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Sperm banking for male reproductive preservation： a 6-year retrospective multi-centre study in China

Asian Journal of Andrology 2010年第3期12卷 356-362,I0009页

作者： Ping Ping Wen-Bing Zhu Xin-Zong Zhang Kang-Shou yao Peng Xu yi-Ran Huang Zheng Li Department of Urology Shanghai Human Sperm Bank Shanghai Institute of Andrology Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200001 China Instinrte of Human Reproduction and Stem Cell Engineering Human Sperm Bank Central South University Changsha 410078 China Zhejiang Institute of Planned Parenthood Research ＆ Zhejiang Human Sperm Bank Hangzhou 310012 China jinghua Hospital Shenyang East Group Shenyang Reproductive Medicine Centre Shenyang 110005 China

Sperm banking can preserve male fertility effectively, but the current conditions of sperm cryopreservation in China have not been investigated. This retrospective investigation was based on data collected at multiple centres in China from January 2003 to December 2008. The collected data included urogenital history, indication for cryopreservation, semen parameters, use rate, type of assisted reproductive technique （ART） treatment and pregnancy outcome. The study population included 1 548 males who had banked their semen during the study period at one of the clinics indicated above. Approximately 1.9% （30/1 548） of the cryopreserved semen samples were collected from cancer patients; about 88.8% （1 374/1 548） of the patients had banked their semen for ART and 8.6% （134/1 548） had a male infertility disease （such as anejaculation, severe oligozoospermia and obstructive azoospermia）. The total use rate of cryopreserved semen was 22.7% （352/1 548）, with 119 live births. The cancer group use rate was 6.7% （2/30）, with one live birth by intracytoplasmic single sperm injection （ICSI）. The ART group use rate was 23.2% （319/1 374）, with 106 live births. The reproductive disease group use rate was 23.1% （31/134）, with 12 live births. The semen parameters in each category varied; the cancer patient and infertility disease groups had poor semen quality. In vitro fertilization （IVF） and ICSI were the most common ART treatments for cryopreserved sperm. Semen cryopreservation as a salvage method is effective, but in many conditions it is underutilized, especially in cancer patients. Lack of awareness, urgency of cancer treatment and financial constraints are the main causes of the low access rate. The concept of fertility preservation should be popularized to make better use of this medical service in China.

关键词： cancer cryopreservation infertility sperm

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Exploration of IRES Elements within the ORF of the Coxsackievirus B3 Genome

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Biomedical and Environmental Sciences 2022年第4期35卷 322-333页

作者： SONG Qin Qin LUO Xiao Nuan SHI Bing Tian LIU Mi SONG Juan XIA Dong XIA Zhi Qiang WANG Wen jun yao Hai Lan HAN jun State Key Laboratory of Infectious Disease Prevention and Control National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Molecular Immunology Laboratory Capital Institute of PediatricsBeijing 100020China

Objective This study aimed to identify internal ribosome entry sites(IRESs)in the open reading frame(ORF)of the Coxsackievirus B3(CVB3)*** The sequences of P1,P2,or P3 of the CVB3 genome or the truncated sequences from each antithymocyte globulin(ATG)to the end of the P1,P2,or P3 gene were inserted into the *** transfection,possible IRES-dependent green fluorescent protein(GFP)-fused proteins were detected by anti-GFP western *** sequences of possible IRESs were inserted into specific Fluc/Rluc bicistronic vectors,in which the potential IRESs were determined according to the Fluc/Rluc activity *** of Fluc and Rluc mRNA of the bicistronic vector was detected by *** After transfection of full length or truncated sequences of the P1,P2,or P3 plasmids,six GFPfused protein bands in P1,six bands in P2 and nine bands in P3 were detected through western *** IRESs in VP2(1461–1646 nt)and VP1(2784–2983 nt)of P1;one IRES in 2C(4119–4564 nt)of P2;and two IRESs in 3C(5634–5834 nt)and 3D(6870–7087 nt)of P3 were identified according to Fluc/Rluc activity *** cryptic promoter was also excluded by *** Five IRESs are present in the CVB3 coding region.

