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Recent advances in research on natural product inhibitors of SREBPs

Traditional Medicine Research 2022年第3期7卷 55-67页

作者： yi-ping zhang Jing Jin ping Li Hua Yang Zu-Guo Zheng State Key Laboratory of Natural Medicines Department of PharmacognosySchool of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China

Sterol regulatory element-binding proteins(SREBPs)are a class of cholesterol-sensitive transcription factors that play important roles in lipid metabolism.Natural product inhibitors of SREBPs have been shown to inhibit the synthesis of free fatty acids and cholesterol,promote the burning of brown fat,and relieve insulin resistance by inhibiting different links during the synthesis,cleavage,and transport of SREBPs,thereby improving obesity,diabetes,atherosclerosis,and other metabolic diseases and disorders.There are numerous Chinese herbal medicines with verified efficacy in the treatment of metabolic diseases,including Coptis chinensis Franch.and Pueraria peduncularis Grah.for diabetes,Pueraria peduncularis Grah.,Epimedium brevicornum Maxim.,and Panax ginseng C.A.Meyer for osteoporosis,and Nelumbo nucifera Gaertn.and Poria cocos(Schw.)Wolf.for obesity.Present-day research on the mechanisms underlying the activity of traditional Chinese medicine has indicated that certain chemical components of these traditional preparations can be used to treat metabolic diseases by inhibiting SREBPs.Progress in the research on natural product SREBP inhibitors is continuing apace,and the mechanisms of action of certain small molecules have become well established.In this study,we review recent progress in the research on natural small-molecule inhibitors of SREBPs,including flavonoids,saponins,triterpenoids,and alkaloids,which we hope will provide a useful reference for future research and development of drugs for the treatment of metabolic diseases.

关键词： sterol-regulatory element-binding protein lipid metabolism metabolic disease natural product traditional Chinese medicine

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New progress in understanding roles of nitric oxide during hepatic ischemia-reperfusion injury

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World Journal of Hepatology 2022年第3期14卷 504-515页

作者： yi-ping zhang Xin-Ran Liu Mei-Wen Yang Shu-Long Yang Fen-Fang Hong Experimental Center of Pathogen Biology College of MedicineNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Surgery Fuzhou Medical CollegeNanchang UniversityFuzhou 344000Jiangxi ProvinceChina Department of Physiology College of MedicineNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Physiology Fuzhou Medical CollegeNanchang UniversityFuzhou 344000Jiangxi ProvinceChina

Hepatic ischemia-reperfusion injury(HIRI)is a major clinical cause of morbidity and mortality in liver surgery and transplantation.Many studies have found that nitric oxide(NO)plays an important role in the HIRI and its increase or decrease can affect the progression and outcome of HIRI.However,the role of NO in HIRI is controversial and complicated.NO derived by endothelial NO synthase(eNOS)shows a protective role in HIRI,while excessive NO derived by inducible NO synthase(iNOS)accelerates inflammation and increases oxidative stress,further aggravating HIRI.Nevertheless,the overexpression of eNOS may exacerbate HIRI and iNOS-derived NO in some cases reduces HIRI.Here we review the new progress in the understanding of the roles of NO during HIRI:(1)NO possesses different roles in HIRI by increasing NO bioavailability,down-regulating leukotriene C4 synthase,inhibiting the activation of the nuclear factorκB(NFκB)pathway,enhancing cell autophagy,and reducing inflammatory cytokines and reactive oxygen species(ROS).And NO has both protective and deleterious effects by regulating apoptotic factors;(2)eNOS promotes NO production and suppresses its own overexpression,exerting a hepatoprotective effect reversely.Its activation is regulated by the PI3K/Akt and KLF2/AMPK pathways;and(3)iNOS derived NO mainly has deteriorating effects on HIRI,while it may have a protective function under some conditions.Their expression should reach a balance to reduce the adverse side and make NO protective in the treatment of HIRI.Thus,it can be inferred that NO modulating drugs may be a new direction in the treatment of HIRI or may be used as an adjunct to mitigate HIRI for the purpose of protecting the liver.

关键词： Hepatic ischemia-reperfusion injury Nitric oxide Endothelial nitric oxide synthase Inducible nitric oxide synthase

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Seroepidemiology of Syphilis Infection among 2 Million Reproductive-age Women in Rural China：A Population-based, Cross-sectional Study

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Chinese Medical Journal 2017年第18期130卷 2198-2204页

作者： Kai-Ju Liao Shi-Kun zhang Min Liu Qiao-Mei Wang Jue Liu Hai-ping Shen yi-ping zhang Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100191 China Department of Maternal and Child Health National Health and Family Planning Commission of the People's Republic of China Beijing 100044 China

