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Interface Design Strategy for GNS/AZ91 Composites with Semi-Coherent Structure

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 467-483页

作者： jing-Peng Xiong yi-Qi Zeng Jin-Long Liu Wei-Cheng Wang Lan Luo Yong Liu Key Laboratory of Lightweight and High Strength Structural Materials of Jiangxi Province School of Advanced ManufacturingNanchang UniversityNanchang 330031China School of Physics and Materials Science Nanchang UniversityNanchang 330031China

The interfacial structure plays an important role in the mechanical properties of magnesium matrix composite(MMCs)reinforced with graphene nanosheet(GNS)due to their poor wettability with the Mg *** interface design strategy was proposed to form the semi-coherent interfacial structure with superior bonding *** lattice mismatch and interfacial bonding strength between Mg/rare earth oxide/carbon were utilized as key characteristics to evaluate the interfacial *** oxide(La2O3)was selected as the intermediate candidate due to its low lattice mismatch and high interfacial bonding *** identify the interfacial structure of Mg/La2O3/graphene,first-principles calculations were conducted to calculate the ideal work of separation and electronic structure of the *** demonstrated the presence of strong ionic and covalent interactions at the interface,which theoretically verified the strong interfacial bonding strength among Mg/La2O3/graphene *** experimentally validate the interface strength,MMCs with the interface structure of Mg/La2O3/GNS were *** formation of in-situ La2O3 led to the successful attainment of semi-coherent structures between Mg/La2O3 and La2O3/GNS,resulting in high strength and good ductility of the ***,this work proposes a new approach to interface design in MMCs with an enhancement of mechanical properties.

关键词： Interface design strategy Magnesium matrix composite Graphene nanosheets Semi-coherent interface Mechanical properties

Expanding the horizons of targeted protein degradation:A non-small molecule perspective

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2402-2427页

作者： Xiaowei Huang Fengbo Wu jing Ye Lian Wang Xiaoyun Wang Xiang Li Gu he Department of Pharmacy and Department of Dermatology&Venerology West China HospitalSichuan UniversityChengdu 610041China Department of Urology West China HospitalSichuan UniversityChengdu 610041China Laboratory of Dermatology Clinical Institute of Inflammation and ImmunologyFrontiers Science Center for Disease-Related Molecular Network and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Targeted protein degradation(TPD)represented by proteolysis targeting chimeras(PROTACs)marks a significant stride in drug discovery.A plethora of innovative technologies inspired by PROTAC have not only revolutionized the landscape of TPD but have the potential to unlock functionalities beyond ***-small-molecule-based approaches play an irreplaceable role in this field.A wide variety of agents spanning a broad chemical spectrum,including peptides,nucleic acids,antibodies,and even vaccines,which not only prove instrumental in overcoming the constraints of conventional small molecule entities but also provided rapidly renewing *** we summarize the burgeoning non-small molecule technological platforms inspired by PROTACs,including three major trajectories,to provide insights for the design strategies based on novel paradigms.

关键词： Targeted protein degradation Proteolysis targeting chimera Endocytosis Autophagy Proximity-inducing modality Post-translational modification

GametesOmics:A Comprehensive Multi-omics Database for Exploring the Gametogenesis in Humans and Mice

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 121-130页

作者： Jianting An jing Wang Siming Kong Shi Song Wei Chen Peng Yuan Qilong he yidong Chen Ye Li yi Yang Wei Wang Rong Li Liying Yan Zhiqiang Yan Jie Qiao State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Key Laboratory of Assisted Reproduction Ministry of EducationPeking UniversityBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100871China Beijing Advanced Innovation Center for Genomics Beijing 100191China

Gametogenesis plays an important role in the reproduction and evolution of *** transcriptomic and epigenetic alterations in this process can influence the reproductive capacity,fertilization,and embryonic *** rapidly increasing single-cell studies have provided valuable multi-omics ***,data from different layers and sequencing platforms have not been uniformed and integrated,which greatly limits their use for exploring the molecular mechanisms that underlie oogenesis and ***,we develop GametesOmics,a comprehensive database that integrates the data of gene expression,DNA methylation,and chromatin accessibility during oogenesis and spermatogenesis in humans and *** provides a user-friendly website and various tools,including Search and Advanced Search for querying the expression and epigenetic modification(s)of each gene;Tools with Differentially expressed gene(DEG)analysis for identifying DEGs,Correlation analysis for demonstrating the genetic and epigenetic changes,Visualization for displaying single-cell clusters and screening marker genes as well as master transcription factors(TFs),and MethylView for studying the genomic distribution of epigenetic *** also provides Genome Browser and Ortholog for tracking and comparing gene expression,DNA methylation,and chromatin accessibility between humans and *** offers a comprehensive resource for biologists and clinicians to decipher the cell fate transition in germ cell development,and can be accessed at http://***/.

