslinking,which could resemble complex architectures of tissue construct in vivo[2].Here,we adopted a noninvasive bioprinting procedure to imitate the regenerative microenvironment that could simultaneously direct the sweat gland(SG)and vascular differentiation from MSCs and ultimately promote the replacement of glandular tissue in situ(Fig.1a).

关键词： Sweat gland GelMA In situ niche Cell differentiation Tissue incorporation Vascularization

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