Background：Quantifying syphilis prevalence is important for planning interventions and advocating for resources on syphilis.However,data on large sample studies regarding the prevalence of syphilis among reproductive-age women in rural China were not available for analysis.The aim of the study was to determine the prevalence,epidemiological characteristics,and related factors of syphilis infection among reproductive-age women in rural China.Methods：Data were obtained from a nationwide,population-based,cross-sectional study under the National Free Preconception Health Examination Project which covered all the 31 provinces in China's Mainland.Women intending to get pregnant within the next 6 months were enrolled between January 1,2010,and December 31,2012.Sociodemographic,gynecological and obstetric characteristics,and other relevant information were obtained through face-to-face interviews.Treponema pallidum particle agglutination assay test was used to detect positive samples of syphilis.Univariate and multivariate logistic regressions were performed to assess the associations between syphilis seropositivity and related factors.Results：The overall seroprevalence of syphilis （SPS） among the 2,044,126 women who received syphilis screening test during 2010-2012 was 0.37% （95% confidence interval [CI]：0.36-0.37%）.The SPS appeared 0.24% （95% CI：0.23-0.26%） and 0.66% （95% CI：0.59-0.72%） in women at 21-24 and 40-44 years of age,respectively,showing an increase of SPS,parallel with age,and the difference was significant.SPS was significantly higher in ethnic minorities than that in Han nationality （0.58% vs.0.35%,respectively,odds ratio [OR] =1.41,95% CI：1.30-1.53） and higher in workers than that in farmers （0.45% vs.0.36%,respectively,OR =1.27,95% CI：1.14-1.41）.Women with primary school or below level had a higher SPS as compared to those with college or above educational level （0.61% vs.0.32%,respectively,OR =2.49,95% CI：2.14-2.89）,and the increase reversely correlated with the levels of education.Women whose spouses w

关键词： Preconception Care Reproductive-age Women Seroprevalence：, Syphilis

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Technical comments on rodent spinal cord injuries models

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Neural Regeneration Research 2014年第5期9卷 453-455页

作者： Zoe zhang yi ping zhang Lisa B.E.Shields Christopher B.Shields Department of Neurosurgery University of Minnesota Norton Neuroscience Institute Norton Healthcare

Spinal cord injuries （SCI） in rodents have been created by laceration, contusion, compression, or intramedullary injection of toxic agents. The choice of an appropriate SCI model should be made for each study based on the experimental design, with care taken to avoid unintended complications such as hemorrhage. Technical comments will be made in this communication describing the 1） importance of vertebral stabi- lization, 2） injury preparation, and 3） landmarks to improve the preci- sion and reproducibility of the SCI.

关键词： SCI Technical comments on rodent spinal cord injuries models LISA zhang

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Theoretical elastoplastic analysis for foundations with geosynthetic-encased columns

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第7期13卷 506-518页

作者： Yuan-yu DUAN yi-ping zhang Dave CHAN Ya-nan YU College of Civil Engineering and Architecture Zhejiang UniversityHangzhou 310058China Department of Civil and Environmental Engineering University of AlbertaEdmontonAlbertaCanada

As a new technique in ground improvement, geosynthetic-encased columns (GECs) have promising applications in soft soil foundation. By assuming yielding occurs in the columns while the surrounding soil and the geosynthetic remain elastic, an elastoplastic analytical procedure for foundations improved by GECs is proposed. The radial stresses that the geosynthetic provides and the elastoplastic deformations of the foundation resting on a rigid base are derived. A comparison with finite element analysis shows that the proposed method is effective and can provide a reasonable prediction of a GEC's deformation. Subsequent parametric analysis indicates that higher geosynthetic stiffness leads to better performance of the composite foundation. The optimum length of encasement is related to the load acting on the foundation and the permissible vertical and radial displacements of the column. Moreover, as the dilation angle of the column increases, the settlement decreases, especially under high loading. The influence of the encasement is more significant in soils with smaller elastic modulus.

关键词： Geosynthetic-encased columns (GECs) Equal vertical strain Elastoplastic deformation Analytical procedure

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Simulation of filling construction of permeable geosynthetic tubes

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第6期11卷 425-431页

作者： Wei-chao LIU yi-ping zhang Tao LI Ya-nan YU College of Civil Engineering and Architecture Zhejiang University Hangzhou 310058 China Zhejiang Water Conservancy and Hydropower College Hangzhou 310018 China

The filling construction of permeable geosynthetic tubes is considered.First,an analytical approach is developed to determine the internal pressure,tension and shape of the cross section of a geosynthetic tube based on its volume.An analytical solution for the drainage rate of the tube is then derived.The course of the filling construction is divided into several time intervals and the volume of the tube after each interval is obtained from the equilibrium of flow calculated from the drainage rate and filling rate.The validity of our analytical approach is tested by comparing our results with previously published experimental result.The results of this comparison indicate that our method is applicable for simulating the filling construction of permeable geosynthetic tubes.