关键词： Gametogenesis Oogenesis Spermatogenesis Transcriptomics Epigenomics

FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury

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Military Medical Research 2024年第4期11卷 521-542页

作者： Mi Zhou Yang-Wu-Yue Liu Yu-Hang he jing-Yu Zhang Hao Guo Hao Wang Jia-Kui Ren yi-Xun Su Teng Yang Jia-Bo Li Wen-Hui he Peng-Jiao Ma Man-Tian Mi Shuang-Shuang Dai Department of Biochemistry and Molecular Biology School of Basic MedicineArmy Medical UniversityChongqing 400038China Research Center for Nutrition and Food Safety Chongqing Key Laboratory of Nutrition and HealthInstitute of Military Preventive MedicineArmy Medical UniversityChongqing 400038China Department of Neurosurgery Daping HospitalArmy Medical UniversityChongqing 400042China Department of Trauma and Emergency Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Histology and Embryology Chongqing Key Laboratory of NeurobiologyBrain and Intelligence Research Key Suyixun Laboratory of Chongqing Education CommissionArmy Medical UniversityChongqing 400038China Research Center Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhen 518107GuangdongChina

Background:Neutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury(TBI).However,the heterogeneity,multifunctionality,and time-dependent modulation of brain damage and outcome mediated by neutrophils after TBI remain poorly ***:Using the combined single-cell transcriptomics,metabolomics,and proteomics analysis from TBI patients and the TBI mouse model,we investigate a novel neutrophil phenotype and its associated effects on TBI outcome by neurological deficit scoring and behavioral *** also characterized the underlying mechanisms both invitro and invivo through molecular simulations,signaling detections,gene expression regulation assessments[including dual-luciferase reporter and chromatin immunoprecipitation(ChIP)assays],primary cultures or co-cultures of neutrophils and oligodendrocytes,intracellular iron,and lipid hydroperoxide concentration measurements,as well as forkhead box protein O1(FOXO1)conditional knockout ***:We identified that high expression of the FOXO1 protein was induced in neutrophils after TBI both in TBI patients and the TBI mouse *** of these FOXO1high neutrophils in the brain was detected not only in the acute phase but also in the chronic phase post-TBI,aggravating acute brain inflammatory damage and promoting late TBI-induced *** the acute stage,FOXO1 upregulated cytoplasmic Versican(VCAN)to interact with the apoptosis regulator B-cell lymphoma-2(BCL-2)-associated X protein(BAX),suppressing the mitochondrial translocation of BAX,which mediated the antiapoptotic effect companied with enhancing interleukin-6(IL-6)production of FOXO1high *** the chronic stage,the“FOXO1-transferrin receptor(TFRC)”mechanism contributes to FOXO1high neutrophil ferroptosis,disturbing the iron homeostasis of oligodendrocytes and inducing a reduction in myelin basic protein,which contributes to the progression of late depression afte

关键词： Traumatic brain injury(TBI) Neutrophil Forkhead box protein O1(FOXO1) Acute stage Chronic stage

Particle Swarm Optimization Bat Algorithm Path Automatically Planning Research for Police Drones in Hilly Cities

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Journal of Systems Science and Information 2024年第1期12卷 125-144页

作者： jing XUE Zefu TAN Nina DAI Guoping LEI Chao he Chongqing Three Gorges University Chongqing 404020China

Mountain cities are complex asymmetric dynamic network architectures,and the flight of UAVs in this environment is subject to various constraints,while efficiency is a crucial factor in the trajectory planning of police UAVs,which need to maintain high efficiency and safe flight paths between their starting and ending points,but the traditional trajectory planning method cannot meet the requirements of rapid maneuvering of police *** achieve this,a 3D terrain map is built,an objective function is established for the flight cost in the UAV trajectory planning process,and a planning algorithm called particle swarm optimization bat algorithm(PSOBA)is *** combines the characteristics of the bat algorithm(BA)and the particle swarm optimization algorithm(PSO)to improve population diversity and resolve the delayed convergence issue in the last phases of *** results show that PSOBA is more effective than BA,with a search time for the best solution that is approximately 20.43%shorter and a convergence value of the objective function that is approximately 38%*** is also able to plan a quicker,shorter,and safer flight path compared to other trail planning algorithms that enhance the bat *** findings suggest that PSOBA is a powerful algorithm with potential application value in UAV trajectory planning control in the mobile intelligence *** to the service of public social security.

关键词： hilly cities police drones asymmetrical trajectory planning particle swarm bat algorithm

Design and preparation of highly crystalline K-intercalated W@PCN:an efficient material for aniline elimination

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Rare Metals 2024年第3期43卷 1337-1342页

作者： Hao-Fei Li Kai-Wen Yu Xiao-Bi jing Lei Duan yi-Yang Zhang School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou225002China School of Mechanical Engineering Yangzhou UniversityYangzhou225127China School of Material Science and Engineering Huazhong University of Science and TechnologyWuhan430071China School of Chemical Engineering and Materials Changzhou Institute of TechnologyChangzhou213032China Department of Basic Courses Army Engineering University of PLANanjing211101China

In this paper,we designed and prepared the polymeric carbon nitride-supported tungsten(W@PCN)*** were employed as the catalysts for photocatalytic oxidation of aniline in *** the process,H_(2)O_(2)was initially generated via the PCN-catalyzed *** by supported tungsten,aniline was oxidized by the in situ generated H_(2)O_(2)to obtain less toxicpoly aniline.