关键词： CVB3 ORF P1 P2 P3 IRESs

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Morphological Variation of Eutectic Carbide in Twin-Roll Casting Strip of W9Cr4Mo2

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Journal of Iron and Steel Research International 2003年第4期10卷 68-70页

作者： QIU yi-qing LUO Zong-an WANG jun-sheng LIU Xiang-hua WANG Guo-dong Northeastern University

The netlike eutectic carbide in twin-roll casting strip of W9Cr4V2 was dissolved and broken up gradually with increasing heating temperature during annealing *** all eutectic carbides exist in granular form with heating temperature up to 950 ℃.It is considered that the refining of lamellar spacing made it possible for eutectic carbide to be granulated.

关键词： annealing treatment heating temperature eutectic carbide twin-roll casting strip

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Biosynthesis of artemisinic acid in engineered Saccharomyces cerevisiae and its attractiveness to the mirid bug Apolygus lucorum

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Journal of Integrative Agriculture 2022年第10期21卷 2984-2994页

作者： TENG Dong LIU Dan-feng Khashaveh ADEL SUN Pei-yao GENG Ting ZHANG Da-wei ZHANG Yong-jun State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China Laboratory of Ecology and Evolutionary Biology Yunnan UniversityKunming 650091P.R.China Langfang Scientific Research Trial Station Institute of Plant ProtectionChinese Academy of Agricultural SciencesLangfang 065000P.R.China Institute of Plant Protection Gansu Academy of Agricultural SciencesLanzhou 730070P.R.China

Artemisia annua is an important preferred host of the mirid bug Apolygus lucorum in *** emitted from *** attract *** artemisinic acid of *** is a precursor of artemisinin that has been widely investigated in the Chinese herbal medicine ***,little is known at this point about the biological roles of artemisinic acid in regulating the behavioral trends of *** this study,we collected volatiles from *** at the seedling stage by using headspace solid phase microextraction(HS-SPME).Gas chromatography-mass spectrometry(GC-MS) analysis showed that approximately 11.03±6.00 and 238.25±121.67 ng hartemisinic acid were detected in volatile samples and milled samples,***,a key gene for artemisinic acid synthesis,the cytochrome P450 gene cyp71 av1,was expressed in engineered Saccharomyces cerevisiae to catalyze the production of artemisinic *** the addition of exogenous artemisinic alcohol or artemisinic aldehyde,artemisinic acid was identified as the product of the expressed *** electroantennogram(EAG) recordings,3-day-old adult *** showed significant electrophysiological responses to artemisinic alcohol,artemisinic aldehyde and artemisinic ***,3-day-old female bugs were significantly attracted by artemisinic acid and artemisinic alcohol at a concentration of 10 mmol L,whereas 3-day-old male bugs were attracted significantly by 10 mmol Lartemisinic acid and artemisinic *** propose that artemisinic acid and its precursors could be used as potential attractant components for the design of novel integrated pest management strategies to control ***.

关键词： artemisinic acid CYP71AV1 biosynthesis Apolygus lucorum electrophysiological responses behavioral trends

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青少年被动性社交网站使用、身体监控与身体羞耻的交叉滞后分析

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中国临床心理学杂志 2024年第1期32卷 193-197页

作者：张斌曾成伟熊思成陈芸侯思伟张安琪曾奕欣杨莹张淑君湖南中医药大学人文与管理学院心理系长沙410208 河南中医药大学第一附属医院郑州450000

目的:考察青少年被动性社交网站使用、身体监控与身体羞耻之间的关系。方法:采用被动性社交网站使用问卷、身体监控量表和身体羞耻量表对348名青少年进行为期一年的三阶段追踪调查,并使用交叉滞后模型和多组结构方程比较对数据进行分析... 详细信息

目的:考察青少年被动性社交网站使用、身体监控与身体羞耻之间的关系。方法:采用被动性社交网站使用问卷、身体监控量表和身体羞耻量表对348名青少年进行为期一年的三阶段追踪调查,并使用交叉滞后模型和多组结构方程比较对数据进行分析。结果:(1)前测被动性社交网站使用对后测身体监控有预测作用,前测身体监控对后测身体羞耻有预测作用,T1身体羞耻对T2身体监控有预测作用;(2)三者间的交叉滞后关系不存在显著的性别差异。结论:青少年被动性社交网站使用能直接预测身体监控,身体监控和身体羞耻存在循环作用关系。

