GametesOmics:A Comprehensive Multi-omics Database for Exploring the Gametogenesis in Humans and Mice
作者机构：State Key Laboratory of Female Fertility PromotionCenter for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Key Laboratory of Assisted ReproductionMinistry of EducationPeking UniversityBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive TechnologyBeijing 100191China Peking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China Beijing Advanced Innovation Center for GenomicsBeijing 100191China
出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)
年 卷 期：2024年第22卷第1期
页 面：121-130页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种]
基 金：supported by the National Natural Science Foundation of China(Grant Nos.82125013 and 82101741) the National Key R&D Program of China(Grant No.2019YFA0801400) the Beijing Natural Science Foundation,China(Grant No.7232203) The authors thank Professor Fan Guo for providing detailed information about their previous study and Doctors Tong Chen and Pu Xue(EHBIO Gene Technology)for their technical assistance
主 题：Gametogenesis Oogenesis Spermatogenesis Transcriptomics Epigenomics
摘 要：Gametogenesis plays an important role in the reproduction and evolution of *** transcriptomic and epigenetic alterations in this process can influence the reproductive capacity,fertilization,and embryonic *** rapidly increasing single-cell studies have provided valuable multi-omics ***,data from different layers and sequencing platforms have not been uniformed and integrated,which greatly limits their use for exploring the molecular mechanisms that underlie oogenesis and ***,we develop GametesOmics,a comprehensive database that integrates the data of gene expression,DNA methylation,and chromatin accessibility during oogenesis and spermatogenesis in humans and *** provides a user-friendly website and various tools,including Search and Advanced Search for querying the expression and epigenetic modification(s)of each gene;Tools with Differentially expressed gene(DEG)analysis for identifying DEGs,Correlation analysis for demonstrating the genetic and epigenetic changes,Visualization for displaying single-cell clusters and screening marker genes as well as master transcription factors(TFs),and MethylView for studying the genomic distribution of epigenetic *** also provides Genome Browser and Ortholog for tracking and comparing gene expression,DNA methylation,and chromatin accessibility between humans and *** offers a comprehensive resource for biologists and clinicians to decipher the cell fate transition in germ cell development,and can be accessed at http://***/.
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