关键词： Geosynthetic tube Filling construction Simulation Volume of the tube Drainage rate

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New timing of the Indosinian intracontinental deformation from the Triassic growth strata in the Kuqa Depression,Southern Tianshan,China

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China Geology 2022年第4期5卷 771-773页

作者： Xiang Qin Xuan-hua Chen Zhao-gang Shao yi-ping zhang Yong-chao Wang Chinese Academy of Geological Sciences China Geological SurveyMinistry of Natural ResourcesBeijing 100037China

1.Objectives In the Indosinian duration,series of Gondwana-related plates pieced together and formed the geological sketch of China for the first time,i.***.the Yangtze,Sino Korean,Tarim plates,and other sub-plates that had been isolated for a long time.Subduction and collision among the Tarim,Qaidam,and Qiangtang blocks in Triassic,as well as the closure of the Paleo-Tethys Ocean,reactivated Late Paleozoic suture zones in the Tianshan orogen region(Hendrix MS et al.,1992).

关键词： Tianshan Triassic strata

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Immobilized Ruthenium Catalyst for Carbon Dioxide Hydrogenation

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Chinese Chemical Letters 2006年第8期17卷 1097-1100页

作者： ying Min YU Jin Hua FEI yi ping zhang Xiao Ming ZHENG Institute of Catalysis Zhejiang University Hangzhou 310028 Department of Chemistry Zhejiang Education Institute Hangzhou 310012

Three kinds of cross linked polystyrene resin （PS） supported ruthenium complexes were developed as catalysts for the synthesis of formic acid from carbon dioxide hydrogenation. Many factors, such as the functionalized supports, solvents and ligands, could influence their activities and reuse performances greatly. These immobilized catalysts also offer the industrial advantages such as easy separation.

关键词： Immobilization resin supported Ru catalyst hydrogenation CO2-expanded solvent.

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Ruthenium Bisphosphine Catalyst on Functionalized Silica: Novel Efficient Catalyst for Carbon Dioxide Hydrogenation to Formic Acid

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Chinese Chemical Letters 2006年第2期17卷 261-264页

作者： yi ping zhang Jin Hua FEI ying Min YU Xiao Ming ZHENG Institute of Catalysis Xixi Campus Zhejiang University Hangzhou 310028 Department of Chemistry Zhcjiang Education Institute Hangzhou 310012

A novel efficient catalyst for the hydrogenation of carbon dioxide to formic acid ruthenium bisphosphine on functionalized silica was in situ synthesized, affording turnover frequency （TOF） of 1190 h^-1 at 100% selectivity under 80℃ with total pressure of 16.0 MPa. The catalyst can be separated from the reaction mixture easily and reused with moderate loss of activity.

关键词： Immobilized ruthenium silica bis（1,2-diphenylphosphino）ethane （dppe） formic acid.

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Intra-continental deformation and tectonic evolution of the West Junggar Orogenic Belt,Central Asia:Evidence from remote sensing and structural geological analyses

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Geoscience Frontiers 2020年第2期11卷 651-663页

作者： Wei-Cui Ding Ting-Dong Li Xuan-Hua Chen Jian-ping Chen Sheng-Lin Xu yi-ping zhang Bing Li Qiang Yang School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China SinoProbe Center Chinese Academy of Geological Sciences and China Geological SurveyBeijing 100037China Center for Hydrogeology and Environmental Geology CGSBaodingHebei 071051China

The West Junggar Orogenic Belt(WJOB)in northwestern Xinjiang,China,is located in the core of the western part of the Central Asian Orogenic Belt(CAOB).It has suffered two stage tectonic evolutions in Phanerozoic,before and after the ocean–continental conversion in Late Paleozoic.The later on intracontinental deformation,characterized by the development of the NE-trending West Junggar sinistral strike-slip fault system(WJFS)since Late Carboniferous and Early Permian,and the NW-trending Chingiz-Junggar dextral strike-slip fault(CJF)in Mesozoic and Cenozoic,has an important significance for the tectonic evolution of the WJOB and the CAOB.In this paper,we conduct geometric and kinematic analyses of the WJOB,based on field geological survey and structural interpretation of remote sensing image data.Using some piercing points such as truncated plutons and anticlines,an average magnitude of^73 km for the left-lateral strike-slip is calculated for the Darabut Fault,a major fault of the WJFS.Some partial of the displacement should be accommodated by strike-slip fault-related folds developed during the strike-slip faulting.Circular and curved faults,asymmetrical folds,and irregular contribution of ultramafic bodies,implies potential opposite vertical rotation of the Miao’ergou and the Akebasitao batholiths,resulted from the sinistral strike-slipping along the Darabut Fault.Due to conjugate shearing set of the sinistral WJFS and the dextral CJF since Early Mesozoic,superimposed folds formed with N–S convergence in southwestern part of the WJOB.

关键词： Remote sensing Structural analysis Strike-slip fault system Darabut fault West Junggar Central Asian orogenic belt

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