关键词：被动性社交网站使用身体监控身体羞耻交叉滞后分析

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A retrospective study of electroencephalography burst suppression in children undergoing general anesthesia

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Pediatric Investigation 2021年第4期5卷 271-276页

作者： Zhengzheng Gao Jianmin Zhang Xiaoxue Wang Mengnan yao Lan Sun yi Ren Dongyu Qiu Department of Anesthesiology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Importance:In children,anesthesia dosages are based on population pharmacokinetics and patient hemodynamics rather than patient-specific brain *** function is highly susceptible to the effects of ***:The primary objective of this retrospective pilot study was to assess the prevalence of electroencephalography(EEG)burst suppression-a sign of deep anesthesia-in children undergoing general ***:We analyzed EEG in patients aged 1-36 months who received sevoflurane or propofol as the primary *** enrollment was stratified into two age groups:1-12 months and 13-36 *** suppression(voltage≤5.0 mV,lasting>0.5 seconds)was characterized by occurrence over anesthesia *** with patient demographics and anesthetics were ***:In total,54 patients(33 males and 21 females)were included in the study[age 11.0(5.0-19.5)months;weight 9.2(6.5-11.0)kg].The total prevalence of burst suppression was 56%(30/54).Thirty-three percent of patients experienced burst suppression during the surgical *** greatest proportion of burst suppression occurred during the induction *** burst suppression event occurrences(18/30)were observed in the patient under sevoflurane anesthesia(P=0.024).Virtually all patients who received propofol boluses had burst suppression(P=0.033).More burst suppression occurred in patients with hypotension(P<0.001).During the surgical phase,a younger age was associated with more burst suppression(P=0.002).Interpretation:EEG burst suppression was associated with younger age,inhalation anesthetics,propofol bolus,and lower arterial pressure.

关键词： Electroencephalography(EEG) Burst suppression General anesthesia Children

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Brain motor control function in a patient with subacute, ncomplete, asymmetrical spinal cord injury

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Chinese Medical Journal 2010年第13期123卷 1812-1814页

作者： LIU Shu-jia WANG yi WEI Peng-xu XU Jian-min LI Jian-jun Department of Spine and Spinal Injury Surgery China Rehabilitation Research Center Capital Medical University School of Rehabilitation Medicine Beijing 100068 China Department of Clinical Laboratory China Rehabilitation Research Center Capital Medical University School of Rehabilitation Medicine Beijing 100068 China Department of Traditional Chinese Medicine China Rehabilitation Research Center Capital Medical University School of Rehabilitation Medicine Beijing 100068 China Department of Radiology China Rehabilitation Research Center Capital Medical University School of Rehabilitation Medicine Beijing 100068 China

Spinal cord injury （SCI） is a major cause of disability. A serious consequence of SCI is the loss or partialloss of motor control. A number of therapies are currently being developed for restoring motor function in SCI patients. However, such approaches generally require intact neural motor systems for driving limb movements. There is evidence that SCI can generate such conditions in the brain,

关键词： motor control functional magnetic resonance imaging spinal cord injury

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Recent advances regarding the role of ABC subfamily C member 10(ABCC10) in the efflux of antitumor drugs

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Chinese Journal of Cancer 2014年第5期33卷 223-230页

作者： Rishil J.Kathawala yi-jun Wang Charles R.Ashby Jr Zhe-Sheng Chen Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s University

ABCC10,also known as multidrug-resistant protein 7(MRP7),is the tenth member of the C subfamily of the ATP-binding cassette(ABC) ***10 mediates multidrug resistance(MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor *** ABCC10 transporter is a 171-kDa protein that is localized on the basolateral cell ***10 is a broad-specificity transporter of xenobiotics,including antitumor drugs,such as taxanes,epothilone B,vinca alkaloids,and cytarabine,as well as modulators of the estrogen pathway,such as *** recent years,ABCC10 inhibitors,including cepharanthine,lapatinib,erlotinib,nilotinib,imatinib,sildenafil,and vardenafil,have been reported to overcome ABCC10-mediated *** review discusses some recent and clinically relevant aspects of the ABCC10 drug efflux transporter from the perspective of current chemotherapy,particularly its inhibition by tyrosine kinase inhibitors and phosphodiesterase type 5 inhibitors.

