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Synthesis and Pharmacological Evaluation of Novel Conjugates of Indomethacin with Antioxidant Activity

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Chinese Journal of Chemistry 2005年第11期23卷 1523-1529页

作者： ZHANG, yi-Chun chen, Ping-tao GUAN, Hua-Shi LI, ying-Xia Key Laboratory of Marine Drugs The Ministry of Education of China Marine Drug and Food Institute Ocean University of China Qingdao Shandong 266003 China

A series of new conjugates of indomethacin with phenolic anfioxidants were synthesized for enhanced antiinflammatory activity as well as reduced ulcerogenic potency. It was found that all conjugates were very potent antioxidants in vitro. They could inhibit lipid peroxidafion significantly, while 11b-11e and 13b-13e could also interact with DPPH. However these conjugates showed little inhibition against croton oil induced mouse ear swelling.

关键词： antioxidant indomethacin antiinflammation conjugate nonsteroidal antiinflammatory drugs (NSAID)

CHARACTERIZATION OF IMPACT POLYPROPYLENE COPOLYMERS BY SOLVENT FRACTIONATION

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Chinese Journal of Polymer Science 2012年第1期30卷 122-129页

作者： Xiao-ying Lu Jian-jun yi Shang-tao chen Feng-hua Zu Rong-bo Li Petrochina-Petrochemical Research Institute Being 100195 China

The compositional heterogeneity of two impact polypropylene copolymers（IPCs） was studied by a combinatory investigation of temperature rising elution fractionation（TREF） and solvent *** chain structures and composition of fractions obtained from solvent fractionation were examined in *** TREF results shows that there are much more E-P segmented copolymer and more uniform distribution of ethylene sequence in IPC-1,which is responsible for its better comprehensive mechanical *** fractions from hexane and heptane are ethylene-propylene rubber phase and E-P block copolymers *** result of solvent fractionation method also shows that custom hexane or heptane extractions can not extract the E-P copolymer completely.

关键词： Fractionation Impact polypropylene copolymer Composition Chain structure

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二冬二母二草汤的化痰作用研究

中国实用医药 2024年第17期19卷 177-180页

作者：李惠惠袁维蔚陈奕涛陈洪惠州市中医医院 516000

目的研究二冬二母二草汤的化痰作用。方法选择50只KM小鼠,以10只为1组,随机分成5组,根据其给药不同将组名命名为空白对照组(蒸馏水);盐酸溴己新组(9.6 mg/kg);二冬二母二草汤组高剂量组(18.6 g生药/kg)、中剂量组(9.3 g生药/kg)、低剂量... 详细信息

目的研究二冬二母二草汤的化痰作用。方法选择50只KM小鼠,以10只为1组,随机分成5组,根据其给药不同将组名命名为空白对照组(蒸馏水);盐酸溴己新组(9.6 mg/kg);二冬二母二草汤组高剂量组(18.6 g生药/kg)、中剂量组(9.3 g生药/kg)、低剂量组(4.65 g生药/kg),分析二冬二母二草汤对小鼠气管酚红排泌的影响。选择50只英国种豚大鼠,以10只为1组,随机分成5组,根据其给药不同将组名命名为空白对照组(蒸馏水);盐酸溴己新组(5.6 mg/kg);二冬二母二草汤组高剂量组(18.6 g生药/kg)、中剂量组(9.3 g生药/kg)、低剂量组(4.65 g生药/kg),分析二冬二母二草汤对大鼠痰液的影响。结果KM小鼠实验中,二冬二母二草汤中剂量组、低剂量组和盐酸溴己新组的小鼠酚红浓度分别为(0.88±0.17)、(1.21±0.18)、(0.91±0.31)μg/ml,对比空白对照组的(0.71±0.16)μg/ml显著升高,差异具有统计学意义(P<0.05或<0.01或<0.001)。英国种豚大鼠实验中,二冬二母二草汤高剂量组、中剂量组、低剂量组和盐酸溴己新组的痰液长度分别为(13.95±6.05)、(19.61±7.83)、(17.02±5.20)、(16.12±5.03)cm,对比空白对照组的(7.09±2.87)cm显著延长,差异具有统计学意义(P<0.05或<0.01或<0.001)。结论二冬二母二草汤的化痰效果显著,可广泛用于治疗肺阴亏虚型咳嗽。

关键词：二冬二母二草汤化痰小鼠气管酚红排泌法大鼠毛细玻管法肺阴亏虚咳嗽

Hematite-facilitated microbial ammoxidation for enhanced nitrogen removal in constructed wetlands