关键词： materials aniline crystalline

Bacterial and cancerous cell membrane fused liposome coordinates with PD-L1 inhibitor for cancer immunotherapy

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Nano Research 2024年第9期17卷 8389-8401页

作者： Xianjin Luo Chenglong Li Zhaofei Guo Hairui Wang Penghui he Yuanhao Zhao yi Lin Chunting he yingying Hou Yongshun Zhang Guangsheng Du Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610064China Pharmaceutical Biotechnology Department of PharmacyLMU MunichButenandt Strasse 5-13Munich 81377Germany Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing 100871China

Although tumor cell membranes with broad-spectrum antigens have been explored for cancer vaccines for decades,their relatively poor capacity to stimulate immune responses,especially cellular immune responses,has limited their ***,we presented a novel bacterial and cancerous cell membrane fusogenic liposome for co-delivering cell membrane-derived antigens and ***,a programmed death-ligand 1(PD-L1)inhibitor,JQ-1,was incorporated into the formulation to tackle the up-regulated PD-L1 expression of antigen-presenting cells(APCs)upon vaccination,thereby augmenting its anti-tumor *** fusogenic liposomes demonstrated significantly improved cellular uptake by APCs and effectively suppressed PD-L1 expression in bone marrow-derived dendritic cells(BMDCs)in *** subcutaneous vaccination,the nano-vaccines efficiently drained to the tumor-draining lymph nodes(TDLNs),and significantly inhibited PD-L1 expression of both dendritic cells(DCs)and macrophages within the TDLNs and *** a result,the liposomal vaccine induced robust innate and cellular immune responses and inhibited tumor growth in a colorectal carcinoma-burden mouse *** summary,the fabricated cell membrane-based fusogenic liposomes offer a safe,effective,and easily applicable strategy for tumor immunotherapy and hold potential for personalized cancer immunotherapy.

关键词： fusogenic liposome tumor cell membrane adjuvant programmed death-ligand 1(PD-L1)inhibitor tumor draining lymph nodes

Numerical study of submerged bending vegetation under unidirectional flow

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Water Science and Engineering 2024年第1期17卷 92-100页

作者： Pei-pei Zhang yi-qing Gong Ken Vui Chua Jie Dai jing-qiao Mao College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China Institute of Water Science and Technology Hohai UniversityNanjing 210098China School of Engineering Cardiff UniversityCardiff CF243AAUK

Submerged vegetation commonly grows and plays a vital role in aquatic ecosystems,but it is also regarded as a barrier to the passing *** simulations of flow through and over submerged vegetation were carried out to investigate the effect of vegetation density on flow *** simulations were computationally set up to replicate flume experiments,in which vegetation was mimicked with flexible plastic *** fluid-structure interaction between flow and flexible vegetation was solved by coupling the two modules of the COMSOL *** cases with different vegetation densities were simulated,and the results were successfully validated against the experimental *** contours of the simulated time-averaged streamwise velocity and Reynolds stress were extracted to highlight the differences in mean and turbulent flow *** turbulence intensity was found to be more sensitive to vegetation density than the time-averaged *** developing length increased with the spacing between *** snapshots of the bending vegetation under instantaneous velocity and vorticity revealed that flexible vegetation responded to the effects of eddies in the shear layer by swaying *** first two rows of vegetation suffered stronger approaching flow and were prone to more streamlined *** addition,the origin of tip vortices was investigated via the distribution of *** results reveal the variation of flow properties with bending submerged vegetation and provide useful reference for optimizationofrestorationprojects.

关键词： Computational fluid dynamics Fluid-structure interaction Turbulence Flexible and submerged vegetation

General radical difluoromethylation using difluoroacetic anhydride via photoredox catalysis

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Science China Chemistry 2024年第8期67卷 2637-2646页

作者： Meng he Yankai Yang heng Zhang Zhipeng Guan Zhi-Bing Dong Hong yi Aiwen Lei School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430205China College of Chemistry and Molecular Sciences and Institute for Advanced Studies(IAS) Wuhan UniversityWuhan 430072China

CF_(2)H-containing molecules play pivotal roles in diverse fields from medicinal chemistry to materials science. However, the application of existing CF_(2)H reagents as a source of CF_(2)H radical is limited by their reactivity and preparation. herein, we develop a simple and general visible-light-catalyzed radical difluoromethylation reaction of alkenes, dienes, and heteroaromatics using commercially available, easy-to-handle, and low-cost difluoroacetic anhydride as the CF_(2)H reagent. This scalable protocol enables the convenient synthesis of a range of CF_(2)H-containing compounds under mild conditions, exhibiting a broad substrate scope and functional group tolerance. Potential applications are further demonstrated by gram-scale synthesis, sunlight experiments, derivatization experiments as well as the synthesis of bioactive molecules.

关键词： radical difluoromethylation alkenes/dienes/heteroaromatics difluoroacetic anhydride photoredox