关键词：抗肿瘤药物家族酪氨酸激酶抑制剂外排多药耐药磷酸二酯酶转运体埃坡霉素

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MBE脱氧条件与InGaAs/InP APD性能的相关性

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红外与毫米波学报 2024年第1期43卷 63-69页

作者：郭子路王文娟曲会丹范柳燕诸毅诚王亚杰郑长林王兴军陈平平陆卫中国科学院上海技术物理研究所红外物理国家重点实验室上海200083 中国科学院大学北京100049 上海科技大学物质科学与技术学院上海201210 上海量子科学研究中心上海201315 复旦大学应用表面物理国家重点实验室和物理学系上海200438

InP基InGaAs/InP雪崩光电二极管(APD)对近红外光具有高敏感度,使其成为微弱信号和单光子探测的理想光电器件。然而随着先进器件结构越来越复杂,厚度尺寸从量子点到几微米不等,性能越来越受材料中晶格缺陷的影响和工艺条件的制约。采用... 详细信息

InP基InGaAs/InP雪崩光电二极管(APD)对近红外光具有高敏感度,使其成为微弱信号和单光子探测的理想光电器件。然而随着先进器件结构越来越复杂,厚度尺寸从量子点到几微米不等,性能越来越受材料中晶格缺陷的影响和工艺条件的制约。采用固态源分子束外延(MBE)技术分别在As和P气氛保护下对InP衬底进行脱氧处理并外延生长晶格匹配的In_(0.53)Ga_(0.47)As薄膜和APD结构材料。实验结果表明,As脱氧在MBE材料质量方面比P脱氧具有明显的优势,可获得陡直明锐的异质结界面,降低载流子浓度,提高霍尔迁移率,延长少子寿命,并抑制器件中点缺陷或杂质缺陷引起的暗电流。因此,As脱氧可以有效提高MBE材料的质量,这项工作优化了InP衬底InGaAs/InP外延生长参数和器件制造条件。

关键词：分子束外延 P/As切换异质界面扩散 InGaAs/InP雪崩光电二极管

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A review of the effect of tungsten alloying on the microstructure and properties of steels

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Tungsten 2023年第4期5卷 440-466页

作者： jun-Jie Lian Xiao-Guang Ma Zheng-yi Jiang Chong Soo Lee Jing-Wei Zhao College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan030024China Engineering Research Center of Advanced Metal Composites Forming Technology and Equipment Ministry of EducationTaiyuan030024China Taiyuan University of Technology-University of Wollongong(TYUT-UOW)Joint Research Center Taiyuan University of TechnologyTaiyuan030024China School of Mechanical MaterialsBiomedical and Mechatronic EngineeringUniversity of WollongongWollongongNSW2522Australia TYUT‑UOW Joint Research Center University of WollongongWollongongNSW2522Australia Graduate Institute of Ferrous and Energy Materials Technology Pohang University of Science and TechnologyPohang37673South Korea

With the continuous development of science and technology,the increasingly severe service environment makes people put forward higher requirements for the performance of alloy *** has unique properties such as excellent strength,high density and good hardness,and its addition as an alloying element will change the properties of alloy *** paper aims to summarize the effect of the addition of tungsten on the micro structure and mechanical properties of alloy *** background of research and application of tungsten alloyed steel is presented ***,the preparation methods of tungsten alloyed steel are ***,the effect of tungsten incorporation on the microstructure of alloy steel is ***,the effects of tungsten addition on the mechanical properties,corrosion resistance and hydrogen embrittlement resistance of the alloy steel are *** review provides an outlook on the development of tungsten alloyed steel,which will stimulate more in-depth research and ultimately promote the practical application of tungsten alloyed steel.

关键词： Tungsten Alloy steel Microstructure Properties

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