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 35-45页

作者： Hao Qin Wenbo Nie Duo yi Dongxu Yang Mengli chen tao Liu yi chen Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment(Ministry of Education) Chongqing UniversityChongqing 400045China College of Environment and Ecology Chongqing UniversityChongqing 400045China Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 610031China

Constructed wetlands(CWs)are widely applied for decentralized wastewater ***,achieving efficient removal of ammonia(NH+-N)has proven challenging due to insufficient *** this study,natural hematite(Fe,O3)was employed as a CW substrate(H-CWs)for the first time to drive anaerobic ammonia oxidation coupled with iron(I)reduction(Feammox).Compared to gravel constructed wetlands(G-CWs),ammonia removal was enhanced by 38.14%to 54.03%and nitrous oxide(N_(2)0)emissions were reduced by 34.60%in *** synergistic removal of ammonia and nitrate by H-CWs also resulted in the absence of ammoxidation *** and 15N isotope tracer incubations showed that Feammox accounting for approximately 40%of all ammonia removal in the *** enrichment of iron phosphate(Fe_(3)Fe_(4)(PO_(4))_(6))promoted the accumulation of the Feammox intermediate compound *** nanowires were observed on the surface of H-CW substrates as well,suggesting that the observed biological ammoxidation was most likely related to extracellular electron transfer(EET).Microbial and metagenomics analysis revealed that H-CWs elevated the integrity and enhanced the abundance of functional microorganisms and genes associated with nitrogen ***,the efficient ammonia removal in the absence of O2 together with a reduction in N_(2)O emissions as described in this study may provide useful guidance for hematite-mediated anaerobic ammonia removal in CWs.

关键词： Constructed wetlands Nitrogen removal Feammox Hematite Iron cycle

A blockchain-empowered authentication scheme for worm detection in wireless sensor network

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Digital Communications and Networks 2024年第2期10卷 265-272页

作者： Yuling chen Xiong Yang tao Li yi Ren Yangyang Long State Key Laboratory of Public Big Data College of Computer Science and TechnologyGuizhou UniversityGuiyang550025China School of Computing Science University of East AngliaNorwichNR57TJUK

Wireless Sensor Network(WSN)is a distributed sensor network composed a large number of nodes with low cost,low performance and *** special structure of WSN brings both convenience and *** example,a malicious participant can launch attacks by capturing a physical ***,node authentication that can resist malicious attacks is very important to network ***,blockchain technology has shown the potential to enhance the security of the Internet of Things(IoT).In this paper,we propose a Blockchain-empowered Authentication Scheme(BAS)for *** our scheme,all nodes are managed by utilizing the identity information stored on the ***,the simulation experiment about worm detection is executed on BAS,and the security is evaluated from detection and infection *** experiment results indicate that the proposed scheme can effectively inhibit the spread and infection of worms in the network.

关键词： Wireless Sensor Network(WSN) Node authentication Blockchain Tangle Worm detection

NFHP-RN:AMethod of Few-Shot Network Attack Detection Based on the Network Flow Holographic Picture-ResNet

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 929-955页

作者： tao yi Xingshu chen Mingdong Yang Qindong Li yi Zhu School of Cyber Science and Engineering Sichuan UniversityChengdu610065China CyberScience Research Institute Sichuan UniversityChengdu610065China chengdu Fengwei Technology Co. Ltd.Chengdu610041China

Due to the rapid evolution of Advanced Persistent Threats(APTs)attacks,the emergence of new and rare attack samples,and even those never seen before,make it challenging for traditional rule-based detection methods to extract universal rules for effective *** the progress in techniques such as transfer learning and meta-learning,few-shot network attack detection has ***,challenges in few-shot network attack detection arise from the inability of time sequence flow features to adapt to the fixed length input requirement of deep learning,difficulties in capturing rich information from original flow in the case of insufficient samples,and the challenge of high-level abstract *** address these challenges,a few-shot network attack detection based on NFHP(Network Flow Holographic Picture)-RN(ResNet)is ***,leveraging inherent properties of images such as translation invariance,rotation invariance,scale invariance,and illumination invariance,network attack traffic features and contextual relationships are intuitively represented in *** addition,an improved RN network model is employed for high-level abstract feature extraction,ensuring that the extracted high-level abstract features maintain the detailed characteristics of the original traffic behavior,regardless of changes in background ***,a meta-learning model based on the self-attention mechanism is constructed,achieving the detection of novel APT few-shot network attacks through the empirical generalization of high-level abstract feature representations of known-class network attack *** results demonstrate that the proposed method can learn high-level abstract features of network attacks across different traffic detail *** state-of-the-artmethods,it achieves favorable accuracy,precision,recall,and F1 scores for the identification of unknown-class network attacks through cross-validation onmultiple datasets.

关键词： APT attacks spatial pyramid pooling NFHP(network flow holo-graphic picture) ResNet self-attention mechanism meta-learning

Localization of q-form fields on a de Sitter brane in chameleon gravity

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Frontiers of physics 2024年第3期19卷 11-18页

作者： yi Zhong tao-tao Sui School of Physics and Electronics Science Hunan UniversityChangsha 410082China Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Provinceand Key Laboratory of Quantum Theory and Applications of MoELanzhou UniversityLanzhou 730000China College of Physics Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Recently,it was found that the vector field can be naturally localized on the thick brane in chameleon *** this work,we extend this study to encompass de Sitter brane *** focus on the localization of q-form *** scalar and vector fields can be localized on the de Sitter brane,while the KR field cannot be *** condition for localization of the scalar and vector fields is ***,we investigate the localization characteristics in two examples with given conformal factor b(ϕ).In the first case,the effective potentials and KK modes of the matter fields are obtained asymmetric even though the de Sitter brane has Z2 *** the second case,volcano-like effective potentials are generated in the de Sitter brane model.

关键词： brane q-form field chameleon gravity

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风淬钢渣的微观结构变化研究

包钢科技 2024年第3期50卷 28-32页

作者：汪志勇朱宗建林春红陈儀涛中铁四局安徽中铁工程材料科技有限公司安徽合肥230041

通过观察风淬钢渣中各物相随时间的变化,利用Photoshop和Image J软件计算各物相的颗粒个数与面积,研究风淬钢渣的微观结构变化。结果发现,风淬钢渣的物相种类随时间不发生变化,衍射峰强度略有降低。渣中硅酸二钙相的颗粒个数随时间延长... 详细信息

通过观察风淬钢渣中各物相随时间的变化,利用Photoshop和Image J软件计算各物相的颗粒个数与面积,研究风淬钢渣的微观结构变化。结果发现,风淬钢渣的物相种类随时间不发生变化,衍射峰强度略有降低。渣中硅酸二钙相的颗粒个数随时间延长而明显减少,相的总面积变化很小。20天内,颗粒平均尺寸由4.96μm增长到6.06μm,而其他物相没有明显变化。可见,硅酸二钙颗粒尺寸的增大,不是由其他物相转变而来,而是其自身发生了重组现象。风淬钢渣中硅酸二钙的相变方程为1-(1-α)^(1/3)=0.039 T。

关键词：风淬钢渣微观结构硅酸二钙铁酸二钙重组

Organic heterostructures composed of one-and two-dimensional polymorphs for photonic applications

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Science China Chemistry 2020年第10期63卷 1477-1482页

作者： Yue Yu yi-chen tao Sheng-Nan Zou Zhi-Zhou Li Chang-Cun Yan Ming-Peng Zhuo Xue-Dong Wang Liang-Sheng Liao Department of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123China Department of Organic Optoelectronics Jiangsu Industrial TechnologyResearch Institute(JITR1)Wujiang 215211China

Organic heterostructures(OHSs)consist of organic micro/nanocrystals are of essential importance for the construction of integrated optoelectronics in the ***,the scarcity of materials and the problem of phase separation still hinder the fine synthesis of ***,based on theαphase one-dimensional(1D)microrods and theβphase 2D microplates of one organic compound 3,3′-((1 E,1′E)-anthracene-9,10-diylbis(ethane-2,1-diyl))dibenzonitril(m-B2BCB),we facilely synthesized the OHSs composed of these two polymorph phases,whose growth mechanism is attributed to the low lattice mismatch rate of5.8%between(001)plane ofαphase(trunk)and(010)crystal plane ofβphase(branch).Significantly,the multiport in/output channels can be achieved in the OHSs,which demonstrates the structure-dependent optical signals with the different output channels in the ***,our experiment exhibits the great prospect of polymorphism in OHSs,which could provide further applications on multifunctional organic integrated photonics circuits.

关键词： fine synthesis polymorph heterostructure integrated optoelectronics lattice mismatch